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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | Epstein-Barr virus and Burkitt lymphoma显示文摘In 1964,a new herpesvirus,Epstein-Barr virus(EBV),was discovered in cultured tumor cells derived from a Burkitt lymphoma(BL)biopsy taken from an African patient.This was a momentous event that reinvigorated research into viruses as a possible cause of human cancers.Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B cells,and that all cases of BL carried characteristic chromosomal translocations resulting in constitutive activation of the c-MYC oncogene.These results hinted at simple oncogenic mechanisms that would make Burkitt lymphoma paradigmatic for cancers with viral etiology.In reality,the pathogenesis of this tumor is rather complicated with regard to both the contribution of the virus and the involvement of cellular oncogenes.Here,we review the current understanding of the roles of EBV and c-MYC in the pathogenesis of BL and the implications for new therapeutic strategies to treat this lymphoma. | Martin Rowe Leah Fitzsimmons Andrew I Bell | 2014 | Chinese Journal of Cancer2014，33，12： | 14 |
| 4 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 5 | Amine-silica composites for CO_2 capture: A short review显示文摘Amine-silica composite materials for post-combustion CO_2 capture have attracted considerable attention because of their high CO_2 uptake at low CO_2 concentrations, excellent CO_2 capture selectivity in the presence of moisture, and lower energy requirements for sorbent regeneration. This review discusses the recent advances in amine-silica composites for CO_2 capture, including adsorbent preparation and characterization, CO_2 capture under dry and moisture conditions at different CO_2 partial pressures, sorbent regeneration, and stability after many cyclic sorption-desorption runs. | Chao Chen Siqian Zhang Kyung Ho Row Wha-Seung Ahn | 2017 | Journal of Energy Chemistry2017，26，5： | 5 |
| 6 | Goldman, Andrea S., Opera and the City: The Politics of Culture in Beijing, 1770-1900. Stanford: Stanford University Press, 2012. ISBN 978-0-804-77831-2. 386pp. $55.00 (hardcover).显示文摘 | William T. Rowe | 2013 | Frontiers of History in China2013，8，3： | 5 |
| 7 | 第6篇:基于嵌入式操作系统的物联网安全显示文摘当今社会的很多商业行为,如通信、金融交易及娱乐在很大程度上依赖于互联网。随着越来越多的设备连接到物联网(IoT)中,对互联网的依赖性将不断增加。如果设备不安全,这种依赖将导致互联网存在重大的安全漏洞,并使设备遭到攻击和破坏。 | Rowebots Kim Rowe 张爱华 何小庆 | 2015 | 单片机与嵌入式系统应用2015，15，1： | 4 |
| 8 | PROPERTIES, WELDABILITY AND APPLICATIONS OF ADVANCED WROUGHT SUPERALLOYS FOR GAS TURBINE ENGINES显示文摘Alloy selection and alloy design both require consideration of an array of material attributes, including in-service properties, weldability and fabricability. Critical properties of advanced wrought superaUoys for gas turbine applications include high temperature strength, thermal stability, oxidation resistance and fatigue resistance. In this paper, the properties of twelve wrought solid-solution-strengthened and six age-hardenable superalloys are compared. Weldability is an important attribute and can be a major limiting factor in the use of certain alloys. Weldability test methods are discussed and the resistance of alloys to solidification cracking and strain-age cracking is compared. The use of weldability testing in the development of modern wrought superalloys is discussed with several examples cited. Finally, alloy selection for gas turbine components is outlined, taking into account both alloy properties and fabricability. | D.L. Klarstrom V.R. Ishwar M.D. Rowe | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，1： | 4 |
| 9 | Extraction of Catechin Compounds from Green Tea with a New Green Solvent显示文摘 | ZHANG Heng TANG Baokun ROW Kyungho | 2014 | Chemical Research in Chinese Universities2014，30，1： | 3 |
| 10 | AJCN:过敏症来袭怎么办?新型益生菌组合疗法显神效显示文摘当进入过敏季节我们可能并不太会拿出手帕或者打喷嚏来预防过敏。日前,一项刊登在国际杂志The American Journal of Clinical Nutrition上的研究报告中。来自佛罗里达大学的研究人员通过研究发现。一种益生菌组合或许能够帮助减轻花粉症的症状。 | Jennifer C Dennis-Wall Tyler Culpepper Carmelo Nieves Jr. Cassie C Rowe Alyssa M Burns Carley T Rusch Ashton Federico Maria Ukhanova Sheldon Waugh Volker Mai Mary C Christman Bobbi Langkamp-Henken | 2017 | 现代生物医学进展2017，17，18： | 3 |
| 11 | Accommodation of China's Industrial Heritage in Urban Conservation Practices (I) | Peter G. Rowe Har Ye Kan | 2012 | China City Planning Review2012，21，1： | 3 |
| 12 | PSMA配体的前列腺癌PET显像显示文摘近年来,用68Ga和18F标记PET显像剂靶向前列腺特异膜抗原(PSMA)逐渐受到重视。多项回顾性研究指出,与常规影像相比,PSMA配体前列腺癌PET/CT显像具有较高的检测效能,前列腺癌生化复发已被世界多个地区确立为PSMA配体前列腺癌PET/CT显像的临床适应证。对于高危原发前列腺癌,越来越多的证据表明该显像方式有助于探测隐匿性淋巴结和前列腺癌骨转移;对于原发和复发性前列腺癌的临床适应证,初步研究证实其对临床管理有着重要影响;另有证据表明,其对前列腺内的肿瘤定位、治疗分期和特定临床情况下的晚期病灶治疗监测将成为未来的适应证。随着有关生理性和病理性摄取模式和误区文献数量的剧增,PSMA配体PET显像报告的标准也在不断改进。文章旨在对PSMA配体PET显像的现状进行概述,包括显像程序和解释、临床适应证、诊断潜力及其对治疗计划的影响。 | 黎翔(译) 杨卫东(译) 汪静(审校) Sarah M.Schwarzenboeck Isabel Rauseher Christina Bluemel Wolfgang P.Fendler Steven P. Rowe Martin G.Pomper Ali Asfhar-Oromieh Ken Herrrnann Matthias Eiber | 2019 | 中华核医学与分子影像杂志2019，39，2： | 3 |
| 13 | Antioxidant therapy for chronic hepatitis C after failure of interferon:Results of phase Ⅱ randomized,double-blind placebo controlled clinical trial显示文摘AIM:TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus(HCV) infection. METHODS:One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo,or oral treatment alone. Primary end points were liver enzymes,HCV-RNA levels and histology. RESULTS:Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo(P= 0.05).Histology activity index(HAI)score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo(P=0.21).HCV-RNA levels decreased by 1-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo(P=NS).In partⅡof the trial,oral administration of antioxidants was not associated with significant alterations in any of the end points. CONCLUSION:Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients. | Ezra Gabbay Ehud Zigmond Orit Pappo Nila Hemed Mina Rowe George Zabrecky Robert Cohen Yaron Ilan | 2007 | World Journal of Gastroenterology2007，13，40： | 2 |
| 14 | Selective Solid-phase Extraction of Aloe Emodin from Aloe by Molecularly Imprinted Polymers显示文摘 | TIAN Ming-lei LEE Yu-ri PARK Dong-wha ROW Kyung-ho | 2013 | Chemical Research in Chinese Universities2013，29，4： | 2 |
| 15 | Pausing phenomena: Influence on the quality of instruction显示文摘 | Mary Budd Rowe | 1974 | Journal of Psycholinguistic Research1974，，3： | 2 |
| 16 | Characteristics of Missed or Interval Colorectal Cancer and Patient Survival: A Population-Based Study显示文摘 | N. Jewel Samadder Karen Curtin Thérèse M.F. Tuohy Lisa Pappas Ken Boucher Dawn Provenzale Kerry G. Rowe Geraldine P. Mineau Ken Smith Richard Pimentel Anne C. Kirchhoff Randall W. Burt | 2014 | Gastroenterology2014，，4： | 2 |
| 17 | A Predictive Model for Lymph Node Yield in Colon Cancer Resection Specimens显示文摘 | Garrett M. Nash David Row Alexander Weiss Jinru Shia Jose G. Guillem Philip B. Paty Mithat Gonen Martin R. Weiser Larissa K. Temple Garrett Fitzmaurice W. Douglas Wong | 2011 | Annals of Surgery2011，，2： | 2 |
| 18 | Geography of Talent in China During 2000-2015:An Eigenvector Spatial Filtering Negative Binomial Approach显示文摘The increase in China’s skilled labor force has drawn much attention from policymakers,national and international firms and media.Understanding how educated talent locates and re-locates across the country can guide future policy discussions of equality,firm localization and service allocation.Prior studies have tended to adopt a static cross-national approach providing valuable insights into the relative importance of economic and amenity differentials driving the distribution of talent in China.Yet,few adopt longitudinal analysis to examine the temporal dynamics in the stregnth of existing associations.Recently released official statistical data now enables space-time analysis of the geographic distribution of talent and its determinants in China.Using four-year city-level data from national population censuses and 1%population sample surveys conducted every five years between 2000 and 2015,we examine the spatial patterns of talent across Chinese cities and their underpinning drivers evolve over time.Results reveal that the spatial distribution of talent in China is persistently unequal and spatially concentrated between 2000 and 2015.It also shows gradually strengthened and significantly positive spatial autocorrelation in the distribution of talent.An eigenvector spatial filtering negative binomial panel is employed to model the spatial determinants of talent distribution.Results indicate the influences of both economic opportunities and urban amenities,particularly urban public services and greening rate,on the distribution of talent.These results highlight that urban economic-and amenity-related factors have simultaneously driven China’s talent’s settlement patterns over the first fifteen years of the 21st century. | GU Hengyu Francisco ROWE LIU Ye SHEN Tiyan | 2021 | Chinese Geographical Science2021，31，2： | 2 |
| 19 | Dupilumab治疗常年性变应性鼻炎并发哮喘患者的疗效和安全性显示文摘背景Dupilumab是一种抗IL-4受体α亚基的抗体,可以阻断IL-4/IL-13的信号转导。IL-4/IL-13是2型/Th2型免疫疾病(如特应性/过敏性疾病)的关键驱动因子。一项重要的2b期临床研究(NCT01854047)显示,在使用了中高剂量吸入激素联合长效β2受体激动剂(ICS/LABA)后仍控制不佳的持续性哮喘患者中,dupilumab可减少哮喘重度急性发作,改善患者的肺功能和生活质量,且耐受性良好。目的探讨在哮喘并发常年性变应性鼻炎(PAR)患者中,dupilumab对SNOT-22的总分及其中变应性鼻炎(AR)相关症状评分的影响。方法对2b临床研究中每2周(q2w) 200 mg和300 mg dupilumab治疗后的数据进行析因分析。这两种剂量的dupilumab目前正在3期临床研究(NCT02414854)中进行验证。PAR定义为:在研究开始时,患者出现对典型的常年性抗原产生特异性应答(Ig E≥0. 35 Ku/L)。结果总共241例(61%)患者患有PAR。与安慰剂相比,每两周300 mg dupilumab显著改善了在哮喘并发PAR的患者中SNOT-22的总分(最小二乘平均差,-5. 98; 95%CI,-10. 45~-1. 5; P=0. 009)和4项AR相关症状的评分(鼻塞,-0. 60; 95%CI,-0. 96~-0. 25;流鼻涕,-0. 67; 95%CI,-1. 04~-0. 31;打喷嚏,-0. 55; 95%CI,-0. 89~-0. 21;鼻后分泌物,-0. 49;95%CI,-0. 83~-0. 16; 4项评分都P <0. 01);每两周200 mg dupilumab治疗减少了并发PAR的患者的SNOT-22总分(-1. 82; 95%CI,-6. 46~2. 83; P=0. 443)和AR相关的症状评分,但与安慰剂相比无统计学差异。在无PAR的哮喘患者中,dupilumab与安慰剂治疗这些评分无差异。结论每两周300 mg dupilumab治疗显著改善了在控制不佳的持续性哮喘并发PAR患者中的AR相关的鼻部症状。 | Steven F.Weinstein Rohit Katial Shyamalie Jayawardena Gianluca Pirozzi Heribert Staudinger Laurent Eckert Vijay N.Joish Nikhil Amin Jaman Maroni Paul Rowe Neil M.H.Graham Ariel Teper 黄庭萱(翻译) 刘春涛(审校) | 2018 | 中华临床免疫和变态反应杂志2018，12，5： | 2 |
| 20 | Optimization and Application of Liquid Chromatography Determination of Dispersive Liquid-liquid Microextraction Purified Astaxanthin in Shrimp Waste显示文摘 | ZHU Tao ROW Kyung-ho | 2013 | Chemical Research in Chinese Universities2013，29，3： | 2 |
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