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| 1 | Lens Epithelial Cell Proliferation and Cell Density in Human Age-related Cataract显示文摘Purpose: To discuss the potential effect of the lens epithelial cell proliferation inage-related cataract.Methods: In vitro cell proliferation was assayed by MTT method to evaluate the lensepithelial cell density, index, and proliferation capacity in normal lens and all kinds ofage-related cataract. Capsulotomy specimens from all kinds of patients who underwentcataract phacoemulsification extraction surgery were compared with the lens epithelialspecimens from non-cataract lenses of Eye Bank eyes.Results:Lens epithelial cell density of central anterior capsule(LECD) in female normallens was higher than that in male, LECD in nuclear cataract (> NⅢ) was higher thanthat in normal lens, but in the mature cortical cataract, LECD was lower. Mitotic indexof three kinds of age-related cataracts in vivo had no statistical difference, neither didcell proliferation capacity of cultivated cells in vitro.Conclusion: The individual difference of lens epithelial cell density and proliferationcapacity in vivo may be | Xialin Liu, Yizhi Liu, Jianliang Zheng, Qiang Huang, Ruling ZhengZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China | 2000 | 眼科学报2000，16，3： | 3 |
| 2 | Dnmt3a is required for the tumor stemness of B16 melanoma cells显示文摘The relationship of carcinogenesis and DNA methyltransferases has attracted extensive attention in tumor research. We reported previously that inhibition of de novo DNA methyltransferase 3a (Dnmt3a) in murine B16 melanoma cells significantly suppressed tumor growth and metastasis in xenografted mouse model. Here, we further demonstrated that knockdown of Dnmt3a enhanced the proliferation in anchor-independent conditions of B16 cells, but severely disrupted its multipotent differentiation capacity in vitro. Furthermore, transforming growth factor β1, a key trigger in stem cell differentiation and tumor cell epithelial–mesenchymal transition (EMT), mainly induced apoptosis, but not EMT in Dnmt3a-deficient B16 cells. These data suggested that Dnmt3a is required for maintaining the tumor stemness of B16 cells and it assists B16 cells to escape from death during cell differentiation. Thus it is hypothesized that not only extraordinary self-renewal ability, but also the capacity of multipotent differentiation is necessary for the melanoma tumorigenesis. Inhibition of multipotent differentiation of tumor cells may shed light on the tumor treatment. | Haoyue Wang Ying Kuang Jun Li Ruling Shen Ruilin Sun Danyi Huang Zhejin Sheng Jiahao Shi Mengjie Zhang Fang Huang Hua Yang Jian Fei | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 0 |
| 3 | An EGF receptor-targeting amphinase recombinant protein mediates anti-tumor activity in vitro and in vivo显示文摘利用连接到作为反肿瘤药指向分子的肿瘤的细胞毒素的蛋白质是一条有希望的途径。然而,从细菌或植物导出的大多数细胞毒素有象大分子的重量那样的固有的问题,他们触发强壮的免疫系统反应,它导致药失败和严肃的副作用。Amphinase (Amph ) 是有在北豹青蛙卵母细胞被发现的低分子的重量的 ribonuclease。它在 vivo 在 vitro 和弱 immunogenicity 对肿瘤房间线有强壮的 cytotoxicity,并且是在指向的药的发展的一个有希望的候选人。转变生长因素 --(TGF-) 那绑到表皮的生长因素受体(EGFR ) 为 EGFR 高表示的肿瘤的处理被用作一个指向的分子。在这研究,我们从 Escherichia coli 独立表示了并且净化 recombinant amphinase 和它的 TGF- 熔化蛋白质(AGT ) 。AGT 在 vivo 在 EGFR 高表示的肿瘤房间线,和更强壮的反肿瘤效果上在 vitro 展出了更重要的 cytotoxicity。这熔化蛋白质也展出了不平常的 thermostability,在 vivo immunogenicity,和副作用低。我们的结果为与低 immunogenicity 指向生物代理人的新奇、高度有效的反肿瘤的发展提供一个新入口点。 | Ruling Shen Danrong Ye Qin Huang Jun Li Qingcheng Wang Jian Fei | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 0 |
| 4 | Recent progress on electro-sorption technology for lithium recovery from aqueous sources显示文摘Lithium is known as the“white petroleum”of the electrification era,and the global demand for lithium grows rapidly with the quick development of new energy industry.The aqueous solutions,such as salt lake brine,underground brine,and seawater,have large lithium reserves,thus this kind of lithium resource has become a research hotspot recently.Compared with other lithium extraction technologies,electro-sorption method shows good prospects for practical applications with advantages in the aspects of efficiency,recovery ratio,cost,and environment.Herein,this review covers recent progress on electro-sorption technology for lithium recovery from aqueous solutions,including the concept illustration,research progress of the applied working electrodes and counter electrodes,and the evaluation indicators of electro-sorption system.Meanwhile,some prospects for the development of this technology are also proposed.We hope this review is beneficial for the construction of high-efficient electrochemical lithium recovery system to achieve an adequate lithium supply in the future. | Qichen Lu Peng Liu Tianyi Zhou Ruling Huang Kexin Zhang Lin Hu Rong Liu Zhibo Ren Jinyi Wang Xiaolong Wang | 2024 | Nano Research2024，17，4： | 0 |
| 5 | Layered K_(0.54)Mn_(0.78)Mg_(0.22)O_(2)as a high-performance cathode material for potassium-ion batteries显示文摘Layered Mn-based oxides are one of the promising cathode materials for potassium-ion batteries(KIBs)owing to their high theoretical capacities,abundant material supply,and simple synthesis method.However,the structural deterioration resulting from the Jahn-Teller effect of Mn ions hinders their further development in KIBs.Herein,a novel Mn-based layered oxide,K_(0.54)Mn_(0.78)Mg_(0.22)O_(2),is successfully designed and fabricated as KIBs cathode for the first time.It delivers smooth charging/discharging curves with high specific capacity of 132.4 mAh·g^(‒1)at 20 mA·g^(‒1)and good high-rate cycling stability with a capacity retention of 84%over 100 cycles at 200 mA·g^(‒1).Combining in-situ X-ray diffraction(XRD)and ex-situ X-ray photoelectron spectroscopy(XPS)analysis,the storage of K-ions by K_(0.54)Mn_(0.78)Mg_(0.22)O_(2)is revealed to be a solid-solution processes with reversible slip of the crystal lattice.The studies suggest that the rational doping of inactive Mg2+can effectively suppress the Jahn-Teller effect and provide outstanding structure stability.This work deepens the understanding of the structural evolution of Mn-based layered materials doped with inactive materials during de/potassiation processes. | Ruling Huang Qing Xue Jiao Lin XiXue Zhang Jiahui Zhou Feng Wu Li Li Renjie Chen | 2022 | Nano Research2022，15，4： | 0 |
| 6 | PVDF-HFP-SN-based gel polymer electrolyte for high-performance lithium-ion batteries显示文摘Gel polymer electrolytes(GPEs)have attracted extensive attention in lithium-ion batteries due to their high security and excellent electrochemical performance.However,their inferior Li-ion transference number,low room-temperature ionic conductivity,and poor long cycle stability raise challenges in practical applications.Herein,a flexible poly(vinylidene fluoride-cohexafluoropropylene)-butanedinitrile(PVDF-HFP-SN)-based GPE(PSGPE)is synthesized successfully by a general immersion precipitation method.The resultant PSGPEs have numerous connecting pores to ensure sufficient space for liquid electrolytes.Moreover,the reduced crystallinity of PVDF-HFP and the high polarity of SN can reduce the energy barrier of Li-ions shuttling between pores.The synergistic effect possesses a high ionic conductivity of 1.35 mS·cm^(-1)at room temperature with a high Li-ion transference number of 0.69.The PVDF-HFP-SN-based GPE is applied in a LiFePO_(4)/graphite battery,which can realize stable cycling performance for 350 cycles and good rate performance at room temperature.These results demonstrate that the novel PSGPE possesses advantage in simplified production process,which can improve the practicability of gel polymer lithium-ion batteries. | Ruling Huang Ruochen Xu Jiangtao Zhang Jiayun Wang Tianyi Zhou Mingyi Liu Xiaolong Wang | 2023 | Nano Research2023，16，7： | 0 |
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