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| 1 | Nucleic acid-based diagnostics for infectious diseases in public health affairs显示文摘Infectious diseases,mostly caused by bacteria and viruses but also a result of fungal and parasitic infection,have been one of the most important public health concerns throughout human history.The first step in combating these pathogens is to get a timely and accurate diagnosis at an affordable cost.Many kinds of diagnostics have been developed,such as pathogen culture,biochemical tests and serological tests,to help detect and fight against the causative agents of diseases.However,these diagnostic tests are generally unsatisfactory because they are not particularly sensitive and specific and are unable to deliver speedy results.Nucleic acid-based diagnostics,detecting pathogens through the identification of their genomic sequences,have shown promise to overcome the above limitations and become more widely adopted in clinical tests.Here we review some of the most popular nucleic acid-based diagnostics and focus on their adaptability and applicability to routine clinical usage.We also compare and contrast the characteristics of different types of nucleic acid-based diagnostics. | Albert Cheung-Hoi Yu Greg Vatcher Xin Yue Yan Dong Mao Hua Li Patrick H.K.Tam Parker Y.L.Tsang April K.Y.Wong Michael H.K.Hui Bin Yang Hao Tang Lok-Ting Lau | 2012 | Frontiers of Medicine2012，6，2： | 8 |
| 2 | Spontaneous intramural duodenal hematoma in type 2B von Willebrand disease显示文摘Intramural duodenal hematoma is a rare cause of a proximal gastrointestinal tract obstruction.Presentation of intramural duodenal hematoma most often occurs following blunt abdominal trauma in children,but spontaneous non-traumatic cases have been linked to anticoagulant therapy,pancreatitis,malignancy,vasculitis and endoscopy.We report an unusual case of spontaneous intramural duodenal hematoma presenting as an intestinal obstruction associated with acute pancreatitis in a patient with established von Willebrand disease,type 2B.The patient presented with abrupt onset of abdominal pain,nausea,and vomiting.Computed tomography imaging identified an intramural duodenal mass consistent with blood measuring 4.7 cm×8.7 cm in the second portion of the duodenum abutting on the head of the pancreas.Serum lipase was 3828 units/L.Patient was managed conservatively with bowel rest,continuous nasogastric decompression,total parenteral nutrition,recombinant factorⅧ(humateP)and transfusion.Symptoms resolved over the course of the hospitalization.This case highlights an important complication of an inherited coagulopathy. | Derrick D Eichele Meredith Ross Patrick Tang Grant F Hutchins Mark Mailliard | 2013 | World Journal of Gastroenterology2013，19，41： | 3 |
| 3 | Brain MRI of hippocampal volumetry in patients with refractory temporal lobe epilepsy显示文摘Objective To detect for hippocampal sclerosis presurgically in a group of patients with refractory temporal lobe epilepsy Methods Eighty four consecutive patients with refractory temporal lobe epilepsy were subjected to brain MRI of hippocampal volumetry A ratio of smaller to larger hippocampal volume was determined and unilateral hippocampal atrophy (HA) was diagnosed if the ratio is less than 0 91 Results Unilateral HA was diagnosed in 42 patients (50%) and bilateral HA in 1 patient Other MRI abnormalities were detected in 18 patients with or without coexisting HA Conclusions Hippocampal sclerosis can be detected presurgically in many patients by brain MRI Additional abnormalities not detected by brain CT can also be | Ka Kui Philip Ng, Kwok Wing Tang, Yuk Ling James Cheung and Patrick Chung Ki Li | 2000 | Chinese Medical Journal2000，，3： | 3 |
| 4 | Yielding to (cyber)-temptation: Exploring the buffering role of self-control in the relationship between organizational justice and cyberloafing behavior in the workplace显示文摘 | Simon Lloyd D. Restubog Patrick Raymund James M. Garcia Lemuel S. Toledano Rajiv K. Amarnani Laramie R. Tolentino Robert L. Tang | 2011 | Journal of Research in Personality2011，，2： | 2 |
| 5 | Chromite-induced magnesium isotope fractionation during mafic magma differentiation显示文摘To better understand the mechanism of Mg isotopic variation in magma systems, here we report high precision Mg isotopic data of 17 bulk rock samples including dunite, clinopyroxenite, hornblendite and gabbro and 10 pairs of dunite-hosted olivine and chromite separates from the well-characterized Alaskan-type Xiadong intrusion in NW China, which formed by continuous and high degree of lithological differentiation from mafic magmas. Chromite separates have highly variable δ^(26)Mg values from -0.10‰ to 0.40‰, and are consistently heavier than coexisting olivine separates(-0.39‰ to -0.15 T‰). Both mineral δ^(26)Mg values and the degrees of inter-mineral fractionation are well correlated with geochemical indicators of magma differentiation, indicating that these inter-sample and inter-mineral Mg isotope fractionations are caused by magma evolution. The δ^(26)Mg values range from -0.20‰ to -0.02‰ in the dunite,-043‰ in the clinopyroxenite,-043‰ to -0.28‰ in the hornblendite, 0.18 T‰ in the chromite-bearing hornblendite, and -0.56 T‰ to -0.16‰ in the gabbro. The Mg isotopic variations in different types of rocks are closely related to fractional crystallization and accumulation of different proportions of oxides vs. silicates. Chromite crystallization and accumulation is the most important factor in controlling Mg isotope fractionation during the formation of the Xiadong intrusion. Compared to basaltic and granitic magmas, differentiation of the Alaskan-type intrusions occurs at a relatively high oxygen fugacity, which favors chromite crystallization and consequently significant Mg isotope fractionations at both mineral and whole-rock scales. Therefore, Mg isotope systematics can be used to trace the degree of magma differentiation and related-mineralization. | Ben-Xun Su Yan Hu Fang-Zhen Teng Ke-Zhang Qin Yang Bai Patrick Asamoah Sakyi Dong-Mei Tang | 2017 | Science Bulletin2017，62，22： | 2 |
| 6 | Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups显示文摘 | Dong-Hai Xiong Xiao-Gang Liu Yan-Fang Guo Li-Jun Tan Liang Wang Bao-Yong Sha Zi-Hui Tang Feng Pan Tie-Lin Yang Xiang-Ding Chen Shu-Feng Lei Laura M. Yerges Xue-Zen Zhu Victor W. Wheeler Alan L. Patrick ClareAnn H. Bunker Yan Guo Han Yan Yu-Fang Pei Yin-Pi | 2009 | The American Journal of Human Genetics2009，，3： | 1 |
| 7 | Subduction-induced mantle heterogeneity beneath Eastern Tianshan and Beishan: Insights from Nd–Sr–Hf–O isotopic mapping of Late Paleozoic mafic–ultramafic complexes显示文摘 | Ben-Xun Su Ke-Zhang Qin He Sun Dong-Mei Tang Patrick Asamoah Sakyi Zhu-Yin Chu Ping-Ping Liu Qing-Hua Xiao | 2011 | LITHOS2011，，： | 1 |
| 8 | Platelet-Derived Growth Factor-AB Promotes the Generation of Adult Bone Marrow–Derived Cardiac Myocytes显示文摘 | Munira Xaymardan Lilong Tang Leze Zagreda Benedetta Pallante Jingang Zheng Joseph L. Chazen Andrew Chin Inga Duignan Patrick Nahirney Shahin Rafii Takashi Mikawa Jay M. Edelberg | 2004 | Circulation Research: Journal of The American Heart Association2004，，5： | 1 |
| 9 | U–Pb ages and Hf–O isotopes of zircons from Late Paleozoic mafic–ultramafic units in the southern Central Asian Orogenic Belt: Tectonic implications and evidence for an Early-Permian mantle plume显示文摘 | Ben-Xun Su Ke-Zhang Qin Patrick Asamoah Sakyi Xian-Hua Li Yue-Heng Yang He Sun Dong-Mei Tang Ping-Ping Liu Qing-Hua Xiao Sanjeewa P.K. Malaviarachchi | 2010 | Gondwana Research2010，，2： | 1 |
| 10 | Neurocognitive and psychological profiles of adult patients with epilepsy in Hong Kong显示文摘 | Venus Tang Patrick Kwan W.S. Poon | 2013 | Epilepsy & Behavior2013，，2： | 1 |
| 11 | SIMS zircon U-Pb geochronology and Sr-Nd isotopes of Ni-Cu-bearing mafic-ultramafic intrusions in Eastern Tianshan and Beishan in correlation with flood basalts in Tarim basin (NW China):constraints on a ca,280 Ma mande plume显示文摘 | Qin KZ Su BX Patrick Asamoah Sakyi Tang DM Li XH Xiao QH Liu PP | | 0，，： | 1 |
| 12 | Oxygen Transmission of Multilayer EVOH Films after Microwave Sterilization显示文摘 | MOKWENA K Khanah TANG Juming DUNNE C Patrick | 2009 | Journal of Food Engineering2009，29，： | 1 |
| 13 | Pheophorbide a, a major antitumor component purified from scutellaria Barbata, induces apoptosis in human hepatocellular carcinoma cells显示文摘 | Judy Yoet-Wa Chan Patrick Ming-Kuen Tang | 2006 | Plant Med2006，72，1： | 1 |
| 14 | Secure Overlay Cloud Storage with File Assured Deletion 显示文摘 | Yang Tang Patrick P C Lee John C S Lui | 2010 | Computer Science and Engi- neering Monday2010，，11： | 1 |
| 15 | Comparison of workability and mechanical properties of self- compacting lightweight concrete and normal self- compacting concrete 显示文摘 | Lo T Y Cui H Z Tang Patrick W C | 2007 | Materials Research Innovation2007，11，1： | 1 |
| 16 | Fermented beverages of pre-and proto-historic China显示文摘 | Patrick E Juzhong Zhang Jigen Tang | 2004 | PNAS2004，101，17： | 1 |
| 17 | Secure overlaycloud storage with access control and assured deletion显示文摘 | Tang Yang Lee Patrick P C Lui John C S | 2012 | IEEETransactions on Dependable and Secure Computing2012，9，6： | 1 |
| 18 | Stability and Change in Levels of Depression and Personality: A Follow-up Study of Postpartum Depressed Mothers That Were Hospitalized in a Mother-Infant Unit显示文摘 | Nicole Vliegen Patrick Luyten Avi Besser Sara Casalin Stefan Kempke Eileen Tang | 2010 | The Journal of Nervous and Mental Disease2010，，1： | 1 |
| 19 | Novel Role of gp91phox-Containing NAD(P)H Oxidase in Vascular Endothelial Growth Factor–Induced Signaling and Angiogenesis显示文摘 | Masuko Ushio-Fukai Yan Tang Tohru Fukai Sergey I. Dikalov Yuxian Ma Mitsuaki Fujimoto Mark T. Quinn Patrick J. Pagano Chad Johnson R. Wayne Alexander | 2002 | Circulation Research: Journal of the American Heart Association2002，，12： | 1 |
| 20 | Sins of the parents: Self-control as a buffer between supervisors’ previous experience of family undermining and subordinates’ perceptions of abusive supervision显示文摘 | Christian Kiewitz Simon Lloyd D. Restubog Thomas J. Zagenczyk Kristin D. Scott Patrick Raymund James M. Garcia Robert L. Tang | 2012 | The Leadership Quarterly2012，，5： | 1 |
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