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| 1 | Role of tissue microenvironment resident adipocytes in colon cancer显示文摘Colorectal cancer(CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment(TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors(angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, neoangiogenesis, evasion of immune surveillance and therapy resistance. Furthermore, adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells. Interestingly, a relationship between obesity and molecular variants in CRC has recently been identified. Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored. This editorial highlights the major findings related to crosstalk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression. Furthermore, we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells. This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression. | Maria Tabuso Shervanthi Homer-Vanniasinkam Raghu Adya Ramesh P Arasaradnam | 2017 | World Journal of Gastroenterology2017，23，32： | 6 |
| 2 | Protective Actions of Globular and Full-Length Adiponectin on Human Endothelial Cells: Novel Insights into Adiponectin-Induced Angiogenesis显示文摘 | Adya Raghu Tan Bee K Chen Jing Randeva Harpal S | 2012 | Journal of Vascular Research2012，，6： | 2 |
| 3 | Visfatin induces human endot helial VEGF and MMP22/9 production via MAPK and PI3K/Akt signalling pathways:novel insight s into visfatin induced angiogenesis显示文摘 | Adya R Tan BK Punn A | 2008 | Cardiovasc Res2008，78，2： | 1 |
| 4 | Omentin-1,a noveladipokine,is decreased in overweight insulin-resistantwomen with polycystic ovary syndrome:ex vivo and in vivoregulation of omentin-1 by insulin and glucose显示文摘 | Tan BK Adya R Farhatullah S | 2008 | Diabe-tes2008，57，4： | 1 |
| 5 | Identification of chemerin receptor (ChemR23) in human endothelial cells: Chemerin- induced endothelial angiogenesis显示文摘 | Kaur J Adya R Tan BK | 2010 | Biochem Biophys Res Commun2010，391，4： | 1 |
| 6 | Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signaling pathway:novel insights into visfatin-induced angiogenesis 显示文摘 | Adya R Tan BK Punn A | 2008 | Cardiovasc Res2008，78，2： | 1 |
| 7 | Pre-B cell colony enhancing factor(PBEF)/ visfatin induces secretion of MCP-1 in human endothelial cells: mle in visfatin induced angiogenesis 显示文摘 | Adya R Tan BK Chen J | 2009 | Athemsclerosis2009，205，1： | 1 |
| 8 | Visfatin induces human endothelial VEGF and MMP2/9 production via MAPK and P13K/ Akt signaling pathways:novel insights into visfatin-induced angiogenesis显示文摘 | Adya R Tan BK Puan A | 2008 | Cardiovase Res2008，78，2： | 1 |
| 9 | Identification of chemerin receptor (ChemR23) in human endotheli- al cells: chemerin-induced endothelial angiogenesis 显示文摘 | KAUR J ADYA R TAN B K | 2010 | Biochem Biophys Res Commun2010，391，： | 1 |
| 10 | Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways:novel insights into visfatin-induced angiogenesis显示文摘 | Adya R Tan BK Punn A | 2008 | Cardiovasc Res2008，78，2： | 1 |
| 11 | Metformin treatment may in-crease omentin levels in women with polycystic ovary syndrome 显示文摘 | Tan BK Adya R Farhatullah S | 2010 | Diabetes2010，59，12： | 1 |
| 12 | Characterization of anatomical features and silica distribution in rice husk using microscopic and micro-analytical techniques显示文摘 | Byung-Dae Park Seung Gon Wi Kwang Ho Lee Adya P. Singh Tae-Ho Yoon Yoon Soo Kim | 2003 | Biomass and Bioenergy2003，，3： | 1 |
| 13 | Omentin-1,a Novel Adipokine,is decreased in Overweight Insulin Resistant Women with the Polycys-tic Ovary Syndrome:ex vivo and in vivo Regulation of Omentin-1by Insulin and Glucose显示文摘 | Tan BK Adya R Farhatullah S | 2008 | Diabetes2008，57，： | 1 |
| 14 | Host carbon sources modulate cell wall architecture,drug resistance and virulence in a fungal pathogen 显示文摘 | Ene IV Adya AK Wehmeier S | 2012 | Cellular Microbiology2012，14，9： | 1 |
| 15 | Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways:novel insights into visfatin-induced angiogenesis显示文摘 | Adya R Tan BK Punn A et al | 2008 | Cardiovasc Res2008，78，2： | 1 |
| 16 | Metformin Treatment May Incr-ease Omentin-1Levels in Women With Polycystic Ovary Syndrome显示文摘 | Tan BK Adya R Farhatullah S | 2010 | Diabetes2010，59，： | 1 |
| 17 | Visfafin induces human endothelial VEGF and MMP-2/9 production via MAPK and P13K/Akt signalling pathways:novel insights into visfatin induced anglogenesis 显示文摘 | Adya R Tan BK Punn A | 2008 | Cardiovasc Res2008，78，2： | 1 |
| 18 | Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways:novel insights into visfatin-induced angiogenesis显示文摘 | Adya R Tan BK Punn A | 2008 | Cardiovasc Res2008，78，： | 1 |
| 19 | Identification of chemerin receptor (ChemR23) in human endothelial cells:Chemerin-induced endothelial angiogenesis显示文摘 | Kaur J Adya R Tan BK | | 0，，4： | 1 |
| 20 | Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis 显示文摘 | ADYA R TAN B K PUNN A | 2008 | Cardiovasc Res2008，78，2： | 1 |
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