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| 1 | Self-monitoring of blood glucose in type 2 diabetic patients in China:current status and influential factors显示文摘 | Yuan Li Guo Xiaohui Xiong Zhenzhen Lou Qingqing Shen Li Zhao Fang Sun Zilin Li Jianwei | 2014 | Chinese Medical Journal2014，，2： | 21 |
| 2 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 3 | Changes in visibility with PM_(2.5) composition and relative humidity at a background site in the Pearl River Delta region显示文摘In fall–winter, 2007–2013, visibility and light scattering coefficients(b sp) were measured along with PM_(2.5)mass concentrations and chemical compositions at a background site in the Pearl River Delta(PRD) region. The daily average visibility increased significantly(p < 0.01) at a rate of 1.1 km/year, yet its median stabilized at ~13 km. No haze days occurred when the 24-hr mean PM_(2.5)mass concentration was below 75 μg/m^3. By multiple linear regression on the chemical budget of particle scattering coefficient(b sp), we obtained site-specific mass scattering efficiency(MSE) values of 6.5 ± 0.2, 2.6 ± 0.3, 2.4 ± 0.7 and 7.3 ± 1.2 m2/g,respectively, for organic matter(OM), ammonium sulfate(AS), ammonium nitrate(AN) and sea salt(SS). The reconstructed light extinction coefficient(b ext) based on the Interagency Monitoring of Protected Visual Environments(IMPROVE) algorithm with our site-specific MSE revealed that OM, AS, AN, SS and light-absorbing carbon(LAC) on average contributed 45.9% ± 1.6%,25.6% ± 1.2%, 12.0% ± 0.7%, 11.2% ± 0.9% and 5.4% ± 0.3% to light extinction, respectively.Averaged b ext displayed a significant reduction rate of 14.1/Mm·year(p < 0.05); this rate would be 82% higher if it were not counteracted by increasing relative humidity(RH) and hygroscopic growth factor(f(RH)) at rates of 2.5% and 0.16/year-1(p < 0.01), respectively, during the fall–winter, 2007–2013. This growth of RH and f(RH) partly offsets the positive effects of lowered AS in improving visibility, and aggravated the negative effects of increasing AN to impair visibility. | Xiaoxin Fu Xinming Wang Qihou Hu Guanghui Li Xiang Ding Yanli Zhang Quanfu He Tengyu Liu Zhou Zhang Qingqing Yu Ruqing Shen Xinhui Bi | 2016 | Journal of Environmental Sciences2016，28，2： | 18 |
| 4 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 5 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 6 | Biological drug and drug delivery-mediated immunotherapy显示文摘The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld. | Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 15 |
| 7 | Genome-Wide Expression Pattern Analyses of the Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases显示文摘像受体的蛋白质 kinases (RLK ) 是在房间房间和房间环境通讯起关键作用的 transmembrane 蛋白质的一个大组。基于细胞外的领域结构, RLK 被分类进超过 21 个亚科,充满白氨酸的重复 RLK (LRR-RLKs ) 在象 Arabidopsis 和米饭那样的植物在之中属于最大的亚科。在 Arabidopsis,有近似 223LRR-RLKs,但是哪个中的仅仅大约 60 个机能上地迄今为止被描述了。为了系统地在调整调查 LRR-RLKs 的 theroles,种生长,开发,和压力改编,我们产生了 promoter::GUS 为在 Arabidopsis 的所有 223 LRR-RLK 基因的转基因的植物并且在各种各样的发展舞台分析了他们的详细表达式模式。Theresults 提供 forfunctionally 阐明的珍贵资源这个大、必要的发信号的蛋白质亚科。 | Yunzhe Wu Qingqing Xun Yi Guo Jinghua Zhang Kaili Cheng Tao Shi Kai He Suiwen Hou Xiaoping Gou Jia Li | 2016 | Molecular Plant2016，9，2： | 13 |
| 8 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 9 | OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection显示文摘 | Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li | 2014 | Molecular Plant2014，7，6： | 11 |
| 10 | Present Geothermal Fields of the Dongpu Sag in the Bohai Bay Basin显示文摘The Dongpu sag is located in the south of the Bohai Bay basin, China, and has abundant oil and gas reserves. To date, there has been no systematic documentation of its geothermal fields. This study measured the rock thermal conductivity of 324 cores from 47 wells, and calculated rock thermal conductivity for different formations. The geothermal gradient and terrestrial heat flow were calculated for 192 wells on basis of 892 formation-testing data from 523 wells. The results show that the Dongpu sag is characterized by a medium-temperature geothermal field between stable and active tectonic areas, with an average geothermal gradient of 32.0°C/km and terrestrial heat flow of 65.6 mW/m2. The geothermal fields in the Dongpu sag is significantly controlled by the Changyuan, Yellow River, and Lanliao basement faults. They developed in the Paleogene and the Dongying movement occurred at the Dongying Formation depositional period. The geothermal fields distribution has a similar characteristic to the tectonic framework of the Dongpu sag, namely two subsags, one uplift, one steep slope and one gentle slope. The oil and gas distribution is closely associated with the present geothermal fields. The work may provide constraints for reconstructing the thermal history and modeling source rock maturation evolution in the Dongpu sag. | ZUO Yinhui QIU Nansheng HAO Qingqing ZHANG Yunxian PANG Xiongqi LI Zhongchao GAO Xia | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 9 |
| 11 | MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling显示文摘发信号的 BMP 怎么集成到并且使动摇人的 pluripotent 干细胞(hPSCs ) 的 pluripotency 电路开始区别进单个细菌层是一个长期的难题。这里,我们报导肌肉片断 homeobox 2 (MSX2 ) , msh 家庭的一个 homeobox 抄写因素, BMP 发信号的直接目标基因和 hPSC 到 mesendoderm 的区别的一个主人调停人。MSX2 的强制表示足够废除 pluripotency 并且导致 hPSCs 的指导 mesendoderm 区别,当 MSX2 弄空损害 mesendoderm 正式就职时。MSX2 是在 hPSCs 的 BMP 小径的直接目标基因,并且能被 Wnt 信号 synergistically 在 mesendoderm 正式就职期间经由 LEF1 激活。而且, MSX2 使动摇通过到 SOX2 倡导者和 SOX2 抄写的压抑的直接绑定的 pluripotency 电路,当 MSX2 通过节的倡导者的直接绑定和激活由 SOX2 的同时的抑制和节的表示的正式就职控制 mesendoderm 系承诺时。有趣地, SOX2 能支持 MSX2 蛋白质的降级,建议在在干细胞命运的控制的二个指定系的因素之间的相互的对抗。一起,我们的调查结果揭示使动摇的关键新机制在 hPSCs 的 pluripotency 和指导系承诺。 | Qingqing Wu Leisheng Zhang Pei Su Xiaohua Lei Xin Liu Hongtao Wang Lisha Lu Yang Bai Tao Xiong Dong Li Zhengmao Zhu Enkui Duan Erlie Jiang Sizhou Feng Mingzhe Hang Yuanfu Xu Fei Wang Jiaxi Zhou | 2015 | Cell Research2015，25，12： | 8 |
| 12 | Aboveground biomass and corresponding carbon sequestration ability of four major forest types in south China显示文摘We estimated aboveground biomass carbon (TABC) and net carbon accumulation rates (TNEP) for trees in four major forest types based on national forest inventory data collected in 1994-1998 and 1999-2003. The four types were Pinus massoniana forest, Cunninghamia lanceolata forest, hard broad-leaved evergreen forest and soft broad-leaved evergreen forest. We analyzed variations in TABC and TNEP for five stand ages (initiation, young, medium, mature and old). In both time periods, estimated TABC in all four forest types increased consistently with forest stand age and the oldest stage had the largest TABC compared with other stages. Broad-leaved forests (hard and soft) had higher TABC than needle-leaved forests (Pinus massoniana and Cunninghamia lanceolata) for each of the five age stages. The difference of TABC between broad-leaved and needle-leaved forests increased with forest stand age. Comparison of estimated TNEP by age category indicated TNEP increased from the initiation stage to the young stage, and then decreased from the mature stage to old stage in all four forest types. TNEP for any particular stage depended on the forest type; for instance, broad-leaved forests at both the mature and old stages had greater TNEP than in needle-leaved forests. A logistic curve was applied to fit the relationship between TABC and forest stand age. In each period, correlations in all four forest types were all statistically significant (P < 0.01) with R2 > 0.95. TABC was therefore predicted by these regression functions from 2000 to 2050 and the mean TNEP during the predicted period was estimated to be about 41.14, 31.53, 75.50 and 75.68 gCm-2a-1 in Pinus massoniana forest, Cunninghamia lanceolata forest, hard broad-leaved forest and soft broad-leaved forest, respectively. Results from both forest inventory and regression prediction suggest broad-leaved forests are greater carbon sinks, and hence have greater carbon sequestration ability especially in the mature and old stages when compared to needle-leaved forests. Broad-leaved forests should have high levels of carbon sequestration when compared with needle-leaved forests in south China. | CHEN QingQing XU WeiQiang LI ShengGong FU ShengLei YAN JunHua | 2013 | Chinese Science Bulletin2013，58，13： | 8 |
| 13 | Deep ultraviolet light-emitting diodes based on a well-ordered AlGaN nanorod array显示文摘The nanorod structure is an alternative scheme to develop high-efficiency deep ultraviolet light-emitting diodes(DUV LEDs). In this paper, we first report the electrically injected 274-nm AlGaN nanorod array DUV LEDs fabricated by the nanosphere lithography and dry-etching technique. Nanorod DUV LED devices with good electrical properties are successfully realized. Compared to planar DUV LEDs, nanorod DUV LEDs present>2.5 times improvement in light output power and external quantum efficiency. The internal quantum efficiency of nanorod LEDs increases by 1.2 times due to the transformation of carriers from the exciton to the free electron–hole, possibly driven by the interface state effect of the nanorod sidewall surface. In addition, the nanorod array significantly facilitates photons escaping from the interior of LEDs along the vertical direction, contributing to improved light extraction efficiency. A three-dimensional finite-different time-domain simulation is performed to analyze further in detail the TE-and TM-polarized photon extraction mechanisms of the nanostructure. Our results demonstrate the nanorod structure is a good candidate for high-efficiency DUV emitters. | LIANG ZHANG YANAN GUO JIANCHANG YAN QINGQING WU YI LU ZHUOHUI WU WEN GU XUECHENG WEI JUNXI WANG JINMIN LI | 2019 | Photonics Research2019，7，9： | 8 |
| 14 | Preparation and Applications of Soybean Residue CNF Films显示文摘In this study, soybean residues were treated with HCl and soybean residue cellulose was extracted, which was used to prepare cellulose nanofiber (CNF) using the high-pressure homogenization method. The maximum yield of CNF, the reaction temperature, reaction time, and HCl concentration were optimized. The optimum HCl concentration for acid treatment was 6%, the reaction time was 60 min, the reaction temperature was 80℃, and the maximum yield of soybean residue cellulose was 78.8%. The different CNF films were then prepared;the color, mechanical property, and light transmittance of the CNF films were studied. Compared to the properties of the CNF film prepared with the soybean residue cellulose by high-pressure homogenization 15 times (HGT-15 film), the mechanical properties of the CNF film with soybean residue cellulose by decolorizing treatment decreased, but the light transmittance increased. The film prepared by adding HGT- 15 CNF to whey protein was investigated for its mechanical property, light transmittance, and solubility. Unlike the pure whey protein film, addition of 2.0% CNF to the whey protein enhanced the mechanical property and water vapor transmission rate (WVT) of the film. With the increase in CNF content, the solubility of the whey protein film decreased, and then stabilized. | Peiyi Li Hezhen Liu Qingqing Hou Yumeng Wang Xinping Li | 2019 | Paper And Biomaterials2019，4，3： | 7 |
| 15 | Chemical vapor deposition of monolayer WS2 nano- sheets on Au foils toward direct application in hydrogen evolution显示文摘Monolayer tungsten disulfide (WS2), a typical member of the semiconducting transition metal dichalcogenide family has drawn considerable interest because of its unique properties. Intriguingly the edge of WS2 exhibits an ideal hydrogen binding energy which makes WS2 a potential alternative to Pt-based electrocatalysts for the hydrogen evolution reaction (HER). Here, we demonstrate for the first time the successful synthesis of uniform monolayer WS2 nanosheets on centimeter- scale Au foils using a facile, low-pressure chemical vapor deposition method. The edge lengths of the universally observed triangular WS2 nanosheets are tunable from -100 to N1,000 nm. The WS2 nanosheets on Au foils featuring abundant edges were then discovered to be efficient catalysts for the HER, exhibiting a rather high exchange current density of -30.20 μA/cm2 and a small onset potential of Nl10 mV. The effects of coverage and domain size (which correlate closely with the active edge density of WS2) on the electrocatalytic activity were investigated. This work not only provides a novel route toward the batch-production of monolayer WS2 via the introduction of metal foil substrates but also opens up its direct application for facile HER. | Yanshuo Zhang Jianping Shi Gaofeng Han Minjie Li Qingqing Ji Donglin Ma Yu Zhang Cong Li Xingyou Lang Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，9： | 7 |
| 16 | Suitability Evaluation of Rural Settlements Based on Accessibility of Production and Living: A Case Study of Tingzu Town in Hubei Prov- ince of China显示文摘Rural settlements are the main carriers of agriculture, rural areas and farmers; thus, optimizing the production and living space of rural settlements is highly significant to rural development. Taking the effective allocation of resources as the starting point, a suitability evaluation system of rural settlements, based on accessibility of production and living, was proposed in this study to provide scientific basis for the optimization of production and living space. The accessibility of production and living was measured by an improved two-step floating catchment area method, which considered proximity and availability based on the inclination of rural residents. The suitability evaluation system consisted of traditional suitability evaluation and newly proposed limiting factor identification based on the loss score proportion of suitability. Tingzu Town of Hubei Province, China, was chosen as the case study area. Based on the results of the suitability evaluation system, corresponding suggestions on rural land consolidation, industry division, as well as the layout of health care and education facilities were proposed to optimize the production and living space of rural settlements in Tingzu Town. It is found that the suitability evaluation based on accessibility of production and living is more scientific and accurate than the traditional ones which significantly overestimate production and living convenience. Moreover, the limiting factor identification can help us put forward suggestions according to local conditions and bring about the highly targeted optimization of production and living space of rural settlements. | LIU Yaolin YE Qingqing LI Jiwei KONG Xuesong JIAO Limin | 2016 | Chinese Geographical Science2016，26，4： | 7 |
| 17 | Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 18 | Meso–Cenozoic Tectono-Thermal Evolution History in Bohai Bay Basin, North China显示文摘The thermal history of sedimentary basins is a key factor for hydrocarbon accumulation and resource assessment, and is critical in the exploration of lithospheric tectono-thermal evolution. In this paper, the Cenozoic thermal histories of nearly 200 wells and the Mesozoic thermal histories of 15 wells are modeled based on the vitrinite reflectance and apatite fission track data in Bohai Bay Basin, North China. The results show that the basin experienced Early Cretaceous and Paleogene heat flow peaks, which reveals two strong rift tectonic movements that occurred in the Cretaceous and the Paleogene in the basin, respectively. The thermal evolution history in Bohai Bay Basin can be divided into five stages including(1) the low and stable heat flow stage from the Triassic to the Jurassic, with the heat flow of 53 to 58 m W/m2;(2) the first heat flow peak from the Early Cretaceous to the middle of the Late Cretaceous, with a maximum heat flow of 81 to 87 m W/m2;(3) the first post-rift thermal subsidence stage from the middle of the Late Cretaceous to the Paleocene, with the heat flow of 65 to 74 m W/m2 at the end of the Cretaceous;(4) the second heat flow peak from the Eocene to the Oligocene, with a maximum heat flow of 81 to 88 m W/m2; and(5) the second thermal subsidence stage from the Neogene to present, with an average heat flow of 64 m W/m2. | Yinhui Zuo Nansheng Qiu Jiawei Li Qingqing Hao Xiongqi Pang Zhongying Zhao Qi Zhu | 2015 | Journal of Earth Science2015，26，3： | 6 |
| 19 | A direct H2O2 production based on hollow porous carbon sphere-sulfur nanocrystal composites by confinement effect as oxygen reduction electrocatalysts显示文摘Carbon-sulfur composites have draw n in creasing interest in various fields including electrocatalysis because of their unique structures.However,carb on-sulfur composite with tiny sulfur nano crystals has still received little attention.Herein,hollow porous carb on sphere-sulfur composite(HPCS-S)which possesses excellent electrochemical performance towards H2O2 has been prepared for the first time via a simple silica template method.The 2-5 nm sulfur nan ocrystals being restricted in the cha nnel of the hollow porous carb on spheres are un der a strong compressive stress,which was further con firmed by high-resoluti on tran smissi on electr on microscopy(HRTEM)and GPA.The HPCS-S nano crystals show better con ductivity tha n amorphous sulfur clusters because of the reducti on of the steric hindrance which efficie ntly promotes the electron transportation.Consequently,the higher activity and selectivity towards the 2e^oxygen reduction reaction(ORR)to H2O2 in alkaline solution was obtained.The H2O2 selectivity rises from 20%to over 70%after the sulfur addition and the H2O2 production rate achieves 183.99 mmol-gcataiyst-1 with the Faradaic efficiency of 70%.Furthermore,performance enhancement mechanism was also investigated using the den sity functional theory(DFT)calculatio ns.After the in troduci ng of sulfur nano crystals,the appeara nee of S-S bond greatly decreases the overpotential compared with S-doping,which results in significant enhancement of the electrocatalytic property.Consequently,the HPCS-S can be an efficient H2O2 production electrocatalyst in alkaline solution. | Guanyu Chen Jiwei Liu Qingqing Li Pengfei Guan Xuefeng Yu Linshen Xing Jie Zhang Renchao Che | 2019 | Nano Research2019，12，10： | 6 |
| 20 | Authentic compound-free strategy for simultaneous determination of primary coumarins in Peucedani Radix using offline high performance liquid chromatography–nuclear magnetic resonance spectroscopy–tandem mass spectrometry显示文摘Herein, a strategy is proposed for the simultaneous determination of primary coumarins in Peucedani Radix(Chinese name: Qianhu). The methodology consists of three consecutive steps: 1) Semi-preparative LC in combination with a home-made automated fraction collection module to fragment the universal metabolome standard into ten fractions(Frs. I–X); 2) LC–accurate MS/MS and quantitative1 H NMR spectroscopy conducted in parallel to acquire the qualitative and quantitative data of each fraction; 3) Robust identification and quantification of components by use of LC coupled to multiple reaction monitoring. In this final step, the most significant fractions(Frs. III–X) were pooled to serve as the pseudo-mixed standard solution. Meticulous online parameter optimization was performed to obtain the optimal parameters, including ion transitions and collision energies. Concerns were particularly paid onto pursuing the parameters being capable of monitoring regiospecific isomers, notably praeruptorin E vs. 3′-isovaleryl-4′-angeloylkhellactone. The quantitative performance of the method was validated according to diverse assays. Eleven primary coumarins(1–11) were unambiguously identified and absolutely quantified, even though no external reference compound was used. Above all, the integrated strategy not only provides a feasible pipeline for the quality assessment of Peucedani Radix, but more importantly, shows the potential for authentic compound-free quantitative evaluation of traditional Chinese medicines. | Yao Liu Qingqing Song Wenjing Liu Peng Li Jun Li Yunfang Zhao Liang Zhang Pengfei Tu Yitao Wang Yuelin Song | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
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