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| 1 | Dupilumab治疗常年性变应性鼻炎并发哮喘患者的疗效和安全性显示文摘背景Dupilumab是一种抗IL-4受体α亚基的抗体,可以阻断IL-4/IL-13的信号转导。IL-4/IL-13是2型/Th2型免疫疾病(如特应性/过敏性疾病)的关键驱动因子。一项重要的2b期临床研究(NCT01854047)显示,在使用了中高剂量吸入激素联合长效β2受体激动剂(ICS/LABA)后仍控制不佳的持续性哮喘患者中,dupilumab可减少哮喘重度急性发作,改善患者的肺功能和生活质量,且耐受性良好。目的探讨在哮喘并发常年性变应性鼻炎(PAR)患者中,dupilumab对SNOT-22的总分及其中变应性鼻炎(AR)相关症状评分的影响。方法对2b临床研究中每2周(q2w) 200 mg和300 mg dupilumab治疗后的数据进行析因分析。这两种剂量的dupilumab目前正在3期临床研究(NCT02414854)中进行验证。PAR定义为:在研究开始时,患者出现对典型的常年性抗原产生特异性应答(Ig E≥0. 35 Ku/L)。结果总共241例(61%)患者患有PAR。与安慰剂相比,每两周300 mg dupilumab显著改善了在哮喘并发PAR的患者中SNOT-22的总分(最小二乘平均差,-5. 98; 95%CI,-10. 45~-1. 5; P=0. 009)和4项AR相关症状的评分(鼻塞,-0. 60; 95%CI,-0. 96~-0. 25;流鼻涕,-0. 67; 95%CI,-1. 04~-0. 31;打喷嚏,-0. 55; 95%CI,-0. 89~-0. 21;鼻后分泌物,-0. 49;95%CI,-0. 83~-0. 16; 4项评分都P <0. 01);每两周200 mg dupilumab治疗减少了并发PAR的患者的SNOT-22总分(-1. 82; 95%CI,-6. 46~2. 83; P=0. 443)和AR相关的症状评分,但与安慰剂相比无统计学差异。在无PAR的哮喘患者中,dupilumab与安慰剂治疗这些评分无差异。结论每两周300 mg dupilumab治疗显著改善了在控制不佳的持续性哮喘并发PAR患者中的AR相关的鼻部症状。 | Steven F.Weinstein Rohit Katial Shyamalie Jayawardena Gianluca Pirozzi Heribert Staudinger Laurent Eckert Vijay N.Joish Nikhil Amin Jaman Maroni Paul Rowe Neil M.H.Graham Ariel Teper 黄庭萱(翻译) 刘春涛(审校) | 2018 | 中华临床免疫和变态反应杂志2018，12，5： | 2 |
| 2 | Predictive Value of Callous-Unemotional Traits in a Large Community Sample显示文摘 | Paul Moran Richard Rowe Clare Flach Jacqueline Briskman Tamsin Ford Barbara Maughan Stephen Scott Robert Goodman | 2009 | Journal of the American Academy of Child & Adolescent Psychiatry2009，，11： | 1 |
| 3 | Iterative image reconstruction techniques: Applications for cardiac CT显示文摘 | Matthias Renker Ashok Ramachandra U. Joseph Schoepf Rainer Raupach Paul Apfaltrer Garrett W. Rowe Sebastian Vogt Thomas G. Flohr J. Matthias Kerl Ralf W. Bauer Christian Fink Thomas Henzler | 2011 | Journal of Cardiovascular Computed Tomography2011，，4： | 1 |
| 4 | The association of A?2 amyloid and composite cognitive measures in healthy older adults and MCI显示文摘 | Karra D. Harrington Yen Ying Lim Kathryn A. Ellis Carly Copolov David Darby Michael Weinborn David Ames Ralph N. Martins Greg Savage Cassandra Szoeke Christopher Rowe Victor L. Villemagne Colin L. Masters Paul Maruff | 2013 | International Psychogeriatrics2013，，10： | 1 |
| 5 | Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease显示文摘 | Reisa A. Sperling Paul S. Aisen Laurel A. Beckett David A. Bennett Suzanne Craft Anne M. Fagan Takeshi Iwatsubo Clifford R. Jack Jeffrey Kaye Thomas J. Montine Denise C. Park Eric M. Reiman Christopher C. Rowe Eric Siemers Yaakov Stern Kristine Yaffe Mari | 2011 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011，，3： | 1 |
| 6 | Intestinal endometriosis-A rare cause of colonic perforation显示文摘Endometriosis is the ectopic growth of viable endometrium outside the uterus, affecting approximately 7% of females. It commonly affects pelvic structures including the bowel. Perforation of the colon by endometriosis is very rare and the patients generally present with an asymptomatic or painful pelvic mass, often in the left iliac fossa. Our patient presented acutely unwell and her symptoms were more suggestive of pyelonephritis or diverticulitis. We therefore report an unusual cause of acute abdomen. The purpose of the following case report is to elucidate certain diagnostic and therapeutic problems of the disease, concerning both surgeons and gynaecologists. In summary, intestinal endometriosis should be considered in the differential diagnosis of all post-menarche women with episodic gastrointestinal symptoms. A past history of endometriosis or co-existent gynaecological symptoms should increase the index of suspicion, and laparoscopy prior to formal laparotomy should be considered. Our patient, in retrospect, had a history of mild endometriosis, but we feel that this case serves as a reminder of a rare, but important, differential diagnosis of acute abdomen in females. | Neeraj Kumar Garg Nitin Babulal Bagul Sam Doughan Paul Harold Rowe | 2009 | World Journal of Gastroenterology2009，15，5： | 1 |
| 7 | DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae显示文摘 | Lori A. Rowe Natalya Degtyareva Paul W. Doetsch | 2008 | Free Radical Biology and Medicine2008，，8： | 1 |
| 8 | What is balance?显示文摘 | Alexandra S Pollock Brian R Durvcard Philip J Rowe and John P Paul | 2000 | Chnical rehabilitation2000，，14： | 1 |
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