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| 1 | Renal function in diabetic nephropathy显示文摘Diabetic nephropathy is the kidney disease that occurs as a result of diabetes.Cardiovascular and renal complications share common risk factors such as blood pressure,blood lipids,and glycemic control.Thus,chronic kidney disease may predict cardiovascular disease in the general population.The impact of diabetes on renal impairment changes with increasing age.Serum markers of glomerular filtration rate and microalbuminuria identify renal impairment in different segments of the diabetic population,indicating that serum markers as well as microalbuminuria tests should be used in screening for nephropathy in diabetic older people.The American Diabetes Association and the National Institutes of Health recommend Estimated glomerular filtration rate(eGFR) calculated from serum creatinine at least once a year in all people with diabetes for detection of kidney dysfunction.eGFR remains an independent and significant predictor after adjustment for conventional risk factors including age,sex,duration of diabetes,smoking,obesity,blood pressure,and glycemic and lipid control,as well as presence of diabetic retinopathy.Cystatin-C(Cys C) may in future be the preferred marker of diabetic nephropathy due differences in measurements of serum creatinine by various methods.The appropriate reference limit for Cys C in geriatric clinical practice must be defined by further research.Various studies have shown the importance of measurement of albuminuria,eGFR,serum creatinine and hemoglobin level to further enhance the prediction of end stage renal disease. | Pradeep Kumar Dabla | 2010 | World Journal of Diabetes2010，1，2： | 16 |
| 2 | Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes显示文摘Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results. | Vishal Gupta Saket Kumar Vivek Gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit Chandra | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 8 |
| 3 | Computational Identification of Sweet Wormwood (Artemisia annua) microRNA and Their mRNA Targets显示文摘Despite its efficacy against malaria, the relatively low yield (0.01%-0.8%) of artemisinin in Artemisia annua is a serious limitation to the commercialization of the drug. A better understanding of the biosynthetic pathway of artemisinin and its regulation by both exogenous and endogenous factors is essential to improve artemisinin yield. Increasing evidence has shown that microRNAs (miRNAs) play multiple roles in various biological processes. In this study, we used previously known miRNAs from Arabidopsis and rice against expressed sequence tag (EST) database of A. annua to search for potential miRNAs and their targets in A. annua. A total of six potential miRNAs were predicted, which belong to the miR414 and miR1310 families. Furthermore, eight potential target genes were identified in this species. Among them, seven genes encode proteins that play important roles in ar- temisinin biosynthesis, including HMG-CoA reductase (HMGR), amorpha-4,11-diene synthase (ADS), farnesyl pyrophosphate synthase (FPS) and cytochrome P450. In addition, a gene coding for putative AINTEGUMENTA, which is involved in signal transduction and development, was also predicted as one of the targets. This is the first in silico study to indicate that miRNAs target genes encoding enzymes involved in artemisinin biosynthesis, which may help to understand the miRNA-mediated regulation of artemisinin biosynthesis in A. annua. | Alok Pani Rajani Kanta Mahapatra Niranjan Behera Pradeep Kumar Naik | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 7 |
| 4 | Soil Carbon Dynamics Under Changing Climate A Research Transition from Absolute to Relative Roles of Inorganic Nitrogen Pools and Associated Microbial Processes:A Review显示文摘It is globally accepted that soil carbon(C) dynamics are at the core of interlinked environmental problems, deteriorating soil quality and changing climate. Its management remains a complex enigma for the scientific community due to its intricate relationship with soil nitrogen(N) availability and moisture-temperature interactions. This article reviews the management aspects of soil C dynamics in light of recent advances, particularly in relation to the availability of inorganic N pools and associated microbial processes under changing climate. Globally, drastic alterations in soil C dynamics under changing land use and management practices have been primarily attributed to the variation in soil N availability, resulting in a higher decomposition rate and a considerable decline in soil organic C(SOC) levels due to increased soil CO_2 emissions, degraded soil quality, and increased atmospheric CO_2 concentrations,leading to climate warming. Predicted climate warming is proposed to enhance SOC decomposition, which may further increase soil N availability, leading to higher soil CO_2 efflux. However, a literature survey revealed that soil may also act as a potential C sink, if we could manage soil inorganic N pools and link microbial processes properly. Studies also indicated that the relative, rather than the absolute, availability of inorganic N pools might be of key importance under changing climate, as these N pools are variably affected by moisture-temperature interactions, and they have variable impacts on SOC turnover. Therefore, multi-factorial studies are required to understand how the relative availability of inorganic N pools and associated microbial processes may determine SOC dynamics for improved soil C management. | pratap srivastava rishikesh singh sachchidanand tripathi pardeep singh shikha singh hema singh akhilesh singh raghubanshi pradeep kumar mishra | 2017 | Pedosphere2017，27，5： | 5 |
| 5 | Effects of 42-year long-term fertilizer management on soil phosphorus availability, fractionation,adsorption–desorption isotherm and plant uptake in flooded tropical rice显示文摘Soil phosphorus(P) fractionation, adsorption, and desorption isotherm, and rice yield and P uptake were investigated in flooded tropical rice(Oryza sativa L.) following 42-year fertilizer and manure application. The treatments included low-input [unfertilized control without N, P, or K(C0N0)], farmyard manure(FYM)(C1N0), NP(C0NP), NPK(C0NPK), FYM + NP(C1NP), and high-input treatment, FYM + NPK(C1NPK). Grain yield was increased significantly by 74%over the control under the combined application of FYM + NPK. However, under low- and high-input treatments, yield as well as P uptake was maintained at constant levels for 35 years.During the same period, high yield levels and P uptake were maintained under the C0 NP, C0 NPK,and C1 NPK treatments. These are unique characteristics of a tropical flooded ecosystem, which is a self-sustaining system for rice production. The Fe–P fraction was highest compared to the Ca–P and Al–P fractions after 42 years of fertilizer application and was significantly higher under FYM + NPK treatment. The P adsorption capacity of soil was highest under the low-input treatment and lowest under long-term balanced fertilization(FYM + NPK). In contrast, P desorption capacity was highest under NPK and lowest in the control treatment. Long-term balanced fertilization in the form of FYM + NPK for 42 years lowered the bonding energy and adsorption capacity for P in soil but increased its desorption potential, increasing P availability to the plant and leading to higher P uptake and yield maintenance. | Pratap Bhattacharyya Amaresh Kumar Nayak Mohammad Shahid Rahul Tripathi Sangita Mohanty Anjani Kumar Rajagounder Raja Bipin Bihari Panda Banwari Lal Priyanka Gautam Chinmaya Kumar Swain Koushik Singha Roy Pradeep Kumar Dash | 2015 | The Crop Journal2015，3，5： | 5 |
| 6 | Two Distinct Fluorescent Quantum Clusters of Gold Starting from Metallic Nanoparticles by pH-Dependent Ligand Etching显示文摘Two fl uorescent quantum clusters of gold,namely Au25 and Au8,have been synthesized from mercaptosuccinic acid-protected gold nanoparticles of 45 nm core diameter by etching with excess glutathione.While etching at pH~3 yielded Au_(25),that at pH 7-8 yielded Au_(8).This is the fi rst report of the synthesis of two quantum clusters starting from a single precursor.This simple method makes it possible to synthesize well-defined clusters in gram quantities.Since these clusters are highly fl uorescent and are highly biocompatible due to their low metallic content,they can be used for diagnostic applications. | Madathumpady Abubaker Habeeb Muhammed Subramani Ramesh Sudarson Sekhar Sinha Samir Kumar Pal Thalappil Pradeep | 2008 | Nano Research2008，1，4： | 5 |
| 7 | 食源性致病菌菌株多相异质性对微生物风险评估的影响研究进展显示文摘微生物风险评估是当前保障食品安全的重要科学工具之一,被广泛应用于食品安全政策、法规和标准的制定。菌株多相异质性是微生物的固有特性,普遍存在于各类致病菌之中,影响着风险评估的准确性和不确定性。本文概述了国内外食品微生物菌株多相异质性的相关研究,总结了菌株多相异质性的概念,从生长和失活异质性、被膜形成异质性、毒力异质性和耐药异质性4 个方面全面系统地分析了菌株多相异质性的存在形式。在此基础上探讨了菌株多相异质性对微生物风险评估的影响,进一步展望了降低该影响的4 种解决措施,提出微生物风险评估宏模型的概念,以期提高食品安全风险评估的准确性和可靠性。 | 俞文英 张昭寰 刘海泉 Pradeep Kumar MALAKAR 潘迎捷 赵勇 | 2019 | 食品科学2019，40，13： | 4 |
| 8 | Detection of Bluetongue Virus Group-specific Antigen Using Monoclonal Antibody Based Sandwich ELISA显示文摘A monoclonal antibody (MAb) specific for the bluetongue virus (BTV) group specific antigen (VP7) was characterized for its reactivity with purified virus and recombinant BTV VP7 (rVP7) protein and its suitability for use in the sandwich ELISA.The MAb,designated as 5B5 was specific to VP7 and belongs to IgG2a subclass and was selected for the development of the sELISA in this study.The MAb had a titer of 1:25 with BTV and 1:2 with the rVP7 protein.The sELISA is based on capturing of BTV antigen with VP7 specific MAb followed by detection using BTV polyclonal antiserum raised in rabbits.The assay was evaluated with six cell culture adapted serotypes of BTV that have been isolated from India,1,2,15,17,18 and 23.The assay could detect BTV antigen as early as day 8 in blood.It was also successfully applied for the detection of BTV group specific antigen in clinical samples of blood,washed RBCs,buffy coat and plasma.A total of 102 field samples from animals,suspected of being infected with BTV,were tested and 29.42% were positive.The blood samples were also amplified in cell culture which improved the sensitivity of the assay.Results confirmed that the sELISA is rapid and specific. | Pradeep Narayan Gandhale Veerakyathappa Bhanuprakash Vinayagamurthy Balamurugan Madhusudhan Hosamani Gnanavel Venkatesan Raj Kumar Singh | 2010 | Virologica Sinica2010，25，6： | 4 |
| 9 | Treatment of perforated giant gastric ulcer in an emergency setting显示文摘AIM:To study and assess clinical outcomes of various modes of treatment for perforated giant gastric ulcer in an emergency setting.METHODS:From May 2010 to February 2013,20cases of perforated giant gastric ulcer(>2 cm)were operated on in an emergency setting.All the patients presented with features of peritonitis and were resuscitated aggressively before taking for surgery.In the first4 cases,primary closure was done after taking a biopsy and among these,the 3rdcase also underwent partial distal gastrectomy and gastrojejunostomy and the 4th case underwent a radical subtotal gastrectomy with D2 lymphadenectomy and gastrojejunostomy for malignancy.All the remaining 16 cases underwent partial distal gastrectomy and gastrojejunostomy.RESULTS:Among the first 4 cases,2 had an uneventful recovery and were discharged on the 6thpostoperative day.The 3rdand 4thpatients developed gastricfistula,leading to prolonged hospitalization.For the 3rd patient,conservative management was tried for 1 wk,followed by partial distal gastrectomy and gastrojejunostomy,and he was discharged on the 20thday after admission,while the 4thpatient underwent a radical subtotal gastrectomy with D2 lymphadenectomy and gastrojejunostomy.Postoperatively,he developed adult respiratory distress syndrome,multiorgan dysfunction syndrome and expired on the 3rdpostoperative day of the second surgery.All the remaining 16 patients underwent partial distal gastrectomy and gastrojejunostomy and recovered well.Among these,4 of them were malignant and the remaining were benign ulcers.All had an uneventful recovery.The percentage of malignancy in our series was 30%(6 out of 20 cases).In our study,86%had an uneventful recovery,complications were seen in about 10%,and mortality was about 5%.CONCLUSION:In giant gastric ulcer,the chances of malignancy and leak after primary closure are high.So,we feel that partial distal gastrectomy and gastrojejunostomy is better. | Pradeep Kumar Hosni Mubarak Khan Safarulla Hasanrabba | 2014 | World Journal of Gastrointestinal Surgery2014，6，1： | 3 |
| 10 | CFD modeling to study the effect of particle size on dispersion in 20l explosion chamber: An overview显示文摘Mine disasters occur predominantly due to methane or coal dust explosion or a combination of both.Among the top ten worst coal mine disasters in India, nine are due to coal dust explosion. The current paper describes a general overview of the parameters causing dispersion leading to coal dust explosion,and computational fluid dynamics(CFD) simulation study to observe the effects of particle size on dispersion in Indian coal mines. Turbulent kinetic energy(TKE) and velocity vector path of dust-air mixture and dust-free air were simulated to understand their effects on coal dust dispersion. The TKE contours and velocity vector paths for dust-free air were uniform and symmetrical due to resistance-free path available. The TKE contours and velocity vector paths for dust-air mixture shows the asymmetrical distribution of contours, due to entrainment of air with dust particles. Vortices were observed in velocity vector paths which gradually diminish on increment of time sequence. These vortices are dead centres where velocity and coal dust particles concentration are both zero. | Santosh Kumar Ray Niroj Kumar Mohalik Asfar Mobin Khan Debashish Mishra Nikhil Kumar Varma Jai Krishna Pandey Pradeep Kumar Singh | 2020 | International Journal of Mining Science and Technology2020，30，3： | 3 |
| 11 | Value of multi-disciplinary input into laparoscopic management of rectal cancer-An observational study显示文摘AIM To assess the impact of multi-disciplinary teams(MDTs)management in optimising the outcome for rectal cancers.METHODS We undertook a retrospective review of a prospectively maintained database of patients with rectal cancers(defined as tumours≤15 cm from anal verge)discussed at our MDT between Jan 2008 and Jan 2011.The data was validated against the national database to ensure completeness of dataset.The clinical course and follow-up data was validated using the institution’s electronic patient records.The data was analysed in terms of frequencies and percentages.Significance of any differences were analysed usingχ2 test.A Kaplan-Meier analysis was performed for overall survival and disease free survival.RESULTS Following appropriate staging,one hundred and thirtythree patients were suitable for potentially curative resections.Seventy two(54%)were upper rectal cancer(URC)-tumour was>6 cm from the anal verge and 61(46%)were lower rectal cancers(LRC)-lower extent of the tumour was palpable≤6 cm.Circumferential resection margin(CRM)appeared threatened on preoperative MRI in 19/61(31%)patients with LRC requiring neo-adjuvant therapy(NAT).Of the 133 resections,118(89%)were attempted laparoscopically(5%conversion rate).CRM was positive in 9(6.7%)patients;Median lymph node harvest was 12(2-37).Major complications occurred in 8(6%)patients.Median follow-up was 53 mo(0-82).The 90-d mortality was 2(1.5%).Over the followup period,disease related mortality was 11(8.2%)and overall mortality was 39(29.3%).Four(3%)patients had local recurrence and 22(16.5%)patients had distant metastases.CONCLUSION Management of rectal cancers can be optimized with multidisciplinary input to attain acceptable long-term oncological outcomes even when incorporating a laparoscopic approach to rectal cancer resection. | Pawan Kumar Dhruva Rao Sooriyaratchige Pradeep Manjula Peiris Seema Safia Arif Rhodri A Davies Ashraf Gergies Masoud Puthucode Narayanan Haray | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 2 |
| 12 | Hydrochemistry and sediment characteristics of polar periglacial lacustrine environments on Fisher Island and Broknes Peninsula,East Antarctica显示文摘Fisher Island and Broknes Peninsula in the Larsemann Hills constitute part of a polar lowland periglacial environment between marine and glacial ecosystems.The landscape is characterized by gently rolling hills and broad valleys interspersed with lakes formed in glacially scoured basins.We analyzed the physicochemical parameters and the ionic constituents of water samples from 10 lakes in each of these two locations.Our results showed considerable differences between the two regions and demonstrated the influence of lithology and processes including weathering,evaporation,and atmospheric precipitation.All major cations and anions in the lake waters showed positive correlations indicating balanced ionic concentrations.Unconsolidated sediments were sparsely distributed and scattered over glacial deposits,valley fills,and occasional moraine ridges.The type and rate of sedimentation was mainly controlled by surface run-off and aeolian influx.The sediment samples from lake beds and the catchment area on Fisher Island were immature and poorly to very poorly sorted,consisting of gravelly sand with negligible silt and finer fractions.Sediments had a polymodal grain size distribution with the two major populations lying between-2 and-1 phi and between 0 and 1.5 phi.The sediments were lithic arenite to arkosic in composition and the microtextures imprinted over quartz grains were dominated by mechanical textures resulting from several stages of glacial crushing and grinding.The presence of deep dissolution cavities,cryptocrystalline precipitation,and euhedral crystal growth signified the effect of chemical activity after the deposition of grains in the lacustrine environment. | Rajesh Asthana Prakash Kumar Shrivastava Hari Bahadur Srivastava Mirza Javed Beg Pradeep Kumar | 2013 | Advances in Polar Science2013，24，4： | 2 |
| 13 | Primary endoscopic stapedotomy using 3 mm nasal endoscope:Audiologic and clinical outcomes显示文摘Objective:To report the use of a 3 mm rigid nasal endoscope in primary endoscopic stapedotomy and clinical and audiological outcomes.Materials and methods:Thirty patients diagnosed with primary otosclerosis underwent endoscopic stapedotomy that was performed using a 3 mm nasal endoscope(Karl Storz).At 6 months follow-up,the patients were evaluated for intraoperative findings,postoperative hearing outcomes and complications.Results:Canaloplasty was performed in 2(6.66%)patients,and no curettage of the canal wall was required in 12(40%)patients.Transposition of the chorda tympani nerve was conducted in 11(36.66%)patients.The average duration of surgery was 36 min(range 31e65 min).The air-bone gap(ABG)was 35 dB(range 24e50 dB)preoperatively and 14.63 dB(range 9e20 dB)postoperatively(p?0.00).At 6 months follow-up,<20 dB ABG was achieved in 93.33%of the patients.No major intraoperative/postoperative complications were detected.Conclusion:A 3 mm rigid nasal endoscope can be effectively used in stapedotomy to obtain adequate audiological outcomes.It can be considered as a better alternative to the standard microscope or 4 mm endoscope in preserving the posterior canal wall and chorda tympani nerve while minimizing operative time without causing significant complications. | Pradeep Pradhan Chappity Preetam Pradipta kumar Parida | 2020 | Journal of Otology2020，15，4： | 2 |
| 14 | Noradrenaline vs. terlipressin in the treatment of hepatorenal syndrome: A randomized study显示文摘 | Virendra Singh Souvik Ghosh Baljinder Singh Pradeep Kumar Navneet Sharma Ashish Bhalla A.K. Sharma N.S. Choudhary Yogesh Chawla C.K. Nain | 2012 | Journal of Hepatology2012，，6： | 2 |
| 15 | Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibility显示文摘 | Pradeep Kumar Upendra Yadav Vandana Rai | 2015 | Meta Gene2015，，： | 1 |
| 16 | Crosslinked electrospun PVA nanofibrous membranes: Elu- cidation of their physicochemical, physicomechanieal and molecular disposition显示文摘 | Rubina P Shaikh Pradeep Kumar Yahya E Choonara | 2012 | Biofabrication2012，4，02： | 1 |
| 17 | Analysis of community question-answering issues via machine learning and deep learning:State-of-the-art review显示文摘Over the last couple of decades,community question-answering sites(CQAs)have been a topic of much academic interest.Scholars have often leveraged traditional machine learning(ML)and deep learning(DL)to explore the ever-growing volume of content that CQAs engender.To clarify the current state of the CQA literature that has used ML and DL,this paper reports a systematic literature review.The goal is to summarise and synthesise the major themes of CQA research related to(i)questions,(ii)answers and(iii)users.The final review included 133 articles.Dominant research themes include question quality,answer quality,and expert identification.In terms of dataset,some of the most widely studied platforms include Yahoo!Answers,Stack Exchange and Stack Overflow.The scope of most articles was confined to just one platform with few cross-platform investigations.Articles with ML outnumber those with DL.Nonetheless,the use of DL in CQA research is on an upward trajectory.A number of research directions are proposed. | Pradeep Kumar Roy Sunil Saumya Jyoti Prakash Singh Snehasish Banerjee Adnan Gutub | 2023 | CAAI Transactions on Intelligence Technology2023，8，1： | 1 |
| 18 | Fluid Flow and Mixing in a Six Strand Billet Caster Tundish: A Parametric Study 显示文摘 | K Jha Pradeep Dash Sukanta K Kumar Sanjay | 2001 | ISIJ International2001，41，12： | 1 |
| 19 | Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells显示文摘 | Angeline Wei Ling Chua Hui Sin Hay Peramaiyan Rajendran Muthu K. Shanmugam Feng Li Pradeep Bist Evelyn S.C. Koay Lina H.K. Lim Alan Prem Kumar Gautam Sethi | 2010 | Biochemical Pharmacology2010，，10： | 1 |
| 20 | MTHFR C677T polymorphism and its homocysteine‐driven effect on blood pressure显示文摘 | K. N. Saraswathy Priyanka Rani Garg Kabita Salam Shipra Joshi Suraj Singh Huidrom Pradeep Kumar Ghosh | 2014 | Int J Stroke2014，，： | 1 |
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