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| 1 | Association of emergency room visits for respiratory diseases with sources of ambient PM2.5显示文摘Previous studies have reported associations of short-term exposure to different sources of ambient fine particulate matter(PM2.5)and increased mortality or hospitalizations for respiratory diseases.Few studies,however,have focused on the short-term effects of source-specific PM2.5 on emergency room visits(ERVs)of respiratory diseases.Source apportionment for PM2.5 was performed with Positive Matrix Factorization(PMF)and generalized additive model was applied to estimate associations between source-specific PM2.5 and respiratory disease ERVs.The association of PM2.5 and total respiratory ERVs was found on lag4(RR=1.011,95%CI:1.002,1.020)per interquartile range(76μg/m3)increase.We found PM2.5 to be significantly associated with asthma,bronchitis and chronic obstructive pulmonary disease(COPD)ERVs,with the strongest effects on lag5(RR=1.072,95%CI:1.024,1.119),lag4(RR=1.104,95%CI:1.032,1.176)and lag3(RR=1.091,95%CI:1.047,1.135),respectively.The estimated effects of PM2.5 changed little after adjusting for different air pollutants.Six primary PM2.5 sources were identified using PMF analysis,including dust/soil(6.7%),industry emission(4.5%),secondary aerosols(30.3%),metal processing(3.2%),coal combustion(37.5%)and traffic-related source(17.8%).Some of the sources were identified to have effects on ERVs of total respiratory diseases(dust/soil,secondary aerosols,metal processing,coal combustion and traffic-related source),bronchitis ERVs(dust/soil)and COPD ERVs(traffic-related source,industry emission and secondary aerosols).Different sources of PM2.5 contribute to increased risk of respiratory ERVs to different extents,which may provide potential implications for the decision making of air quality related policies,rational emission control and public health welfare. | Rui Chi Hongyu Li Qian Wang Qiangrong Zhai Daidai Wang Meng Wu Qichen Liu Shaowei Wu Qingbian Ma Furong Deng Xinbiao Guo | 2019 | Journal of Environmental Sciences2019，31，12： | 8 |
| 2 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 4 |
| 3 | Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China显示文摘 | Gu Jun Li Maolan Dong Ping Lu Jianhua Tan Zhujun Wu Xiangsong Mu Jiasheng Zhang Lin Wu Wenguang Ding Qichen Yang Jiahua Cao Yang Ding Qian Weng Hao Liu Yingbin | 2014 | Chinese Medical Journal2014，，3： | 2 |
| 4 | Simultaneous enhancement in electrical conductivity and Seebeck coefficient by single-to double-valley transition in a Dirac-like band显示文摘SnTe possesses a single-to double-valley transition in the conduction band minimum when a compressive strain is applied.Through a tight-binding analysis,it is shown that the variation of the band structure is attributed to the strain-induced delocalization of both the Sn-5s orbitals and Te-5p orbitals with different angular momenta.This effect can largely increase the electron density of states near the band edge and thus keep the Fermi level of the compressed SnTe closer to it,where the electrons have lower scattering rates.The strain-induced double valleys lead to simultaneous increases in the electrical conductivity and the Seebeck coefficient and thereby nearly four times the enhancement of the power factor at the doping concentration of 5×10^(19) cm^(–3).This work suggests a feasible concept that can be employed to promote the power factor of a Dirac semiconductor via manipulating the valley degeneracy in the conduction band minimum. | Yu Dai Wenjiang Zhou Hyun-Jung Kim Qichen Song Xin Qian Te-Huan Liu Ronggui Yang | 2022 | npj Computational Materials2022，，1： | 1 |
| 5 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 6 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 1 |
| 7 | Efficient Entity Relation Discovery on Web显示文摘 | He Jing Liu Yuan Tu Qichen | 2007 | Journal of Computational Information Systems2007，3，2： | 1 |
| 8 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 9 | Ground-Based Atmospheric CO_(2),CH_(4),and CO Column Measurements at Golmud in the Qinghai-Tibetan Plateau and Comparisons with TROPOMI/S5P Satellite Observations显示文摘Measurements of carbon dioxide(CO_(2)),methane(CH_(4)),and carbon monoxide(CO)are of great importance in the Qinghai-Tibetan region,as it is the highest and largest plateau in the world affecting global weather and climate systems.In this study,for the first time,we present CO_(2),CH_(4),and CO column measurements carried out by a Bruker EM27/SUN Fourier-transform infrared spectrometer(FTIR)at Golmud(36.42°E,94.91°N,2808 m)in August 2021.The mean and standard deviation of the column-average dry-air mixing ratio of CO_(2),CH_(4),and CO(XCO_(2),XCH_(4),and XCO)are 409.3±0.4 ppm,1905.5±19.4 ppb,and 103.1±7.7 ppb,respectively.The differences between the FTIR co-located TROPOMI/S5P satellite measurements at Golmud are 0.68±0.64%(13.1±12.2 ppb)for XCH_(4) and 9.81±3.48%(–10.7±3.8 ppb)for XCO,which are within their retrieval uncertainties.High correlations for both XCH_(4) and XCO are observed between the FTIR and S5P satellite measurements.Using the FLEXPART model and satellite measurements,we find that enhanced CH_(4) and CO columns in Golmud are affected by anthropogenic emissions transported from North India.This study provides an insight into the variations of the CO_(2),CH_(4),and CO columns in the Qinghai-Tibetan Plateau. | Minqiang ZHOU Qichen NI Zhaonan CAI Bavo LANGEROCK Jingyi JIANG Ke CHE Jiaxin WANG Weidong NAN Yi LIU Pucai WANG | 2023 | Advances in Atmospheric Sciences2023，40，2： | 1 |
| 10 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 11 | Potential active sites of Mo single atoms for electrocatalytic reduction of N_(2)显示文摘Single atom catalysts(SACs) with isolated metal atoms dispersed on supports exhibit distinctive performances for electrocatalysis reactions.The designable realization of well-dispersed single metal atoms is still a great challenge owing to their ease of aggregation.Here,Mo single atomic sites(Mo-N_(3)C)combined with some ultrasmall Mo_(2)C/MoN clusters(Mo-SA/Mo_(2)C-MoN-Cs,mean diameter <2 nm) on nitrogen-doped porous carbon were synthesized via a simple pyrolysis of bimetallic Zn/Mo metalorganic frameworks.X-ray absorption near edge spectra(XANES) in combination with various characterizations show that most of Mo species in sample exist in the form of single sites and the exact structure is Mo-N_(3)C.Density functional theory(DFT) calculation further shows that as the number of Ncoordination in the Mo-NxC moieties increases,the positive cha rge of Mo atoms increases.The single Mo atoms in Mo-N_(3)C have the best capability of N_(2) adsorption,which may serve as main active sites for further electrochemical N2 reduction. | Lei Chen Chaozheng He Ran Wang Qian Li Jian Zeng Wei Liu Yuchao Wang Qichen Wang Tong Ye Yougen Tang Yongpeng Lei | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 12 | Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion显示文摘 | Maolan Li Jun Shen Xiangsong Wu Bingtai Zhang Rui Zhang Hao Weng Qian Ding Zhujun Tan Guofeng Gao Jiasheng Mu Jiahua Yang Yijun Shu Runfa Bao Qichen Ding Wenguang Wu Yang Cao Yingbin Liu | 2013 | Medical Oncology2013，，2： | 1 |
| 13 | NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells显示文摘 | Zhujun Tan Maolan Li Wenguang Wu Lin Zhang Qichen Ding Xiangsong Wu Jiasheng Mu Yingbin Liu | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 14 | Synthesis and characterization of N -(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride for potential application in gene delivery显示文摘 | Bo Xiao Ying Wan Xiaoyu Wang Qichen Zha Haoming Liu Zhiye Qiu Shengmin Zhang | 2011 | Colloids and Surfaces B: Biointerfaces2011，，： | 1 |
| 15 | Nano-refinement of the face-centered cubic Zr(Fe,Cr)_(2)secondary phase particles in Zircaloy-4 alloy via localized-shearing/bending-driven fracture under high-temperature compression显示文摘Nanoparticles are extensively introduced to improve the mechanical,physical,and chemical properties of alloys.In the present study,the underlying nano-refinement mechanisms of face-centered cubic Zr(Fe,Cr)_(2)secondary phase particles(SPPs)that precipitated in Zircaloy-4 alloy under high-temperature compression were investigated in detail by utilizing high-resolution transmission electron microscopy(HRTEM)and conventional TEM techniques.The frequently observed Zr(Fe,Cr)_(2)SPPs were incoherent with the matrix and exhibited brittle fracture behaviors without measurable plasticity.HRTEM observations revealed two mechanisms underlying the nano-refinement of incoherent micro-sized SPPs via localized shear fracture on{11¯2}SPP and nanoprecipitate-assisted bending fracture,respectively.The latter was,for the first time,found to occur when the movements of large SPPs were blocked by nanometer-sized SPP during alloy deformation.Accordingly,two force models were proposed to visualize their potential nano-refinement processes.The knowledge attained from this study sheds new light on the deformation behaviors of Zr(Fe,Cr)_(2)SPPs and their associated size refinement mechanisms under high-temperature compression,and is expected to greatly benefit the process optimization of zirconium alloys to achieve precipitate nano-refinement. | Fuzhou Han Geping Li Fusen Yuan Wenbin Guo Jie Ren Qichen Wang Yingdong Zhang Ali Muhammad Chengze Liu Hengfei Gu | 2023 | Journal of Materials Science & Technology2023，，34： | 0 |
| 16 | Low-coordination environment design of single Co atoms for efficient CO_(2) photoreduction显示文摘Photocatalytic carbon dioxide(CO_(2))to carbon monoxide(CO)offers a promising way for both alleviating the greenhouse effect and meeting the industrial demand.Herein,we constructed a Co single-atom catalyst with intentional low-coordination environment design on porous ZnO(denoted as Co1/ZnO).Impressively,Co1/ZnO exhibited a remarkable activity with a CO yield rate of 22.25 mmol·g^(-1)·h^(-1) and a selectivity of 80.2%for CO_(2) photoreduction reactions under visible light.The incorporation of single Co atoms provided an additional photo-generated electron transfer channel,which suppressed the carrier recombination of photocatalysts.Moreover,the unsaturated Co active sites were capable to adsorb CO_(2) molecule spontaneously,thus facilitating the activation of CO_(2) molecule during CO_(2) reduction course. | Zhentao Ma Qingyu Wang Limin Liu Rong-Ao Zhang Qichen Liu Peigen Liu Lihui Wu Chengyuan Liu Yu Bai Yida Zhang Haibin Pan Xusheng Zheng | 2024 | Nano Research2024，17，5： | 0 |
| 17 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 18 | Synthetic lethal screening identifies DHODH as a target for MEN1-mutated tumor cells显示文摘Dear Editor,Multiple endocrine neoplasia 1(MEN1)syndrome,a tumor predisposition disease caused by MEN1 germline mutation,is characterized by combined occurrence of neuroendocrine tumors(NETs)in multiple organsJ Pancreatic neuroendocrine tumors(PanNETs)are the major cause of the increased mortality in MEN1 patie nts due to the most maligna nt potential. | Yarui Ma Qing Zhu Xiaobing Wang Mei Liu Qichen Chen Liming Jiang Yihebali Chi Yi-Xin Zeng Hong Zhao Yuchen Jiao | 2022 | Cell Research2022，32，6： | 0 |
| 19 | Recent progress on electro-sorption technology for lithium recovery from aqueous sources显示文摘Lithium is known as the“white petroleum”of the electrification era,and the global demand for lithium grows rapidly with the quick development of new energy industry.The aqueous solutions,such as salt lake brine,underground brine,and seawater,have large lithium reserves,thus this kind of lithium resource has become a research hotspot recently.Compared with other lithium extraction technologies,electro-sorption method shows good prospects for practical applications with advantages in the aspects of efficiency,recovery ratio,cost,and environment.Herein,this review covers recent progress on electro-sorption technology for lithium recovery from aqueous solutions,including the concept illustration,research progress of the applied working electrodes and counter electrodes,and the evaluation indicators of electro-sorption system.Meanwhile,some prospects for the development of this technology are also proposed.We hope this review is beneficial for the construction of high-efficient electrochemical lithium recovery system to achieve an adequate lithium supply in the future. | Qichen Lu Peng Liu Tianyi Zhou Ruling Huang Kexin Zhang Lin Hu Rong Liu Zhibo Ren Jinyi Wang Xiaolong Wang | 2024 | Nano Research2024，17，4： | 0 |
| 20 | Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms显示文摘Background and purpose Light transmission aggregometry(LTA)and CYP2C19 genotype analysis are commonly used to evaluate the antiplatelet effects of clopidogrel during the interventional treatment of intracranial aneurysms.The aim of this study was to determine which test can predict ischaemic events during these treatments.Methods Patient demographic information,imaging data,laboratory data and ischaemic complications were recorded.LTA and CYP2C19 genotype results were compared,and multiple linear regression was performed to examine factors related to platelet reactivity.Multivariate regression analysis was performed to determine whether LTA and CYP2C19 could predict ischaemic complications and to identify other clinical risk factors.Receiver operating characteristic curve analysis was conducted to calculate the cut-off value for predicting ischaemic complications.A subgroup analysis was also performed for different CYP2C19 genotype metabolisers,as well as for patients with flow diverters and traditional stents.Results A total of 379 patients were included,of which 22 developed ischaemic events.Maximum platelet aggregation induced by ADP(ADP-MPA)could predict ischaemic events(p<0.001;area under the curve,0.752(95%CI 0.663 to 0.842)),and its cut-off value was 41.5%.ADP-MPA(p=0.001)and hypertension duration>10 years(p=0.022)were independent risk factors for ischaemic events,while the CYP2C19 genotype was not associated with ischaemic events.In the subgroup analysis,ADP-MPA could predict ischaemic events in fast metabolisers(p=0.004)and intermediate metabolisers(p=0.003).The cut-off value for ischaemic events was lower in patients with flow diverters(ADP-MPA=36.4%)than in patients with traditional stents(ADP-MPA=42.9%).Conclusions ADP-MPA can predict ischaemic complications during endovascular treatment of intracranial aneurysms.Patients with flow diverters require stronger antiplatelet medication than patients with traditional stents. | Yangyang Zhou Wenqiang Li Chao Wang Ruhang Xie Yongnan Zhu Qichen Peng Limin Zhang Hongqi Zhang Yuxiang Gu Shiqing Mu Jian Liu Xinjian Yang | 2023 | Stroke & Vascular Neurology2023，8，4： | 0 |
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