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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system显示文摘 | G. Rindi G. Kl?ppel A. Couvelard P. Komminoth M. K?rner J. M. Lopes A.-M. McNicol O. Nilsson A. Perren A. Scarpa J.-Y. Scoazec B. Wiedenmann | 2007 | Virchows Archiv2007，，4： | 3 |
| 3 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 3 |
| 4 | Thyroid carcinomas with mixed follicular and C-cell differentiation patterns 显示文摘 | PAPOTH M VOLANTE M KOMMINOTH P | 2000 | Semin Diagn Pathol2000，17，2： | 1 |
| 5 | Antigen retrieval, signal amplification and intensification in immunohistochemistry显示文摘 | Werner M Von Wasielewski R Komminoth P | 1996 | Histochem Cell Biol1996，，105： | 1 |
| 6 | PTEN as a Molecular Marker to Distinguish Metastatic From Primary synchronous Endometrioid carcinomas of the Ovary and uterus显示文摘 | Ricci R Komminoth P Bannwart F | 2003 | Diagn Mol Pathol2003，12，2： | 1 |
| 7 | Rapid detedtion of karyotype changes in interphase bone marrow cells by oligonucleotide primed in situ hybridization (PRINS)显示文摘 | Ludwig Wilkens Paul Komminoth Anette Nasarek | 1997 | Journal of Pathology1997，181，： | 1 |
| 8 | Thyroid car- cinomas with mixed follicular and C-cell differentiation patterns显示文摘 | Papotti M Volante M Komminoth P | 2000 | Semin Diagn Pathol2000，17，2： | 1 |
| 9 | Biopsy diagnosis of Hirschsprung's disease and related disorders显示文摘 | Heitz PU Komminoth P | 1990 | Curr Top Patho1990，81，： | 1 |
| 10 | Biopsy diagnosis of Hirschsprung's disease and related disorders 显示文摘 | Heitz PU Komminoth P | 1990 | Curr Top Patho1990，81，： | 1 |
| 11 | Antigen retrieval, signal amplification and intensification in immunohistochemistry显示文摘 | Martin Werner Reinhard Wasielewski Paul Komminoth | 1996 | Histochemistry and Cell Biology1996，，4： | 1 |
| 12 | Pathology of MEN-1:Morphology, clinopathologic correlations and tumor development显示文摘 | Heitz P Kloppel G | 1998 | IntlJ Med1998，243，： | 1 |
| 13 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 1 |
| 14 | TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system显示文摘 | G. Rindi G. Kl?ppel A. Couvelard P. Komminoth M. K?rner J. M. Lopes A.-M. McNicol O. Nilsson A. Perren A. Scarpa J.-Y. Scoazec B. Wiedenmann | 2007 | Virchows Archiv2007，，4： | 1 |
| 15 | Target and signal amplification:approaches to increase the sensitivity of in situ hybridization显示文摘 | Komminoth P Werner M | 1997 | Histochem Cell Biol1997，108，： | 1 |
| 16 | Amplification methods to increase the sensitivity of in situ hybridization: play card(s) 显示文摘 | Speel E J Hopman A H Komminoth P | 1999 | J Histochem Cytochem1999，47，： | 1 |
| 17 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 1 |
| 18 | Microdissection of tissue sections:application to the molecular genetic characterisation of premalignant lesions显示文摘 | Walch A Komminoth P Hutzler P | 2000 | Pathobiology2000，68，1： | 1 |
| 19 | Amplification methods to increase the sensitivity of in situ hybridization:play card显示文摘 | Speel E J Hopman A H Komminoth P | 1999 | J Histochem Cytochem1999，47，： | 1 |
| 20 | Comparison of 35S-and digoxingenin labelled RNA and oligonucleotide probes for in situ hybridization显示文摘 | Komminoth P Merk FB Leav | 1992 | Histoehemistry1992，98，： | 1 |
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