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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | World Gastroenterology Organisation Global Guideline: Constipation—A Global Perspective显示文摘 | Greger Lindberg Saeed S. Hamid Peter Malfertheiner Ole Ostergaard Thomsen Luis Bustos Fernandez James Garisch Alan Thomson Khean-Lee Goh Rakesh Tandon Suliman Fedail Benjamin C.Y. Wong Aamir Ghafoor Khan Justus H. Krabshuis Anton LeMair | 2011 | Journal of Clinical Gastroenterology2011，，6： | 3 |
| 3 | Analytical Investigation of Soliton Solutions to Three Quantum Zakharov-Kuznetsov Equations显示文摘In the present paper, the two-dimensional quantum Zakharov-Kuznetsov(QZK) equation, three-dimensional quantum Zakharov-Kuznetsov equation and the three-dimensional modified quantum Zakharov-Kuznetsov equation are analytically investigated for exact solutions using the modified extended tanh-expansion based method. A variety of new and important soliton solutions are obtained including the dark soliton solution, singular soliton solution, combined dark-singular soliton solution and many other trigonometric function solutions. The used method is implemented on the Mathematica software for the computations as well as the graphical illustrations. | Rahmatullah Ibrahim Nuruddeen Khalid Suliman Aboodh Khalid K. Ali | 2018 | Communications in Theoretical Physics2018，70，10： | 2 |
| 4 | Changing patterns of hepatitis A prevalence within the Saudi population over the last 18 years显示文摘AIM: To determine the seroprevalence of Hepatitis A (HAV) amongst Saudi children and compare it with previously reported prevalence data from the same population. METHODS: A total of 1357 students were randomly selected between the ages of 16 and 18 years (689 males and 668 females) from three different regions of Saudi Arabia (Madinah, Al-Qaseem, and Aseer) and tested for anti-HAV-IgG. RESULTS: The overall prevalence of anti-HAV-IgG among the study population was 18.6%. There was no difference between males and females but there was a significant difference in the seroprevalence (P = 0.0001) between the three different regions, with Ma- dinah region showing the highest prevalence (27.4%). When classified according to socioeconomic status, lower class students had a prevalence of 36.6%, lower middle class 16.6%, upper middle class 9.6%, and up- per class 5.9% (P = 0.0001). Comparing the current study results with those of previous studies in 1989 and 1997 involving the same population, there was a marked reduction in the overall prevalence of HAV from 52% in 1989, to 25% in 1997, to 18.6% in 2008 (P < 0.0001). CONCLUSION: Over the last 18 years, there has been a marked decline in the prevalence of HAV in Saudi children and adolescents. The current low prevalence rates call for strict adherence to vaccination policies in high-risk patients and raises the question of a univer- sal HAV vaccination program. | Faleh Al Faleh Suliman Al Shehri Saleh Al Ansari Mohammed Al Jeffri Yaqoub Al Mazrou Ahmad Shaffi Ayman A Abdo | 2008 | World Journal of Gastroenterology2008，14，48： | 2 |
| 5 | Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism显示文摘 | Yuping Chen Steve S. Choi Gregory A. Michelotti Isaac S. Chan Marzena Swiderska-Syn Gamze F. Karaca Guanhua Xie Cynthia A. Moylan Francesca Garibaldi Richard Premont Hagir B. Suliman Claude A. Piantadosi Anna Mae Diehl | 2012 | Gastroenterology2012，，5： | 2 |
| 6 | MicroRNAs and JAK/STAT3 signaling:A new promising therapeutic axis in blood cancers显示文摘Blood disorders include a wide spectrum of blood-associated malignancies resulting from inherited or acquired defects.The ineffectiveness of existing therapies against blood disorders arises from different reasons,one of which is drug resistance,so different types of leukemia may show different responses to treatment.Leukemia occurs for a variety of genetic and acquired reasons,leading to uncontrolled proliferation in one or more cell lines.Regarding the genetic defects,oncogene signal transducer and activator of transcription(STAT)family transcription factor,especially STAT3,play an essential role in hematological disorders onset and progress upon mutations,dysfunction,or hyperactivity.Besides,microRNAs,as biological molecules,has been shown to play a dual role in either tumorigenesis and tumor suppression in various cancers.Besides,a strong association between STAT3 and miRNA has been reported.For example,miRNAs can regulate STAT3 via targeting its upstream mediators such as IL6,IL9,and JAKs or directly binding to the STAT3 gene.On the other hand,STAT3 can regulate miRNAs.In this review study,we aimed to determine the role of either microRNAs and STAT3 along with their effect on one another's activity and function in hematological malignancies. | Mehdi Sajjadi-Dokht Talar Ahmad Merza Mohamad Heshu Sulaiman Rahman Marwah Suliman Maashi Svetlana Danshina Navid Shomali Saeed Solali Faroogh Marofi Elham Zeinalzadeh Morteza Akbari Ali Adili Ramin Aslaminabad Majid Farshdousti Hagh Mostafa Jarahian | 2022 | Genes & Diseases2022，9，4： | 2 |
| 7 | Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking显示文摘 | Razao Issa Xiaoying Zhou Christothea M. Constandinou Jonathan Fallowfield Harry Millward-Sadler Marianna D.A. Gaca Emma Sands Ibnauf Suliman Nathan Trim Andreas Knorr Michael J.P. Arthur R.Christopher Benyon John P. Iredale | 2004 | Gastroenterology2004，，7： | 2 |
| 8 | Homocysteinein uremia-a puzzling and conflicting story 显示文摘 | Suliman ME Barany P Kalantar-Eadeh K | 2005 | Nephro Dial Transplant2005，20，1： | 1 |
| 9 | Distally based adipofascial flaps for dorsal foot and ankle soft tissue defects 显示文摘 | Suliman MT | 2007 | Foot Ankle Surg2007，46，6： | 1 |
| 10 | Co -regulation of nuclear respiratory factor - 1 by NFkappaB and CREBlinks LPS - induced inflammation to mitochondrial biogenesis显示文摘 | SULIMAN H B SWEENEY T E WITHERS C M | 2010 | J Cell Sci2010，123，15： | 1 |
| 11 | Stabilization mechanisms of water-in-crude oil emulsions显示文摘 | NOUR A H SULIMAN A HADOWM M | 2008 | Journal of Applied Sciences2008，8，8： | 1 |
| 12 | Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis显示文摘 | Suliman HB Welty-Wolf KE Carraway MS | 2004 | Cardiovascular Research2004，64，2： | 1 |
| 13 | Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochon- drial biogenesis显示文摘 | SULIMAN H B SWEENEY T E WITHERS C M | 2010 | J Cell Sci2010，123，15： | 1 |
| 14 | IL - 6 is associated with pituitary tumour invasiveness 显示文摘 | SULIMAN M BORG S KERRY K | 2001 | Endocrine Pathology2001，12，： | 1 |
| 15 | Novel Links between the Long Pentraxin 3,Endothelial Dysfunction,and Albuminuria in Early and Advanced Chronic Kidney Disease显示文摘 | Mohamed E Suliman Mahmut I Yilmaz Juan J Carrero | 2008 | Clin J Am Soc Nephrol2008，3，4： | 1 |
| 16 | Overestimation of advanced oxidation protein products in uremic plasma due to presence of triglycerides and other endogenous factors显示文摘 | valli A Suliman ME Meert N | 2007 | Clinica Chimica Acta2007，379，： | 1 |
| 17 | The dependence of UMOSFET characteristics and reliability on geometry and procession显示文摘 | Suliman S A Gollagunta N Trabzon L | 2001 | Semiconductor science and technology2001，，： | 1 |
| 18 | Total, free, and protein- bound sulphur amino acids in uremic patients显示文摘 | Suliman ME Anderstam B Lindholm B | 1997 | Nephrol Dial Transplant1997，12，12： | 1 |
| 19 | Nonsurgical cerebrospinal fluid rhinorrhea in invasive macroprolactinoma: incidence, radiologi- cal, and clinicopathological features 显示文摘 | Suliman S G Gurlek A Byrne J V | 2007 | J Clin Endocrinol Metab2007，92，10： | 1 |
| 20 | Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes显示文摘 | Piantadosi CA Suliman HB | 2012 | Biochim Biophys Acta2012，1820，4： | 1 |
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