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| 1 | Interleukin-17 and its expanding biological functions显示文摘Interleukin-17(IL-17)and IL-17-producing cells have been shown to play important roles in inflammation and the immune response.IL-17 is believed to be mainly produced by T helper 17(Th17)cells,a unique helper T-cell subset different from Th1 and Th2 cells.Other subsets of T cells such as cdT and natural killer T(NKT)cells have also been found to produce IL-17 in response to innate stimuli.IL-17 acts as a proinflammatory cytokine that can induce the release of certain chemokines,cytokines,matrix metalloproteinases(MMPs)and antimicrobial peptides from mesenchymal and myeloid cells.This leads to the expansion and accumulation of neutrophils in the innate immune system and links innate and adaptive immunity in vivo.Furthermore,increasing evidence indicates that IL-17 and IL-17-producing cells are involved in the pathogenesis of various diseases such as allergies,autoimmune diseases,allograft transplantation and even malignancy.They may also play protective roles in host defense against infectious diseases and promote induction of cytotoxic T lymphocyte(CTL)responses against cancer.Targeting of the IL-17 axis is under investigation for the treatment of inflammatory disorders. | Sheng Xu Xuetao Cao | 2010 | Cellular & Molecular Immunology2010，7，3： | 50 |
| 2 | Homogenization of temperature field and temperature gradient field显示文摘The homogenization of temperature field and temperature gradient field are very important for many devices, systems and equipments, such as satellites and electronic devices. This paper discusses the distribution optimization of the limited high conductivity material with the simulated annealing algorithm to homogenize the temperature field in a two-dimensional heat conduction problem. At the same time, the temperature gradient field is homogenized with the bionic optimization method. The results show that the two optimization targets are consistent to some extent, while the bionic optimization method could save much computing time. In addition, there are threshold values for the amount of high conductivity material and the ratio of the high conductivity to the low conductivity beyond which further increasing these values brings very little improvement on the homogenization of temperature field and temperature gradient field. | CHENG XueTao XU XiangHua LIANG XinGang | 2009 | Science China(Technological Sciences)2009，52，10： | 35 |
| 3 | Regulation of Toll-like receptor signaling in innate immunity显示文摘Toll-like receptors sense invading pathogens by recognizing a wide variety of conserved pathogen-associated molecular patterns(PAMPs).The members of the TLR family selectively utilize adaptor proteins MyD88,TRIF,TIRAP and TRAM to activate overlapping but distinct signal transduction pathways which trigger production of different panels of mediators such as proinflammatory cytokines and type I interferon.These mediators not only control innate immunity but also direct subsequently developed adaptive immunity.TLR activation is strictly and finely regulated at multiple levels of the signal transduction pathways. | AN HuaZhang,QIAN Cheng & CAO XueTao National Key Laboratory of Medical Immunology & Institute of Immunology,Second Military Medical University,Shanghai 200433,China | 2010 | Science China(Life Sciences)2010，53，1： | 29 |
| 4 | Entransy decrease principle of heat transfer in an isolated system显示文摘The entropy increase principle for an isolated system and the criteria of thermal equilibrium for an isolated system and systems with prescribed temperature and volume can be derived on the basis of the concept of entropy and the first and second laws of thermodynamics. In this paper, the entransy decrease principle for an isolated system is introduced on the basis of the concept of entransy. It is found that the entransy of an isolated system always decreases during heat transfer. This principle can be taken as an expression of the second law of thermodynamics for heat transfer. The thermal equilibrium criteria for an isolated system and a closed system are also introduced. It is found that when an isolated system reaches thermal equilibrium, its entransy is a minimum value. This criterion is referred to as the minimum entransy principle. When a closed system reaches thermal equilibrium, its free entransy is also a minimum value. This criterion is referred to as the minimum free entransy principle. Therefore, like entropy, entransy can be considered an arrow of time in heat transfer and used to describe the thermal equilibrium state. | CHENG XueTao LIANG XinGang GUO ZengYuan | 2011 | Chinese Science Bulletin2011，56，9： | 29 |
| 5 | MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression显示文摘MicroRNAs(miRNAs) are small,noncoding RNAs which can often act as an oncogene or a tumor suppressor.Several miRNAs are associated with the development of hepatocellular carcinoma(HCC).We demonstrated that miR-125b significantly suppresses HCC cell proliferation and promotes apoptosis by inhibiting the gene expression of the anti-apoptotic protein,Bcl-2.Bioinformatic analysis indicated that the 3'UTR of Bcl-2 has binding sites for miR-125b.Luciferase reporter assay confirmed the ability of miR-125b to dramatically suppress Bcl-2 transcription,suggesting that Bcl-2 is a target gene for miR-125b.We concluded that miR-125b acts as a tumor suppressor in hepatic tumor development by targeting Bcl-2 and inducing cancer cell apoptosis. | Aihua Zhao Quan Zeng Xiaoyan Xie Junnian Zhou Wen Yue Yali Li Xuetao Pei | 2012 | Journal of Genetics and Genomics2012，39，1： | 30 |
| 6 | The origin and function of tumor-associated macrophages显示文摘 | Yang Liu Xuetao Cao | 2015 | Cellular & Molecular Immunology2015，12，1： | 27 |
| 7 | Siglecl suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27显示文摘 | Qingliang Zheng Jin Hou Ye Zhou Yingyun Yang Bing Xie Xuetao Cao | 2015 | Cell Research2015，25，10： | 21 |
| 8 | Cellular and molecular regulation of innate inflammatory responses显示文摘由模式识别受体(PRR ) 的病原体的天生的察觉到在在自我和非自我部件之间的天生的辨别起必要作用,导致天生的有免疫力的防卫和煽动性的回答的产生。天生的煽动性的反应的开始,激活和分辨率被相互作用的一个复杂网络在有免疫力、非有免疫力的系统的众多的细胞、分子的部件之中调停。当时一控制并且有益的天生的煽动性的反应是批评的因为病原体的消除和织物动态平衡, dysregulated 或持续发炎的维护导致象长期的感染那样的病理学的条件,煽动性的自体免疫的疾病。在这评论,我们为天生的免疫和煽动性的回答的建立和规定在我们细胞、分子的机制的理解讨论一些最近的进展。 | Juan Liu Xuetao Cao | 2016 | Cellular & Molecular Immunology2016，13，6： | 20 |
| 9 | Radiative entransy flux in enclosures with non-isothermal or non-grey,opaque,diffuse surfaces and its application显示文摘The spectral radiative entransy flux and the total radiative entransy flux are defined for the steady radiative heat transfer processes in enclosures composed of non-isothermal or non-grey,opaque,diffuse surfaces.Based on the definitions,the radiative entransy flux balance equation and the radiative entransy dissipation functions are introduced under spectral and total wavelength condition.Furthermore,the minimum principle of radiative entransy loss,the extreme principle of radiative entransy dissipation and the minimum principle of radiative thermal resistance are developed.The minimum principle of radiative entransy loss shows that the potential and the net radiative heat flux distribution which meet the control equations and the boundary conditions would make the radiative entransy loss minimum if the net radiative heat flux or the potential distribution of the radiative heat transfer system is given.The extreme principle of radiative entransy dissipation indicates that the minimum radiative entransy dissipation leads to the minimum average potential difference for the prescribed total radiative heat exchange and the maximum radiative entransy dissipation leads to the maximum radiative heat exchange for the prescribed average potential difference.Moreover,the minimum principle of radiative thermal resistance tells us that the aforementioned extreme values of radiative entransy dissipation both correspond to the minimum value of radiative thermal resistance.Application examples are given for the extreme principle of spectral radiative entransy dissipation and the minimum principle of spectral radiative thermal resistance,and the principles are proved to be applicable. | CHENG XueTao XU XiangHua LIANG XinGang | 2011 | Science China(Technological Sciences)2011，54，9： | 20 |
| 10 | Immunosuppressive exosomes from TGF-pl gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells显示文摘 | Zhijian Cai Wei Zhang Fei Yang Lei Yu Zhou Yu JihHung Pan Lie Wang Xuetao Cao Jianli Wang | 2012 | Cell Research2012，22，3： | 20 |
| 11 | Application of entransy to optimization design of parallel thermal network of thermal control system in spacecraft显示文摘For distribution optimization of the flow rate of cold fluid and heat transfer area in the parallel thermal network of the thermal control system in spacecraft,a physical and mathematical model is set up,analyzed and discussed with the entransy theory.It is found that the optimization objective of this problem and the optimization direction of the extremum entransy dissipation principle are consistent in theory.For a two-branch thermal network system,the distributions of the flow rate of the cold fluid and the heat transfer area are optimized by calculating the extremum entransy dissipation with the Newton method.The influential factors of the optimized distributions are also analyzed and discussed.The results show that the main influence factors are the heat transfer rate of the branches and the total heat transfer area.The total flow rate of the cold fluid has a threshold,beyond which further increasing its value brings very little influence on the optimization results.Moreover,the difference between the extremum entransy dissipation principle and the minimum entropy generation principle is also discussed when they are used to analyze the problem in this paper,and the extremum entransy dissipation principle is found to be more suitable.In addition,the Newton method is mathematically efficient to solve the problem,which could accomplish the optimized distribution in a very short time for a ten-branch thermal network system. | CHENG XueTao XU XiangHua LIANG XinGang | 2011 | Science China(Technological Sciences)2011，54，4： | 19 |
| 12 | Optimization of heat transfer and heat-work conversion based on generalized heat transfer law显示文摘Examples of heat transfer and heat-work conversion are optimized with entropy generation and entransy loss,respectively based on the generalized heat transfer law in this paper.The applicability of entropy generation and entransy loss evaluation in these optimization problems is analyzed and discussed.The results show that the entransy loss rate reduces to the entransy dissipation rate in heat transfer processes,and that the entransy loss evaluation is effective for heat transfer optimization.However,the maximum heat transfer rate does not correspond to the minimum entropy generation rate with prescribed heat transfer temperature difference,which indicates that the entropy generation minimization is not always appropriate to heat transfer optimization.For heat-work conversion processes,the maximum entransy loss rate and the minimum entropy generation rate both correspond to the maximum output power,and they are both appropriate to the optimization of the heat-work conversion processes discussed in this paper. | CHENG XueTao WANG WenHua LIANG XinGang | 2012 | Science China(Technological Sciences)2012，55，10： | 19 |
| 13 | TGF-β1 gene-modified,immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4^(+)Foxp3^(+)regulatory T cells显示文摘Inflammatory bowel disease(IBD)is caused by an uncontrolled immune response in the intestinal lumen,leading to inflammation in genetically predisposed individuals.Immunotherapy may be a promising approach to the treatment of IBD.Here,we show that transforming growth factor-β1(TGF-β1)gene-modified immature dendritic cells(imDCs)could enhance the inhibitory function of imDCs and delay the progress of IBD induced by dextran sodium sulfate in mice.The results of fluorescence-activated cell sorter(FACS)demonstrated that this protective effect is mediated partially by inducing CD4^(+)Foxp3^(+)regulatory T cells(Tregs)in mesentery lymph nodes to control inflammation.In vitro experiments also supported this hypothesis.In conclusion,we provide evidence that TGF-b1-modified bone marrow-derived imDCs may have a therapeutic effect to IBD. | Zhijian Cai Wei Zhang Min Li Yinpu Yue Fei Yang Lei Yu Xuetao Cao Jianli Wang | 2010 | Cellular & Molecular Immunology2010，7，1： | 18 |
| 14 | Lightweight and robust rGO/sugarcane derived hybrid carbon foams with outstanding EMI shielding performance显示文摘Increasingly severe electromagnetic pollution is now in urgent need of materials with lightweight,excellent flame retardancy,and outstanding electromagnetic interference shielding effectiveness(EMI SE).Renewable source-derived carbon foams and graphene have attracted extensive attention due to their 3D porous structure and remarkable electrical conductivity().In this work,annealed sugarcane(ASC)was prepared by removal of lignin from sugarcane via hydrothermal reaction,followed by annealing treatment.Then graphene oxide(GO)was filled by vacuum-assisted impregnation process and thermally annealed to obtain the ASC/reduced graphene oxide(rGO)hybrid foams.When the loading of rGO is 17 wt.%,the ASC/rGO hybrid foam(density,of 0.047 g/cm^3)exhibits the optimal of 6.0 S/cm,EMI SE of 53 dB,specific SE(SSE=SE/)/thickness(t)of 3830 dB·cm^2/g,and compressive strength of 1.33 MPa,which is 76%,36%,13%and 6%higher than those of ASC,respectively.Moreover,ASC/rGO presents excellent flame retardancy,thermal stability,and heat insulation,which remains constant under burning on an alcohol lamp and presents low thermal conductivity of 115.19 mW(m·K),close to the requirement for heat insulation.Synergistic effect of ASC and rGO not only significantly increase of ASC/rGO,but fully utilizes the capability of ASC and rGO to attenuate electromagnetic waves by virtue of unique porous structures and abundant interfaces.Such kind of lightweight EMI materials with excellent mechanical property,shielding performance,flame retardancy,and heat insulation is expected to tackle the key scientific and technical bottleneck problems of EMI materials,and will greatly expand the application of carbon nanomaterials in the field of aerospace industry. | Lei Wang Xuetao Shi Junliang Zhang Yali Zhang Junwei Gu | 2020 | Journal of Materials Science & Technology2020，52，17： | 18 |
| 15 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 16 | Long noncoding RNAs in innate immunity显示文摘长 noncoding RNA (lncRNAs ) 被显示了通过不同机制在有免疫力的房间开发和有免疫力的回答起重要作用,例如剂量赔偿,印, enhancer 功能,和 transcriptional 规定。尽管大多数 lncRNAs 的功能是不清楚的,某 lncRNAs 被发现了经由蛋白质蛋白质相互作用的新方法控制 transcriptional 或天生、适应的有免疫力的回答的 post-transcriptional 规定或与 DNA 和 RNA 配对。有趣地,增加证据阐明了在在主人和病原体之间的相互作用的 lncRNAs 的重要性。在这评论,行动的 lncRNAs 模式的概述,以及在免疫的 lncRNAs 的重要、多样化的角色,被提供,并且在调整天生的有免疫力的回答的 lncRNAs 的一个新兴的范例被加亮。 | Yuan Zhang Xuetao Cao | 2016 | Cellular & Molecular Immunology2016，13，2： | 17 |
| 17 | Entransy analysis of open thermodynamic systems显示文摘The concept of entransy developed in recent years can describe the heat transport ability.This paper extends this concept to the open thermodynamic system and defines the concept of enthalpy entransy.The entransy balance equation of steady open thermodynamic systems,as well as the concept of entransy loss,is developed.The entransy balance equation is applied to analyzing and discussing the air standard cycle.It is found that the entransy loss rate can describe the change in net power output from the cycle but the entropy generation rate cannot when the heat absorbed by the working medium is from the combustion reaction of the gas fuel.When the working medium is heated by a high temperature stream,both the maximum entransy loss rate and the minimum entropy generation rate correspond to the maximum net power output from the cycle.Hence,the concept of entransy loss is an appropriate figure of merit that describes the cycle performance. | CHENG XueTao WANG WenHua LIANG XinGang | 2012 | Chinese Science Bulletin2012，57，22： | 16 |
| 18 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota显示文摘The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the brain.Iin this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4))as a coenzyme.Here,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut bacteria.Oral BBR acts in a way similar to vitamins.The L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to dopamine.To verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)mice.The bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria alone.Moreover,2,4,6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain dopamine.Theseresults demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the gut.Furthermore,a study of 28 patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the intestinalbacteria.Hence,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect. | Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou Xiao-Yang Li Xian-Feng Zhang Zheng-Wei Zhang Jie Fu Bao-Ying Wen Jin-Bo Yu Xuetao Cao Jian-Dong Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 19 | Full-thickness tissue engineered skin constructed with autogenic bone marrow mesenchymal stem cells显示文摘To explore the feasibility of repairing clinical cutaneous deficiency, autogenic bone marrow mesen-chymal stem cells (BMSCs) were isolated and differentiated into epidermal cells and fibroblasts in vitro supplemented with different inducing factors and biomaterials to construct functional tissue- engineered skin. The results showed that after 72 h induction, BMSCs displayed morphologic changes such as typical epidermal cell arrangement, from spindle shape to round or oval; tonofibrils, melano-somes and keratohyaline granules were observed under a transmission electronic microscope. The differentiated cells expressed epidermal stem cell surface marker CK19 (59.66% ± 4.2%) and epidermal cells differentiation marker CK10. In addition, the induced epidermal cells acquired the anti-radiation capacity featured by lowered apoptosis following exposure to UVB. On the other hand, the collagen microfibrils deposition was noticed under a transmission electronic microscope after differentiating into dermis fibroblasts; RT-PCR identified collagen type I mRNA expression in differentiated cells; radioimmunoassay detected the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) (up to 115.06 pg/mL and 0.84 ng/mL, respectively). Further in vivo implanting BMSCs with scaffold material short-ened skin wound repair significantly. In one word, autogenic BMSCs have the potential to differentiate into epidermal cells and fibroblasts in vitro, and show clinical feasibility acting as epidermis-like and dermis-like seed cells in skin engineering. | HE LiJuan, NAN Xue, WANG YunFang, GUAN LiDong, BAI CiXian, SHI ShuangShuang, YUAN HongFeng, CHEN Lin, LIU DaQing & PEI XueTao Laboratory of Stem Cells and Regenerative Medicine, Institute of Blood Transfusion, Academy of Military Medical Sciences, Beijing 100850, China | 2007 | Science China(Life Sciences)2007，50，4： | 16 |
| 20 | Modeling and Operation of the Power-to-Gas System for Renewables Integration: A Review显示文摘Power-to-Gas(P2G)plays an important role in enhancing large-scale renewable energy integration in power systems.As an emerging inter-disciplinary subject,P2G technology requires knowledge in electrochemistry,electrical engineering,thermodynamic engineering,chemical engineering and system engineering.Aiming at P2G modeling and operational problems concerning the research field of power systems and the energy internet,this paper briefly reviews the main technologies and application potentials of the P2G system,and makes systematic summaries of major progresses related to P2G’s integration into the power grid in a bottom-top manner,including the modeling of high/room-temperature electrolysis cells,steady-state/dynamic optimization control of the P2G system,P2G’s integrated model and operational strategies at the grid level.In the final part of this paper,suggestions are put forward on future research directions of P2G systems from the aspects of modeling and operational optimization. | Xuetao Xing Jin Lin Yonghua Song You Zhou Shujun Mu Qiang Hu | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 15 |
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