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| 1 | Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma显示文摘AIM: To explore the expression of leukemia related protein 16 (LRP16) in colorectal carcinoma, and analyze its correlation with clinicopathologic features and prognosis. METHODS: Immunohistochemistry for LRP16 was performed in 201 cases of colorectal carcinoma and 60 cases of distal normal mucosa. Medical records were reviewed and clinicopathological analysis was performed. RESULTS: LRP16 expression was detected in 117 of 201 cases of the colorectal carcinoma and in 21 cases of 60 distal normal mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa (χ 2 = 9.999, P = 0.002). LRP16 protein expression was found in 43.3% (52/120) of carcinoma at stage Ⅰ and Ⅱ , and 80.2% (65/81) of carcinoma at stage Ⅲ and Ⅳ (χ 2 =27.088, P = 0.001). Correlation between LRP16 expression and clinicopathological factors was significant in differentiation (P = 0.010), tumor size (P = 0.001), infiltrative depth (P = 0.000) and distant metastasis (P = 0.027). The difference of median survival time between cancer patients with LRP16 expression (38.0 mo) and those without was statistically significant (105.0 mo, Log rank = 41.455, P = 0.001). The multivariate survival analysis revealed that LRP16 expression was correlated significantly (Cox’s regression: P = 0.001, relative risk = 2.082) with shortened survival in the patients with colorectal cancer. CONCLUSION: The expression of LRP16 is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma. | Xi, Hong-Qing Zhao, Po Han, Wei-Dong | 2010 | World Journal of Gastroenterology2010，16，13： | 10 |
| 2 | Advanced oxidation of bromide-containing drinking water: A balance between bromate and trihalomethane formation control显示文摘Addition of H2O2 has been employed to repress bromate formation during ozonation of bromide-containing source water.However,the addition of H2O2 will change the oxidation pathways of organic compounds due to the generation of abundant hydroxyl radicals,which could afect the removal efcacy of trihalomethane precursors via the combination of ozone and biological activated carbon(O3-BAC).In this study,we evaluated the efects of H2O2 addition on bromate formation and trihalomethane formation potential(THMFP)reduction during treatment of bromide-containing(97.6–129.1μg/L)source water by the O3-BAC process.At an ozone dose of 4.2 mg/L,an H2O2/O3(g/g)ratio of over 1.0 was required to maintain the bromate concentration below 10.0μg/L,while a much lower H2O2/O3ratio was sufcient for a lower ozone dose.An H2O2/O3(g/g)ratio below 0.3 should be avoided since the bromate concentration will increase with increasing H2O2 dose below this ratio.However,the addition of H2O2 at an ozone dose of 3.2 mg/L and an H2O2/O3 ratio of 1.0 resulted in a 43% decrease in THMFP removal when compared with the O3-BAC process.The optimum H2O2/O3(g/g) ratio for balancing bromate and trihalomethane control was about 0.7–1.0.Fractionation of organic materials showed that the addition of H2O2 decreased the removal efcacy of the hydrophilic matter fraction of DOC by ozonation and increased the reactivity of the hydrophobic fractions during formation of trihalomethane,which may be the two main reasons responsible for the decrease in THMFP reduction efcacy.Overall,this study clearly demonstrated that it is necessary to balance bromate reduction and THMFP control when adopting an H2O2 addition strategy. | Yongjing Wang Jianwei Yu Po Han Jing Sha Tao Li Wei An Juan Liu Min Yang | 2013 | Journal of Environmental Sciences2013，25，11： | 9 |
| 3 | Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients显示文摘AIM:To investigate the expression of leukemia related protein 16 (LRP16), and the possible relationship between LRP16 expression and clinicopathological indices in 336 gastric carcinoma patients.METHODS: Immunohistochemistry was used to detect LRP16 expression in 336 cases of paraffin-embedded gastric carcinoma tissues and 60 cases of distal normal mucosa. The relationships between LRP16 expression and patients' age, tumor size, histological grade, clinical stage, metastatic status and prognosis were analysed.RESULTS: The expression of LRP16 was 58.6% (197/336) in gastric carcinoma and 31.7% (19/60) in distal normal gastric mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa tissues (χ2=14.929, P=0.001). LRP16 protein expression was found in 44.1% (63/143) carcinomas at stage and,and 69.4%(134/193) carcinomas at stage and (χ2=21.804,P=0.001),and in 56.9%(182/320)of cancers without metastasis but 93.8%(15/16)of those with metastasis(χ2=8.543,P=0.003).The expression of LRP16 was correlated with tumor size,infiltrative depth,clinical stage,lymphatic invasion and distant metastasis(all P<0.05). Follow-up data showed that there was a significant difference in median survival time between cancer patients with expression of LRP16 (27.0 mo) and those without (48.0 mo, Log rank=31.644, P=0.001).CONCLUSION: The expression of LRP16 may be associated with invasion, metastasis and prognosis of gastric cancer. | Ya-Zhuo Li Po Zhao Wei-Dong Han | 2009 | World Journal of Gastroenterology2009，15，38： | 8 |
| 4 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 5 | MAP kinase gene STK1 is required for hyphal, conidial, and appressorial development, toxin biosynthesis, pathogenicity, and hypertonic stress response in the plant pathogenic fungus Setosphaeria turcica显示文摘The mitogen-activated protein kinase(MAPK), a key signal transduction component in the MAPK cascade pathway, regulates a variety of physiological activities in eukaryotes. However, little is known of the role MAPK plays in phytopathogenic fungi. In this research, we cloned the MAPK gene STK1 from the northern corn leaf blight pathogen Setosphaeria turcica and found that the gene shared high homology with the high osmolality glycerol(HOG) MAPK gene HOG1 of Saccharomyces cerevisiae. In addition, gene knockout technology was employed to investigate the function of STK1. Gene knockout mutants(KOs) were found to have altered hyphae morphology and no conidiogenesis, though they did show similar radial growth rate compared to the wild-type strain(WT). Furthermore, microscope observations indicated that STK1 KOs did not form normal appressoria at 48 h post-inoculation on a hydrophobic surface. STK1 KOs had reduced virulence, a significantly altered Helminthosporium turcicum(HT)-toxin composition, and diminished pathogenicity on the leaves of susceptible inbred corn OH43. Mycelium morphology appeared to be significantly swollen and the radial growth rates of STK1 KOs declined in comparison with WT under high osmotic stress. These results suggested that STK1 affects the hyphae development, conidiogenesis, and pathogenicity of S. turcica by regulating appressorium development and HT-toxin biosynthesis. Moreover, the gene appears to be involved in the hypertonic stress response in S. turcica. | LI Po GONG Xiao-dong JIA Hui FAN Yong-shan ZHANG Yun-feng CAO Zhi-yan HAO Zhi-min HAN Jian-min GU Shou-qin DONG Jin-gao | 2016 | Journal of Integrative Agriculture2016，15，12： | 7 |
| 6 | Quantifying the effectiveness of SiO_2/Au light trapping nanoshells for thin film poly-Si solar cells显示文摘In order to enhance light absorption of thin film poly-crystalline silicon(TF poly-Si)solar cells over a broad spectral range, and quantify the effectiveness of nanoshell light trapping structure over the full solar spectrum in theory,the effective photon trapping flux(EPTF)and effective photon trapping efficiency(EPTE)were firstly proposed by considering both the external quantum efficiency of TF poly-Si solar cell and scattering properties of light trapping structures.The EPTF,EPTE and scattering spectrum exhibit different behaviors depending on the geometric size and density of nanoshells that form the light trapping layer.With an optimum size and density of SiO2/Au nanoshell light trapping layer,the EPTE could reach up to 40%due to the enhancement of light trapping over a broad spectral range,especially from 500 to 800 nm. | BAI YiMing 1 ,WANG Jun 2 ,CHEN NuoFu 1,3 ,YAO JianXi 1 ,YIN ZhiGang 3 ,ZHANG Han 3 , ZHANG XingWang 3 ,HUANG TianMao 3 ,WANG YanShuo 3 &YANG XiaoLi 3 1School of Renewable Energy Engineering,North China Electric Power University,Beijing 102206,China 2 National Engineering Research Center for Optoelectronic Devices,Institute of Semiconductors, Chinese Academy of Sciences,PO Box 912,Beijing 100083,China 3 Key Laboratory of Semiconductor Materials Science,Institute of Semiconductors, Chinese Academy of Sciences,PO Box 912,Beijing 100083,China | 2010 | Science China(Technological Sciences)2010，53，8： | 4 |
| 7 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 8 | Stk2,a Mitogen-Activated Protein Kinase from Setosphaeria turcica,Specifically Complements the Functions of the Fus3 and Kss1 of Saccharomyces cerevisiae in Filamentation,Invasive Growth,and Mating Behavior显示文摘Setosphaeria turcica,an essential phytopathogenic fungus,is the primary cause of serious yield losses in corn;however,its pathogenic mechanism is poorly understood.We cloned STK2,a newly discovered mitogen-activated protein kinase gene with a deduced amino acid sequence that is 96%identical to MAK2 from Phaeosphaeria nodorum,56%identical to KSS1 and 57%identical to FUS3 from Saccharomyces cerevisiae.To deduce Stk2 function in S.turcica and to identify the genetic relationship between STK2 and KSS1/FUS3 from S.cerevisiae,a restructured vector containing the open reading frame of STK2 was transformed into a fus3/kss1 double deletion mutant of S.cerevisiae.The results show that the STK2complementary strain clearly formed pseudohyphae and ascospores,and the strain grew on the surface of the medium after rinsing with sterile water and the characteristics of the complementary strain was the same as the wild-type strain.Moreover,STK2 complemented the function of KSS1 in filamentation and invasive growth,as well as the mating behavior of FUS3 in S.cerevisiae,however,its exact functions in S.turcica will be studied in the future research. | GU Shou-qin YANG Yang LI Po ZHANG Chang-zhi FAN Yu ZHANG Xiao-yu TIAN Lan HAO Zhi-min CAO Zhi-yan GONG Xiao-dong FAN Yong-shan HAN Jian-min DONG Jin-gao | 2013 | Journal of Integrative Agriculture2013，12，12： | 3 |
| 9 | Mitochondria Redistribution in Enterovirus A71 Infected Cells and Its Effect on Virus Replication显示文摘Enterovirus A71(EV-A71)is one of the main causative agents of hand,foot and mouth disease(HFMD)and it also causes severe neurologic complications in infected children.The interactions between some viruses and the host mitochondria are crucial for virus replication and pathogenicity.In this study,it was observed that EV-A71 infection resulted in a perinuclear redistribution of the mitochondria.The mitochondria rearrangement was found to require the microtubule network,the dynein complex and a low cytosolic calcium concentration.Subsequently,the EV-A71 non-structural protein 2BC was identified as the viral protein capable of inducing mitochondria clustering.The protein was found localized on mitochondria and interacted with the mitochondrial Rho GTPase 1(RHOT1)that is a key protein required for attachment between the mitochondria and the motor proteins,which are responsible for the control of mitochondria movement.Additionally,suppressing mitochondria clustering by treating cells with nocodazole,EHNA,thapsigargin or A23187 consistently inhibited EV?A71 replication,indicating that mitochondria recruitment played a crucial role in the EV-A71 life cycle.This study identified a novel function of the EV-A71 2BC protein and provided a potential model for the regulation of mitochondrial motility in EV-A71 infection. | Yang Yang Haolong Cong Ning Du Xiaodong Han Lei Song Wenliang Zhang Chunrui Li Po Tien | 2019 | Virologica Sinica2019，34，4： | 2 |
| 10 | Following the recovery of naso-pharyngeal cancer patients by trace elements in hair using statistical pattern recognition methods显示文摘 | Po Lau Leung Han Ming Huang | 1998 | Biological Trace Element Research1998，，3： | 1 |
| 11 | A Novel, Self-Expanding, Nitinol Stent in Medically Refractory Intracranial Atherosclerotic Stenoses: The Wingspan Study显示文摘 | Arani Bose Marius Hartmann Hans Henkes Hon Man Liu Michael M.H. Teng Istvan Szikora Ansgar Berlis Jurgen Reul Simon C.H. Yu Michael Forsting Matt Lui Winston Lim Siu Po Sit | 2007 | Stroke2007，，5： | 1 |
| 12 | Optimal Stiffness Design of Compostite Laminates for a Train Carbody by an Expert System and Enumeration Method显示文摘 | Kim Jung Seok Kim Nam Po Han Seong Ho | 2005 | Composite Structures2005，68，2： | 1 |
| 13 | A Novel, Self-Expanding, Nitinol Stent in Medically Refractory Intracranial Atherosclerotic Stenoses: The Wingspan Study显示文摘 | Arani Bose Marius Hartmann Hans Henkes Hon Man Liu Michael M.H. Teng Istvan Szikora Ansgar Berlis Jurgen Reul Simon C.H. Yu Michael Forsting Matt Lui Winston Lim Siu Po Sit | 2007 | Stroke2007，，5： | 1 |
| 14 | Influence of fat on ultrasound measurements of the os calcis显示文摘 | Kotzki PO Buyck D Hans D | 1994 | Calcif Tissue Int1994，54，2： | 1 |
| 15 | Surgical resection versus transarterial chemoembolization for BCLC stage C hepatocellular carcinoma显示文摘 | Po‐Hong Liu Cheng‐Yuan Hsia Yun‐Hsuan Lee Chia‐Yang Hsu Yi‐Hsiang Huang Chien‐Wei Su Rheun‐Chuan Lee Han‐Chieh Lin Teh‐Ia Huo | 2015 | J. Surg. Oncol2015，，4： | 1 |
| 16 | An advanced quantum- inspired evolutionary algorithm for unit commitment 显示文摘 | CHUNG C Y YU Han WONG Kit Po | 2011 | IEEE Transactions on Power Systems2011，26，2： | 1 |
| 17 | Increasing the success of reverse sural flap from proximal part of posterior calf for traumatic foot and ankle reconstruction: Patient selection and surgical refinement显示文摘 | Johnlong Tsai Han Tsung Liao Po Fang Wang Chien Tzung Chen Chih Hung Lin | 2013 | Microsurgery2013，，5： | 1 |
| 18 | Predictors of in‐hospital mortality after acute variceal bleeding in patients with hepatocellular carcinoma and concurrent main portal vein thrombosis显示文摘 | Ming‐Lun Han Chieh‐Chang Chen Shih‐Hao Kuo Wen‐Feng Hsu Jyh‐Ming Liou Ming‐Shiang Wu Hsiu‐Po Wang | 2014 | J Gastroenterol Hepatol2014，，2： | 1 |
| 19 | Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial显示文摘 | Masatoshi Kudo Guohong Han Richard S. Finn Ronnie T.P. Poon Jean‐Frederic Blanc Lunan Yan Jijin Yang Ligong Lu Won‐Young Tak Xiaoping Yu Joon‐Hyeok Lee Shi‐Ming Lin Changping Wu Tawesak Tanwandee Guoliang Shao Ian B. Walters Christine Dela Cruz Valerie Po | 2014 | Hepatology2014，，5： | 1 |
| 20 | Ribozyme-mediated resistance to rice dwarf virus and the transgene silencing in the progeny of transgenic rice plants显示文摘 | Shengcheng Han Zujian Wu Huaiyi Yang Rong Wang Yin Yie Lianhui Xie Po Tien | 2000 | Transgenic Research2000，，3： | 1 |
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