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| 1 | Modern treatment of gastric gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors (GIST) are rare mesenchymal smooth muscle sarcomas that can arise anywhere within the gastrointestinal tract. Sporadic mutations within the tyrosine kinase receptors of the interstitial cells of Cajal have been identified as the key molecular step in GIST carcinogenesis. Although many patients are asymptomatic, the most common associated symptoms include: abdominal pain, dyspepsia, gastric outlet obstruction, and anorexia. Rarely, GIST can perforate causing life-threatening hemoperitoneum. Most are ultimately diagnosed on cross-sectional imaging studies (i.e., computed tomography and/or magnetic resonance imaging in combination with upper endoscopy. Endoscopic ultrasonographic localization of these tumors within the smooth muscle layer and acquisition of neoplastic spindle cells harboring mutations in the c-KIT gene is pathognomonic. Curative treatment requires a complete gross resection of the tumor. Both open and minimally invasive operations have been shown to reduce recurrence rates and improve long-term survival. While there is considerable debate over whether GIST can be benign neoplasms, we believe that all GIST have malignant potential, but vary in their propensity to recur after resection and metastasize to distant organ sites. Prognostic factors include location, size (i.e., > 5 cm), grade (> 5-10 mitoses per 50 high power fields and specific mutational events that are still being defined. Adjuvant therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to reduce the risk of recurrence after one year of therapy. Treatment of locally-advanced or borderline resectable gastric GIST with neoadjuvant imatinib has been shown to induce regression in a minority of patients and stabilization in the majority of cases. This treatment strategy potentially reduces the need for more extensive surgical resections and increases the number of patients eligible for curative therapy. The modern surgical treatment of gastric GIST combines the novel use of targeted therapy and aggressive minimally invasive surgical procedures to provide effective treatment for this lethal, but rare gastrointestinal malignancy. | Kevin K Roggin Mitchell C Posner | 2012 | World Journal of Gastroenterology2012，18，46： | 17 |
| 2 | Transhiatal versus transthoracic esophagectomy for esophageal cancer显示文摘Esophageal cancer continues to represent a formidable challenge for both patients and clinicians. Relative 5-year survival rates for patients have improved over the past three decades, probably linked to a combination of improved surgical outcomes, progress in systemic chemotherapy and radiotherapy, and the increasing acceptance of multimodality treatment. Surgical treatment remains a fundamental component of the treatment of localized esophageal adenocarcinoma. Multiple approaches have been described for esophagectomy, which can be thematically grouped under two major categories: either transthoracic or transhiatal. The main controversy rests on whether a more extended resection through thoracotomy provides superior oncological outcomes as opposed to resection with relatively limited morbidity and mortality through a transhiatal approach. After numerous trials have addressed these issues, neither approach has consistently proven to be superior to the other one, and both can provide excellent short-term results in the hands of experienced surgeons. Moreover, the available literature suggests that experience of the surgeonand hospital in the surgical management of esophageal cancer is an important factor for operative morbidity and mortality rates, which could supersede the type of approach selected. Oncological outcomes appear to be similar after both procedures. | J Camilo Barreto Mitchell C Posner | 2010 | World Journal of Gastroenterology2010，16，30： | 16 |
| 3 | Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design显示文摘 | Matthew H. G. Katz Robert Marsh Joseph M. Herman Qian Shi Eric Collison Alan P. Venook Hedy L. Kindler Steven R. Alberts Philip Philip Andrew M. Lowy Peter W. T. Pisters Mitchell C. Posner Jordan D. Berlin Syed A. Ahmad | 2013 | Annals of Surgical Oncology2013，，8： | 4 |
| 4 | Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of Hepatitis B after liver transplantation显示文摘 | R. Todd Stravitz Mitchell L. Shiffman Melissa Kimmel Puneet Puri Velimir A. Luketic Richard K. Sterling Arun J. Sanyal Adrian H. Cotterell Marc P. Posner Robert A. Fisher | 2012 | Liver Int2012，，7： | 3 |
| 5 | Surveillance for Hepatocellular Carcinoma in Patients with Cirrhosis Improves Outcome显示文摘 | Richard Todd Stravitz Douglas M. Heuman Nisha Chand Richard K. Sterling Mitchell L. Shiffman Velimir A. Luketic Arun J. Sanyal Adil Habib Anastasios A. Mihas Ho-Chong S. Giles Daniel G. Maluf Adrian H. Cotterell Marc P. Posner Robert A. Fisher | 2008 | The American Journal of Medicine2008，，2： | 3 |
| 6 | A Phase II Trial of Neoadjuvant Chemoradiation and Local Excision for T2N0 Rectal Cancer: Preliminary Results of the ACOSOG Z6041 Trial显示文摘 | Julio Garcia-Aguilar MD PhD Qian Shi PhD Charles R. Thomas MD Emily Chan MD PhD Peter Cataldo MD Jorge Marcet MD David Medich MD Alessio Pigazzi MD Samuel Oommen MD Mitchell C. Posner MD | 2012 | Annals of Surgical Oncology2012，，2： | 2 |
| 7 | Cognitive and emotional influences in anterior cingulate cortex显示文摘 | George Bush Phan Luu Michael I. Posner | 2000 | Trends in Cognitive Sciences2000，，： | 2 |
| 8 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 9 | Single Pediatric Kidney Transplantation in Adult Recipients: Comparable Outcomes With Standard-Criteria Deceased-Donor Kidney Transplantation显示文摘 | Amit Sharma Rajesh Ramanathan Martha Behnke Robert Fisher Marc Posner | 2013 | Transplantation Journal2013，，11： | 2 |
| 10 | Docetaxel induction therapy in locally advanced squamous cell carcinoma of the head and neck 显示文摘 | Posner MR Lefebvre JL | 2003 | J Cancer2003，88，1： | 1 |
| 11 | Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle显示文摘 | D'ANGELO J G BORD N C POSNER GH | 2009 | J Antimicrob Chemother2009，63，1： | 1 |
| 12 | Management of central nervous system metastasis显示文摘 | POSNER J B | 1977 | Semin Oncol1977，4，1： | 1 |
| 13 | Antimalari,antiproliferative,and antitumor activities of artemisininderived,chemically robust,trioxane dimers显示文摘 | Posner GH Ploypradith P Parker MH | 1999 | J Med Chem1999，42，21： | 1 |
| 14 | Hospitalizations with respiratory illness among pregnant women during influenza season显示文摘 | Cox S Posner SF Mcpheeters M | 2006 | Obstet Gynecol2006，107，6： | 1 |
| 15 | The specific adsorption of divalent Cd, Co, Cu, Pb and Zn on goethite 显示文摘 | FORBES E A POSNER A M QUIRK J P | 1976 | J Soil Sci1976，27，： | 1 |
| 16 | Cognitive and emotional influences in anterior cingnlate cortex 显示文摘 | Bush G Luu P Posner MI | 2000 | Trends Cogn Sci2000，4，： | 1 |
| 17 | The American society of anesthesiologists postoperative visual loss registry:a- nalysis of 93 spine surgery cases with postoperative vis- ual loss 显示文摘 | Lee LA Roth S Posner KL | 2006 | Anesthesiology2006，105，4： | 1 |
| 18 | Anti-Hu associated paraneoplsfic encephalomyelitis/sensory neuropathy:a clinical study of 71 patients显示文摘 | Dalmau J Graus F Rosenblum MK Posner JB | 1992 | Medicine1992，71，： | 1 |
| 19 | The American Society of Anesthesiologists postoperative visual loss registry: Analysis of 93 spine surgery cases with postoperative visual loss显示文摘 | LA Roth S Posner KL | 2006 | Anesthesiology2006，105，： | 1 |
| 20 | International Trade and Technical Change显示文摘 | Posner M | 1961 | Oxford Economic Papers1961，，3： | 1 |
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