|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting inflammation in diabetes: Newer therapeutic options显示文摘Inflammation has been recognised to both decrease beta cell insulin secretion and increase insulin resis-tance. Circulating cytokines can affect beta cell function directly leading to secretory dysfunction and increased apoptosis. These cytokines can also indirectly affect beta cell function by increasing adipocyte inflamma-tion.The resulting glucotoxicity and lipotoxicity further enhance the inflammatory process resulting in a vicious cycle. Weight reduction and drugs such as metformin have been shown to decrease the levels of C-Reactive Protein by 31% and 13%, respectively. Pioglitazone, insulin and statins have anti-inflammatory effects. In-terleukin 1 and tumor necrosis factor-α antagonists are in trials and NSAIDs such as salsalate have shown an improvement in insulin sensitivity. Inhibition of 12-lipo-oxygenase, histone de-acetylases, and activation of sirtuin-1 are upcoming molecular targets to reduce in-flammation. These therapies have also been shown to decrease the conversion of pre-diabetes state to diabe-tes. Drugs like glicazide, troglitazone, N-acetylcysteine and selective COX-2 inhibitors have shown benefit in diabetic neuropathy by decreasing inflammatory mark-ers. Retinopathy drugs are used to target vascular en-dothelial growth factor, angiopoietin-2, various protein-ases and chemokines. Drugs targeting the proteinases and various chemokines are pentoxifylline, inhibitors of nuclear factor-kappa B and mammalian target of rapa-mycin and are in clinical trials for diabetic nephropathy. Commonly used drugs such as insulin, metformin, per-oxisome proliferator-activated receptors, glucagon like peptide-1 agonists and dipeptidyl peptidase-4 inhibitors also decrease inflammation. Anti-inflammatory thera-pies represent a potential approach for the therapy of diabetes and its complications. | Neeraj Kumar Agrawal Saket Kant | 2014 | World Journal of Diabetes2014，5，5： | 41 |
| 2 | Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes显示文摘Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results. | Vishal Gupta Saket Kumar Vivek Gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit Chandra | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 8 |
| 3 | Retroperitoneal Lymphangioma in an Adult: A Case Report of a Rare Clinical Entity显示文摘 | Mayank Tripathi Sanjeev Parshad Rajender Kumar Karwasra Ashish Gupta Saket Srivastva Ankush Sarwal Gabriel Sandblom | 2015 | Case Reports in Surgery2015，，： | 1 |
| 4 | Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum显示文摘 | Subash Chandra Mohapatra Hemandra Kumar Tiwari Manisha Singla Brijesh Rathi Arun Sharma Kuldeep Mahiya Mukesh Kumar Saket Sinha Shyam Singh Chauhan | 2010 | JBIC Journal of Biological Inorganic Chemistry2010，，3： | 1 |
| 5 | Laparoscopic ventral mesh rectopexy for complete rectal prolapse: A retrospective study evaluating outcomes in North Indian population显示文摘AIM: To analyze the outcomes of laparoscopic ventral mesh rectopexy in the management of complete rectal prolapse(CRP) in North Indian patients with inherent bulky and redundant colon. METHODS: The study was conducted at a tertiary health care center of North India. Between January 2010 and October 2014, 15 patients who underwent laparoscopic ventral mesh repair for CRP, were evaluated in the present study. Perioperative outcomes, improvement in bowel dysfunction or appearance of new complications were documented from the hospital records maintained prospectively. RESULTS: Fifteen patients(9 female) with a median age of 50 years(range, 15-68) were included in the study. The median operative time was 200 min(range, 180-350 min) and the median post-operative stay was 4 d(range, 3-21 d). No operative mortality occurred. One patient with inadvertent small bowel injury required laparotomy on post-operative day 2. At a median follow-up of 22 mo(range, 4-54 mo), no prolapse recurrence was reported. No mesh-related complication was encountered. Wexner constipation score improved significantly from the preoperative value of 17(range, 5-24) to 6(range, 0-23)(P < 0.001) and the fecal incontinence severity index score from 24(range, 0-53)to 2(range, 0-53)(P = 0.007). No de novo constipation or fecal incontinence was recorded during the followup. On personal conversation, all patients expressed satisfaction with the outcome of their treatment. CONCLUSION: Our experience indicates that laparoscopic ventral mesh rectopexy is an effective surgical option for CRP in North Indian patients having a bulky redundant colon. | Abhijit Chandra Saket Kumar Ajeet Pratap Maurya Vishal Gupta Vivek Gupta Rahul | 2016 | World Journal of Gastrointestinal Surgery2016，8，4： | 1 |
| 6 | Enhanced electrical and photocatalytic activities in Na_(0.5)Bi_(0.5)TiO_(3) through structural modulation by using anatase and rutile phases of TiO_(2)显示文摘This paper deals with an in-depth analysis on the role of the microstructure phase of titanium dioxide(TiO_(2))precursor in sodium bismuth titanate(Na_(0.5)Bi_(0.5)TiO_(3),hereafter represented as NBT)ceramics prepared through the hydrothermal method.The comparison of the grain size,microstructure,crystal structure,and electrical properties of the NBT ceramics is carried out using anatase and rutile TiO_(2).NBT ceramics with anatase TiO_(2)(denoted by NBT_(A))displayed superior dielectric and ferro/piezoelectric properties along with the additional functionality in terms of photocatalysis.Systematic studies of functional properties such as piezoelectric,ferroelectric,and dielectric stressed the far-reaching influence of effects on grain size.The mechanisms and functional properties of grain quantitative effects are also discussed.Grain boundaries volume fraction increment has decreased the dielectric peak but increased the diffusiveness in the case of the NBT with rutile TiO_(2) precursor(denoted as NBT_(R)).Similarly,elastic stiffness increment restricts the movement of the domain wall and led to a decrement in remnant polarization along with an increase in the values of the corresponding piezoelectric coefficient in finegrain NBT_(R) samples. | Cilaveni Goutham Kinjarapu Venkata Ashok Kumar Sai Santosh Kumar Raavi Challapalli Subrahmanyam Saket Asthana | 2022 | Journal of Materiomics2022，8，1： | 0 |
| 7 | Avoiding second donor site and the second set of neck vessels in a case of absent peroneal skin perforators显示文摘This report describes the procedure of a case in which the skin paddle of the free fibula flap derived its supply solely from a soleal musculocutaneous perforator originating from the posterior tibial system.In contrast,the osteo-muscular component was supplied by the peroneal vascular system.We harvested the skin paddle with its vascular supply from the posterior tibial artery separately,and the osteo-muscular fibula was harvested with its supply from peroneal vessels.In this way,we avoided violation of the second donor site for the skin paddle.In addition,we used the distal end of peroneal vessels to salvage our skin paddle instead of sacrificing another set of neck vessels for anastomosis.This technique may also be utilised in cases where the neck vessels may not be available due to previous surgeries,radiation therapy,or decision by the surgery team to not sacrifice two sets of neck vessels for anastomosis. | Aditya Narayan Choudhary Rajan Arora Kripa Shanker Mishra Ravi Kiran Naalla Saket Srivastava Ajay Kumar Dewan | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员