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| 1 | Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice显示文摘Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study, we discovered bivalent hormetic functions of PXR/CAR modulating the richness of the gut microbiome using genetically engineered mice. The absence of PXR or CAR increased microbial richness, and absence of both receptors synergistically increased microbial richness. PXR and CAR deficiency increased the pro-inflammatory bacteria Helicobacteraceae and Helicobacter. Deficiency in both PXR and CAR increased the relative abundance of Lactobacillus, which has bile salt hydrolase activity, corresponding to decreased primary taurine-conjugated bile acids(BAs) in feces, which may lead to higher internal burden of taurine and unconjugated BAs, both of which are linked to inflammation, oxidative stress, and cytotoxicity. The basal effect of PXR/CAR on the gut microbiome was distinct from pharmacological and toxicological activation of these receptors. Common PXR/CAR-targeted bacteria were identified, the majority of which were suppressed by these receptors. h PXR-TG mice had a distinct microbial profile as compared to wild-type mice. This study is the first to unveil the basal functions of PXR and CAR on the gut microbiome. | Mallory Little Moumita Dutta Hao Li Adam Matson Xiaojian Shi Gabby Mascarinas Bruk Molla Kris Weigel Haiwei Gu Sridhar Mani Julia Yue Cui | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 2 | Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish 显示文摘 | Meijer A H Gabby Krens S Medina Rodriguez I A | 2004 | Molecular Immunology2004，40，11： | 1 |
| 3 | Social capital and op- portunity in corporate R:D the contingent effect of con- tact density on mobility expectations显示文摘 | GABBY S M ZUCKERMAiN E W | 1998 | Social Science Re- search1998，27，2： | 1 |
| 4 | Contrast-enhanced ultrasound evaluation of splenic em- bolization in patients with definite left-sided infective en- docarditis 显示文摘 | MENOZZI G MACCABRUNI V GABBI E | 2013 | Ultrasound Med Biol2013，39，11： | 1 |
| 5 | Financial systems in financial crisis — An analysis of banking systems in the EU显示文摘 | Daniel Detzer Jerome Creel Fabien Labondance Sandrine Levasseur Mimoza Shabani Jan Toporowski Judith Tyson Costanza Consolandi Giampaolo Gabbi Massimo Matthias Pietro Vozzella Carlos A. Carrasco Patricia Peinado Carlos A. Rodriguez Gonzalez | 2014 | Intereconomics2014，，2： | 1 |
| 6 | Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish 显示文摘 | Meijer AH Gabby Krens SF | 2004 | Mol Immunol2004，40，11： | 1 |
| 7 | Which Fac- tors Affect Corporate Bond Pricing? Evidence from Eu- robonds Primary Market Spreads显示文摘 | Giampaolo Gabbi Andrea Sironti | 2005 | The European Journal of Finance2005，11，： | 1 |
| 8 | Expression analysis of the toll-like receptor and tir domain adaptor families of zebrafish显示文摘 | Meijer AH Gabby KS Medina RI and 4 others | | 0，，11： | 1 |
| 9 | Nonalcoholic fatty liverdisease induced by leuprorelin acetate显示文摘 | Gabbi C Carubbi F Losi L | 2008 | J Chin Gastroenterol2008，42，1： | 1 |
| 10 | Neurological complications of herpes zoster显示文摘 | Guidetti D Gabbi E Motti L | 1990 | Ital J Neurol Sci1990，11，6： | 1 |
| 11 | Reactive oxygen species,cell signaling,and cell injnry显示文摘 | Hensien YK Kobinson KA Gabbi TA | 2002 | Free Radie Biol Med2002，28，5： | 1 |
| 12 | Review article: hyperlipidaemia and cardiovascular risk 显示文摘 | BERTOLOTTI M MAURANTONIO M GABBI C | 2005 | Aliment Pharmacol Ther2005，22，2： | 1 |
| 13 | Ice volume distribution and implications on runoff projections in a glacierised catchment 显示文摘 | Gabbi J Farinotti D Bander A | 2012 | Hydrology and Earth System Sciences2012，16，12： | 1 |
| 14 | Thermal behaviour of hydroxyapatiteintendedformedicalapplications显示文摘 | Locardi B Pazzaglia U E Gabbi C | 1993 | Biomaterials1993，14，6： | 1 |
| 15 | A comparison of em- pirical and physically based glacier surface melt models for long- term simulations of glacier response显示文摘 | Gabbi J Carenzo M Pellicciotti F | 2014 | Journal of Glaciology2014，60，224： | 1 |
| 16 | Liver X receptor β (LXRβ) : A link between β-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia显示文摘 | Kim H J Fan X Gabbi C | 2008 | Proc Natl Acad Sci USA2008，105，： | 1 |
| 17 | Chediak- Higashi syndrome with parkinsonism 显示文摘 | Silveira-Moriyama L Moriyama TS Gabbi TV | 2004 | Mov Disord2004，19，4： | 1 |
| 18 | Surgical anatomy of the hepatic arteries in 1000 cases显示文摘 | Hiatt JR Gabby J Busuttil RW | 1994 | Ann Surg1994，200，1： | 1 |
| 19 | Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish显示文摘 | Meijer A H Gabby Krens SF Medina Rodriguez IA | 2004 | Mol Immunol2004，40，： | 1 |
| 20 | Inconsistency handling inmuhiperspective specifications显示文摘 | FINKELSTEIN A GABBY D HUNTER A | 1994 | IEEE Trans on Software Engineering1994，20，8： | 1 |
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