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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 3 | Prognostic biomarkers for prediction of recurrence of hepatocellular carcinoma:Current status and future prospects显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer death worldwide,with region specific etiologies.Despite improvements made in the diagnosis of HCC,the prognosis of HCC patients remains poor due to the high recurrence rate of HCC.There is an urgent need for development of prognostic biomarkers to predict the risk of recurrence in HCC patients after'curative'treatment.Such stratification may aid in patient management and development of personalized medicine for HCC treatment.Omics based studies facilitate the study of global changes in biomolecules in a disease in a high throughput manner,and hence are well poised to understand the complex changes which led to HCC recurrence.The quantitative nature of data obtained from omics based studies allow for development of prognostic biomarkers based on changes in gene,protein and metabolite expression.In this review,we surveyed the ap-plication of transcriptomics,proteomics and metabolomics in the study of HCC recurrence.We summarised the data in the literature from these three fields of studies that claimed to be prognostic for HCC recurrence.We critiqued on the limitations of each area of research and the challenges faced in translating the research results for clinical application in predicting HCC recurrence. | Seow Chong Lee Hwee Tong Tan Maxey Ching Ming Chung | 2014 | World Journal of Gastroenterology2014，20，12： | 11 |
| 4 | Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma:A critical appraisal of the evidence显示文摘AIM To perform a systematic review to determine the survival outcomes after curative resection of intermediate and advanced hepatocellular carcinomas(HCC).METHODS A systematic review of the published literature was performed using the PubM ed database from 1 st January 1999 to 31 st Dec 2014 to identify studies that reported outcomes of liver resection as the primary curative treatment for Barcelona Clinic Liver Cancer(BCLC) stage B or C HCC. The primary end point was to determine the overall survival(OS) and disease free survival(DFS) of liver resection of HCC in BCLC stage B or C in patients with adequate liver reserve(i.e., Child's A or B status). The secondary end points were to assess the morbidity and mortality of liver resection in large HCC(defined as lesions larger than 10 cm in diameter) and to compare the OS and DFS after surgical resection of solitary vs multifocal HCC.RESULTS We identified 74 articles which met the inclusion criteria and were analyzed in this systematic review. Analysis of the resection outcomes of the included studies were grouped according to(1) BCLC stage B or C HCC,(2) Size of HCC and(3) multifocal tumors. The median 5-year OS of BCLC stage B was 38.7%(range 10.0-57.0); while the median 5-year OS of BCLC stage C was 20.0%(range 0.0-42.0). The collective median 5-year OS of both stages was 27.9%(0.0-57.0). In examining the morbidity and mortality following liver resection in large HCC, the pooled RR for morbidity [RR(95%CI) = 1.00(0.76-1.31)] and mortality [RR(95%CI) = 1.15(0.73-1.80)] were not significant. Within the spectrum of BCLC B and C lesions, tumors greater than 10 cm were reported to have median 5-year OS of 33.0% and multifocal lesions 54.0%.CONCLUSION Indication for surgical resection should be extended to BCLC stage B lesions in selected patients. Further studies are needed to stratify stage C lesions for resection. | Ye Xin Koh Hwee Leong Tan Weng Kit Lye Juinn Huar Kam Adrian Kah Heng Chiow Siong San Tan Su Pin Choo Alexander Yaw Fui Chung Brian Kim Poh Goh | 2018 | World Journal of Hepatology2018，10，6： | 10 |
| 5 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 6 | An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats显示文摘Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects. | Ji Yeong Kim Woo Joo Jeon Dong Hwee Kim Im Joo Rhyu Young Hwan Kim Inchan Youn Jong Woong Park | 2014 | Neural Regeneration Research2014，9，14： | 6 |
| 7 | Recurrent surgical site infection after anterior cruciate ligament reconstruction: A case report显示文摘BACKGROUND Surgical site infections following anterior cruciate ligament(ACL)reconstruction are an uncommon but potentially devastating complication.In this study,we present an unusual case of recurrent infection of the knee after an ACL reconstruction,and discuss the importance of accurate diagnosis and appropriate management,including the issue of graft preservation versus removal.CASE SUMMARY A 33-year-old gentleman underwent ACL reconstruction using a hamstring tendon autograft with suspensory Endobutton fixation to the distal femur and an interference screw fixation to the proximal tibia.Four years after ACL reconstruction,he developed an abscess over the proximal tibia and underwent incision and drainage.Remnant suture material was found at the base of the abscess and was removed.Five years later,he re-presented with a lateral distal thigh abscess that encroached the femoral tunnel.He underwent incision and drainage of the abscess which was later complicated by a chronic discharging sinus.Repeated magnetic resonance imaging revealed a fistulous communication between the lateral thigh wound extending toward the femoral tunnel with suggestion of osteomyelitis.Decision was made for a second surgery and the patient was counselled about the need for graft removal should there be intraarticular involvement.Knee arthroscopy revealed the graft to be intact with no evidence of intra-articular involvement.As such,the decision was made to retain the ACL graft.Re-debridement,excision of the sinus tract and removal of Endobutton was also performed in the same setting.Joint fluid cultures did not grow bacteria.However,tissue cultures from the femoral tunnel abscess grew Enterobacter cloacae complex,similar to what grew in tissue cultures from the tibial abscess five years earlier.In view of the recurrent and indolent nature of the infection,antibiotic therapy was escalated from Clindamycin to Ertapenem.He completed a six-week course of intravenous antibiotics and has been well for six months since surgery,with excellent knee function and no evidence of any further infection.CONCLUSION Prompt and accurate diagnosis of surgical site infection following ACL reconstruction,including the exclusion of intra-articular involvement,is important for timely and appropriate treatment.Arthroscopic debridement and removal of implant with graft preservation,together with a course of antibiotics,is a suitable treatment option for extra-articular knee infections following ACL reconstruction. | Don Koh Shi Ming Tan Andrew Hwee Chye Tan | 2019 | World Journal of Orthopedics2019，10，6： | 5 |
| 8 | 钢纤维水泥砂浆加固砌体墙的平面外受力性能显示文摘用钢纤维混凝土加固修复工程结构是一种提高其极限承载力和延性的有效方法。该文研究了钢纤维水泥砂浆加固砌体墙的平面外受力性能,试验了4个1000mm×1000mm×115mm的砌体墙,采用30mm厚、纤维体积含量分别为1.0%、1.5%、2.0%和2.5%的钢纤维水泥砂浆加固。试验结果表明:用体积含量为1.5%的钢纤维水泥砂浆加固效果最好;同时该文数值模拟了钢纤维水泥沙浆加固砌体墙的平面外极限承载力,数值模拟结果与试验结果吻合较好。 | 陈升平 TAN Kiang Hwee | 2010 | 工程力学2010，27，4： | 4 |
| 9 | 反分析法确定钢纤维水泥砂浆拉应力与裂缝张开位移关系显示文摘在数值模拟钢纤维混凝土结构或构件和用基于断裂力学理论的设计方法设计钢纤维混凝土结构或构件时,钢纤维混凝土材料σ-w关系是一个重要的材料参数。该文根据三点弯曲缺口梁的荷载与裂缝张开位移(CMOD)曲线用反分析法确定了钢纤维水泥砂浆的σ-w关系。试验制作了五种不同体积含量的钢纤维水泥砂浆单轴拉伸试件、圆柱体压缩试件和梁试件,钢纤维体积含量分别为0.5%、1.0%、1.5%、2.0%和2.5%。试验发现,当钢纤维体积含量较小时,三点弯曲缺口梁的荷载与裂缝张开位移曲线呈现CMOD软化特性;而当钢纤维体积含量较大时,三点弯曲缺口梁的荷载与裂缝张开位移曲线呈现CMOD强化特性。对有CMOD软化特性的钢纤维水泥砂浆,可用三折线软化模型来模拟钢纤维水泥砂浆的σ-w关系;对有CMOD强化特性的钢纤维水泥砂浆,可用应力跌落-常残余强度模型来拟合。 | 陈升平 Kiang Hwee Tan | 2008 | 工程力学2008，25，4： | 4 |
| 10 | 持荷10年的钢筋钢纤维混凝土梁正常使用极限状态可靠度分析显示文摘为分析持续荷载作用下钢筋钢纤维混凝土梁正常使用极限状态下可靠性的时变规律,基于持荷10 a的钢筋钢纤维混凝土梁抗弯试验结果,考虑随服役时间延长混凝土材料劣化、钢筋截面积削弱、钢筋和混凝土之间黏结系数降低和计算模式不定性系数等多因素影响机制,建立了基于裂缝宽度控制和挠度控制的时变可靠度分析模型。分别就持荷水平不变、钢纤维掺量改变和持荷水平改变、钢纤维掺量不变两组试件共10根梁,将等效抗力法和一次二阶矩法相结合,求得持荷10 a的钢筋钢纤维混凝土梁正常使用极限状态的时变可靠度指标。结果表明:钢纤维的掺入可有效抑制混凝土梁的裂缝宽度开展和挠度变形,未掺钢纤维梁的可靠指标明显低于掺入钢纤维梁的可靠指标。且钢纤维掺量越高,可靠度指标越大,裂缝宽度越小,挠度变形越小;持荷水平越小,梁的裂宽和挠度变形越小,基于裂缝宽度和基于挠度控制的可靠度指标均越大,且当持荷水平越接近,可靠度指标越接近,与试验结果吻合良好,可为钢筋钢纤维混凝土梁理论分析和设计提供参考。 | 李艺 董金霞 Tan Kiang Hwee | 2015 | 建筑结构学报2015，36，S2： | 3 |
| 11 | Is there a difference in adenoma detection rates between gastroenterologists and surgeons?显示文摘AIM To compare the adenoma detection rate(ADR) between gastroenterologists and colorectal surgeons at Box Hill Hospital, Melbourne, Australia.METHODS A total of 300 colonoscopies performed by gastroenterologists and colorectal surgeons at Box Hill Hospital were retrospectively reviewed from May 2016 to June 2017. Exclusion criteria were: Patients ≤ 50 years old, colonoscopies with failure of caecal intubation, patients who previously had colon cancer and/or a colonic resection, history of polyposis syndromes or inflammatory bowel disease, or a colonoscopy within the last 10 years. Patient demographics, indications, symptoms and procedural-related outcomes were measured.RESULTS The ADR was not significantly different between gastroenterologists and colorectal surgeons(34% vs 34.67%; P = 0.90). The adjusted odds ratio correcting for gender, age, 1^(st) degree relative with colorectal cancer, previous colonoscopy, trainee involvement and caecal or terminal ileum intubation rate was 1.19(0.69-2.05).CONCLUSION Both specialties at our institution exceed benchmark standards suggested by published Australian and American guidelines. An association between endoscopist specialty and ADR was not observed. | Adele Hwee Hong Lee Nuttaradee Lojanapiwat Vikram Balakrishnan Raaj Chandra | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，6： | 2 |
| 12 | Adropin Is a Novel Regulator of Endothelial Function显示文摘 | Fina Lovren Yi Pan Adrian Quan Krishna K. Singh Praphulla C. Shukla Milan Gupta Mohammed Al-Omran Hwee Teoh Subodh Verma | 2010 | Circulation . 2010 (11 S)2010，，： | 2 |
| 13 | Lumbar degenerative spinal deformity:Surgical options of PLIF,TLIF and MI-TLIF显示文摘 | Hwee Weng Dennis Hey Hwan Tak Hee | 2010 | Indian J Orthop2010，44，2： | 1 |
| 14 | Statin Effects on LDL and HDL Cholesterol in South Asian and White Populations显示文摘 | Milan Gupta Manoela F. B. Braga Hwee Teoh Michelle Tsigoulis Subodh Verma | 2009 | Journal of Clinical Pharmacology2009，，： | 1 |
| 15 | Identification of Circulating MicroRNA Signatures for Breast Cancer Detection显示文摘 | Maurice Chan Chiew Suan Liaw Shen Mo Ji Hwee Huang Tan Chow Yin Wong Aye Aye Thike Puay Hoon Tan Gay Hui Ho Ann Siew-Gek Lee | 2013 | Clinical Cancer Research2013，，： | 1 |
| 16 | K, Tiong, Model on cash flow forecasting and risk analysis for contracting firms显示文摘 | Ng Ghim Hwee Robert L | 2002 | International Journal of Project Management2002，20，35： | 1 |
| 17 | A numerical study of the Hampson-type miniature Joule-Thomson cryocooler 显示文摘 | Tui Tong Chua Wang Xiaolin Hwee Yean Teo | 2006 | International Journal of Heat and Mass Transfer2006，49，： | 1 |
| 18 | Trends in incidence of diabetes in pregnancy and serious perinatal outcomes: a large, population- based study in Ontario, Canada, 1996-2010 显示文摘 | Feig DS Hwee J Shah BR | 2014 | Diabetes Care2014，37，6： | 1 |
| 19 | Development of a simplified assay for the detection of neutralizing antibodies to Japanese encephalitis virus显示文摘 | Shirley H.L. Ting E’ein See Hwee Cheng Tan May Ann Lee Eng Eong Ooi | 2001 | Journal of Virological Methods2001，，1： | 1 |
| 20 | Googling for a diagnosis-use of Google as a diagnostic aid:internet based study显示文摘 | Hangwi Tang Jennifer Hwee Kwoon Ng | 2006 | BMJ2006，333，： | 1 |
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