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| 1 | Analytical formulation for the bend loss in single-ring hollow-core photonic crystal fibers显示文摘Understanding bend loss in single-ring hollow-core photonic crystal fibers(PCFs)is becoming of increasing importance as the fibers enter practical applications.While purely numerical approaches are useful,there is a need for a simpler analytical formalism that provides physical insight and can be directly used in the design of PCFs with low bend loss.We show theoretically and experimentally that a wavelength-dependent critical bend radius exists below which the bend loss reaches a maximum,and that this can be calculated from the structural parameters of a fiber using a simple analytical formula.This allows straightforward design of single-ring PCFs that are bend-insensitive for specified ranges of bend radius and wavelength.It also can be used to derive an expression for the bend radius that yields optimal higher-order mode suppression for a given fiber structure. | MICHAEL H.FROSZ PAUL ROTH MEHMET C.GüNENDI PHILIP ST.J.RUSSELL | 2017 | Photonics Research2017，5，2： | 5 |
| 2 | G蛋白信号转导调节因子5的缺失激活脑卒中时的神经血管保护显示文摘在缺血性脑卒中发生时,血脑屏障的破坏加重了脑损伤。周细胞脱离导致血脑屏障破坏和神经血管功能障碍,但对其在脑卒中中的调节知之甚少。在该研究中,研究者研究了周细胞中G蛋白信号转导调节因子5(Gprotein signaling5,RGS5)的缺失如何影响脑卒中时血脑屏障的破坏及其后果。 | zen I Roth M Barbariga M Gaceb A Deierborg T Genové G Paul G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 2 |
| 3 | Reduction of aromatic nitro compounds with hydrazine hydrate in the presence of an iron oxide hydroxide catalyst显示文摘 | Ronny Roth Paul Rys | 1999 | Applied Catalysis1999，，： | 1 |
| 4 | Role of ICAM-1 in invasion of human ovarian cancer ceils 显示文摘 | Caridad Rosette Richard B Roth Paul Oeth | 2005 | Carcinogenesis2005，26，5： | 1 |
| 5 | Subcellular localisation of VEGF in different pituitary cells. Changes of its expression in oestrogen induced prolactinomas显示文摘 | Jorge Humberto Mukdsi Ana Lucía De Paul Silvina Gutiérrez Félix Daniel Roth Agustín Aoki Alicia Inés Torres | 2005 | Journal of Molecular Histology (-)2005，，8： | 1 |
| 6 | Charactering and predicting outcomes of communication delay in infants and toddlers:implications for clinical practices显示文摘 | Paul R Roth FP | 2011 | Lang Speech Hear Serv Sch2011，42，： | 1 |
| 7 | Sleep Problems, Comorbid Mental Disorders, and Role Functioning in the National Comorbidity Survey Replication显示文摘 | Thomas Roth Savina Jaeger Robert Jin Anupama Kalsekar Paul E. Stang Ronald C. Kessler | 2006 | Biological Psychiatry2006，，12： | 1 |
| 8 | Visualize your forest-Using forest simulation software to communicate forest management concepts to private forestland owners显示文摘 | Roth Paul Finley J C | 2007 | Journal of Forestry2007，105，1： | 1 |
| 9 | Influence of human biokinetics of strontium on internal ingestion dose of 90St and absorbed dose of 89Sr to organs and metastases 显示文摘 | Li Wei Bo Hollriegl Vers Roth Paul | 2008 | Radiation and environmental biophysics2008，47，2： | 1 |
| 10 | Laparoscopic Nissen Fundoplication Effectively Relieves Symptoms in Patients with Laryngopharyngeal Reflux显示文摘 | Robert A. Catania Stephen M. Kavic J. Scott Roth Tommy H. Lee Tanya Meyer George T. Fantry Paul F. Castellanos Adrian Park | 2007 | Journal of Gastrointestinal Surgery2007，，12： | 1 |
| 11 | Laparoscopic Nissen Fundoplication Effectively Relieves Symptoms in Patients with Laryngopharyngeal Reflux显示文摘 | Robert A. Catania Stephen M. Kavic J. Scott Roth Tommy H. Lee Tanya Meyer George T. Fantry Paul F. Castellanos Adrian Park | 2007 | Journal of Gastrointestinal Surgery2007，，12： | 1 |
| 12 | Current Challenges and Controversies in Drug-Induced Liver Injury显示文摘 | Corsini Alberto Ganey Patricia Ju Cynthia Kaplowitz Neil Pessayre Dominique Roth Robert Watkins Paul B Albassam Mudher Liu Baolian Stancic Saray Suter Laura Bortolini Michele | 2012 | Drug Safety2012，，12： | 1 |
| 13 | Guiding principles and clinical appli- cations for speech-language pathology practice in early intervention 显示文摘 | Paul D Roth FP | 2011 | Language Speech and Hearing Serv- ices in Schools2011，42，3： | 1 |
| 14 | Cardiac-Specific Overexpression of Caveolin-3 Attenuates Cardiac Hypertrophy and Increases Natriuretic Peptide Expression and Signaling显示文摘 | Yousuke T. Horikawa Mathivadhani Panneerselvam Yoshitaka Kawaraguchi Yasuo M. Tsutsumi Sameh S. Ali Ravi C. Balijepalli Fiona Murray Brian P. Head Ingrid R. Niesman Timo Rieg Volker Vallon Paul A. Insel Hemal H. Patel David M. Roth | 2011 | Journal of the American College of Cardiology2011，，22： | 1 |
| 15 | Visualize your forest-Using forest simulation software to communicate forest management concepts to private forestland owners显示文摘 | Roth Paul Finley J C | 2007 | Journal of Forestry2007，105，1： | 1 |
| 16 | Losses of Chromosomes 1p and 3q Are Early Genetic Events in the Development of Sporadic Pheochromocytomas显示文摘 | Hilde Dannenberg Ernst J.M. Speel Jianming Zhao Parvin Saremaslani Erwin van der Harst Jürgen Roth Philipp U. Heitz H. Jaap Bonjer Winand N.M. Dinjens Wolter J. Mooi Paul Komminoth Ronald R. de Krijger | 2000 | The American Journal of Pathology2000，，2： | 1 |
| 17 | Integrating satellite remote sensing techniques for detection and analysis of uncontrolled coal seam fires in North China显示文摘 | Stefan Voigt Anke Tetzlaff Jianzhong Zhang Claudia Künzer Boris Zhukov Günter Strunz Dieter Oertel Achim Roth Paul van Dijk Harald Mehl | 2004 | International Journal of Coal Geology2004，，1： | 1 |
| 18 | Semantic Integration in Text: From Ambiguous Names to Identifiable Entities显示文摘 | Xin Li Paul Morie Dan Roth | 2005 | AIMagazine2005，26，1： | 1 |
| 19 | PTCA失败后的急症冠状动脉搭桥术:20年的经验回顾(英文)显示文摘目的 :评价经皮冠状动脉血管成形术失败后 (fPTCA)的急症冠状动脉搭桥术 (eCABG) 2 0年的经验。方法 从 1977年至 1997年 ,共有 10 1例病人在fPTCA后行eCABG术。全组平均年龄 (5 6± 5 )岁 (32~78岁 ) ,在fPTCA后 (85± 2 5 )h(1~ 16 8h)行eCABG。平均术前左室射血分数 (5 7± 9) % (30 %~ 75 % )。所有病人中 ,单支病变 (SVD)占 5 5 % ,二支病变 (twVD) 39% ,三支病变 (TrVD) 15 % ,前降支 (LAD)受累 74 %。15 %病人在eCABG前作过心肺复苏。结果 fPTCA的eCABG的发生率从 2 9% (1977~ 82 )下降至 6 %(1983~ 87) ,0 0 2 % (1988~ 92 )下降至 0 0 0 4 % (1993~ 97) (P =0 0 0 1)。病人平均年龄从 (5 0± 10 )岁 (1977~82 )上升至 (6 2± 10 )岁 (1993~ 97) (P =0 0 0 0 1)。三支病变的发生率从 4 % (1977~ 82 )上升至 6 8% (1993~ 97)(P =0 0 0 0 1) ,LAD扩张的发生率从 76 % (1977~ 82 )降为 36 % (1993~ 97) (P =0 0 0 9)。eCABG的死亡率5 % ,在各个时间都稳定。左乳内动脉的使用从 8% (1977~ 82 )上升至 5 4 % (1993~ 97) (P =0 0 0 6 )。 (14± 4 )年 (1~ 2 0年 )后 ,实际生存率 (84± 8) % ,(70± 11) %免予心肌梗死 ,(5 8± 17) %免予二次手术。 | Ares K.Menon Martin C.Heidt Peter Roth Joerg BabinEbell Zoltan Szalay Marko I.Turina Paul R.Vogt | 2003 | 中华胸心血管外科杂志2003，19，5： | 1 |
| 20 | K_(2P)18.1 translates T cell receptor signals into thymic regulatory T cell development显示文摘It remains largely unclear how thymocytes translate relative differences in T cell receptor(TCR)signal strength into distinct developmental programs that drive the cell fate decisions towards conventional(Tconv)or regulatory T cells(Treg).Following TCR activation,intracellular calcium(Ca^(2+))is the most important second messenger,for which the potassium channel K_(2P)18.1 is a relevant regulator.Here,we identify K_(2P)18.1 as a central translator of the TCR signal into the thymus-derived Treg(tTreg)selection process.TCR signal was coupled to NF-κB-mediated K_(2P)18.1 upregulation in tTreg progenitors.K_(2P)18.1 provided the driving force for sustained Ca^(2+) influx that facilitated NF-κB-and NFAT-dependent expression of FoxP3,the master transcription factor for Treg development and function.Loss of K_(2P)18.1 ion-current function induced a mild lymphoproliferative phenotype in mice,with reduced Treg numbers that led to aggravated experimental autoimmune encephalomyelitis,while a gain-of-function mutation in K_(2P)18.1 resulted in increased Treg numbers in mice.Our findings in human thymus,recent thymic emigrants and multiple sclerosis patients with a dominant-negative missense K_(2P)18.1 variant that is associated with poor clinical outcomes indicate that K_(2P)18.1 also plays a role in human Treg development.Pharmacological modulation of K_(2P)18.1 specifically modulated Treg numbers in vitro and in vivo.Finally,we identified nitroxoline as a K_(2P)18.1 activator that led to rapid and reversible Treg increase in patients with urinary tract infections.Conclusively,our findings reveal how K_(2P)18.1 translates TCR signals into thymic T cell fate decisions and Treg development,and provide a basis for the therapeutic utilization of Treg in several human disorders. | Tobias Ruck Stefanie Bock Steffen Pfeuffer Christina B.Schroeter Derya Cengiz Paul Marciniak Maren Lindner Alexander Herrmann Marie Liebmann Stjepana Kovac Lukas Gola Leoni Rolfes Marc Pawlitzki Nils Opel Tim Hahn Udo Dannlowski Thomas Pap Felix Luessi Julian A.Schreiber Bernhard Wunsch Tanja Kuhlmann Guiscard Seebohm Bjorn Tackenberg Patricia Seja Frank Doring Erhard Wischmeyer Achmet Imam Chasan Johannes Roth Luisa Klotz Gerd Meyer zu Hörste Heinz Wiendl Tobias Marschall Stefan Floess Jochen Huehn Thomas Budde Tobias Bopp Stefan Bittner Sven G.Meuth | 2022 | Cell Research2022，32，1： | 1 |
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