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| 1 | The Y.D.and climate abrupt events in the early and middle Holocene:Stalagmite oxygen isotope record from Maolan,Guizhou,China显示文摘The isotope records which range from 3.9 kaBP to 15.7 kaBP with an average resolution of 90 a have been obtained from 45 cm to 193.6 cm of the upper part of D4 stalagmite from Dongguo Cave in Libo, Guizhou, by using system TIMS U-series dating and carbon and oxygen stable isotope analyses.The study indicates that the last cold event, the YD (Younger Dryas) event, of the last glacial period was apparently shown in D4 record, which started from 12.80 kaBP and ended in 11.58 kaBP, with a great range of drop in temperature. The end of the last glacial period was consistent with the termination I in oceanic isotope records and was with time limit of 11.3 kaBP. The three most distinct cold events in the early and middle Holocene occurred respectively in 10.91 kaBP, 8.27 kaBP and 4.75 kaBP, with a range of drop in tem- perature reaching 2—5℃. The climate abrupt events in thousand and hundred years scale re- corded in stalagmite δ O can be compared to those in GISP2 ice cores from Greenland in their 18 happening time and the range of their lasting time. The cold events in 8.27 kaBP and 4.75 kaBP can also be compared to CC3 stalagmite records in Ireland, which indicate that climate changes of short range in China monsoon areas, western Europe and polar regions, have the same driv- ing factor. This has a global significance. In addition, the trend of record curves in some time- stages is apparently different, which reflects probably the difference between environment in monsoon climate areas and in polar regions. | QIN Jiaming1, YUAN Daoxian1, CHENG Hai2, LIN Yushi1, ZHANG Meiliang1, WANG Fuxing1, R. L. Edwards2, WANG Hua1 & RAN Jingcheng3 1. The Karst Dynamic Laboratory, IKG, CAGS, Guilin 541004, China 2. Geology and Geophysics Department, Minnesota University, MN55455, USA 3. The Management of Maolan National Nature Reserve, Libo 558400, China | 2005 | Science China Earth Sciences2005，48，4： | 23 |
| 2 | Study of heavy metal speciation in branch sediments of Poyang Lake显示文摘这研究在波伊昂·莱克,的六个分支专注于沉积的公害水平在中国的最大的淡水湖。这在湖的六个分支是重金属(Cu,公司, Cd, Pb,和 Ni ) 的种形成分析上的第一份系统的报告。包含五步的顺序的抽取的一个报导分析过程被用于 particulating 重金属的分区。沉积样品用火焰被分析原子吸收光谱学(FAAS ) 。从五获得的试验性的结果在点表明了的采样复制河的底部表面沉积的样品顺序的抽取过程的相对标准差通常比 10% 好(Cd 除了) 。五个元素的平均提取内容,不管怎么说分析了五步,被发现是(mg/kg ) 为 Cu:26.89,公司:16.25, Cd:1.08, Pb:37.98,并且 Ni:20.46。可交换的种类的内容通常更低。除了 Cu,到有机物的种类契约的百分比比 20% 低。为 Cu,公司,和 Ni 包含大多数金属的部分是残余(52.26% , 45.28% ,和 74.82% ,分别地) 。 | LUO Mingbiao LI Jianqiang CAO Weipeng WANG Maolan | 2008 | Journal of Environmental Sciences2008，20，2： | 11 |
| 3 | Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases显示文摘Objective: To evaluate the feasibility and safety of total mesopancreas excision(TMpE) in the treatment of pancreatic head cancer. Methods: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. Results: The mean operative time was(275.0±50.2) min and the average intra-operative blood loss was(390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted. The specimen margins were measured in three dimensions, and 86 patients(71.6%) achieved R0 resection. Conclusions: TMpE is safe and feasible for pancreatic head cancer and is particularly helpful to increase the R0 resection rate. | Wenguang Wu Xu'an Wang Xiangsong Wu Maolan Li Hao Weng Yang Cao Ruifa Bao Sijun Su Jianhua Lu Wei Gong Weibin Shi Jun Gu Xuefeng Wang Yingbin Liu Zhiwei Quan Shuyou Peng | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 4 | Nested-loop Mechanism Based Modular Multilevel Converter Topology and Optimal Design显示文摘普通模块化多电平换流器(modular multilevelconverter,MMC)拓扑中,因子模块数量较多,系统需采集和处理的信息量大,导致控制系统硬件构成复杂。提出一种基于循环嵌套机理的MMC拓扑,其电平输出能力得到显著提升。通过上下两组子模块的协调投切,相对于普通MMC拓扑,新型拓扑输出相同电平数所需的子模块及控制设备数量大幅减少。阐述该新型拓扑的构成方式及基本参数选取原则;针对循环嵌套结构,设计相应的模块协调控制策略;分别以模块用量最小化和换流器运行损耗最小化为目标,优化设计拓扑构成方案。在RTDS中搭建换流器模型,仿真结果表明,新型拓扑具备更强的电平输出能力,并达到大幅减少子模块数量、简化控制系统硬件构成的目标。 | LIU Xinghua ZHAO Chengyong PENG Maolan GUO Chunyi ZHANG Baoshun | 2013 | 中国电机工程学报2013，33，9： | 7 |
| 5 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 4 |
| 6 | Hepatopancreatoduodenectomy for advanced biliary malignancies显示文摘Background:Hepatopancreatoduodenectomy(HPD)has been considered the only curative treatment for metastatic cholangiocarcinoma and some locally advanced gallbladder cancers(GBCs).However,HPD has not yet been included in treatment guidelines as a standard surgical procedure in consideration of its morbidity and mortality rates.The aim of this study was to evaluate the safety and effectiveness of HPD in treating biliary malignancies.Methods:The medical records of 57 patients with advanced biliary cancer undergoing HPD from January 2009 to December 2019 were retrospectively retrieved.A case-control analysis was conducted at our department.Patients with advanced GBC who underwent HPD(HPD-GBC group)were compared with a control group(None-HPD-GBC group).Baseline characteristics,preoperative treatments,tumor pathologic features,operative results,and prognosis were assessed.Results:Thirteen patients with cholangiocarcinoma and 44 patients with GBC underwent HPD at our department.Significant postoperative complications(grade III or greater)and postoperative pancreatic fistula were observed in 24(42.1%)and 15(26.3%)patients,respectively.One postoperative death occurred in the present study.Overall survival(OS)was longer in patients with advanced cholangiocarcinoma than in those with GBC(median survival time[MST],31 months vs.11 months;P<0.001).In the subgroup analysis of patients with advanced GBC,multivariate analysis demonstrated that T4 stage tumors(P=0.012),N2 tumors(P=0.001),and positive margin status(P=0.004)were independently associated with poorer OS.Patients with either one or more prognostic factors exhibited a shorter MST than patients without those prognostic factors(P<0.001).Conclusion:HPD could be performed with a relatively low mortality rate and an acceptable morbidity rate in an experienced highvolume center.For patients with advanced GBC without an N2 or T4 tumor,HPD can be a preferable treatment option. | Xiangsong Wu Maolan Li Wenguang Wu Xu’an Wang Huaifeng Li Runfa Bao Yijun Shu Jun Shen Jun Gu Xuefeng Wang Wei Gong Shuyou Peng Yingbin Liu | 2022 | Chinese Medical Journal2022，135，23： | 3 |
| 7 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 8 | Single-phase P2-type layered oxide with Cu-substitution for sodium ion batteries显示文摘The development of high-performance layered oxide cathodes for sodium ion batteries (SIBs) continues to facing be hindered by severe challenges to date.Herein,a single-phase P2-Na0.67Mn0.6Ni0.2Co0.1Cu0.1O2(NMNCC) comprising multiple-layer-oriented stacked nanoflakes is designed and synthesized via a simple sol-gel method.The large lattice parameters ensure a large three-dimensional frame,which enables the diffusion of sodium ions.Owing to its optimal morphology structure modulation transition metal substitution strategy,the MNCC electrode delivers a reversible capacity of 131.3 mAh g^-1 at 0.1 C with retention of 86.7%after 200 cycles.In addition,it provides an initial capacity of 86.7 mAh g^-1,and a retention of 80.0%after 500 cycles even at a current density of up to 1 A g^-1.The stable single-phase structure and slight volume shrinkage observed after Na+extraction further delay structural degradation.High Na+mobility and low Na+diffusion resistance are also guarantee the excellent rate performance of the NMNCC electrode.Thus,we determine that the NMNCC cathode is significant in the advancement of promising novel layered oxide cathodes. | Tao Chen Weifang Liu Yi Zhuo Hang Hu Maolan Zhu Ruizheng Cai Xinxin Chen Jun Yan Kaiyu Liu | 2020 | Journal of Energy Chemistry2020，29，4： | 2 |
| 9 | Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China显示文摘 | Gu Jun Li Maolan Dong Ping Lu Jianhua Tan Zhujun Wu Xiangsong Mu Jiasheng Zhang Lin Wu Wenguang Ding Qichen Yang Jiahua Cao Yang Ding Qian Weng Hao Liu Yingbin | 2014 | Chinese Medical Journal2014，，3： | 2 |
| 10 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 11 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 1 |
| 12 | Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer显示文摘Dear Editor,Gallbladder cancer(GBC),the most common malignant tumor of the biliary tract,is a highly invasive form of cancer.Surgical resection is currently the first line approach to effectively treat GBC;however,very few patients have the opportunity to receive radical surgical treatment due to lack of obvious symptoms.1 The median survival of patients with GBC is only 12 months and 5-year survival rate is<5%,indicating GBC is extremely poor prognosis.Therefore,it is urgent to identify novel key molecules that can potentially serve as early diagnostic biomarkers and/or therapeutic targets.The current study focused on the potential role of bone morphogenetic protein 2 inducible kinase(BMP2K),a serine/threonine kinase,which was recently identified as clathrin-coated vesicle-associated protein in the development of GBC;the outcome may hold diagnostic and therapeutic promising for clinical practice. | Xiaoling Song Maolan Li Wenguang Wu Wei Dang Yuan Gao Rui Bian Runfa Bao Yunping Hu Defei Hong Jun Gu Yingbin Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 13 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 14 | Study on SoilImprovement of TBM’S Commencement and Arrival in Water-rich Sand Stratum显示文摘 | Hua Jiang Yusheng Jiang Maolan Huang | 2011 | Applied Mechanics and Materials2011，90，3： | 1 |
| 15 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 16 | Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion显示文摘 | Maolan Li Jun Shen Xiangsong Wu Bingtai Zhang Rui Zhang Hao Weng Qian Ding Zhujun Tan Guofeng Gao Jiasheng Mu Jiahua Yang Yijun Shu Runfa Bao Qichen Ding Wenguang Wu Yang Cao Yingbin Liu | 2013 | Medical Oncology2013，，2： | 1 |
| 17 | NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells显示文摘 | Zhujun Tan Maolan Li Wenguang Wu Lin Zhang Qichen Ding Xiangsong Wu Jiasheng Mu Yingbin Liu | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 18 | Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis , inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin显示文摘 | Ping Dong Yong Zhang Jun Gu Wenguang Wu Maolan Li Jiahua Yang Lin Zhang Jianhua Lu Jiasheng Mu Lei Chen Songgang Li Jianwei Wang Yingbin Liu | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
| 19 | Tourism Development Idea of Yaogu Buyi Village in Guizhou Maolan Biosphere Reserve in China显示文摘After the survey of tourist resources of Yaogu Buyi Village in Maolan Biosphere Reserve,it has found that this village has abundant tourist resources and beautiful natural environment,and villagers have a strong desire to acquire wealth through tourism development.At the same time,the paper has pointed out that buildings in the village have been seriously destroyed,its environment is poor and it is lack of villagers for cultural inheritance.On this basis,it has proposed the general positioning of Yaogu national village development,and the idea and layout for tourist products' development.By depending on the natural scenery of Maolan Biosphere Reserve,with 'ancient Buyi,the source of folk custom' as the theme and 'one corridor and four zones' as the general layout,national cultural tourist products' development can be achieved through the integration of village's protection,cultural inheritance and economic development. | YU Dengli1,RAN Jingcheng1,LIU Shaofei1,PENG Zhuode2(1.Guizhou Maolan National Nature Reserve Administration,Libo,Guizhou 558400,China 2.Guangzhou Office of Beijing Lvwei Chuangjing Planning and Design Institure,Shenzhen,Guangdong 518040,China) | 2012 | Journal of Landscape Research2012，4，7： | 0 |
| 20 | Intelligent deformation of biomedical polyurethane显示文摘Polyurethane is a general term for a class of polymerscontaining a carbamate group(-NHCOO-)in its mainchain structure,including thermoplastic elastomers,flexi-ble and rigid foams,and other species[1-2].The existenceof thermodynamically incompatible soft segments and hardsegments in the structure of polyurethane can causemicrophase separation,which gives polyurethane somesuperior characteristics.Its performance can be adjusted byredesigning the proportion and the structure of soft andhard segments[3-5]. | Maolan ZHANG Huan WANG Junjie MAO Da SUN Xiaoling LIAO | 2021 | Frontiers of Materials Science2021，15，1： | 0 |
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