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| 1 | Eucommia ulmoides Oliv.antagonizes H_2O_2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3,6,7,and 9显示文摘Eucommia ulmoides Oliv.(EuO),also known as Duzhong,native to China,has been reported to have antioxidative function,but its cellular mechanism is not fully examined yet.We investigated inhibitory effects of EuO leaf ethanol extracts on H2O2-induced apoptosis in rat osteoblastic MC3T3-E1 cells and underlying mechanisms.Locally-grown Duzhong leaves were extracted with ethanol.MC3T3-E1 cells were treated with EuO (6.25,12.5,25,50,and 100 μg/ml) for 24 h,and then H2O2 (800 μmol/L) for an additional 24 h.Cell survival rate,percentage of apoptosis,and expressions of caspases 3,6,7,and 9 were examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay,microscopic analysis,Western blotting,and reverse transcription polymerase chain reaction (RT-PCR).The final EuO leaf ethanol extract powder was detected to contain caffeotannic acid at 58 mg/g and geniposide at 3.45 mg/g by high performance liquid chromatography (HPLC).EuO remarkably restrained cell oxidative damage and increased cell survival rate in a dose-dependent manner: 0 μg/ml,0.21;6.25 μg/ml,0.28;12.5 μg/ml,0.31;25 μg/ml,0.48;50 μg/ml,0.54;and 100 μg/ml,0.66 (P<0.05),with the half-effective concentration being around 25 μg/ml.MTT results were confirmed by microscopic analysis.Western blotting and RT-PCR analyses showed that the expressions of caspases 3,6,7,and 9 were significantly decreased in the EuO-treated cells compared with the control (EuOand H2O2-free) (P<0.05),with the half-effective concentration of EuO ranging from 12.5 to 25 μg/ml.We conclude that the ethanol-extracted EuO leaf extracts promoted the growth of MC3T3-E1 cells,and suppressed the H2O2-induced apoptosis in a rat MC3T3-E1 osteogenic cell model,likely due to the inhibition of caspases’ activities.The results indicate that EuO is a potent antioxidant,which may contribute to its many cellular protective functions,including the promotion of bone growth. | Jun LIN Yi-jing FAN Christian MEHL Jia-jun ZHU Hong CHEN Ling-yan JIN Jing-hong XU Hui-ming WANG | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，1： | 18 |
| 2 | 通过手机进行健康干预报告的指南:移动医疗证据报告和评估检查表显示文摘为提升移动医疗(mHealfh)干预报告的完整性,WH0mHealth技术证据评审小组开发了mHealth证据报告和评估(mERA)检查表。该mERA开发过程包括成立专家组,提出合适的路径,召集全球专家评审小组以研发检查表,并进行小规模测试。制定这些标准的指导原则是以最少的信息集合来定义mHealth干预是什么(内容),在哪儿应用(环境),如何应用(技术特性),以便支持干预的可重复性。该文档由16个选项表构成,附带各项内容的详细解释和说明,以及说明性的报告范例。通过广泛征求意见,我们希望该指南的应用可规范mHealth证据报告的质量,间接提升mHealth证据的质量。 | Smisha Agarwal Amnesty E LeFevre Jaime Lee Kelly L'Engle Garrett Mehl Chaitali Sinha Alain Labriquel 沈锡宾(译) 涂宏钢(校) | 2016 | 英国医学杂志中文版2016，19，11： | 6 |
| 3 | Liver transplantation and the management of progressive familial intrahepatic cholestasis in children显示文摘Progressive familial intrahepatic cholestasis(PFIC) is a constellation of inherited disorders that result in the impairment of bile flow through the liver that predominantly affects children. The accumulation of bile results in progressive liver damage, and if left untreated leads to end stage liver disease and death. Patients often present with worsening jaundice and pruritis within the first few years of life. Many of these patients will progress to end stage liver disease and require liver transplantation. The role and timing of liver transplantation still remains debated especially in the management of PFIC1. In those patients who are appropriately selected, liver transplantation offers an excellent survival benefit. Appropriate timing and selection of patients for liver transplantation will be discussed, and the short and long term management of patients post liver transplantation will also be described. | Ashley Mehl Humberto Bohorquez Maria-Stella Serrano Gretchen Galliano Trevor W Reichman | 2016 | World Journal of Transplantation2016，6，2： | 6 |
| 4 | Applications of the Hilbert-Huang Transform for Microtremor Data Analysis Enhancement显示文摘In this paper we discuss the use of the Hilbert-Huang transform(HHT) to enhance the time-frequency analysis of microtremor measurements. HHT is a powerful algorithm that combines the process of empirical mode decomposition(EMD) and the Hilbert transform to compose the HilbertHuang spectrum that contains the time-frequency-energy information of the recorded signals. HHT is an adaptive algorithm and does not require the signals to be linear or stationary. HHT is advantageous for analyzing microtremor data, since observed microtremors are commonly contaminated by nonstationary transient noises close to the recording instruments. This is especially true when microtremors are measured in an urban environment. In our data processing HHT was used to(1) eliminate the unwanted short-duration transient constituents from microtremor data and use only the coherent portion of the data to carry out the widely used horizontal to vertical spectral ratio(H/V) method;(2) identify and eliminate the continuous industrial noise in certain frequency band; and(3) enhance the H/V analysis by using the Hilbert-Huang spectrum(HHS). The efficacy of this proposed approach is demonstrated by the examples of applying it to microtremor data acquired in the metropolitan Beijing area. | Lanbo Liu Robert Mehl Weijun Wang Qi-Fu Chen | 2015 | Journal of Earth Science2015，26，6： | 4 |
| 5 | Review on thermal energy storage with phase change: materials, heat transfer analysis and applications显示文摘 | Belén Zalba José M a Mar??n Luisa F. Cabeza Harald Mehling | 2002 | Applied Thermal Engineering2002，，3： | 3 |
| 6 | Tapping the tree-ring archive for studying effects of resin extraction on the growth and climate sensitivity of Scots pine显示文摘Background: In the German Democratic Republic(GDR), resin tapping in Scots pine(Pinus sylvestris L.) forests was a major economic activity, and resin-tapped stands are frequently found up until this day. In this study, we investigate how the mechanical damage caused by resin tapping affects the growth and climate sensitivity of Scots pine using a dendroecological approach.Methods: Tree-ring samples were collected from resin-tapped and non-tapped trees in two forest areas in northeastern Germany, and tree-growth patterns were analyzed. For elucidating effects of resin tapping on the climate sensitivity of pine growth, climate-growth relationships and pointer years were studied.Results: We observed that resin tapping positively affects tree growth at breast height, likely as wood formation is concentrated on the living part of the bole(i.e. after tapping there is no growth taking place on the tapping face due to the mechanical damage done to the cambium). We observed no differences in the climate sensitivity of tapped and non-tapped trees, nor in the occurrence of extreme growth responses.Conclusion: Our results highlight that resin extraction is, apart from inflicting mechanical damage, not altering the sensitivity of Scots pine growth to climatic conditions. | Ernst van der Maaten Annemarie Mehl Martin Wilmking Marieke van der Maaten-Theunissen | 2017 | Forest Ecosystems2017，4，3： | 2 |
| 7 | Transformation from austenite in alloy steels显示文摘 | R. W. K. Honeycombe R. F. Mehl | 1976 | Metallurgical Transactions A1976，，6： | 2 |
| 8 | Advanced Coronary and Carotid Arteriopathy in Young Adults With Childhood-Onset Chronic Renal Failure显示文摘 | Jun Oh Rainer Wunsch Martin Turzer Malte Bahner Paolo Raggi Uwe Querfeld Otto Mehls Franz Schaefer | 2002 | Circulation: Journal of the American Heart Association2002，，1： | 2 |
| 9 | The Formation of Proeutectoid Ferrite in Carbon Steels 显示文摘 | Dube C A Aaronson H I Mehl R F | 1958 | Rev Met1958，55，3： | 1 |
| 10 | Development and Evaluation of a Local Grid Refinement Method for Block-Centered Nite-Difference Ground- water Models Using Shared Nodes 显示文摘 | Mehl S Hill M C | 2002 | Advances in Water Resources2002，25，： | 1 |
| 11 | Peritoneal loss of growth hormone in children on automated peritoneal dialysis显示文摘 | Haffner D Hofstetter C Mehls O | 1999 | Perit Dial Int1999，19，4： | 1 |
| 12 | Reaction kinetics in processes of nucleation and growth显示文摘 | Johnson W A Mehl R F | 1939 | Trans AIME1939，135，： | 1 |
| 13 | Hyperspectral reflectance and fluorescence imaging system for food quality and safety显示文摘 | Kim M S Chen Y R P Mehl M | 2001 | Transactions of the ASAE2001，44，3： | 1 |
| 14 | Heat transfer enhance- merit of fatty acids when used as PCMs in thermal energy storage 显示文摘 | Mazman M Cabeza L F Mehling H | 2008 | Int J Energy Res2008，32，2： | 1 |
| 15 | Myocardial viability assessment in patients with highly impaired left ventricular function : comparison of delayed enhancement, dobutamine stress MRI, end-diastolic wall thick- ness, and T1201-SPECT with functional recovery after revascularization 显示文摘 | Gutberlet M Frohlich M Mehl S | 2005 | Eur Radiol2005，15，： | 1 |
| 16 | The Colorado newborn hearing screening project, 1992-1999: on the threshold of effective population-based universal newborn hearing screening显示文摘 | Mehl A L Thomson V | 2002 | Pediatrics2002，109，1： | 1 |
| 17 | Nucleotide sequence of Streptomycete 16S rDNA: towards a specific identification system for streptomycetes using PCR显示文摘 | MEHLING A WEHMEIER U PIEPERSBERG W | 1995 | Micro1995，141，： | 1 |
| 18 | Detection of defects on selected apple cultivars using hyperspectral and multispectral image analysis显示文摘 | Mehl P M Chao K Kim M | 2002 | Applied Engineering in Agriculture2002，18，2： | 1 |
| 19 | Hyperspectral reflectance and fluorescence imaging system for food quality and safety 显示文摘 | Kim M S Chen Y R Mehl P M | 2001 | American Society of Agricultural Engineers2001，44，： | 1 |
| 20 | Marginal quality and mic- roleakage of adhesive classV restorations 显示文摘 | Mnahart J ChenHY Mehl A | 2001 | J Dent2001，29，2： | 1 |
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