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| 1 | Diarylheptanoid-myricanone isolated from ethanolic extract of Myrica cerifera shows anticancer effects on HeLa and PC3 cell lines:signalling pathway and drug-DNA interaction显示文摘OBJECTIVE:To test if myricanone(C_(21)H_(24)O_5),a cyclic diarylheptanoid,has anticancer effects on two different cancer cell lines HeLa and PC3.The present study was conducted with a note on the drug-DNA interaction and apoptotic signalling pathway.METHODS:Several studies like cytotoxicity,nuclear damage,annexin-V-fluorescein isothiocyanate(FITC)/propidium iodide(Pl)-labelled apoptotic assay and cell cycle arrest,immunoblot and reverse transcriptase-polymerase chain reaction(RT-PCR)were used following standard protocols.Circular dichroism(CD)spectroscopy was also done to evaluate whether myricanone effectively interacted with DNA to bring about conformational changes that could strongly inhibit the cancer cell proliferation.RESULTS:Myricanone showed a greater cytotoxic effect on PC3 cells than on HeLa cells.Myricanone promoted G_0/G_1 arrest in HeLa cells and S phase arrest in PC3 cells.Nuclear condensation and annexin V-FITC/PI studies revealed that myricanone promoted apoptotic cell death.CD spectroscopic data indicated that myricanone had an interaction with calf thymus DNA that changed DNA structural conformation.RT-PCR and immunoblot studies revealed that myricanone activated the apoptotic signalling cascades through down-regulation of transcription factors like nuclear factor-κB(NF-κB)(p65),and signal transducers and activators of transcription 3(STAT3);cell cycle regulators like cyclin D1,and survivin and other signal proteins like Bcl-2 and up-regulation of Bax,caspase-9 and caspase-3.CONCLUSION:Myricanone induced apoptosis in both types of cancer cells by triggering caspase activation,and suppression of cell proliferation by down-regulation of NF-κB and STAT3signalling cascades,which makes it a suitable candidate for possible use in the formulation of therapeutic agent for combating cancer. | Avijit Paul Sreemanti Das Jayeeta Das Asmita Samadder Kausik Bishayee Ratan Sadhukhan Anisur Rahman Khuda-Bukhsh | 2013 | Journal of Integrative Medicine2013，11，6： | 4 |
| 2 | Characteristics of Missed or Interval Colorectal Cancer and Patient Survival: A Population-Based Study显示文摘 | N. Jewel Samadder Karen Curtin Thérèse M.F. Tuohy Lisa Pappas Ken Boucher Dawn Provenzale Kerry G. Rowe Geraldine P. Mineau Ken Smith Richard Pimentel Anne C. Kirchhoff Randall W. Burt | 2014 | Gastroenterology2014，，4： | 2 |
| 3 | 海南蒲桃提取物对L6细胞砷中毒缓解作用的体外实验(英文)显示文摘目的:研究海南蒲桃提取物对砷酸盐引起的L6骨骼肌细胞葡萄糖内稳态破坏及线粒体功能异常的缓解作用。方法:通过测量多个指标如丙酮酸激酶活性、葡糖激酶、线粒体膜电位等衡量细胞内葡萄糖水平及线粒体功能,并测量相关标志物的蛋白质及mRNA表达情况,如葡萄糖转运体4、胰岛素受体基质1、胰岛素受体基质2、葡糖激酶等以分析可能有关的信号通路。结果:海南蒲桃提取物能够通过葡萄糖转运体4通路改善砷中毒的L6细胞内诸多标志物的表达,使其正常化,与模型组相比差异有统计学意义。结论:海南蒲桃提取物对细胞砷中毒有明显的缓解作用,未来可考虑将其用于治疗砷中毒相关疾病如高血糖症等。 | Asmita Samadder Jayeeta Das Sreemanti Das Raktim Biswas Anisur Rahman Khuda-Bukhsh | 2012 | 中西医结合学报2012，10，11： | 2 |
| 4 | Poly(lactide-co-glycolide)nano-encapsulation of chelidonine,an active bioingredient of greater celandine(Chelidonium majus),enhances its ameliorative potential against cadmium induced oxidative stress and hepatic injury in mice显示文摘 | Paul A Das J Samadder A | 2013 | Environ Toxicol Pharmacol2013，36，3： | 1 |
| 5 | Rhodamine-Based Bis-Sulfonamide as a Sensing Probe for Cu2+ and Hg2+ Ions显示文摘 | Ghosh K Sarkar T Samadder A | 2012 | New J Chem2012，36，10： | 1 |
| 6 | Prevalence of any size ad- enomas and advanced adenomas in 40-to 49-year-old individuals undergoing screening colonoscopy because of a family history of colorectal carcinoma in a first-degree relative 显示文摘 | Gupta AK Samadder J Elliott E | 2011 | Gastrointest Endosc2011，74，1： | 1 |
| 7 | A glycosylated antitumor ether lipid kills cells viaparap-tosis-like cell death 显示文摘 | Pranati Samadder Robert Bittman Hoe-Sup Byun etal | 2009 | Biochem Cell Biol2009，87，2： | 1 |
| 8 | Prevalence of adenomas and advanced adenomas in patients in the 40- to 49-year age group undergoing screening colonoscopy because of a family history of adenoma/polyp in a first-degree relative显示文摘 | Akshay Gupta Jewel Samadder Eric Elliott Saurabh Sethi Philip Schoenfeld | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 9 | Psorinum 6× triggers apoptosis signals in human lung cancer cells显示文摘OBJECTIVE: To provide in vitro evidence of Psorinum treatment against cancer cells in a controlled study. METHODS: Effects of homeopathic Psorinum 6× on cell viability were initially determined in several cancer cell lines, including A549, Hep G2 and MCF-7, using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and an ethanol 6× control. The cell line that exhibited highest inhibition was selected and used in the following experiments. A range of Psorinum 6× doses was used to explore treatment effects on cell cycle arrest, cell death(apoptosis), generation of reactive oxygen species(ROS) and change in mitochondrial membrane potential(MMP) using fl ow cytometry and fl uorescence microscopy, respectively. Expression of several signal proteins related to apoptosis and cell survival were quantified with Western blotting and confocal microscopy. Further, circular dichroism(CD) spectroscopy was used to determine possible drug-DNA interactions, as well as the induction of conformational changes. RESULTS: Treatment of cancer cell lines with Psorinum showed greater anticancer effects in A549 cells than in others. In A549 cells Psorinum treatment inhibited cell proliferation at 24 h after treatment, and arrested cell cycle at sub-G1 stage. It also induced ROS generation, MMP depolarization, morphological changes and DNA damage, as well as externalization of phosphatidyl serine. Further, increases in p53 expression, Bax expression, cytochrome c release, along with reduction of Bcl-2 level and caspase-3 activation were observed after Psorinum 6× treatment, which eventually drove A549 cells towards the mitochondria-mediated caspase-3-dependent pathway. CD spectroscopy revealed direct interaction of Psorinum with DNA, using calf thymus-DNA as target.CONCLUSION: Psorinum 6× triggered apoptosis in A549 cells via both up- and down-regulations of relevant signal proteins, including p53, caspase-3, Bax and Bcl-2. | Jesmin Mondal Asmita Samadder Anisur Rahman K huda-Bukhsh | 2016 | Journal of Integrative Medicine2016，14，2： | 1 |
| 10 | 显示文摘 | GHOSH K SARKAR T SAMADDER A | 2012 | Org Biomol Chem2012，10，： | 1 |
| 11 | Fistulization of self-expanding metal stent from right colon into duode- num显示文摘 | Samadder N J Fang J Adler D G | 2012 | Endoscopy2012，44，2： | 1 |
| 12 | A glycosylated anti-tumor ether lipid kills cells via paraptosis -like cell death 显示文摘 | Samadder P Bittman R Byun H S | 2009 | Biochem Cell Biol2009，87，2： | 1 |
| 13 | Associations between colorectal cancer molecular markers and path- ways with clinicopathologic features in older women 显示文摘 | Samadder NJ Vierkant RA Tillmans LS | 2013 | Gastroenterology2013，145，2： | 1 |
| 14 | Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women显示文摘 | Samadder N J Vierkant R A Tillmans L S | 2013 | Gastroenterology2013，145，2： | 1 |
| 15 | Transcriptional and posttranscriptional enhancement of gene expression by the 5' UTR intron of rice rubi3 gene in transgenic rice cells显示文摘 | Samadder P Sivamani E Lu J | | 0，，04： | 1 |
| 16 | Epidemiology and Familial Risk of Synchronous and Metachronous Colorectal Cancer: A Population-Based Study in Utah显示文摘 | N. Jewel Samadder Karen Curtin Jathine Wong Thérèse M.F. Tuohy Geraldine P. Mineau Ken Robert Smith Richard Pimentel Lisa Pappas Ken Boucher Ignacio Garrido–Laguna Dawn Provenzale Randall W. Burt | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 17 | Antihyperglycemic potentials of a threatened plant,Helonias dioica:antioxidative stress responses and the signaling cascade显示文摘 | Chakraborty D Samadder A Dutta S Khuda-Bukhsh AR | | 0，，： | 1 |
| 18 | Epidemiology and familial risk of synchronous and metachronous colorectal cancer: a population-based study in Utah显示文摘 | Samadder N J Curtin K Wong J | 2014 | Clin Gastroenterol Hepatol2014，12，12： | 1 |
| 19 | Associations Between Colorectal Cancer Molecular Markers and Pathways With Clinicopathologic Features in Older Women显示文摘 | N.Jewel Samadder Robert A. Vierkant Lori S. Tillmans Alice H. Wang Daniel J. Weisenberger Peter W. Laird Charles F. Lynch Kristin E. Anderson Amy J. French Robert W. Haile John D. Potter Susan L. Slager Thomas C. Smyrk Stephen N. Thibodeau James R. Cerhan | 2013 | Gastroenterology2013，，2： | 1 |
| 20 | 变黑白头翁提取物降低亚砷酸盐对小鼠精细胞的毒性(英文)显示文摘目的:研究变黑白头翁提取物降低亚砷酸盐对小鼠精细胞毒性的作用。方法:给予实验小鼠亚砷酸钠(20mg/kg每日),并分别在第30、60、90天对小鼠进行检测。亚砷酸盐中毒小鼠被分为2组,其中一组给予变黑白头翁提取物(35mg/kg),另一组给予85%乙醇。通过检测小鼠精细胞凋亡标志蛋白CYP1A1、p53及caspase3的活性,确定细胞及DNA的损伤情况,并测定睾丸毒性标志物的水平。通过圆二色光谱仪及熔化温度数据检测变黑白头翁提取物与DNA的相互作用情况。结果:亚砷酸盐中毒小鼠的所有细胞凋亡标志蛋白及睾丸毒性标志物的水平均有所上升,而经变黑白头翁提取物治疗的小鼠上述各项指标均降低或恢复至正常水平。变黑白头翁提取物与DNA相互作用,引起了DNA结构和构象的变化。结论:变黑白头翁提取物可作为砷中毒引起的生殖功能损害的治疗药物给予研究和开发。 | Asmita Samadder Jayeeta Das Sreemanti Das Durba Das Arnab De Kakali Bhadra Anisur Rahman Khuda-Bukhsh | 2012 | 中西医结合学报2012，10，12： | 1 |
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