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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | 乳腺管状小叶癌E-cadherin/cate-nin的表达显示文摘 | Esposito N N Chivukula M Dabbs D J 魏兵(摘译) 步宏(审校) | 2007 | 临床与实验病理学杂志2007，23，3： | 8 |
| 3 | Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model显示文摘 | Janaiah Kota Raghu R. Chivukula Kathryn A. O’Donnell Erik A. Wentzel Chrystal L. Montgomery Hun-Way Hwang Tsung-Cheng Chang Perumal Vivekanandan Michael Torbenson K. Reed Clark Jerry R. Mendell Joshua T. Mendell | 2009 | Cell2009，，6： | 2 |
| 4 | Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model显示文摘 | Kota J Chivukula R R O'Donnell K A | 2009 | Cell2009，137，6： | 1 |
| 5 | Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model显示文摘 | Kota J Chivukula RR O'Donnell KA | | Cell0，，： | 1 |
| 6 | Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin 显示文摘 | Dabbs D J Bhargava R Chivukula M | 2007 | Am J Surg Pathol2007，31，3： | 1 |
| 7 | Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model显示文摘 | Kota J Chivukula RR O'Donnell KA | 2009 | Cell2009，137，6： | 1 |
| 8 | Therapeutic microR- NA delivery suppresses tumorigenesis in a murine liver cancer model 显示文摘 | Kota J Chivukula RR O'Donnell KA | 2009 | Ce112009，137，6： | 1 |
| 9 | Therapeutic microR- NA delivery suppresses tumorigenesis in a murine liver cancer model 显示文摘 | Kota J Chivukula RR O'Donnell KA | 2009 | Cell2009，137，6： | 1 |
| 10 | Histogram thresholding by minimizing graylevel fuzziness 显示文摘 | Murthy Chivukula A Pal Sankar K | 1992 | Information Sciences (S0020-0255)1992，60，： | 1 |
| 11 | Limi- tations of the criteria used to diagnose histologic endometritis in epidemiologic pelvic inflammatory disease research 显示文摘 | Vicetti Miguel R D Chivukula M Krishnamurti U | 2011 | Pathol Res Pract2011，，： | 1 |
| 12 | The spectrum of morphomo-lecular abnormalities of the E - cadherin/catenin complex in pleomorphic lobular carcinoma of the breast 显示文摘 | Dabbs D J Kaplai M Chivukula M | 2007 | Appl Immunohistoehem Mol blorphol2007，15，3： | 1 |
| 13 | Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model显示文摘 | Kota J Chivukula RR O'Donnell KA | 2009 | Cell2009，137，6： | 1 |
| 14 | Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway显示文摘 | KENT OA CHIVUKULA RR MULLENDORE M | | 0，，24： | 1 |
| 15 | Limitations of the criteria used to diagnose histologic en- dometritis in epidemiologic pelvic inflammatory disease research显示文摘 | Vicetti Miguel RD Chivukula M Krishnamurti U | 2011 | Pathol Res Pract2011，207，11： | 1 |
| 16 | Therapeutic microRNAdelivery suppresses tumorigenesis in a murine liver cancer model 显示文摘 | Kota J Chivukula RR O Donnell KA | 2009 | Cell2009，137，6： | 1 |
| 17 | Outcomes After En- doscopic Port Surgery for Spontaneous Intracerebral Hemato- mas显示文摘 | Ochalski P Chivukula S Shin S | 2014 | J Neurol Surg A2014，75，3： | 1 |
| 18 | Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model显示文摘 | Kota J Chivukula RR O'Donnell KA | 2009 | Cell2009，137，6： | 1 |
| 19 | Therapeutic microR NA delivery suppresses tumorigenesis in a murine liver cancer model显示文摘 | Kota J Chivukula RR YDonnell KA | 2009 | Cell2009，137，6： | 1 |
| 20 | Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model 显示文摘 | Kota J Chivukula RR O'Donnell KA | 2009 | Cell2009，137，6： | 1 |
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