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| 1 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 2 | Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: final results of open-label prospective trial显示文摘 | Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Juan C. Ayala Jorge Saba Alberto Perez-Castilla Manoel Galvao Neto Michael D. Crowell | 2013 | Surgical Endoscopy2013，，4： | 2 |
| 3 | Financial systems in financial crisis — An analysis of banking systems in the EU显示文摘 | Daniel Detzer Jerome Creel Fabien Labondance Sandrine Levasseur Mimoza Shabani Jan Toporowski Judith Tyson Costanza Consolandi Giampaolo Gabbi Massimo Matthias Pietro Vozzella Carlos A. Carrasco Patricia Peinado Carlos A. Rodriguez Gonzalez | 2014 | Intereconomics2014，，2： | 1 |
| 4 | Autoimmune Hepatitis and Primary Sclerosing Cholangitis in Children and Adolescents.显示文摘 | Claudia Patricia Rojas Rajasekhar Bodicharla German Campuzano-Zuluaga Lina Hernandez Maria Matilde Rodriguez | 2014 | Fetal & Pediatric Pathology2014，，4： | 1 |
| 5 | hTERT methylation and expression in gastric cancer显示文摘 | Carolina Oliveira Gigek Mariana Ferreira Leal Patricia Natalia Oliveira Silva Luara Carolina Frias Lisboa Eleonidas Moura Lima Danielle Queiroz Calcagno Paulo Pimentel Assump??o Rommel Rodriguez Burbano Marilia de Arruda Cardoso Smith | 2009 | Biomarkers2009，，8： | 1 |
| 6 | Two -year results of Lower Esophageal Sphincter Stimulation for the Treatment of Gastroesophageal Reflux Disease显示文摘 | Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Juan C. Ayala Daniel Oxenberg Alberto Perez-Castilla Manoel G. Netto Edy Soffer W. John Boscardin Michael D. Crowell | 2014 | Surgery2014，，： | 1 |
| 7 | A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine显示文摘 | Ian E. Krop Patricia LoRusso Kathy D. Miller Shanu Modi Denise Yardley Gladys Rodriguez Ellie Guardino Michael Lu Maoxia Zheng Sandhya Girish Lukas Amler Eric P. Winer Hope S. Rugo | 2012 | Journal of Clinical Oncology2012，，26： | 1 |
| 8 | One-year along-beach variation in the maximum depth of erosion resulting from irregular shoreline morphology显示文摘 | Antonio B. Rodriguez Patricia L. Rodriguez Stephen R. Fegley | 2011 | Marine Geology2011，，： | 1 |
| 9 | Chinese Dream:Harmony for the World显示文摘The Chinese Dream in Full SwingSpeech Extracts from the International Dialogue on the Chinese Dream ForumTHE Chinese Dream takes into consideration the ancient wisdom that it is more important to attain the domestic political capability needed to fulfill China’s aspirations towards a harmonious and stable society and to exert a positive influence on the world than it is to strive for economic or military might.The Chinese Dream is based on the concept of seeking individual and collective happiness. | PATRICIA RODRIGUEZ HOLKEMEYER | 2014 | China Today2014，63，9： | 0 |
| 10 | Single-fraction stereotactic ablative body radiation therapy for primary and metastasic lung tumor:A new paradigm?显示文摘Stereotactic ablative body radiotherapy(SABR)is an effective technique comparable to surgery in terms of local control and efficacy in early stages of non-small cell lung cancer(NSCLC)and pulmonary metastasis.Several fractionation schemes have proven to be safe and effective,including the single fraction(SF)scheme.SF is an option costeffectiveness,more convenience and comfortable for the patient and flexible in terms of its management combined with systemic treatments.The outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic has driven this not new but underutilized paradigm,recommending this option to minimize patients’visits to hospital.SF SABR already has a long experience,strong evidence and sufficient maturity to reliably evaluate outcomes in peripheral primary NSCLC and there are promising outcomes in pulmonary metastases,making it a valid treatment option;although its use in central locations,synchronous and recurrencies tumors requires more prospective safety and efficacy studies.The SABR radiobiology study,together with the combination with systemic therapies,(targeted therapies and immunotherapy)is a direction of research in both advanced disease and early stages whose future includes SF. | Castalia Fernandez Arturo Navarro-Martin Andrea Bobo Joaquin Cabrera-Rodriguez Patricia Calvo Rodolfo Chicas-Sett Javier Luna Nuria Rodriguez de Dios Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，2： | 0 |
| 11 | Effect of Ambient Temperature and Humidity Conditions on the Efficacy of Organic Treatments against Varroa destructor in Different Climatic Zones of Chile显示文摘 | Aldea Patricia Rodriguez Rafael Olivares Alejandra Farffin Macarena Riveros Daniel Nfifiez Fanny Trivelli Luz | 2013 | Journal of Agricultural Science and Technology(A)2013，3，6： | 0 |
| 12 | Post-Mortem Study of Refractory Concretes Exposed to Corrosive Effect of Synthetic Slag of Petroleum Coke显示文摘 | Rodrigo Puente Ornelas Ana Maria Guzman Hernandez Tushar Kanty Das Roy Guadalupe Alan Castillo Rodriguez Carlos Javier Lizcano Zulaica Patricia del Carmen Zambrano Robledo | 2010 | 材料科学与工程(中英文版)2010，4，10： | 0 |
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