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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 5 | 荨麻属药用植物的研究进展显示文摘目的:荨麻属植物的化学成分多样,药理活性明显,且应用广泛。本文综述近二十年的研究现状,为其进一步开发利用提供科学依据。方法:结合国内外相关文献,对药用荨麻属植物的化学成分、药理作用、质量控制、安全性评价、开发应用等方面进行综述。结果:从荨麻属药用植物中分离鉴定了黄酮、木脂素、香豆素、甾体、有机酸类成分。药用荨麻属植物具有良好的抑制良性前列腺增生、抗风湿、降血糖、镇痛、抗炎、抗菌、抗氧化等活性。临床主要应用于良性前列腺增生、风湿、类风湿关节炎等,疗效显著。今后应加强药用荨麻的质量评价、安全性控制等方面的研究。结论:荨麻属植物具有较高的研究价值。 | LUU THI THANH THUY 王梦月 | 2015 | 中国民族民间医药2015，24，12： | 5 |
| 6 | Simulation of stabilizing process of dielectric nanoparticle in optical trap using counter-propagating pulsed laser beams显示文摘The stabilizing process of glass particle in water by optical trap using the pulsed counter-propagating Gaussian beams is investigated.The influence of the optical power and the particle dimension on the rate and time of the stabilizing process is simulated and discussed. | Ho Quang Quy Mai Van Luu Hoang Dinh Hai Donan Zhuang | 2010 | Chinese Optics Letters2010，8，3： | 5 |
| 7 | 荨麻根脂溶性化学成分研究显示文摘目的对荨麻根的脂溶性成分进行研究。方法采用硅胶、Sephadex LH-20、ODS柱色谱以及半制备HPLC等方法分离、纯化,根据化合物的理化性质和光谱数据鉴定结构。结果从荨麻根乙酸乙酯部位分离鉴定了21个成分,分别为:(-)-荨麻醇(1)、(-)-开环异落叶松脂素(2)、23-羟基白桦脂酸(3)、2α,3β,24-三羟基-齐墩果-12-烯-28-羧酸(4)、臭矢菜素A(5)、二氢-4-羟基-5-羟甲基-2(3H)-呋喃酮(6)、绿原酸甲酯(7)、山柰酚(8)、松脂素单甲基醚-4'-O-β-D-葡萄糖苷(9)、罗汉松脂素-4'-O-β-D-葡萄糖苷(10)、环橄榄脂素-6-O-β-D-吡喃葡萄糖苷(11)、豆甾醇-3-O-β-D-葡萄糖苷(12)、烟酰胺(13)、反式咖啡酸-4-O-β-D-葡萄糖苷(14)、七叶苷(15)、5-羟基-7-甲氧基香豆素-8-O-β-D-葡萄糖苷(16)、6-甲氧基-木犀草素-7-O-β-D-葡萄糖苷(17)、木犀草素-7-O-β-D-葡萄糖苷(18)、槲皮素-3-O-(4″-甲氧基)-α-L-吡喃鼠李糖苷(19)、2'-脱氧尿苷(20)和芹菜素-6,8-二-C-β-D-葡萄糖苷(21)。结论除化合物8、12外,其余19个成分均为首次从荨麻中分得;化合物5、6、9、10、11、14、16、17、19均为首次从荨麻科植物中发现。 | 冯晓茹 李晓波 LUU THI THANH THUY 王梦月 | 2017 | 中国药学杂志2017，52，14： | 5 |
| 8 | Recent advances in nanorobotic manipulation inside scanning electron microscopes显示文摘A scanning electron microscope(SEM)provides real-time imaging with nanometer resolution and a large scanning area,which enables the development and integration of robotic nanomanipulation systems inside a vacuum chamber to realize simultaneous imaging and direct interactions with nanoscaled samples.Emerging techniques for nanorobotic manipulation during SEM imaging enable the characterization of nanomaterials and nanostructures and the prototyping/assembly of nanodevices.This paper presents a comprehensive survey of recent advances in nanorobotic manipulation,including the development of nanomanipulation platforms,tools,changeable toolboxes,sensing units,control strategies,electron beam-induced deposition approaches,automation techniques,and nanomanipulation-enabled applications and discoveries.The limitations of the existing technologies and prospects for new technologies are also discussed. | Chaoyang Shi Devin K Luu Qinmin Yang Jun Liu Jun Chen Changhai Ru Shaorong Xie Jun Luo Ji Ge Yu Sun | 2016 | Microsystems & Nanoengineering2016，2，1： | 4 |
| 9 | 不同终压对火龙果切片真空预冷效果的影响显示文摘研究了不同终压(400~800Pa)下真空预冷对火龙果切片降温速率、失水率以及预冷后在4℃冷藏温度下72h内的持水性、pH值、硬度和色泽指标的影响。结果表明:终压变化对降温速率和失重率的影响都不大,然而,适当的升高终压却可以延缓持水性、pH值、硬度及色泽的变化。综合比较得知,预冷终压在700~800Pa时火龙果切片在4℃冷藏温度下产品货架期最长,为60h。 | Nguyen Van Luu 宋晓燕 刘宝林 华泽钊 王欣 | 2012 | 制冷学报2012，33，1： | 4 |
| 10 | 越南火龙果冷藏现状分析显示文摘随着全球化经济的快速发展,食品冷藏技术日益重要。文中综述了越南火龙果的现有冷藏技术及其存在的问题,并提出解决方案。 | Ha Khiet Nghi 刘宝林 Nguyen Van Luu 宋晓燕 | 2011 | 低温与超导2011，39，4： | 4 |
| 11 | Super-Resolved and Dynamic Imaging of Membrane Proteins in Plant Cells Reveal Contrasting Kinetic Profiles and Multiple Confinement Mechanisms显示文摘Dear Editor, Microscopic techniques allow either a global mobility analysis of proteins with fluorescence recovery after photobleaching (FRAP) or single-protein mobility characterization with single-particle or quantum dot tracking.For instance,total internal reflection fluorescence microscopy allowed single-particle tracking (SPT) of Arabidopsis plasma membrane (PM) proteins,revealing their heterogeneous distribution,low lateral diffusion,and dynamic properties in response to salt stress (Li et al.,2011).Studies of SPT based on green fluorescent protein are unfortunately restricted by the density of proteins at the surface,since diffracted emission fluorescence prevents tracking of individual proteins separated by less than 1 μm.The recent emergence of high-density SPT techniques based on temporal emission decorrelation,such as single-particle tracking with photoactivated localization microscopy (sptPALM),allowed the diffraction limit of classic light microscopy to be broken and reach nanometerlevel spatial resolutions (Manley et al.,2008).Application of these techniques has rendered possible the characterization of the structural and dynamic heterogeneity of PM proteins with an accuracy of ~20-80 nm (Rossier et al.,2012).Such super-resolved dynamic imaging of membrane proteins has not yet been applied to any plant system.Here,we report the first use in plants of the live-cell sptPALM technique,providing a high-density super-resolved nanoscale map of individual membrane-protein motions. | Eric Hosy Alexandre Martiniere Daniel Choquet Christophe Maurel Doan- Trung Luu | 2015 | Molecular Plant2015，8，2： | 3 |
| 12 | Azithromycin inhibits neutrophil accumulation in airways by affecting interleukin- 17 downstream signals显示文摘 | Nguyen Van Luu Yang Jiong Qu Xue-ju Guo Ming Wang Xin Xian Qiao-yang Tang Zhi-jiao Huang Zhi-xiang Wang Yong | 2012 | Chinese Medical Journal2012，，3： | 3 |
| 13 | Preventing crash in stock market:The role of economic policy uncertainty during COVID‑19显示文摘This paper investigates the impact of economic policy uncertainty(EPU)on the crash risk of US stock market during the COVID-19 pandemic.To this end,we use the GARCHS(GARCH with skewness)model to estimate daily skewness as a proxy for the stock market crash risk.The empirical results show the significantly negative correlation between EPU and stock market crash risk,indicating the aggravation of EPU increase the crash risk.Moreover,the negative correlation gets stronger after the global COVID-19 outbreak,which shows the crash risk of the US stock market will be more affected by EPU during the epidemic. | Peng‑Fei Dai Xiong Xiong Zhifeng Liu Toan Luu Duc Huynh Jianjun Sun | 2021 | Financial Innovation2021，7，1： | 2 |
| 14 | 应用AccuMap多焦视觉诱发电位客观视野检测法观察晶状体混浊对青光眼视野检测结果的影响显示文摘目的探讨AccuMap多焦视觉诱发电位客观视野检测法观察晶状体混浊对青光眼视野检测结果的影响及与Humphrey自动视野检测结果之间的相关性。方法观察和比较原发性青光眼伴有中等程度晶状体混浊患者白内障术前后AccuMap与Humphrey视野计检测结果。术前由同一位有经验的眼科医师观察并记录(采用LOCSⅢ标准)患者晶状体的混浊程度。结果符合入选标准并完成观察者共22例。(1)AccuMap视野检测平均振幅术前为(308.0±96.6)nV,术后为(382.6±146.7)nV,术前与术后平均振幅差异有统计学意义(P=0.01)。平均视野损害严重程度指数(accumapseverityindex,ASI)术前为90.0±54.8,术后为48.6±42.4,术后比术前ASI显著下降(P<0.001)。潜伏期术前后无明显变化,术前平均为(1207.5±67.7)ms,术后为(1191.2±61.9)ms(P=0.289)。(2)晶状体混浊程度与AccuMap振幅的变化AccuMap振幅的变化与晶状体混浊程度无明显相关性(Spearman秩相关分析,P=0.09)。(3)Humphrey视野计检测结果术前平均偏差(meandeviation,MD)为-12.2±7.8,术后为-9.6±8.8,术后与术前MD差异有统计学意义(P<0.001);而模式标准差(patternstandarddeviation,PSD)术前为6.5±3.2,术后为6.3±4.0,差异无统计学意义(P=0.748)。(4)ASI与MD比较术前、术后ASI分别与MD具有相关性(Pearson相关分析,术前P=0.013,术后P<0.001);且术后与术前ASI的变化与MD的变化也具有相关性(Pearson相关分析,P=0.017)。结论AccuMap视野检测法显示晶状体混浊影响青光眼患者的视野检测结果,其中振幅受影响更明显。与Humphrey视野检测结果比较,AccuMap检测的ASI与MD具有相关性。(中华眼科杂志,2006,42972-976) | 才瑜 LIM Boon Ang CHI Luu POR Yongming OEN Francis 晏晓明 CHEW Paul SEAH Steve | 2006 | 中华眼科杂志2006，42，11： | 2 |
| 15 | Numerical Investigation on Dynamics of the Tendon System of A TLP by Applying Absolute Nodal Coordinate Formulation显示文摘In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,generalized elastic force,external load and mass matrices of the element are deduced to perform the element assembling by using the finite element method.Then the motion equation of the tendon/riser is established.In this study,the TLP in the International Ship Structures Committee(ISSC)model under the first and second wave forces is considered as the case study.The simulation is performed in the MATLAB environment.Moreover,the accuracy and reliability of the programs are verified for cases of beam model with theoretical solutions.It is found that the motion response of tendons is affected by the TLP movement and environmental load,simultaneously.Then,the motion response is calculated using the SESAM software and exported as the boundary of ANCF tendons.Finally,the static and dynamic characteristics of the four tendons of ISSC TLP are analyzed systematically by the ANCF method.Performed analysis proves the effectiveness and feasibility of the ANCF method.It is concluded that the proposed method is a powerful scheme for calculating the dynamics of tendon/riser in the field of ocean engineering. | Luu Quang HUNG KANG Zhuang ZHANG Cheng JIE Li-shao | 2021 | China Ocean Engineering2021，35，3： | 2 |
| 16 | Effectiveness on post-stroke hemiplegia in patients:electroacupuncture plus cycling vs electroacupuncture alone显示文摘OBJECTIVE:To evaluate the effectiveness of cycling in combination with electroacupuncture in treatment of poststroke hemiplegia patients at National Hospital of Acupuncture,Vietnam.METHODS:The study was designed as a single-centre,outcome-assessor-blinded parallel randomised controlled trial with 120 post-stroke hemiplegia patients randomly assigned into two groups:electroacupuncture plus cycling(CT group) and electroacupuncture(AT group).Patients were assessed before and after the treatment(using muscle grading,modified Rankin,Barthel,Orgorozo scores and electromyography).Statistical Man–Whitney U test,and Fisher’s exact tests were used to compare between CT and AT groups.RESULTS:The results reported statistically significant improvement in motor function in patients suffering from hemiplegia following ischemic stroke in both CT and AT groups.Patients in CT group experienced a greater improvement compared to those in AT group including better muscle contraction(increased frequency and amplitude of electromyography and increased muscle grading scale);increased recovery(Orgogozo scale),increased independency(Barthel scale) and decreased disability(Modified Rankin scale)(P < 0.01).CONCLUSIONS:Combination with cycling training significantly improves the recovery of post-stroke patients treated with electroacupuncture. | Minh Duc Nguyen Thanh Van Tran Quoc Vinh Nguyen Ninh Khac Nguyen Son Truong Vu Luu Trong Nguyen Linh Vu Phuong Dang | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 2 |
| 17 | Forecasting cryptocurrency returns and volume using search engines显示文摘In the context of the debate on the role of cryptocurrencies in the economy as well as their dynamics and forecasting,this brief study analyzes the predictability of Bitcoin volume and returns using Google search values.We employed a rich set of established empirical approaches,including a VAR framework,a copulas approach,and non-parametric drawings,to capture a dependence structure.Using a weekly dataset from 2013 to 2017,our key results suggest that the frequency of Google searches leads to positive returns and a surge in Bitcoin trading volume.Shocks to search values have a positive effect,which persisted for at least a week.Our findings contribute to the debate on cryptocurrencies/Bitcoins and have profound implications in terms of understanding their dynamics,which are of special interest to investors and economic policymakers. | Muhammad Ali Nasir Toan Luu Duc Huynh Sang Phu Nguyen Duy Duong | 2019 | Financial Innovation2019，5，1： | 2 |
| 18 | Cognitive and emotional influences in anterior cingulate cortex显示文摘 | George Bush Phan Luu Michael I. Posner | 2000 | Trends in Cognitive Sciences2000，，： | 2 |
| 19 | The unsatisfactory nargin in breast cancer surgery 显示文摘 | Luu HH Otis CN Reed WP Jr | 1999 | Am J Surg1999，178，5： | 2 |
| 20 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
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