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| 1 | Sex recognition in brown skuas: do acoustic signals matter?显示文摘 | Tim Janicke Markus S. Ritz Steffen Hahn Hans-Ulrich Peter | 2007 | Journal of Ornithology2007，，： | 1 |
| 2 | Randomness of resting-state brain oscillations encodes Gray’s personality trait显示文摘 | Tim Hahn Thomas Dresler Ann-Christine Ehlis Martin Pyka Alica C. Dieler Claudia Saathoff Peter M. Jakob Klaus-Peter Lesch Andreas J. Fallgatter | 2011 | Neuroimage2011，，2： | 1 |
| 3 | K_(2P)18.1 translates T cell receptor signals into thymic regulatory T cell development显示文摘It remains largely unclear how thymocytes translate relative differences in T cell receptor(TCR)signal strength into distinct developmental programs that drive the cell fate decisions towards conventional(Tconv)or regulatory T cells(Treg).Following TCR activation,intracellular calcium(Ca^(2+))is the most important second messenger,for which the potassium channel K_(2P)18.1 is a relevant regulator.Here,we identify K_(2P)18.1 as a central translator of the TCR signal into the thymus-derived Treg(tTreg)selection process.TCR signal was coupled to NF-κB-mediated K_(2P)18.1 upregulation in tTreg progenitors.K_(2P)18.1 provided the driving force for sustained Ca^(2+) influx that facilitated NF-κB-and NFAT-dependent expression of FoxP3,the master transcription factor for Treg development and function.Loss of K_(2P)18.1 ion-current function induced a mild lymphoproliferative phenotype in mice,with reduced Treg numbers that led to aggravated experimental autoimmune encephalomyelitis,while a gain-of-function mutation in K_(2P)18.1 resulted in increased Treg numbers in mice.Our findings in human thymus,recent thymic emigrants and multiple sclerosis patients with a dominant-negative missense K_(2P)18.1 variant that is associated with poor clinical outcomes indicate that K_(2P)18.1 also plays a role in human Treg development.Pharmacological modulation of K_(2P)18.1 specifically modulated Treg numbers in vitro and in vivo.Finally,we identified nitroxoline as a K_(2P)18.1 activator that led to rapid and reversible Treg increase in patients with urinary tract infections.Conclusively,our findings reveal how K_(2P)18.1 translates TCR signals into thymic T cell fate decisions and Treg development,and provide a basis for the therapeutic utilization of Treg in several human disorders. | Tobias Ruck Stefanie Bock Steffen Pfeuffer Christina B.Schroeter Derya Cengiz Paul Marciniak Maren Lindner Alexander Herrmann Marie Liebmann Stjepana Kovac Lukas Gola Leoni Rolfes Marc Pawlitzki Nils Opel Tim Hahn Udo Dannlowski Thomas Pap Felix Luessi Julian A.Schreiber Bernhard Wunsch Tanja Kuhlmann Guiscard Seebohm Bjorn Tackenberg Patricia Seja Frank Doring Erhard Wischmeyer Achmet Imam Chasan Johannes Roth Luisa Klotz Gerd Meyer zu Hörste Heinz Wiendl Tobias Marschall Stefan Floess Jochen Huehn Thomas Budde Tobias Bopp Stefan Bittner Sven G.Meuth | 2022 | Cell Research2022，32，1： | 1 |
| 4 | Computational Reproducibility Within Prognostics and Health Management显示文摘Scientific research frequently involves the use of computational tools and methods.Providing thorough documentation,open-source code,and data–the creation of reproducible computational research(RCR)–helps others understand a researcher’s work.In this study,we investigate the state of reproducible computational research,broadly,and from within the field of prognostics and health management(PHM).In a text mining survey of more than 300 articles,we show that fewer than 1%of PHM researchers make their code and data available to others.To promote the RCR further,our work also highlights several personal benefits for those engaged in the practice.Finally,we introduce an open-source software tool,called PyPHM,to assist PHM researchers in accessing and preprocessing common industrial datasets. | Tim von Hahn Chris K.Mechefske | 2023 | Journal of Dynamics, Monitoring and Diagnostics2023，2，1： | 0 |
| 5 | 双极经尿道手术中葡萄糖作为冲洗液的吸收标记物显示文摘背景过去,血清钠离子浓度的降低是诊断经尿道前列腺切除术(transurethralresectionoftheprostate,TURP)冲洗液(不含电解质)吸收的诊断标准。在使用双极的TURP中,冲洗液包含了电解质,所以不能依赖血钠浓度来判断冲洗液是否吸收。在本研究中,我们观察了在使用双极的TURP手术中葡萄糖能否成为冲洗液吸收的诊断标准。方法选取250例使用单极行TURP手术的患者,术中膀胱冲洗液为1.5%的甘氨酸或5%的葡萄糖溶液,检测血糖和血钠浓度。选取10名志愿者,持续输注含1%葡萄糖的醋酸林格液(20ml/kg)30分钟,进行葡萄糖代谢动力学分析。计算机通过采集的数据模拟出不同的吸收模式,以列线图总结出葡萄糖浓度和输注液体容量的关系。结果在TURP中5%葡萄糖灌洗液冲洗后,血钠降低,血糖升高,呈明显的负线性关系(r2=0.80)。在冲洗过程中血糖逐渐升高,从4.6(标准差0.4)mmol/L升高至8.3(0.9)mmol/L。无论何种吸收模式均显示体内摄取1L含1%葡萄糖的冲洗液血糖相应的升高3.7(SD1.6)mmol/L,摄取2L冲洗液血糖升高6.9(1.7)mmol/L。结论在使用单极的TURP中,通过检测血钠浓度来观察冲洗液吸收情况,与之相比较,在使用双极的TURP中,含有电解质的冲洗液中加入1%的葡萄糖,可以成为检测冲洗液吸收情况的标记物。 | David Piros, MD Tim Fagerstro, MD Justin W. Collins, MD Robert G. Hahn, MD, PhD 邓希锦(译) 李文志(校) | 2013 | 麻醉与镇痛2013，，5： | 0 |
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