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1Endoscopic management of postoperative bile leaks显示文摘BACKGROUND: Significant bile leak as an uncommon complication after biliary tract surgery may constitute a serious and difficult management problem. Surgical management of biliary fistulae is associated with high morbidity and mortality. Biliary endoscopic procedures have become the treatment of choice for management of biliary Gstulae. METHODS: Ninety patients presented with bile leaks after cholecystectomy ( open cholecystectomy in 45 patients, cholecystectomy with common bile duct exploration in 20 and laparoscopic cholecystectomy in 25). The presence of bile leaks was confirmed by ERCP and the appearance of bile in percutaneous drainage of abdominal collections. Of the 90 patients with postoperative bile leaks, 18 patients had complete transaction of the common bile duct by ERCP and were subjected to bilioenteric anastomosis. In the remaining patients after cholangiography and localization of the site of bile leaks. therapeutic procedures like sphinctero-tomy, biliary stenting and nasobiliary drainage ( NBD ) were performed. If residual stones were seen in the common bile duct, sphincterotomy was followed by stone extraction using dormia basket. Nasobiliary drain or stents of 7F size were placed according to the standard techniques. The NBD was removed when bile leak stopped and closure of the fistula confirmed cholangiographically. The stents were removed after an interval of 6-8 weeks. RESULTS: Bile leaks in 72 patients occurred in the cystic duct (38 patients), the common bile duct (30 ), and the right hepatic duct (4). Of the 72 patients with post-operative bile leak, 24 had associated retained common bile duct stones and 1 had ascaris in common bile duct. All the 72 patients were subjected to therapeutic procedures including sphincterotomy with stone extraction followed by biliary stenting (24 patients), removal of ascaris and biliary stenting (1), sphincterotomy with biliary stenting (18), sphincterotomy with NBD (12), biliary stenting alone (12), and NBD alone (5). Bile leaks stopped in all patients at a median interval of 3 days (range 3-16 days) after endoscopic in- terventions. No difference was observed in efficacy and in time for the treatment of bile leak by sphincterotomy with endoprosthesis or endoprosthesis alone in patients with bile leak after surgery. CONCLUSIONS: Post-cholecystectomy bile leaks occur most commonly in the cystic duct and associated common bile duct stones are found in one-third of cases. Endoscopic therapy is safe and effective in the management of bile leaks and fistulae after surgery. Sphincterotomy with endoprosthesis or endoprosthesis alone is equally effective in the management of postoperative bile leak.Naresh Agarwal Barjesh Chander Sharma Sanjay Garg Rakesh Kumar Shiv K Sarin 2006Hepatobiliary & Pancreatic Diseases International2006,5,2:33
2不同剂量枸橼酸咖啡因和氨茶碱治疗早产儿呼吸暂停的研究显示文摘目的分析不同剂量枸橼酸咖啡因和氨茶碱治疗早产儿呼吸暂停的疗效及安全性。方法选择2013年10月至2015年10月本院新生儿重症监护病房(NICU)收治的呼吸暂停早产儿,随机分为大剂量咖啡因组:负荷量40 mg/(kg·d),维持量20 mg/(kg·d),Qd;小剂量咖啡因组:负荷量20 mg/(kg·d),维持量10 mg/(kg·d),Qd;氨茶碱组:负荷量5 mg/kg,维持量2 mg/kg,Q 12 h(持续给药至呼吸暂停停止7天或纠正胎龄34周)。观察患儿拔管失败率、呼吸暂停发生率、呼吸暂停持续时间、机械通气时间、氧疗时间、住院时间、治疗过程中的不良反应、并发症发生率及死亡率。结果大剂量咖啡因组拔管失败率、呼吸暂停发生率、呼吸暂停持续时间、氧疗时间等均低于小剂量咖啡因组和氨茶碱组,心动过速发生率高于小剂量咖啡因组和氨茶碱组,差异均有统计学意义(P<0.05)。小剂量咖啡因组与氨茶碱组各项指标比较,差异无统计学意义(P>0.05)。各组机械通气时间、持续气道正压通气(CPAP)时间、住院时间及并发症发生率、死亡率等差异无统计学意义(P>0.05)。结论大剂量咖啡因可降低拔管失败率和呼吸暂停发生率,减少呼吸暂停持续时间和氧疗持续时间,除心动过速外,未增加其他不良反应。Sanjay Kumar chaudhari 陈厚炎 谭举方 朱晓芳 2016中国新生儿科杂志2016,31,5:31
3The Receptor-Like Cytoplasmic Kinase (OsRLCK) Gene Family in Rice: Organization, Phylogenetic Relationship, and Expression during Development and Stress显示文摘在植物的像受体的细胞质的 kinases (RLCK ) 属于像受体的 kinases (RLK ) 的超级家庭。这些蛋白质在 kinase 领域显示出相同到 RLK,但是缺乏 transmembrane 领域。一些从植物的机能上地描绘的 RLCK 被显示了在开发和压力回答起作用。以前, 149 和 187 RLCK 编码基因分别地从 Arabidopsis 和米饭被识别。由使用唔基于领域结构和种系发生的关系,我们从米饭识别了 379 OsRLCKs。OsRLCKs 在米饭的所有 12 个染色体上被散布,一些成员位于复制 chromosomal 片断。几 OsRLCKs 也可能经历其他的拼接,仅仅在基因形式的一些有的证据当模特儿。理解他们的可能的函数,表达式模式在用 microarray 和基于 MPSS 的数据的植物、繁殖的开发以及不能生活、关於生命的应力的里程碑阶段期间被分析。为选择很少介绍基因的实时基于 PCR 的表示证实了 microarray 分析的结果。在开发和应力期间为 OsRLCKs 的多数观察的微分表示模式在米饭在多样的功能建议他们的参与。压力应答的 OsRLCKs 的多数也被发现在不能生活的压力 QTL 的印射的区域以内局部性。这研究的结果将在选择器官 / 发展帮助为功能的确认研究上演特定的 OsRLCK 基因 / 目标。Shubha Vij Jitender Giri Prasant Kumar Dansana Sanjay Kapoor Akhilesh K. Tyagi 2008Molecular Plant2008,1,5:21
4Role of live microbial feed supplements with reference to anaerobic fungi in ruminant productivity: A review显示文摘To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials(DFM) for improved animal performance in terms of growth or productivity. This becomes all the more essential in a situation, where a number of the residues of antibiotics and/or other growth stimulants reach in milk and meat with a number of associated potential risks for the consumers. Hence, in the absence of growth stimulants, a positive manipulation of the rumen microbial ecosystem to enhance the feedstuff utilization for improved production efficiency by ruminants has become of much interest to the researchers and entrepreneurs. A few genera of live microbes(i.e., bacteria, fungi and yeasts in different types of formulations from paste to powder) are infrequently used as DFM for the domestic ruminants. These DFM products are live microbial feed supplements containing naturally occurring microbes in the rumen. Among different DFM possibilities, anaerobic rumen fungi(ARF) based additives have been found to improve ruminant productivity consistently during feeding trials. Administration of ARF during the few trials conducted, led to the increased weight gain, milk production, and total tract digestibility of feed components in ruminants. Anaerobic fungi in the rumen display very strong cell-wall degrading cellulolytic and xylanolytic activities through rhizoid development, resulting in the physical disruption of feed structure paving the way for bacterial action. Significant improvements in the fiber digestibility were found to coincide with increases in ARF in the rumen indicating their role. Most of the researches based on DFM have indicated a positive response in nutrient digestion and methane reducing potential during in vivo and/or in vitro supplementation of ARF as DFM. Therefore, DFM especially ARF will gain popularity but it is necessary that all the strains are thoroughly studied for their beneficial properties to have a confirmed ‘generally regarded as safe' status for ruminants.Anil K Puniya Abdelfattah Z M Salem Sanjay Kumar Sumit S Dagar Gareth W Griffith Monica Puniya Sreenivas R Ravella Nikhil Kumar Tejpal Dhewa Ravinder Kumar 2015Journal of Integrative Agriculture2015,14,3:17
5Vasopressors in obstetric anesthesia: A current perspective显示文摘Vasopressors are routinely used to counteract hypotension after neuraxial anesthesia in Obstetrics. The understanding of the mechanism of hypotension and the choice of vasopressor has evolved over the years to a point where phenylephrine has become the preferred vasopressor. Due to the absence of definitive evidence showing absolute clinical benefit of one over the other, especially in emergency and high-risk Cesarean sections, our choice of phenylephrine over the other vasopressors like mephentermine, metaraminol, and ephedrine is guided by indirect evidence on fetalacid-base status. This review article evaluates the present day evidence on the various vasopressors used in obstetric anesthesia today.Deb Sanjay Nag Devi Prasad Samaddar Abhishek Chatterjee Himanshu Kumar Ankur Dembla 2015World Journal of Clinical Cases2015,3,1:15
6Species diversity, regeneration and dominance as influenced by canopy gaps and their characteristics in tropical evergreen forests of Western Ghats, India显示文摘Canopy gaps play a significant role in maintaining structure and composition of tropical forests. This study was carried out in tropical evergreen forests of central Western Ghats in India to understand the influence of canopy gap size and the relationship of gap regime attributes to diversity measures and regeneration. The average gap size in the study area was found to be 396 m2 and around half of gaps were 4–8 years old. Gaps created by natural single tree fall were smaller in size but significantly higher in number. Diversity and regeneration of woody species were compared with canopy gaps and intact vegetation. Species richness and diversity was higher in gaps than in intact vegetation. Macaranga peltata, a shade intolerant species dominated gaps while intact vegetation was dominated by shade tolerant Kingiodendron pinnatum.Gap size significantly influenced species diversity and regeneration. Gap area and age were significantly and negatively correlated with diversity measures but positively correlated with regeneration. Among all the attributes of gaps, regeneration was significantly positively correlated with light intensity. Gaps maintained species diversity and favored regeneration of woody species. In addition to gap size and age, other gap ecological attributes also affected species diversity and regeneration.Guddappa Mahalingappa Devagiri Anil Kumar Khaple Siddagangaiah Mohan Puttanaik Venkateshamurthy Sanjay Tomar Arkalgud Nagaraja Arunkumar Geeta Joshi 2016Journal of Forestry Research2016,27,4:9
7Perfusion computed tomography in renal cell carcinoma显示文摘Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma(RCC). While contrast enhanced computed tomography(CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT(p CT), goes down to the molecular level and provides new perspectives in imaging of RCC. p CT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using p CT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of p CT in staging and response assessment in patients with RCCs.Chandan J Das Usha Thingujam Ananya Panda Sanjay Sharma Arun Kumar Gupta 2015World Journal of Radiology2015,7,7:8
8Load-settlement behaviour of a strip footing resting on iron ore tailings as a structural fill显示文摘This study presents a laboratory investigation of load-settlement behaviour of a strip footing resting on iron ore tailings used as a structural fill.The footing was placed at various depths in the tailings bed.The relative density of the tailings was varied as D_r = 50%,70%and 90%.An incremental load was applied on the footing while observing the settlement until the failure took place.The results obtained for tailings were compared with those for the sandy soil.It is observed that the load-bearing capacity and stiffness increase with an increase in footing embedment depth and relative density.Compared to load-settlement behaviour of Perth sandy soil,the tailings fill could have as high as 22 times and 13.5 times the load-bearing capacity and stiffness,respectively.Therefore,the replacement of sandy soil with iron ore tailings for structural fills is cost-effective,and moreover,this application contributes to environmental sustainability in construction.Kuranchie Francis Atta Shukla Sanjay Kumar Habibi Daryoush Kazi Monir 2016International Journal of Mining Science and Technology2016,26,2:8
9Delayed migration of K-wire into popliteal fossa used for tension band wiring of patellar fracture显示文摘被用于破裂固定的 K 电线和不锈钢电线的破裂不是不平常的,但是移植是稀罕的。我们报导为髌紧张乐队配线使用到腿弯部的窝的破 K 电线的移植的一个案例。破硬件通过手术被移开。我们想建议那 K 电线和电线固定使用了因为膝盖骨的破裂的治疗能移居进膝的以后的分隔空间并且引起临床的症状。在曾经,骨折统一了识别电线的硬件破裂或运动和移动的存在的内部固定以后的近临床、放射学的后续能避免如此的复杂并发症。Sanjay Meena Hira Lal Nag Senthil Kumar Nilesh Barwar Samarth Mittal Amit Singla 2013Chinese Journal of Traumatology2013,16,3:7
10热烫温度和时间对魔芋片干燥动力学和品质的影响(摘选)Vishal Kumar Manish Kumar Sanjay Kumar 2012农业工程2012,2,4:6
11Novel targeting approaches and signaling pathways of colorectal cancer: An insight显示文摘Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC.Ankita Tiwari Shivani Saraf Amit Verma Pritish Kumar Panda Sanjay K Jain 2018World Journal of Gastroenterology2018,24,39:6
12Torque teno virus:Its prevalence and isotypes in North India显示文摘AIM: To investigate the prevalence and genotype dis-tribution of Torque teno virus (TTV) in patients with different liver diseases and chronic renal failure treated at a referral hospital in North India. METHODS: Whereas prevalence of TTV was based on amplification of conserved region of ORF2 of TTV genome,the genotyping of TTV was carried out using restriction fragment length polymorphism (RFLP) procedure on the N22 region of ORF1. RESULTS: TTV-DNA was detected in 137 of 513 (26.7%) patients with liver diseases and 38 of 65 (58.5%) patients with chronic renal failure. TTV was also detected in 27% of healthy controls. The sequence analysis of the PCR product from 10 randomly selected cases failed to show a significant sequence divergence when compared with that of the TRM1 isolate of TTV genotype 1. The results of genotyping in 55 randomly selected patients showed the presence of genotype 1 (G1) in 53 (96.4%) and genotype 2 (G2) in 2 cases (3.6%),respectively. Other genotypes were not identified in this patient subgroup,suggesting that G1 is predominant in this area. The results of genotyping by RFLP were also supported by phylogenetic tree analysis,where G1 was found to be the major genotype. CONCLUSION: These results indicate that TTV is moderately present in Indian patients,with G1 to be the major genotype in North India. The pathogenicity and etiological role of TTV in different diseases is still a question mark and warrant further studies.Mohammad Irshad Shiwani Singh Khushboo Irshad Sanjay Kumar Agarwal Yogendra Kumar Joshi 2008World Journal of Gastroenterology2008,14,39:5
13Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models.VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar 2011Asian Pacific Journal of Tropical Biomedicine2011,1,2:4
14右美托咪定辅助超声引导下腹横肌平面阻滞在高龄危重患者腹股沟斜疝手术中的应用显示文摘目的:观察右美托咪定辅助超声引导下腹横肌平面阻滞在高龄危重患者腹股沟斜疝修补术的安全性和有效性。方法:选择拟行单侧腹股沟斜疝修补术的高龄危重患者40例,年龄65~86岁,体质量50~78kg,ASAⅡ14例,Ⅲ26例,合并严重心肺血管疾病、糖尿病、中枢神经系统疾病和口服抗凝治疗等。缓慢静滴芬太尼1μg/kg、静脉泵注右美托咪定0.4μg/(kg.h)。超声引导下行腹横肌平面阻滞,注入0.4%罗哌卡因25~30ml。若麻醉效果欠佳或失败,静注异丙酚、芬太尼辅助麻醉或者插入喉罩行全麻。监测术中的生命体征和麻醉效果,术后随访尿潴留的发生率以及术后2、6、12、24h和48h时的疼痛评分。结果:围手术期MAP、SrO2无明显变化,循环和呼吸系统维持稳定,HR在术中时减慢,但在安全范围;麻醉效果满意32例,麻醉阻滞不全5例,麻醉失败改喉罩全麻3例。术后尿潴留的发生率15%。无腹横肌平面阻滞相关的任何并发症发生。结论:高龄危重患者腹股沟斜疝修补术选择右美托咪定辅助超声引导下腹横肌平面阻滞,具有麻醉效果确切,对机体生理功能干扰小,操作简单,安全可靠,不受杭凝治疗的影响,术后并发症少,是一种比较理想的麻醉方式。Sanjay Kumar Sigh 夏瑞 李启飞 龚勇 朱琼 2015长江大学学报(自科版)(下旬)2015,12,2:4
15Has the Belt and Road Initiative Improved the Quality of Food Imported by Chinese Enterprises?显示文摘Using micro-level data from 2009-2015 and the difference-in-difference method,this paper empirically examines the impact of the Belt and Road Initiative(BRI)on the quality of food imported by Chinese enterprises from BRI countries.Our baseline results show that the BRI significantly improved the quality of food imported from these countries.Further investigation reveals that trade patterns,ownership types,import regions,transportation methods,and product quality show significant heterogeneous effects in influencing the quality of imported food.A mechanism analysis indicates that the BRI improves the quality of imported food through three main channels:import trade environment enhancement,competition effect,and consumption upgrading,with the competition effect having the largest impact compared with the other two channels.Our findings suggest that China should not only improve the infrastructure in BRI countries but also use the BRI as an opportunity to enhance the level of cooperation with BRI countries and maintain stability and sustainability in cooperation with them.Kexuan Zhou Sanjay Kumar Futao Lu Qiaoyun Fang Linhui Yu 2022China & World Economy2022,30,2:4
16Herbal antioxidant in clinical practice:A review显示文摘Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called'free-radical'reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging compounds.We must acknowledge that such'radicals'have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and folate.Defense strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and carotenoids.This paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall health.It is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell sites.Further evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totallyShashi Alok Sanjay Kumar Jain Amita Verma Mayank Kumar Alok Mahor Monika Sabharwal 2014Asian Pacific Journal of Tropical Biomedicine2014,4,1:4
17An unusual cause of dyspnoea complicating right upper abdominal swelling显示文摘一中年,恰好上面的腹的疼痛地介绍的非瘾君子男性并且与呼吸窘迫胀大。检查揭示了中央青紫,两足动物 pitting 与突出腹上部并且背静脉。肝被扩大,温柔,没有任何脾大或腹水,跨越了 20 厘米。另外的系统是临床上正常的。实验室调查证明有稍微捣乱的肝的 polymorphonuclear 白细胞增多工作。腹的 ultrasonography 与压缩劣等的静脉腔(IVC ) 在肝的正确脑叶显示出脓肿,中间、左的肝的静脉。动脉的血气体(ABG ) 与 orthodeoxia 记录了组织缺氧,空气对比回响心动描记法肺内分流是暗示的。hepato 肺的症候群(HPS ) 的诊断与对阿米巴的肝脓肿第二等的近正常的肝功能被做。它颠倒了肝脓肿的完全后面的成功的处理。Sanjay Kumar Mandal Partha Pratim Chakraborty Rana Bhattacharjee Subhasis Roy Chowdhury Shounak Majumdar 2006World Journal of Gastroenterology2006,12,25:3
18Comparative evaluation of microscopy,OptiMAL® and 18S rRNA gene based multiplex PCR for detection of Plasmodium falciparum & Plasmodium vivax from field isolates of Bikaner,India显示文摘Objective:To evaluate microscopy,OptiMAL? and multiplex PCR for the identification of Plasmodium falciparum(P.falciparum) and Plasmodium vivax(P.vivax) from the field isolates of Bikaner,Rajasthan(Northwest India).Methods:In this study,a multiplex PCR(P.falciparum and P.vivax) was further developed with the incorporation of Plasmodium malariae(P.malariae) specific primer and also a positive control.The performance of microscopy,plasmodium lactate dehydrogenase(pLDH) based malaria rapid diagnostic test OptiMAL? and 18S rRNA gene based multiplex PCR for the diagnosis of P.falciparum and P.vivax was compared.Results:The three species multiplex PCR if.falciparum,P.vivax and P.malariae) with an inbuilt positive control was developed and evaluated.In comparison with multiplex PCR,which showed the sensitivity and specificity of 99.36%(95%CI,98.11%-100.00%) and 100.00%(95%CI,100.00%-100.00%),the sensitivity and specificity of microscopy was 90.44%(95%CI,88.849-95.04%) and 99.22%(95% CI,97.71%-100.00%),and OptiMAL? was 93.58%(95%CI,89.75%-97.42%) and 97.69%(95%CI, 95.10%-100.00%).The efficiencies were 99.65%,95.10%and 95.45%for multiplex PCK.microscopy and OptiMAL?.respectively.Conclusions:Our results raise concerns over the overall sensitivities of microscopy and OptiMAL?,when compared to the multiplex PCR and thus stress the need for new molecular interventions in the accurate detection of the malarial parasites.This further highlights the fact that further developments are needed to improve the performance of rapid diagnostic tests at field level.Deepak Pakalapati Shilpi Garg Sheetal Middha Abhishek Kochar Amit Kumar Subudhi Boopathi Pon Arunachalam Sanjay Kumar Kochar Vishal Saxena Pareek RP Jyoti Acharya Dhanpat Kumar Kochar Ashis Das 2013Asian Pacific Journal of Tropical Medicine2013,6,5:3
19Emerging targets in cancer drug resistance显示文摘Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment.Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways.Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes.This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta 2019Cancer Drug Resistance2019,2,2:3
20Chemical composition and source apportionment of PM2.5 and PM2.5-10 in Trombay (Mumbai, India), a coastal industrial area显示文摘Sandeep Police Sanjay Kumar Sahu Mahesh Tiwari Gauri Girish Pandit 2018Particuology2018,16,2:3
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