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| 1 | Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification显示文摘Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement. | Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay Nor Azhari Mohd Zam Puay Hoon Tan Min-Han Tan | 2011 | Chinese Journal of Cancer2011，30，2： | 6 |
| 2 | A rare case of isolated castrate resistant bilateral testicular metastases in advanced prostate cancer显示文摘Testicular metastasis is rare with the prostate being the most common site of primary cancer.We report a case of a 72-year-old man with castration-resistant prostate cancer(CRPC)and known metastases to bone and lymph nodes,who developed bilateral painful swollen testes 3 years after the initial diagnosis of prostate cancer.He had first presented with lower urinary tract symptoms(LUTS)with suspicious findings on digital rectal examination of the prostate,and an elevated serum prostate specific antigen(PSA)level of 129 ng/mL.Transrectal prostate biopsy revealed Gleason 4þ5 adenocarcinoma.Radiological staging showed locally advanced prostate cancer with extensive metastases to bone and pelvic and retroperitoneal lymph nodes.He was given hormonal therapy for over 2 years until progression to CRPC.Six months later he developed painful bilateral testicular swellings,and serum markers for testicular germ cell cancer were normal.Bilateral orchiectomy was performed,showing metastatic prostate cancer(Gleason 4þ5)on histology.One month postoperatively his PSA level dropped to 0.1 ng/mL from a presurgery level of 6.24 ng/mL. | Jiarui Su Edwin Jonathan Aslim Hakan Aydin Puay Hoon Tan Henry Sun Sien Ho | 2018 | Asian Journal of Urology2018，5，2： | 2 |
| 3 | Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer显示文摘 | Julia Y. S. Tsang Yu-Hua Huang Ming-Hua Luo Yun-Bi Ni Siu-Ki Chan Philip C. W. Lui Alex M. C. Yu Puay Hoon Tan Gary M. Tse | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
| 4 | Identification of Circulating MicroRNA Signatures for Breast Cancer Detection显示文摘 | Maurice Chan Chiew Suan Liaw Shen Mo Ji Hwee Huang Tan Chow Yin Wong Aye Aye Thike Puay Hoon Tan Gay Hui Ho Ann Siew-Gek Lee | 2013 | Clinical Cancer Research2013，，： | 1 |
| 5 | Improved method for efficient production of biodiesel from palm oil显示文摘 | RAHMAN TALUKDER M M MIN BEATRICE K L PUAY SONG O PUAH S CHUAN WU J JAE WON C CHOW Y | 2008 | Energy Fuels2008，22，1： | 1 |
| 6 | PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy显示文摘 | Jing Tan Zhimei Li Puay Leng Lee Peiyong Guan Mei Yee Aau Shuet Theng Lee Min Feng Cheryl Zihui Lim Eric Yong Jing Lee Zhen Ning Wee Yaw Chyn Lim R.K. Murthy Karuturi Qiang Yu | 2013 | Cancer Discovery2013，，10： | 1 |
| 7 | Acoustics evaluation of vertical greenery systems for building walls 显示文摘 | Nyuk Hien Wong Alex Yong Kwang Tan Puay York Tan | 2010 | Joural of Building and Environment2010，，45： | 1 |
| 8 | Coffee,tea, and incident type 2 diabetes:the Singapore Chinese Health Study显示文摘 | Andrew O Odegaard Mark A Pereira Woon- Puay Koh | 2008 | Am J Clin Nutr2008，88，： | 1 |
| 9 | Effect of Zinc oxide nanoparticles on biological wastewater treatment in a sequencing batch reactor 显示文摘 | Puay N Q Qiu G Ting Y P | 2015 | Journal of Cleaner Production2015，88，： | 1 |
| 10 | Factors Affecting a Partner's Perceived Effectiveness of Strategic Business Alliance Some Singaporean Evidence 显示文摘 | B Ramasehan Puay Choon Loo | 1998 | International Business Review1998，，7： | 1 |
| 11 | Factors Affecting a Partner's Perceived Effectiveness of Strategic Business Alliance : Some Singaporean Evidence 显示文摘 | B Ramaseshan Puay Choon Loo | 1998 | International Business Review1998，，7： | 1 |
| 12 | Multiparametric MRI reporting using Prostate Imaging Reporting and Data System version 2.0 (PI-RADSv2) retains clinical efficacy in a predominantly post-biopsy patient population显示文摘Objective:To evaluate the efficacy of multiparametric magnetic resonance imaging(mp-MRI)using Prostate Imaging Reporting and Data System version 2.0(PI-RADSv2)definitions in detecting organ-confined prostate cancer.Methods:All patients who underwent radical prostatectomy between January 1,2014 and December 30,2014 were identified.All underwent mp-MRI within 180 days before surgery.Those with prior pelvic irradiation or androgen deprivation therapy were excluded.Fully embedded,whole-mount histopathology was centrally reviewed and correlated with imaging for tumour location,Gleason score(GS)and stage.Results:There were 39 patients included,of which 35(90%)had mp-MRI done post-biopsy.A total of 93 cancer foci were identified on whole-mount pathology,of which mp-MRI detected 63(68%).Of those detected by mp-MRI,14 were PI-RADS 3(n=6 for GS 6,n=8 for GS 7,no GS≥8)and 49 were PI-RADS 4e5(nZ7 for GS 6,nZ33 for GS 7,and nZ9 for GS≥8).There were 30(32%)cancer foci missed by mp-MRI(n=15 for GS 6,n=13 for GS 7 and n=2 for GS≥8).A lesion classified as PI-RADS 4e5 predicted a higher grade cancer on pathology as compared to PI-RADS 3(for GS 7 lesions,odds ratio[OR]=3.53,95%CI:0.93e13.45,p=0.064).The mp-MRI size detection limit was 20 mm2 and 100 mm2 for 50%and 75%probability of cancer,respectively.In associating with radiological and pathologic stage,the weighted Kappa value was 0.69(p<0.0001).The sensitivity and positive predictive values for this study were 68%(95%CI:57%e77%)and 78%(95%CI:67%e86%),respectively.Conclusion:In this predominantly post-biopsy cohort,mp-MRI using PI-RADSv2 reporting has a reasonably high diagnostic accuracy in detecting clinically significant prostate cancer. | Edwin Jonathan Aslim Yan Mee Law Puay Hoon Tan John Carson Allen Jr Lionel Tim-Ee Cheng Viswanath Anand Chidambaram Li Yan Khor Benjamin Yongcheng Tan Ernest Wencong Eu Christopher Wai Sam Cheng John Shyi Peng Yuen Henry Sun Sien Ho Lui Shiong Lee | 2019 | Asian Journal of Urology2019，6，3： | 1 |
| 13 | Study of thermal performance of extensive rooftop greenery systems in the tropical climate 显示文摘 | Nyuk Hien W Puay Yok T Yu C | 2007 | Building and Environment2007，42，： | 1 |
| 14 | Study of thermal performance of extensive rooftop greenery systems in the tropical climate显示文摘 | WONG NYUK HIEN Tan Puay Yok Chen Yu | 2007 | Building and Environment2007，42，： | 1 |
| 15 | Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases显示文摘 | Naoto Kuroda Sperga Maris Federico A. Monzon Puay Hoon Tan Anjula Thomas Fredrik B. Petersson Zoran Gatalica Anatole Ghazalpour Ryan P. Bender Petr Grossmann Michal Michal Marian Svajdler Zdenka Ovcak Milan Hora Ondrej Hes | 2013 | Human Pathology2013，，： | 1 |
| 16 | The eell eyele inhibitor p27 is an independent prognostic marker in small (T1aTb)invasive brease eareinomas显示文摘 | Puay T Cady B Wamer M | 1999 | Cancer Res1999，57，7： | 1 |
| 17 | Validation of the Gail model for predicting individual breast cancer risk in a prospective na- tionwide study of 28,104 Singapore women显示文摘 | Wen Y Chay Whee S Ong Puay H Tan | 2012 | Breast Cancer Res2012，14，1： | 1 |
| 18 | Thermal evaluation of vertical greenery systems for building walls显示文摘 | Nyuk Hien Wong Alex Yong Kwang Tan Yu Chen Kannagi Sekar Puay Yok Tan Derek Chan Kelly Chiang Ngian Chung Wong | 2009 | Building and Environment2009，，3： | 1 |
| 19 | No association of two Fas gene polymorphisms with hashimotes thyroidifi and Graves disease显示文摘 | Puai MA Besmur F | 2003 | Eur J Endocrinol2003，149，5： | 1 |
| 20 | Thermal evaluation of vertical greenery systems for building walls显示文摘 | Nyuk Hien Wong Alex Yong Kwang Tan Yu Chen Kannagi Sekar Puay Yok Tan Derek Chan Kelly Chiang Ngian Chung Wong | 2009 | Building and Environment2009，，3： | 1 |
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