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| 1 | Changes in visibility with PM_(2.5) composition and relative humidity at a background site in the Pearl River Delta region显示文摘In fall–winter, 2007–2013, visibility and light scattering coefficients(b sp) were measured along with PM_(2.5)mass concentrations and chemical compositions at a background site in the Pearl River Delta(PRD) region. The daily average visibility increased significantly(p < 0.01) at a rate of 1.1 km/year, yet its median stabilized at ~13 km. No haze days occurred when the 24-hr mean PM_(2.5)mass concentration was below 75 μg/m^3. By multiple linear regression on the chemical budget of particle scattering coefficient(b sp), we obtained site-specific mass scattering efficiency(MSE) values of 6.5 ± 0.2, 2.6 ± 0.3, 2.4 ± 0.7 and 7.3 ± 1.2 m2/g,respectively, for organic matter(OM), ammonium sulfate(AS), ammonium nitrate(AN) and sea salt(SS). The reconstructed light extinction coefficient(b ext) based on the Interagency Monitoring of Protected Visual Environments(IMPROVE) algorithm with our site-specific MSE revealed that OM, AS, AN, SS and light-absorbing carbon(LAC) on average contributed 45.9% ± 1.6%,25.6% ± 1.2%, 12.0% ± 0.7%, 11.2% ± 0.9% and 5.4% ± 0.3% to light extinction, respectively.Averaged b ext displayed a significant reduction rate of 14.1/Mm·year(p < 0.05); this rate would be 82% higher if it were not counteracted by increasing relative humidity(RH) and hygroscopic growth factor(f(RH)) at rates of 2.5% and 0.16/year-1(p < 0.01), respectively, during the fall–winter, 2007–2013. This growth of RH and f(RH) partly offsets the positive effects of lowered AS in improving visibility, and aggravated the negative effects of increasing AN to impair visibility. | Xiaoxin Fu Xinming Wang Qihou Hu Guanghui Li Xiang Ding Yanli Zhang Quanfu He Tengyu Liu Zhou Zhang Qingqing Yu Ruqing Shen Xinhui Bi | 2016 | Journal of Environmental Sciences2016，28，2： | 18 |
| 2 | Aboveground biomass and corresponding carbon sequestration ability of four major forest types in south China显示文摘We estimated aboveground biomass carbon (TABC) and net carbon accumulation rates (TNEP) for trees in four major forest types based on national forest inventory data collected in 1994-1998 and 1999-2003. The four types were Pinus massoniana forest, Cunninghamia lanceolata forest, hard broad-leaved evergreen forest and soft broad-leaved evergreen forest. We analyzed variations in TABC and TNEP for five stand ages (initiation, young, medium, mature and old). In both time periods, estimated TABC in all four forest types increased consistently with forest stand age and the oldest stage had the largest TABC compared with other stages. Broad-leaved forests (hard and soft) had higher TABC than needle-leaved forests (Pinus massoniana and Cunninghamia lanceolata) for each of the five age stages. The difference of TABC between broad-leaved and needle-leaved forests increased with forest stand age. Comparison of estimated TNEP by age category indicated TNEP increased from the initiation stage to the young stage, and then decreased from the mature stage to old stage in all four forest types. TNEP for any particular stage depended on the forest type; for instance, broad-leaved forests at both the mature and old stages had greater TNEP than in needle-leaved forests. A logistic curve was applied to fit the relationship between TABC and forest stand age. In each period, correlations in all four forest types were all statistically significant (P < 0.01) with R2 > 0.95. TABC was therefore predicted by these regression functions from 2000 to 2050 and the mean TNEP during the predicted period was estimated to be about 41.14, 31.53, 75.50 and 75.68 gCm-2a-1 in Pinus massoniana forest, Cunninghamia lanceolata forest, hard broad-leaved forest and soft broad-leaved forest, respectively. Results from both forest inventory and regression prediction suggest broad-leaved forests are greater carbon sinks, and hence have greater carbon sequestration ability especially in the mature and old stages when compared to needle-leaved forests. Broad-leaved forests should have high levels of carbon sequestration when compared with needle-leaved forests in south China. | CHEN QingQing XU WeiQiang LI ShengGong FU ShengLei YAN JunHua | 2013 | Chinese Science Bulletin2013，58，13： | 8 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | Diversity and conservation of Chinese wild begonias显示文摘Begonia, one of the most diverse plant taxa and the fifth or sixth largest angiosperm genus, consists of over1800 accepted species. The number of species recognized within this genus has greatly increased over the past 20 years, rising from 80 to 200 species in China alone. Based on recent field surveys, the number of begonia species in China is predicted to be between 250 and 300. Given the large number of begonia species that still remain to be described, further taxonomical work is urgently required. This is especially true for Chinese Begonia, in which there is a huge diversity of habitat, habit, plant size, leaf type, flower and fruit morphology, and most species are narrowly distributed in isolated habitats that are subject to negative disturbances from climate change, as well as agricultural and industrial activities. Although the conservation status for the majority of species has been evaluated using the standards of the International Union for Conservation of Nature, the results don't represent the truth in many species, and also about11.5% of which are data-absent. In addition, illegal collection and over-harvesting of wild begonias for ornamental or medicinal use has increased due to the rapid development of internet commerce. Far more often than predicted, these species should be categorized as rare and endangered and require immediate protection. Ex situ conservation of Chinese begonias started in 1995 and over 60% of the total species have been so far introduced into cultivation by several major botanical gardens in China. However, only few research institutions, limited funds and human resources have been involved in Begonia conservation;moreover, no project has conducted reintroduction. Therefore, more conservation-based work remains to be done. Improved conservation of Chinese begonias in the future depends on further field survey, an improved understanding of population diversity, and integrative approaches, including in situ and ex situ conservation, seed banking, and plant reintroduction. Species-targeted conservation zones should be established for endangered species excluded from the existing nature reserves. Additionally, laws pertaining to plant protection should be extended to prevent the illegal collection and transaction of wild plants, particularly for those species with unique habitats and small populations. | Daike Tian Yan Xiao Yi Tong Naifeng Fu Qingqing Liu Chun Li | 2018 | Plant Diversity2018，40，3： | 4 |
| 5 | Thermal-reductive transformations of carbon dioxide catalyzed by small molecules using earth-abundant elements显示文摘In the present review, we summarize the progress for thermal reductive transformations of CO2 catalyzed by small homogeneous catalysts using earth-abundant elements. Three main types of transformations categorized by the use of different reductants(hydrogen, hydrosilanes, and boranes), in which no C–C bond formation is involved, are surveyed. | Muhua Liu Tian Qin Qingqing Zhang Chi Fang Yao Fu Bo-Lin Lin | 2015 | Science China Chemistry2015，58，10： | 3 |
| 6 | Ultrasound-propelled Janus Au NR-mSiO_(2) nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors显示文摘Varieties of contrast agents have been developed for photoacoustic(PA)and ultrasound(US)imaging of cancers in vivo.However,access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force,preventing their deep penetration into the tissues of the tumors,and hindering the use of PA and US for deep tumor imaging.The concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids,thereby conducting assigned tasks.Herein,US-propelled Janus mesoporous SiO_(2)partially coated gold nanorods(Au NR-mSiO_(2))were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas therapy.Following US irradiation,2,2-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)loaded in mSiO_(2)(Au NR-mSiO_(2)/AIPH)generated N_(2)microbubbles with high efficiency to achieve nanomotor drive.Due to the deep penetration of US,the nanomotors exhibited a capability to travel deep within sites of tumors,providing enhanced PA/US imaging inside the tumors.Furthermore,the nanomotor based cancer therapy was demonstrated through synergistic N_(2)gas and sonodynamic therapy.The US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors. | Jiamin Ye Qinrui Fu Luntao Liu Lanlan Chen Xuan Zhang Qingqing Li Zhi Li Lichao Su Rong Zhu Jibin Song Huanghao Yang | 2021 | Science China Chemistry2021，64，12： | 2 |
| 7 | E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease,and the pathogenesis of SLE has not been fully elucidated.The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins;however,the potential role of FBXW7 in autoimmune diseases is unclear.In the present study,we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2,6,10,14-tetramethylpentadecane(TMPD).Myeloid cell-specific FBXW7-deficient(Lysm+FBXW7f/f)C57BL/6 mice showed decreased immune complex accumulation,glomerulonephritis,glomerular mesangial cell proliferation,and basemembrane thickness in the kidney.Lysm+FBXW7f/f mice produced fewer anti-Sm/RNP and anti-ANA autoantibodies and showed a decreased MHC II expression in B cells.In Lysm+FBXW7f/f mice,we observed that cell apoptosis was reduced and that fewer CD11b+Ly6Chi inflammatory monocytes were recruited to the peritoneal cavity.Consistently,diffuse pulmonary hemorrhage(DPH)was also decreased in Lysm+FBXW7f/f mice.Mechanistically,we clarified that FBXW7 promoted TMPD-induced cell apoptosis by catalyzing MCL1 degradation through K48-linked ubiquitination.Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice,which may provide novel ideas and theoretical support for understanding the pathogenesis of SLE. | Zhenlu Chong Chunjing Bao Jia He Tianxiao Chen Lijia Zhong Gaopeng Li Huanle Li Lutong Fang Yinjing Song Guoxiang Fu Xuyan Yang Lihua Lai Yang Liu Qingqing Wang | 2018 | Cellular & Molecular Immunology2018，15，12： | 2 |
| 8 | An Observational Study of Typhoon Imbudo in 2003显示文摘Typhoon Imbudo was a super-typhoon over the northwestern Pacific in 2003. It caused tremendous damage when it made landfalls in the Philippines and China. This paper documents observational analyses of Typhoon Imbudo during its landfall in China. All available observations are used to study its motion, intensity changes, convection, structure and precipitation. Best-track data indicate that Imbudo moved west-northwestward until 1800 UTC 23 July and then turned northwestward. FNL (final) analysis data show that the motion of Imbudo is dominated by changes of the subtropical high. At Imbudo's mature stage, the minimum sea level pressure dropped to 910 hPa and the maximum sustained winds were as high as 67 m s 1, which is the intensity of a super-typhoon. The surface wind field exhibited asymmetric characteristics. Polar-orbiting satellite imagery also manifested convective asymmetry before Imbudo made landfall in China. Analyzed the vertical wind shear, it is shown that the convection has a downshear-left pattern. All kinds of precipitation data were used to identify the asymmetric characteristic of the rainfall associated with the Imbudo. The maximum rainfalls were located in the southern boundary area between Guangxi and Guangdong. However, the lack of in situ observations limited further analyses of this typhoon. | LI Qingqing FU Gang GUO Jingtian YANG Yuqiang DUAN Yihong | 2005 | Journal of Ocean University of China2005，4，4： | 1 |
| 9 | Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells显示文摘 | Shengming Dai Xiangyang Zhou Baomei Wang Qingqing Wang Yangxin Fu Taoyong Chen Tao Wan Yizhi Yu Xuetao Cao | 2006 | Journal of Molecular Medicine2006，，12： | 1 |
| 10 | Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells显示文摘 | Shengming Dai Xiangyang Zhou Baomei Wang Qingqing Wang Yangxin Fu Taoyong Chen Tao Wan Yizhi Yu Xuetao Cao | 2006 | Journal of Molecular Medicine2006，，12： | 1 |
| 11 | Shape memory effact and mechanical properties of carbon nanotube/shape memory polymer nanocomposites 显示文摘 | Ni Qingqing Zhang Chunsheng Fu Yaqin | 2007 | Composite Structures2007，81，2： | 1 |
| 12 | Shape memory effect and mechanical properties of carbon nano tube/shape memory polymer nanocomposites显示文摘 | Ni Qingqing Zhang Chunsheng Fu Yaqin | 2007 | Compos Struct2007，81，2： | 1 |
| 13 | Therapeutic effects of EGF-modified curcumin/ chitosan nano-spray on wound healing显示文摘Dermal injury,including trauma,surgical incisions,and burns,remain the most prevalent socio-economical health care issue in the clinic.Nanomedicine represents a reliable administration strategy that can promote the healing of skin lesions,but the lack of effective drug delivery methods can limit its effectiveness.In this study,we developed a novel nano-drug delivery system to treat skin defects through spraying.We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor(EGF)to develop an aqueous EGF-modified spray(EGF@CCN)for the treatment of dermal wounds.In vitro assays showed that the EGF@CCN displayed low cytotoxicity,and that curcumin was continuously and slowly released from the EGF@CCN.In vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats,showing that the EGF@CCN had significant advantages in promoting wound healing.On day 12 post-operation,skin defects in the rats of the EGF@CCN group were almost completely restored.These effects were related to the activity of curcumin and EGF on skin healing,and the high compatibility of the nano formulation.We therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds. | Yue Li QingQing Leng XianLun Pang Huan Shi YanLin Liu SuSu Xiao Ling Zhao Ping Zhou ShaoZhi Fu | 2021 | Regenerative Biomaterials2021，8，2： | 1 |
| 14 | Shape memory effect and mechanical properties of carbon nanotube/shape memory polymer nanoeomposites 显示文摘 | Ni Qingqing Zhang Chunsheng Fu Yaqin | 2007 | Compos Struet2007，81，2： | 1 |
| 15 | PARP-1 inhibitors enhance the chemosensitivity of leukemia cells by attenuating NF-κB pathway activity and DNA damage response induced by Idarubicin显示文摘Idarubicin(IDA),an anthracycline antineoplastic drug,is commonly used in the treatment of acute myeloid leukemia(AML)with reasonable response rates and clinical benefits.However,some patients still relapse,or do not respond,and suffer high fatality rates.Recent studies have shown that overexpression of PARP-1 may represent an important risk factor in AML patients.The aim of the present study was to determine the underlying molecular mechanisms by which the PARP-1 inhibitor Olaparib enhances the chemosensitivity of the leukemia cell line K562 and THP1 to IDA.Our data demonstrated that PARP-1 is upregulated in AML patients as well as in K562 and THP1 cells,and that the suppression of PARP-1 activity by Olaparib enhances the inhibitory effect of IDA.A mechanistic study revealed that Olaparib decreases the expressions of p-ATM,p-IκBα,XIAP and p65,and upregulates Bax,cleaved-Caspase-3 andγ-H2AX.Olaparib can enhance the induction of DNA damage by IDA,probably mediated by the inhibition of the ATM-related DNA damage response.Moreover,we also found that the nuclear translocation of p65 and the nuclear export of NEMO are inhibited when IDA and Olaparib are combined.Our results suggest that Olaparib attenuates the activity of the NF-κB pathway and decreases the DNA damage response induced by IDA.Therefore,we conclude that Olaparib is a potentially valuable chemosensitizer for leukemia patients. | Bo Ke Anna Li Huan Fu Chunfang Kong Tingting Liu Qingqing Zhu Yue Zhang Zixia Zhang Chen Chen Chenghao Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
| 16 | Identification and characterization of extracellular cyclic dipeptides as quorum-sensing signal molecules from Shewanella baltica, the specific spoilage organism of Pseudosciaena crocea during 4 ℃ storage显示文摘 | GU Qingqing FU Linglin WANG Yanbo | 2013 | Journal of Agricultural and Food Chemistry2013，61，11： | 1 |
| 17 | Spatio-Temporal Video Motion Detection Using Marked-Watershed and Morphological Operations显示文摘 | Qingqing Fu Mehmet Celenk | 2013 | 通讯和计算机(中英文版)2013，10，9： | 0 |
| 18 | Multicomponent Domino [4+1+1] Carbocyclization Providing an Efficient and Regioselective Strategy to Fluoren-9-ones显示文摘简明、有效的三部件的牙齿[4+1+1 ] 到 K2CO3 支持的高度代替的 fluoren-9-one 衍生物的 carbocyclization 在微波照耀条件下面被开发了。直接 bis-cyanation 和芳基胺化作用居住在 fluoren-9-one 框架在一个壶操作被完成。反应以快率和罐头继续在 30 min 以内被完成,它使 workup 方便给对优秀化学收益好。 | Ying Li Haiwei Xu Liping Fu Qingqing Shi Bo Jiang Shujiang Tu | 2013 | Chinese Journal of Chemistry2013，31，6： | 0 |
| 19 | Leaky Gut Plays a Critical Role in the Pathophysiology of Autism in Mice by Activating the Lipopolysaccharide‑Mediated Toll‑Like Receptor 4-Myeloid Differentiation Factor 88-Nuclear Factor Kappa B Signaling Pathway显示文摘Increased intestinal barrier permeability,leaky gut,has been reported in patients with autism.However,its contribution to the development of autism has not been determined.We selected dextran sulfate sodium(DSS)to disrupt and metformin to repair the intestinal barrier in BTBR T+tf/J autistic mice to test this hypothesis.DSS treatment resulted in a decreased affinity for social proximity;however,autistic behaviors in mice were improved after the administration of metformin.We found an increased affinity for social proximity/social memory and decreased repetitive and anxiety-related behaviors.The concentration of lipopolysaccharides in blood decreased after the administration of metformin.The expression levels of the key molecules in the toll-like receptor 4(TLR4)–myeloid differentiation factor 88(MyD88)–nuclear factor kappa B(NF-κB)pathway and their downstream inflammatory cytokines in the cerebral cortex were both repressed.Thus,“leaky gut”could be a trigger for the development of autism via activation of the lipopolysaccharide-mediated TLR4–MyD88–NF-κB pathway. | Fang Li Haoran Ke Siqi Wang Wei Mao Cexiong Fu Xi Chen Qingqing Fu Xiaori Qin Yonghua Huang Bidan Li Shibing Li Jingying Xing Minhui Wang Wenlin Deng | 2023 | Neuroscience Bulletin2023，39，6： | 0 |
| 20 | Constructing vertical phase separation of polymer blends via mixed solvents to enhance their photovoltaic performance显示文摘A polymer blend comprising poly(3-hexylthiophene)(P3HT)donor and poly[2,7-(9,9′-octyl-fluorene)-alt-5,5-(4′,7′-di-2-thienyl-5′,6′-bis(hexyloxy)-2′,1′,3′-benzothiadiazole)](PFDTBT-OC6)acceptor is used as the active layer to fabricate all-polymer solar cells.The blend morphology variance processed with pure and mixed solvents,and the related photovoltaic performance,are investigated in detail.It is found that,due to its low surface energy,a thin P3HT enrichment layer on the top surface of the active layer greatly increases bimolecular recombination and results in S-kinks of the illuminated current density-voltage curves.With the incorporation of p-xylene(a marginal solvent of P3HT)in the blend solution,the P3HT enrichment atop the active layer surface is effectively decreased because the high boiling-point p-xylene suppresses the diffusion of P3HT chains toward the top surface during the film-drying process.The bimolecular recombination was thus improved and the S-kinks of the photovoltaic curves were completely removed.The overall power conversion efficiencies of the devices are strongly boosted(from 0.88%to 1.41%)when chlorobenzene:p-xylene mixed solvent is used to replace pure chlorobenzene. | Qingqing Yang Jiantai Wang Xiaoqin Zhang Jun Zhang Yingying Fu Zhiyuan Xie | 2015 | Science China Chemistry2015，58，2： | 0 |
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