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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 3 | Thermodynamics and kinetics of phase transformation in rare earth–magnesium alloys:A critical review显示文摘Magnesium and its alloys are significant superior metallic materials for structural components in automobile and aerospace industries due to their excellent physicomechanical properties.The Mg–rare earth(RE)systems have attracted great interests because RE additions can improve both the deformability and the strength of Mg alloys through solid solution strengthening and precipitation hardening mechanisms.This paper focuses on the interface stability,together with thermodynamics and kinetics of nucleation and growth of the key phases and matrix phases in Mg–RE alloys.In this paper,the theory and recent advances on Mg–RE alloys,especially for the interface stability,thermodynamics and kinetics of nucleation and growth of the key phases and matrix phases,together with their relationships with micro-structures,and macroscopic properties,are reviewed.By combining the thermodynamics/kinetics integrated simulations with various advanced experimental techniques,“reverse”design of Mg–RE alloys starting from the target service performance is put forward as a kind of scientific paradigm with rational design. | Qun Luo Yanlin Guo Bin Liu Yujun Feng Jieyu Zhang Qian Li Kuochih Chou | 2020 | Journal of Materials Science & Technology2020，44，9： | 26 |
| 4 | Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction显示文摘Inflammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5′ adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1–7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats. | Yanlin Bi Shuyun Liu Xinjuan Yu Mingshan Wang Yuelan Wang | 2014 | Neural Regeneration Research2014，9，5： | 17 |
| 5 | Autophagy in Atherosclerosis: A Phenomenon Found in Human Carotid Atherosclerotic Plaques显示文摘 | Huihui Liu Yongjun Gag Tong Tong Jijun Shi Yanlin Zhang Yaping Yang Chunfeng Liu | 2015 | Chinese Medical Journal2015，，1： | 16 |
| 6 | Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies显示文摘Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient β-globin synthesis leading to β-thalassemia.These two major forms of β-hemoglobinopathies cause impaired erythropoiesis and life-threatening anemia.Clinical evidence has suggested that reaaivation of fetal γ-globin(HBG)gene expression which is normally silenced after birth by certain genetic mutations can ameliorate the clinical course of β-hemoglobinopathies. | Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li | 2020 | Cell Research2020，30，3： | 14 |
| 7 | Basement of the South China Sea Area:Tracing the Tethyan Realm显示文摘华南海( SCS )和邻近的区域的地下室能被划分成六个部门(区域)在 Beibu 海湾的古生代的 Erathem 指责graben 的地下室分割,在 Yinggehai 的古生代的 Erathem 罢工滑倒拉开流水,在东方海南的古生代的 Erathem 差错消沉,在北 Xisha ( Paracel )的古生代的 Erathem rifted ,古生代的 Erathem 罢工滑倒在在 Nansha 岛延长的南部的 Xisha ,和古生代中生代的 Erathem 延长( Spratly )水。在 SCS 和 Yunkai 大陆人区域的新生代前地下室在在新生代前时期的 Tethyan 构造领域以内是同时代的。他们在 Paleo-Tethyan 构造领域的背景上被形成,并且是东方 Tethyan multi-island-ocean 系统的重要部件。东方 Paleo-Tethys 构造领域,北方 Yunkai,诺思海南,和南方海南海盆的三个分支,演变为北方 Yunkai,诺思海南,和南方海南缝术地区分别地。这为新生代前地下室显示出本地化的一个特殊特征。 Qiongnan (即南方海南)华南海的北边缘上的缝术地区能被认为 Paleo-Tethys 的主要海洋盆的痕迹,并且与 Longmucuo-Shuanghu beltBitu 带 Changning-Menglian-Bentong-Raub 带的缝术地区连接了,华南海的西方上的 Bitu-Changning-MenglianChing Mai beltChanthaburi-Raub-Bentong 带的南方延期,并且与 Lianhua-Taidong 缝术地区(沿着在台湾的纵的山谷的东方方面的一个差错) Hida Qiongbei (诺思海南) 缝术地区可以向东沿着 Wangwu-Wenjiao 差错地区延长了,并且深与 Lufeng-Dapu-Zhenghe-Shangyu (Lianhuashan ) 连接通过珍珠河嘴盆的差错地区。Meso-Tethys 在华南海的南方上发展了。Nansha 马槽可以被认为 Meso-Tethys 的北架的痕迹。 Meso-Tethys 的海洋的外壳向南沿着 subduction-collision-thrust 有 subducted 有华南海的西方上的 Yarlung Zangbo-Mytkyina-Bago 地区的到那些的subduction杆反面的 Nansha 马槽的南部的边缘,并且 Meso-Tethyan (例如 Meso-Tethys 的北 Chichibu 海洋)在在西南日本的侏罗记早的白垩纪地球组的外部带的缝术地区 Butsozo 构造的线,在华南海的东方上。 | LIU Hailing ZHENG Hongbo WANG Yanlin LIN Qiujin WU Chaohua ZHAO Meisong DU Yunkong | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 13 |
| 8 | Acupuncture preconditioning protects hippocampal neurons from transient ischemia/reperfusion injury显示文摘The present study established a model of brain ischemia in aged rats using four-vessel occlusion.We observed hippocampal CA1 neuronal apoptosis and apoptosis-mediated protease caspase-3 expression following preconditioning of electroacupuncture at Baihui(GV 20).Our results showed that the number of hippocampal CA1 normal neurons was decreased,and degenerated neurons were increased 12 hours to 3 days following cerebral ischemia/reperfusion.The number of hippocampal CA1 apoptotic neurons and caspase-3-positive neurons in rats with cerebral ischemia/reperfusion injury was significantly decreased following acupuncture preconditioning.Acupuncture preconditioning protects aged rats against ischemia/reperfusion injury by regulating caspase-3 protein expression. | Mingshan Wang Haipeng Zhou Fei Shi Shilong Ma Yanlin Bi Yuqiu Liu Hong Liu Haiou Li | 2011 | Neural Regeneration Research2011，6，15： | 12 |
| 9 | Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer显示文摘Diabetes is one of the most prevalent diseases in the world with high-mortality and complex complications including diabetic foot ulcer(DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection,change of inflammatory responses, lack of extracellular matrix(ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has been developed by electrospinning with huge porosity, excellent humidity absorption, a better oxygen exchange rate, and some antibacterial activities. That is to say, as a potential material, nanofibers must be a wonderful candidate for the DFU treatment with so many benefits. Careful selection of polymers from natural resource and synthetic resource can widen the nanofibrous application. Popular methods applied for the nanofibrous fabrication consist of uniaxial electrospinning and coaxial electrospinning. Furthermore, nanofibers loading chemical, biochemical active pharmaceutical ingredient(API)or even stem cells can be wonderful dosage forms for the treatment of DFU. This review summarizes the present techniques applied in the fabrication of nanofibrous dressing(ND)that utilizes a variety of materials and active agents to offer a better health care for the patients suffering from DFU. | Yan Liu Shiya Zhou Yanlin Gao Yinglei Zhai | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 10 |
| 10 | The Epidemiological Characteristics of Pulmonary Tuberculosis——Kashgar Prefecture,Xinjiang Uygur Autonomous Region,China,2011-2020显示文摘Introduction:National Notifiable Disease Reporting System(NNDRS)plays an important role in the early detection and control of tuberculosis(TB)in China.This study analyzed the epidemiological characteristics of pulmonary tuberculosis(PTB)in Kashgar Prefecture,Xinjiang Uygur Autnomous Region,China from 2011 to 2020 to provide a scientific basis for developing TB control strategies and measures in Kashgar.Methods:The data were collected from the NNDRS,which included the geographical distribution,age,sex,occupation,and pathogenic classification of reported PTB cases in 12 counties/cities of Kashgar Prefecture from 2011 to 2020.Descriptive statistics were used to describe the characteristic of PTB epidemic in Kashgar.Results:There were 189,416 PTB cases reported during 2011–2020,with a mean annual PTB case notification rate(CNR)of 451.29/100,000.A rising trend in the rate of reported PTB between 2011 and 2017(χ2 trend=26.09,P<0.01)and a declining trend between 2018 and 2020(χ2 trend=314.44,P<0.01)were observed.The months with the highest reported number of PTB cases were March to May and November to December.The mean annual rate of reported PTB was 451.88/100,000 for males and 450.67/100,000 for females.In addition,19.76%of patients were bacteriologically-confirmed(Bac+)cases(37,425/189,416),and the mean annual Bac+CNR was 89.17/100,000,rising from 64.76/100,000 in 2011 to 139.12/100,000 in 2020(χ^(2)_(trend)=74.44,P<0.01).Conclusions:The CNR of reported PTB in Kashgar showed a significant declining trend in the past three years.Males,elderly population,winter and spring,and farmers as an occupation were the main factors associated with high incidence of tuberculosis in Kashgar.Targeted prevention and treatment of TB should be strengthened in key groups in this region. | Diermulati Tusun Maiweilanjiang Abulimiti Xirizhati Mamuti Zhenjiang Liu Da Xu Guanzhen Li Xiaowang Peng Tuerhong Abudureyimu Lijie Zhang Yanlin Zhao Xichao Ou | 2021 | China CDC weekly2021，3，26： | 6 |
| 11 | Technology for high performance TRIP steel显示文摘Thermodynamics of martensite transformation in low alloy TRIP steel was evaluated.It follows from the calculation that ε phase might be formed at above room temperature in the low Mn steel.Tested steel was therefore prepared according to the estimation result.High volume fraction of retained austenite(above 20%) containing 1.37%C was obtained in the steel after continuous annealing treatment.Tensile test showed that the ultimate strength of the steel was 1248 MPa,elongation rate 25%,the product of strength and elongation rate 31200 MPa%,reaching the grade of the third generation automobile steel.XRD detection indicated that after tensile test there existed ' martensite while TEM revealed that ε martensite also existed in the steel.Strengthening-toughening of the steel was thus raised due to the effect of transformation induced plasticity of two kinds of martensite.In addition,the phase stability of carbonitrates containing V was estimated and the complex micro-alloying effect was applied to the steel to control the size of austenite(about 1 μm) and enhance the stability of austenite. | LI Lin GAO Yi ZHU NaQiong HE YanLin LIU RenDong HE ZhongPing SHI Wen ZHANG Mei | 2012 | Science China(Technological Sciences)2012，55，7： | 5 |
| 12 | A New Species of the Asi an Toad Genus Megophrys sensu lato (Anura: Megophryidae) from Guizhou Province, China显示文摘We describe a new species of the genus Megophr ys from Guizhou Province, China. Molecular phylogenetic analyses based on mitochondrial DNA and nuclear DNA sequences all strongly supported the new species as an independent clade nested into the Megophrys clade and sister to M. minor. On morphology,the new species is distinguished from its congeners by a combination of the following characters:(1) small body size with SVL < 39.2 mm in male and SVL < 40.4 mm in female;(2) vomerine teeth absent;(3) tongue not notched behind;(4) a small horn-like tubercle at the edge of each upper eyelid;(5) tympanum distinctly visible, rounded;(6) two or three metacarpal tubercles in hand;(7) relative finger lengths: Ⅰ< Ⅱ< Ⅴ< Ⅲ;(8) toes without webbing;(9) heels overlapped when thighs are positioned at right angles to the body;(10) tibiotarsal articulation reaching tympanum to eye when leg stretched forward;(11) an internal single subgular vocal sac in male;(12) in breeding male, the nuptial pads with black nuptial spines on the dorsal bases of the first and second fingers. | Jing LIU Shize LI Gang WEI Ning XU Yanlin CHENG Bin WANG Jun WU | 2020 | Asian Herpetological Research2020，11，1： | 4 |
| 13 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 14 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 15 | Abscisic acid receptors maintain abscisic acid homeostasis by modulating UGT71C5 glycosylation activity显示文摘Uridine diphosphate-glucosyltransferases(UGTs)maintain abscisic acid(ABA)homeostasis in Arabidopsis thaliana by converting ABA to abscisic acid-glucose ester(ABA-GE).UGT71C5 plays an important role in the generation of ABA-GE.Abscisic acid receptors are crucial upstream components of the ABA signaling pathway,but how UGTs and ABA receptors function together to modulate ABA levels is unknown.Here,we demonstrated that the ABA receptors RCAR12/13 and UGT71 C5 maintain ABA homeostasis in Arabidopsis following rehydration under drought stress.Biochemical analyses show that UGT71C5 directly interacted with RCAR8/12/13 in yeast cells,and the interactions between UGT-71C5 and RCAR12/13 were enhanced by ABA treatment.Enzyme activity analysis showed that ABA-GE contents were significantly elevated in the presence of RCAR12 or RCAR13,suggesting that these ABA receptors enhance the activity of UGT71C5.Determination of the content of ABA and ABA-GE in Arabidopsis following rehydration under drought stress revealed that ABA-GE contents were significantly higher in Arabidopsis plants overexpressing RCAR12 and RCAR13 than in nontransformed plants and plants overexpressing RCAR11 following rehydration under drought stress.These observations suggest that RCAR12 and RCAR13 enhance the activity of UGT71C5 to glycosylate excess ABA into ABA-GE following rehydration under drought stress,representing a rapid mechanism for regulating plant growth and development. | Yanlin Ma Jing Cao Qiaoqiao Chen Jiahan He Zhibin Liu Jianmei Wang Xufeng Li Yi Yang | 2021 | Journal of Integrative Plant Biology2021，63，3： | 3 |
| 16 | Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies显示文摘Homodimeric prodrug-based self-assembled nanoparticles,with carrier-free structure and ultrahigh drug loading,is drawing more and more attentions.Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage.The influence of the linkages on the self-assembly,in vivo fate and antitumor activity of homodimeric prodrugs is the focus of research.Herein,three docetaxel(DTX)homodimeric prodrugs are developed using different lengths of diselenide bond-containing linkages.Interestingly,compared with the other two linkages,the longest diselenide bond-containing linkage could facilitate the self-delivery of DTX prodrugs,thus improving the stability,circulation time and tumor targeting of prodrug nanoassemblies.Besides,the extension of linkages reduces the redox-triggered drug release and cytotoxicity of prodrug nanoassemblies in tumor cells.Although the longest diselenide bond-containing prodrug nanoassemblies possessed the lowest cytotoxicity to 4T1 cells,their stable nanostructure maintained intact during circulation and achieve the maximum accumulation of DTX in tumor cells,which finally“turned the table”.Our study illustrates the crucial role of linkages in homodimeric prodrugs,and gives valuable proposal for the development of advanced nano-DDS for cancer treatment. | Lingxiao Li Shiyi Zuo Fudan Dong Tian Liu Yanlin Gao Yinxian Yang Xin Wang Jin Sun Bingjun Sun Zhonggui He | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 3 |
| 17 | Uranium sorption on oxyhydroxide minerals by surface complexation and precipitation显示文摘During the chemical weathering of the uranium mill tailings,released uranium could be immobilized by the newly formed secondary minerals such as oxyhydroxides.A deeper understanding of the interaction between uranium and common oxyhydroxides under environmental conditions is necessary.In this work,uranium sorption behaviors on Al-,Mn-and Fe-oxyhydroxide minerals(boehmite,manganite,goethite,and lepidocrocite)were investigated by batch experiments.Results showed that the uranium sorption on Al-oxyhydroxide behaved significantly differently from the other three minerals.The sorption edge of the Mn-and Fe-oxyhydroxides located around pH 5,while the sorption edge of boehmite shifted about 1.5 pH unit to near neutral.The sorption isotherms of uranium on manganite,goethite and lepidocrocite at pH 5.0 could be well fitted by the Langmuir model.Instead of surface complexation,sorption on boehmite happened mainly by uranium-bearing carbonates and hydroxides precipitation as illustrated by the characterization results.Both carbonate and phosphate strongly affected the uranium sorption behavior.The removal efficiency of uranium by boehmite exceeded 98%after three sorption-desorption cycles,indicating it may be a potential material for uranium removal and recovery. | Jingyi Wang Wanqiang Zhou Yanlin Shi Yao Li Dongfan Xian Ning Guo Chunli Liu | 2022 | Chinese Chemical Letters2022，33，7： | 3 |
| 18 | The role of charged multivesicular body protein 5 in programmed cell death in leukemic cells显示文摘人(CHMP5 ) 现代人的控告的 multivesicular 身体蛋白质 5 是 multivesicular 身体的一个成员,它用作 anti-apoptotic 蛋白质并且被认为参予引起白血病。在这研究,一条短发卡的基于 RNA 的 RNA 干扰途径被用来在白血病的房间线 U937 禁止 CHMP5 的表示。在 CHMP5 被禁止以后,抗体 microarray 和西方的污点分析被用来在规划房间死亡(PCD ) 学习变化小径。PCD 能被分类进三种类型:apoptosis,坏死,和 autophagy。结果显示出那 caspase 3 在 CHMP5 缺乏的 U937 房间被激活,显示 apoptotic 小径被激活,尽管既不内在外来的 apoptotic 小径也没被激活。我们的结果也证明 Granzyme B/Perforin apoptotic 小径被 CHMP5 silencing 激活。坏死被 caspase 独立的刽子手激活。在这研究,我们证明导致 apoptosis 调停蛋白质的坏死的 PCD 小径在 CHMP5 抑制以后被激活。autophagic PCD 没发生在 CHMP5 缺乏的 U937 房间,这被发现。在结论,在 CHMP5 抑制,两条 Granzyme B/Perforin apoptotic 小径和导致 apoptosis 以后,调停因素的坏死的小径被激活,当 autophagic 小径没被激活时。 | Hairong Wang Jia Liu Feilong Wang Miao Chen Zhenyu Xiao Renrong OuYang Aihua Fei Yanlin Shen Shuming Pan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 3 |
| 19 | A Robust Zero-Watermarking Based on SIFT-DCT for Medical Images in the Encrypted Domain显示文摘Remote medical diagnosis can be realized by using the Internet,but when transmitting medical images of patients through the Internet,personal information of patients may be leaked.Aim at the security of medical information system and the protection of medical images,a novel robust zero-watermarking based on SIFT-DCT(Scale Invariant Feature Transform-Discrete Cosine Transform)for medical images in the encrypted domain is proposed.Firstly,the original medical image is encrypted in transform domain based on Logistic chaotic sequence to enhance the concealment of original medical images.Then,the SIFT-DCT is used to extract the feature sequences of encrypted medical images.Next,zero-watermarking technology is used to ensure that the region of interest of medical images are not changed.Finally,the robust of the algorithm is evaluated by the correlation coefficient between the original watermark and the attacked watermark.A series of attack experiments are carried out on this method,and the results show that the algorithm is not only secure,but also robust to both traditional and geometric attacks,especially in clipping attacks. | Jialing Liu Jingbing Li Yenwei Chen Xiangxi Zou Jieren Cheng Yanlin Liu Uzair Aslam Bhatti | 2019 | Computers, Materials & Continua2019，，7： | 3 |
| 20 | A new gain-of-function OsGS2/GRF4 allele generated by CRISPR/Cas9 genome editing increases rice grain size and yield显示文摘Grain size is one of the most important factors affecting rice grain quality and yield,and attracts great attention from molecular biologists and breeders.In this study,we engineered a CRISPR/Cas9 system targeting the miR396 recognition site of the rice GS2 gene,which encodes growth-regulating factor 4(OsGRF4)and regulates multiple agronomic traits including grain size,grain quality,nitrogen use efficiency,abiotic stress response,and seed shattering.In contrast to most previous genome editing efforts in which indel mutations were chosen to obtain null mutants,a mutant named GS2^(E) carrying an in-frame 6-bp deletion and 1-bp substitution within the miR396-targeted sequence was identified.GS2^(E) plants showed increased expression of GS2 in consistent with impaired repression by miR396.As expected,the gain-of-function GS2^(E) mutant exhibited multiple beneficial traits including increased grain size and yield and bigger grain length/width ratio.Thousand grain weight and grain yield per plant of GS2^(E) plants were increased by 23.5%and 10.4%,respectively.These improved traits were passed to hybrids in a semidominant way,suggesting that the new GS2^(E) allele has great potential in rice improvement.Taken together,we report new GS2 germplasm and describe a novel gene-editing strategy that can be widely employed to improve grain size and yield in rice.This trait-improvement strategy could be applied to other genes containing miRNA target sites,in particular the conserved miR396-GRF/GIF module that governs plant growth,development and environmental response. | Wenshu Wang Weipeng Wang Yanlin Pan Chao Tan Hongjing Li Ya Chen Xingdan Liu Jing Wei Nian Xu Yu Han Han Gu Rongjian Ye Qi Ding Chonglie Ma | 2022 | The Crop Journal2022，10，4： | 3 |
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