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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | 多重复干旱循环对苗木气体交换和水分利用效率的影响显示文摘该文研究了多重复干旱循环对1年生北美短叶松和黑云杉苗木的气体交换速率及水分利用效率的影响.结果表明,多重复干旱循环对它们的气体交换(Cs,Pn,Tr)有显著影响(P<0.5),而对其水分利用效率(WUE)影响不大(P>0.1).尽管北美短叶松的气孔对轻度干旱胁迫不如黑云杉敏感,但是它对中度及严重干旱胁迫的敏感程度却高于黑云杉.在轻度及中度干旱胁迫下,北美短叶松的光合作用主要受非气孔因素的影响,而黑云杉则主要受气孔因素的影响.解除干旱胁迫后,黑云杉的气孔敏感性、光合能力及水分利用效率的恢复都要比北美短叶松更快.轻度的干旱胁迫锻炼可以帮助北美短叶松在更严重的干旱胁迫下保持固有而强劲的耐旱能力.然而,通过多重复干旱循环锻炼后,黑云杉在改善耐旱能力的强度方面大于北美短叶松. | 李吉跃 Blqk.,TJ | 1999 | 北京林业大学学报1999，21，3： | 45 |
| 3 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 4 | ASPECCT研究:帕尼单抗的疗效与西妥昔单抗相当显示文摘本研究中,参加试验的患者(来自北美,南美,欧洲,亚洲,非洲和澳大利亚治疗中心)年龄均在18岁以上,均为化疗难治性转移性结直肠癌,ECOG评分在2分或以下,KRAS外显子2的状态为野生型。使用计算机生成的随机序列,研究人员以1:1分配患者(按地理区域和ECOG评分进行分层)接受帕尼单抗(6 mg/kg,每2周一次)或西妥昔单抗(初始剂量为400 mg/m2,之后250 mg/m2,每周一次)治疗。 | Price TJ Peeters M Kim TW | 2014 | 中华结直肠疾病电子杂志2014，3，2： | 16 |
| 5 | 血管紧张素Ⅱ诱导的高血压所引起的T淋巴细胞活化与血管炎症的中枢和外周机制显示文摘研究者先前就发现,T淋巴细胞对血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)诱导的高血压的发生发展是必需的,但是,高血压发生过程中的T细胞活化机制尚不明确。该文研究者探讨了中枢神经系统和血压升高在AngⅡ导致的T细胞活化与血管炎症中的作用。 | 张玲玉 叶鹏 Marvar PJ Thabet SR Guzik TJ Lob HE McCann LA Weyand C Gordon FJ Harrison DG | 2010 | 中华高血压杂志2010，18，12： | 15 |
| 6 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 7 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 8 | 直接凝固注模成型SiC陶瓷──浆料凝固过程的研究显示文摘直接凝固注模成型是一种新的(准)净尺寸成型陶瓷部件的方法,本文主要研究了此方法的关键步骤一浆料凝固过程,高固相含量(>55vol%)浆料从可浇注的低粘度状态转变为有一定强度的凝固态(坯体)主要有两种方法,即增加浆料中的电解质浓度和移动浆料的pH值至等电点。 | 司文捷 Grau.,TJ | 1996 | 无机材料学报1996，11，1： | 8 |
| 9 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 10 | Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum显示文摘 | Yang PY Almofti MR Lu L Kang H Zhang J Li TJ Rui YC Sun LN Chen WS | 2006 | 第二军医大学学报2006，27，6： | 7 |
| 11 | MR电影成像验证早期家族性扩张型心肌病的状态参数显示文摘目的运用MRI显示核纤层蛋白A/C基因(LMNA)突变携带者心脏解剖结构和功能早期变化的特征,并建立一种分析和显示结果的工具。 | J.R.Koikkalainen M.Antila J.M.P.Ltjnen T.Heli K.Lauerma S.M.Kivist 周路遥 | 2008 | 国际医学放射学杂志2008，31，A06： | 7 |
| 12 | 外源维生素对植物生长和发育的调节作用显示文摘 | Oert.,TJ 熊礼明 | 1989 | 生物科学动态1989，，3： | 6 |
| 13 | 儿童危重症器官功能不全评分和功能预后的关系显示文摘目的儿童危重症常发生短期及长期致残致死事件,危重症患儿严重器官功能不全和院内病死率显著升高相关,但儿童器官功能不全评分做为危重症功能预后预测指标的能力尚未得到评估。设计一项前瞻性观察性队列研究数据进行二次分析。场所一家多学科、三级学术性PICU。 | Matics TJ Pinto NP Sanchez-Pinto N 方伯梁(译) 钱素云(校) | 2019 | 中国小儿急救医学2019，26，10： | 6 |
| 14 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 15 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 16 | HBeAg阴性慢性乙型肝炎患者血清HBV前C区的序列分析显示文摘 | 方钟燎 庄辉 杨进业 葛宪民 王学燕 龚健 李荣成 Ling R Harrison TJ | 2002 | 中华实验和临床病毒学杂志2002，16，1： | 3 |
| 17 | WONCA研究论文摘要汇编——患者安全素养干预对全科医学事故报道的影响:一项整群随机化试验显示文摘背景有益安全素养对有效提高患者安全性来说必不可少。目的评估两种患者安全素养干预对全科医学事故报道的影响。设计和地点使用混合方法进行一项整群随机化试验,在荷兰30所全科医学诊所进行患者安全素养问卷调查(干预1组)、以实践为基础的研讨会作为补充的问卷调查(干预2组)和无干预(控制组),研究这3种情况的效果。方法首要结局指标是全科医学事故报道数量,于研究开始和研究1年后进行评估。使用负二项式模型对数据进行分析。次要结局指标是质量、安全指标和安全素养。对安全素养问卷进行混合效果线性回归分析。结果干预1组与干预2组的全科医学事故报道数量均有所增长,分别增加了82个和224个。依据基线全科医学事故数量、诊所规模和认证状态进行调整,研究表明干预2组诊所全科医学事故报道数量是控制组诊所的42倍〔95%CI(9.81,177.50)〕,干预1组诊所全科医学事故报道数量是控制组诊所的5倍〔95%CI(1.17,25.49)〕。在随访调查中,3组患者安全素养员工感知方面比较,差异无统计学意义(P<0.05)。结论员工接受患者安全素养教育和进行相关讨论能够提高全科医学事故报道数量,增加相关团队智慧投入,有利于提高患者安全性。 | Verbakel NJ Langelaan M Verheij TJ 本刊编辑部 | 2015 | 中国全科医学2015，18，24： | 3 |
| 18 | Effect of polysaccharides of cassiae seeds on the intestinal microflora of piglets显示文摘 | Deng ZY Zhang JW Li J Fan YW Cao SW Huang RL Yin YL Yin, Yu-long Zhong HY Li TJ | 2007 | 中国生物学文摘2007，21，6： | 3 |
| 19 | AerMet100合金—现代航空工业的一种新型超高强度合金显示文摘 | McCa.,TJ 闫洪 | 1994 | 国外金属加工1994，，2： | 3 |
| 20 | The role of inflammation after acute stroke:utility of pursuing anti-adhesion molecule therapy显示文摘 | DeGraba TJ | 1998 | Neurology1998，51，3： | 2 |
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