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| 1 | Novel coumarin–benzimidazole derivatives as antioxidants and safer anti-inflammatory agents显示文摘Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles,novel compounds have been designed by coupling coumarin derivatives at 3-position directly or through amide linkage with benzimidazole nucleus at 2-position.The resultant compounds are expected to exhibit both anti-inflammatory and antioxidant activities along with less gastric toxicity profile.Two series of coumarin–benzimidazole derivatives(4a–e and 5a–e)were synthesized and evaluated for anti-inflammatory activity and antioxidant activity.Compounds 4c,4d and 5a displayed good anti-inflammatory(45.45%,46.75%and 42.85%inhibition,respectively,versus 54.54% inhibition by indomethacin)and antioxidant(IC_(50) of 19.7,13.9 and 1.2 mmol/L,respectively,versus 23.4 mmol/L for butylatedhydroxytoluene)activities.Evaluation of ulcer index and in vivo biochemical estimations for oxidative stress revealed that compounds 4d and 5a remain safe on gastric mucosa and did not induce oxidative stress in tissues.Calculation of various molecular properties suggests the compounds to be sufficiently bioavailable. | Radha Krishan Arora Navneet Kaur Yogita Bansal Gulshan Bansal | 2014 | Acta Pharmaceutica Sinica B2014，4，5： | 6 |
| 2 | Erlotinib usage after prior treatment with gefitinib in advanced non-small cell lung cancer: A clinical perspective and review of published literature显示文摘Erlotinib and gefitinib are among the most widely researched, used and available molecularly targeted therapies for treatment of advanced non-small cell lung cancer(NSCLC). They are both tyrosine kinase inhibitors(TKIs) of the epidermal growth factor receptor(EGFR). In the past decade, there have been reports on clinical benefit from use of erlotinib after gefitinib failure in NSCLC patients. A review of published literature on this focussed topic is provided herein. Pooled analysis of published literature shows that majority of patients were female(60.6%), non-smokers(64.5%), had adenocarcinoma histology(88.3%) and were of East Asian ethnicity(92.3%). Presence of sensitizing EGFR mutation was detected in 48.4% of subjects. Disease control rates with prior gefitinib therapy and with subsequent erlotinib treatment were 79.4% and 45.4% respectively. Based upon our review, the most important predictive factor for clinical benefit from erlotinib identified was previous response to gefitinib. The exact explanations for the potential benefit from erlotinib use in this patient population is still not known and further studies are required to determine the role of molecular mechanismsespecially those related to resistance to initial EGFR TKI therapy. | Navneet Singh Aditya Jindal Digambar Behera | 2014 | World Journal of Clinical Oncology2014，5，5： | 5 |
| 3 | 血管钙化:血管钙化与主要急性冠状动脉事件的演变关系显示文摘冠状动脉(简称冠脉)钙化是冠脉粥样硬化的明确证据。Agatston评分反映钙化程度和密度,其与患者发生主要急性冠脉事件的风险密切相关。动脉粥样硬化发生后,内皮细胞受损,低密度脂蛋白胆固醇(LDLc)渗透至管壁内膜下,内膜下胶原蛋白中的蛋白聚糖对LDLc具有高亲和力,将脂蛋白胆固醇复合物滞留其中。随着内皮损伤的修复,LDLc被捕获至内膜下,滞留的LDLc诱导上覆内皮的炎性反应,使内皮表达趋化肽,趋化肽吸引血液中的单核细胞,使单核细胞沿浓度梯度进入组织,成为巨噬细胞,巨噬细胞吞噬并消化动脉粥样硬化中刺激性的LDLc。在消化LDLc的过程中,巨噬细胞中的酶使LDLc复合物氧化,氧化的低密度脂蛋白(LDL)对巨噬细胞产生毒性,当其数量充足时,可导致巨噬细胞死亡,促进动脉粥样硬化的炎性反应。在坏死性炎性病灶中,调控组织中钙、磷浓度的机制失调,使得磷酸钙的溶度积过高,从而产生微小的磷酸钙晶体。随着炎性反应的持续存在,更多的磷酸钙晶体形成并聚集。当这些聚集的磷酸钙晶体超过1 mm时,就成为临床CT可识别的冠脉钙化。连续的门控心脏CT扫描证实,一旦形成CT可见的钙化,其大小不会明显减少,但可能会增加。 | H.William Strauss Takehiro Nakahara Navneet Narula Jagat Narula 俞雯吉(译) 王跃涛(审校 | 2021 | 中华核医学与分子影像杂志2021，41，12： | 4 |
| 4 | 采用延性损伤模型和数值方法预测Ni-Cr基合金在温成形条件下的断裂极限显示文摘为了确定IN625合金的安全成形和断裂极限,在300和673 K下分别进行拉伸成形和深拉延成形实验。将实验获得的基于应力的断裂成形极限图(FFLD)转变为基于应力的σ-FFLD和有效塑性应变(EPS)跟三轴度(η)的关系曲线,以消除断裂极限对应变的过度依赖。为了预测断裂极限,校准7种不同的损伤模型。结果显示,Oh模型对断裂轨迹的预测能力最好,绝对误差最小。虽然实验得到的断裂极限仅用于数值分析,但没有一个损伤模型预测整个应力三轴度范围(0.33<η<0.66)的断裂应变。在不同的温度和润滑条件下深拉延成形圆柱杯,深拉延工艺窗口有助于确定起皱、安全和断裂区域。在润滑条件下,673 K时达到最大的拉延比2。利用Hill 1948各向异性屈服函数对拉伸成形和深拉延成形过程的数值预测结果均在可接受的误差范围内。 | Ayush MORCHHALE Anand BADRISH Nitin KOTKUNDE Swadesh Kumar SINGH Navneet KHANNA Ambuj SAXENA Chetan NIKHARE | 2021 | Transactions of Nonferrous Metals Society of China2021，31，8： | 3 |
| 5 | Potential role of noninvasive biomarkers during liver fibrosis显示文摘Various types of liver disease exist,such as hepatitis and alcoholic liver disease.These liver diseases can result in scarring of liver tissue,cirrhosis,and finally liver failure.During liver fibrosis,there is an excess and disorganized accumulation of extracellular matrix(ECM)components which cause the loss of normal liver cell functions.For patients with chronic liver disease,fibrosis prediction is an essential part of the assessment and management.To diagnose liver fibrosis,several invasive and noninvasive markers have been proposed.However,the adoption of invasive markers remains limited due to their inherent characteristics and poor patient acceptance rate.In contrast,noninvasive markers can expedite the clinical decision through informed judgment about disease stage and prognosis.These noninvasive markers are classified into two types:Imaging techniques and serum biomarkers.However,the diagnostic values of biomarkers associated with liver fibrosis have also been analyzed.For example,the serum levels of ECM proteins can react to either matrix accumulation or degradation.During virus-host interactions,several regulatory steps take place to control gene expression,such as the change in cellular microRNA expression profiles.MicroRNAs are a class of non-coding RNAs(18-20 long nucleotides)that function by post-transcriptional regulation of gene expression.Although various noninvasive markers have been suggested in recent years,certain limitations have restricted their clinical applications.Understanding the potential of non-invasive biomarkers as a therapeutic option to treat liver fibrosis is still in progress. | Navneet Kaur Gitanjali Goyal Ravinder Garg Chaitanya Tapasvi Sonia Chawla Rajneet Kaur | 2021 | World Journal of Hepatology2021，13，12： | 3 |
| 6 | Arabidopsis RING Peroxins are E3 Ubiquitin Ligases that Interact with Two Homologous Ubiquitin Receptor Proteins显示文摘Peroxisomes are essential eukaryotic organelles that mediate various metabolic processes. Peroxisome import depends on a group of peroxisome biogenesis factors called peroxins, many of which are evolutionarily conserved. PEX2, PEX10, and PEX12 are three RING-finger-domain-containing integral membrane peroxins crucial for protein import. In yeast (Saccharomyces cerevisae), RING peroxins act as E3 ligases, facilitating the recycling of the peroxisome import receptor protein PEX5 through ubiquitination. In plants, RING peroxins are essential to plant vitality. To elucidate the mode of action of the plant RING peroxins, we employed in vitro assays to show that the Arabidopsis RING peroxins also have E3 ligase activities. We also identified a PEX2-interacting protein, DSK2b, which is a member of the ubiquitin receptor family known to function as shuttle factors ferrying polyubiquitinated substrates to the proteasome for degradation. DSK2b and its tandem duplicate DSK2a are localized in the cytosol and the nucleus, and both interact with the RING domain of PEX2 and PEX12. DSK2 artificial microRNA lines did not display obvious defects in plant growth or peroxisomal processes, indicating functional redundancies among Arabidopsis ubiquitin receptor proteins. Our results suggest that Arabidopsis RING peroxins can function as E3 ligases and act together with the ubiquitin receptor protein DSK2 in the peroxisomal membrane-associated protein degradation system. | Navneet Kaur Qingzhen Zhao Qi Xie Jianping Hu | 2013 | Journal of Integrative Plant Biology2013，55，1： | 3 |
| 7 | Interconversion of two commonly used performance tools: An analysis of 5844 paired assessments in 1501 lung cancer patients显示文摘AIM To establish the Karnofsky performance status(KPS) categories which would facilitate the interconversion of the KPS scale to the Eastern Cooperative Oncology Group(ECOG) performance status(PS) scale.METHODS This was a retrospective analysis of all patients attending the lung cancer clinic at a tertiary care center over a 5-year period(September 2009 to August 2014). All patients were assessed with both KPS and ECOG PS scales at each visit. Correlation between KPS and ECOG PS was assessed using Spearman's correlation coefficient. KPS categories equivalent to ECOG PS scores were compared using hit rate and weighted kappa(κw).RESULTS A total of 1501 patients were assessed over the study period, providing 5844 paired KPS and ECOG PS assessments. The study cohort had a mean(standard deviation; SD) age of 58.4(10.8) years, with the majority being current or ex-smokers(76.9%) and males(82.3%). Non-small cell lung cancer was the most common histological type(n = 1196, 79.7%) with the majority having advanced(stage ⅢB/Ⅳ) disease(83.4%). Mean baseline KPS and ECOG PS scores were 77.6(SD = 14.4) and 1.5(SD = 1) respectively. The most frequent KPS score was 80(29%), and the most frequent ECOG PS score was 1(43%). The overall correlation between KPS and ECOG PS was good(Spearman r =-0.84, P < 0.0001) but ranged from-0.727 to-0.972 between visits. KPS categories derived from our cohort [10-40(ECOG 4), 50-60(ECOG 3), 70(ECOG 2), 80-90(ECOG 1), 100(ECOG 0)] performed better [hit rate 78.1%, κw = 0.749(0.736-0.762) P < 0.0001] than those suggested in the past literature.CONCLUSION The current study provides the largest set of paired KPS-ECOG assessments to date. We suggest that the KPS categories 10-40, 50-60, 70, 80-90, and 100 are equivalent to ECOG PS categories of 4, 3, 2, 1, and 0 respectively. | Kuruswamy Thurai Prasad Harpreet Kaur Valliappan Muthu Ashutosh Nath Aggarwal Digambar Behera Navneet Singh | 2018 | World Journal of Clinical Oncology2018，9，7： | 2 |
| 8 | Noradrenaline vs. terlipressin in the treatment of hepatorenal syndrome: A randomized study显示文摘 | Virendra Singh Souvik Ghosh Baljinder Singh Pradeep Kumar Navneet Sharma Ashish Bhalla A.K. Sharma N.S. Choudhary Yogesh Chawla C.K. Nain | 2012 | Journal of Hepatology2012，，6： | 2 |
| 9 | 利用串行RapidIO连接功能增强DSP协处理能力显示文摘目前,对高速通信与超快计算的需求正与日俱增。有线和无线通信标准的应用随处可见,数据处理架构每天都在扩展。较为普遍的有线通信方式是以太网(LAN、WAN和MAN网络)。手机通信是最为常见的无线通信方式,由应用了DSP的架构实现。电话作为语音连接的主要工具,目前正在不断满足日益增强的语音、视频和数据要求。 | Navneet Rao | 2007 | 电子设计应用2007，，12： | 2 |
| 10 | Circulatory and hepatic failure at admission predicts mortality of severe scrub typhus patients: A prospective cohort study显示文摘Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on admission.Methods:This was a prospective observational cohort study conducted between July 2017 and October 2020 at the medical emergency centre of PGIMER,Chandigarh,India.One hundred and twenty-six patients aged≥13 years were diagnosed with scrub typhus.Severe disease was defined as the presence of organ failure based on the Sequential Organ Failure Assessment(SOFA)score on admission.Results:About two-thirds of the patients were from geographic regions outside the endemic sub-Himalayan belt.Fever(99.21%)and dyspnea(79.36%)were the most frequent complaints.Respiratory failure(81.75%)was the most common organ failure,followed by hepatic(52.38%),coagulative(47.62%),circulatory(33.33%),renal(21.43%),and cerebral dysfunction(13.49%).The median(Q1,Q3)SOFA score was 8(6,9),and 48.41%of the patients had a quick-SOFA score≥2.Organ supports with invasive ventilation(40.48%),vasopressors(36.51%),and renal replacement therapy(7.14%)were frequently required.The in-hospital mortality was 11.90% and was independently predicted by circulatory and hepatic failures on multivariate logistic regression(OR 11.12,95%CI 1.73-71.31 and OR 8.49,95%CI 1.18-61.41,respectively).Conclusions:Most patients had pulmonary dysfunction;circulatory or hepatic failure on admission strongly predicts death. | Ashok Kumar Pannu Atul Saroch Saurabh Chandrabhan Sharda Manoj Kumar Debnath Manisha Biswal Navneet Sharma | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，5： | 2 |
| 11 | Altered Redox Status in Erythrocytes From Hypertensive Subjects: Effect of(-)Epicatechin显示文摘Hypertension is a major problem worldwide. There is much evidence to suggest that reactive oxygen species (ROS) radical may play a role in the development of organ damage associated with cardiovascular disease and hypertension. (-)Epicatechin, a member of tea catechins belonging to flavonoid group, is known to be a potent anti-oxidant. The study has been undertaken to evaluate the effect of (-)epicatechin on markers of oxidative stress: reduced glutathione (GSH) and membrane sulfhydryl (-SH) groups in erythrocytes from hypertensive patients. The effect of (-)epicatechin was also compared with a known anti-oxidant L-ascorbic acid. The erythrocyte intracellular GSH content and membrane -SH group content were significantly (P<0.01) decreased in hypertensive subjects. In vitro incubation with (-)epicatechin caused an increase in GSH and -SH content, the effect was more pronounced in hypertensive erythrocytes. Similar results were obtained with L-ascorbic acid. The observed decrease in the level of GSH and -SH groups in hypertension is an indicator of oxidative stress condition. Observation of an increase in red cell GSH content and the protection of membrane -SH group oxidation by (-)epicatechin in hypertensive subjects is a convincing reason to suggest that high dietary intake of foods rich in catechins may help to reduce oxidative stress and concomitant free radical damage in hypertensive patients. | SYED IBRAHIM RIZVI NAVNEET KUMAR | 2005 | 生物化学与生物物理进展2005，32，3： | 2 |
| 12 | Titanium diboride thin films by low- temperature chemical vapor deposition from the single source precursor Ti(BH4 )3 (1,2-dimethoxyethane) 显示文摘 | Navneet Kumar | 2007 | Chem Ma- ter2007，19，： | 1 |
| 13 | Interface traps distribution and temperaturedependent 6H-SiC MOSFET analysis显示文摘 | Navneet Kaushik Subhasis Haldar Mridula Gupta | 2006 | Semicond Sci Technol2006，21，： | 1 |
| 14 | Midodrine in patients with cirrhosis and refractory or recurrent ascites: A randomized pilot study显示文摘 | Virendra Singh Sahdeb P. Dhungana Baljinder Singh Rajesh Vijayverghia Chander K. Nain Navneet Sharma Ashish Bhalla Pramod K. Gupta | 2011 | Journal of Hepatology2011，，2： | 1 |
| 15 | Histograms of Oriented Gradients for Hu- man Detection显示文摘 | Navneet Dalai Bill Triggs | 2005 | CVPR2005，1，20： | 1 |
| 16 | Cdc2-cyclin Binduced G2 to M transition in perch oocyte is dependent on Cdc25显示文摘 | Basu D Navneet A K Dasgupta S | | 0，，03： | 1 |
| 17 | Extrapulmonary small cell carcinoma of lymph node: Pooled analysis of all reported cases显示文摘AIM: To study clinical outcomes and management of lymph nodes extrapulmonary small cell carcinoma(LNEPSCC). METHODS: Herein, we perform a systematic search of published literature in the PubMed and EMBASE databases for studies describing LNEPSCC. For uniformity of reporting, LNEPSCC was staged as limited if it involved either single lymph node station or if surgery with curative intent had been undertaken. The disease was staged extensive if it involved two or more lymph node regions.RESULTS: The systematic literature review yielded eight descriptions(n = 14) involving cervical, submandibular and inguinal lymph nodes. Eleven(64.7%) patients had limited disease(LD) and six(35.3%) had extensive disease(ED) at presentation. Chemotherapy(n = 6, 35.3%) or surgery(n = 4, 23.5%) were the most common form of treatment given to these patients. Complete response was achieved in 12(70.6%) of the patients. Median(interquartile range) progression free survival and overall survival was 15(7-42) mo and 22(12.75-42) mo respectively. Of the three illustrative cases, two patients each had ED at presentation and achieved complete remission with platinum based combination chemotherapy.CONCLUSION: LNEPSCC is a rare disease with less than 15 reported cases in world literature. Surgical resection with curative intent is feasible in those with LD while platinum based combination chemoradiation is associated with favorable outcomes in patients with ED. Prognosis of LNEPSCC is better than that of small cell lung cancer in general. | Inderpaul Singh Sehgal Harpreet Kaur Sahajal Dhooria Amanjit Bal Nalini Gupta Digambar Behera Navneet Singh | 2016 | World Journal of Clinical Oncology2016，7，3： | 1 |
| 18 | Selenium in agriculture: a nutrient or contaminant for crops?显示文摘 | Navneet Kaur Shuchi Sharma Simranjeet Kaur Harsh Nayyar | 2014 | Archives of Agronomy and Soil Science2014，，12： | 1 |
| 19 | Reduced-Intensity Allogeneic Transplant in Patients Older Than 55 Years: Unrelated Umbilical Cord Blood Is Safe and Effective for Patients without a Matched Related Donor显示文摘 | Navneet S. Majhail Claudio G. Brunstein Marcie Tomblyn Avis J. Thomas Jeffrey S. Miller Mukta Arora Dan S. Kaufman Linda J. Burns Arne Slungaard Philip B. McGlave John E. Wagner Daniel J. Weisdorf | 2008 | Biology of Blood and Marrow Transplantation2008，，3： | 1 |
| 20 | Noradrenaline vs terlipressin in the treatment of type 2 hepatorenal syndrome: a randomized pilot study显示文摘 | Saubhik Ghosh Narendra S. Choudhary Arun K. Sharma Baljinder Singh Pradeep Kumar Ritesh Agarwal Navneet Sharma Ashish Bhalla Yogesh K. Chawla Virendra Singh | 2013 | Liver Int2013，，8： | 1 |
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