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| 1 | Topical application of platelet-rich plasma for diabetic foot ulcers: a systematic review显示文摘AIM To determine if topical application of platelet-rich plasma(PRP) to diabetic foot ulcers(DFUs) results in superior healing rates. METHODS A systematic review was registered with PROSPERO and performed using PRISMA guidelines. Level Ⅰ-Ⅳ investigations of topical PRP application in DFUs were sought in multiple databases including: MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials. The search terms used were 'platelet rich plasma', 'diabetes', 'ulcers', and 'wound'. The Modified Coleman Methodology Score(MCMS) was used to analyze study methodological quality. Study heterogeneity and a mostly non-comparative nature of evidence precluded meta-analysis. Only the outcome measurements used by more than 50% of the studies were included in the data synthesis to increase power of the measurement over that of individual studies. A weighted mean of healing rate per week between PRP group vs controls were compared using two-sample z-tests using P-value of less than 0.05 for significance.RESULTS One thousand two hundred and seventeen articles were screened. Eleven articles(322 PRP subjects, 126 controls, PRP subject mean age 58.4 ± 7.2 years, control mean age 58.7 ± 5.9 years) were analyzed. Six articles were level Ⅱ evidence, four were level Ⅲ, and one article was level Ⅳ. The mean MCMS was 61.8 ± 7.3. Healing rate was significantly faster with PRP application compared to controls(0.68 ± 0.56 cm2/wk vs 0.39 ± 0.09 cm2/wk; P < 0.001). Mean heal time to > 90% of the original ulcer area was 7.8 ± 2.7 wk and 8.3 ± 3.7 wk for patients in the PRP group and control groups, respectively(P = 0.115). There were significantly lower adverse effects reported with PRP application compared to controls(7 wound infections, 1 contact dermatitis vs 14 wound infections, 1 maceration; P < 0.001).CONCLUSION The topical application of PRP for DFUs results in statistically superior healing rates and lower complication rates compared to controls. | Takashi Hirase Eric Ruff Salim Surani Iqbal Ratnani | 2018 | World Journal of Diabetes2018，9，10： | 6 |
| 2 | 建立初级卒中中心的修订和更新意见来自脑卒中联盟的总结声明显示文摘背景和目的自从2000年脑卒中联盟发布首份关于建立初级卒中中心的推荐意见以来,初级卒中中心的组建和认证工作已出现迅速发展。本文的目的在于修订和更新我们关于初级卒中中心的推荐意见以反映最新资料和经验。方法我们使用MEDLINE和PubMed数据库回顾了相关文献(2000年3月至2011年1月),主要针对急性卒中的诊断、治疗和护理。如果发现有效且相关,同样对原始文献、汇总分析和其他治疗指南进行回顾并纳入分析。标明证据等级以反映当前指南发展的实际情况。结果基于文献回顾以及针对初级卒中中心的经验,一些要素的重要性已得到进一步的加强,同时增加了几个新的领域。这些内容包括:(1)急诊卒中团队的重要性;(2)配备遥测监控的卒中单元的重要性;(3)MRj和弥散加权序列进行脑成像的实施;(4)用磁共振血管成像或CT血管成像对脑血管系统进行评价;(5)心脏影像学检查;(6)康复治疗的早期启动;(7)由独立机构进行的认证,包括实地考察和疾病评价指标。结论基于上述证据,初级卒中中心的某些要素对于改善急性卒中患者的诊治特别重要。其他要素则集中于脑、脑血管系统和心脏的影像学检查。这些新的要素也许能改善在初级卒中中心接受诊治的卒中患者的治疗和转归。 | Mark J. Alberts Richard E. Latchaw Andy Jagoda Lawrence R Wechsler Todd Crocco Mary G. George E.S. Connolly Barbara Mancini Stephen Prudhomme Daryl Gress Mary E. Jensen Robert Bass Robert Ruff Kathy Foell Rocco A. Armonda Marian Emr Margo Warren Jim Baranski Michael D. Walker 黄志超(译) 张霞(译) 尤寿江(译) 曹勇军(译) 刘春风(译) | 2012 | 国际脑血管病杂志2012，20，7： | 3 |
| 3 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 4 | Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery显示文摘 | Jaya Mishra Catherine Dent Ridwan Tarabishi Mark M Mitsnefes Qing Ma Caitlin Kelly Stacey M Ruff Kamyar Zahedi Mingyuan Shao Judy Bean Kiyoshi Mori Jonathan Barasch Prasad Devarajan | 2005 | The Lancet . 2005 (9466)2005，，： | 2 |
| 5 | Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry显示文摘 | Cédric Bovet Benoit Plet Marc Ruff Sylvia Eiler Florence Granger Andreas Panagiotidis Ryan Wenzel Alexis Nazabal Dino Moras Renato Zenobi | 2009 | Toxicology in Vitro2009，，4： | 2 |
| 6 | Formation and Function of Acute Stroke–Ready Hospitals Within a Stroke System of Care Recommendations From the Brain Attack Coalition显示文摘 | Mark J. Alberts Lawrence R. Wechsler Mary E. Lee Jensen Richard E. Latchaw Todd J. Crocco Mary G. George James Baranski Robert R. Bass Robert L. Ruff Judy Huang Barbara Mancini Tammy Gregory Daryl Gress Marian Emr Margo Warren Michael D. Walker | 2013 | Stroke2013，，12： | 2 |
| 7 | A wind erosion equation显示文摘 | Wood ruff N P Siddoway F H | 1965 | Proc Soil Sci Soc Am1965，，29： | 1 |
| 8 | Neurobehavioral outcome following minor head injury:a three-center study显示文摘 | Levin HS Mattis S Ruff RM | 1987 | J Neurosurg1987，66，： | 1 |
| 9 | Magnetic resonance imaging of coronary arteries and heart valves in a living mouse:techniques and preliminary results显示文摘 | Ruff J Wiesmann F Lanz T | 2000 | J Magn Reson2000，，146： | 1 |
| 10 | A CREB-C/ EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair 显示文摘 | Ruff ell D Mourkioti F Gambardella A | 2009 | Proc Natl Acad Sci U S A2009，106，17： | 1 |
| 11 | Human neutrophil activation and increased adhesion by various resuscitation fluids显示文摘 | Rhee P Wang D Ruff P | 2000 | Crit Care Med2000，28，1： | 1 |
| 12 | A phase II study of o- ral clofazimine in unresectable and metastatic hepatocellu- lar carcinoma 显示文摘 | Ruff P Chasen MR Long JE | 1998 | Ann Oncol1998，9，2： | 1 |
| 13 | Moderate lead poisoning: trends in blood lead levels in unchelated children显示文摘 | Markowitz ME Bijur PE Ruff HA | 1996 | Environ Health Perspect1996，104，： | 1 |
| 14 | CD4+ T cells depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract显示文摘 | Brench JM Schacker TW Ruff LE | 2004 | J Exp Med2004，200，： | 1 |
| 15 | Composition of heart, liver and skeletal muscle from broilers with coccidiosis显示文摘 | RUFF M D ALLEN P C CHUTE M B | 1981 | Poulty Sci1981，60，8： | 1 |
| 16 | Edoxaban versus warfarin in patients with atrial fibrillation显示文摘 | Giugliano RP Ruff CT Braunwald E | 2013 | N Engl J Med2013，369，22： | 1 |
| 17 | Ettlcacy and safety of edoxaban for themanagement of elderly patients with atrial fibrillation: ENGAGE AF-TIMI 48 显示文摘 | Kato ET Giugliano RP Ruff CT | 2014 | Circulation2014，130，16： | 1 |
| 18 | Chemokine receptor 5 antagonist d-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease显示文摘 | ROSI S PERT C B RUFF M R | 2005 | Neuroscience2005，134，2： | 1 |
| 19 | Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effec- tive aNticoaGulation with factor xA next GEneration in Atrial Fi- briliation-Thrombolysis In Myocardial Infarction study 48 ( EN- GAGE AF-TIMI48)显示文摘 | RUFF CT GIUGLIANO RP ANTMAN EM | 2010 | Am Heart J2010，160，4： | 1 |
| 20 | Demand response:reality versus''Resource''显示文摘 | RUFF L E | 2002 | The Electricity Journal2002，，12： | 1 |
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