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| 1 | Novel treatment options for perforations of the upper gastrointestinal tract:Endoscopic vacuum therapy and over-the-scope clips显示文摘Endoscopic management of leakages and perforations of the upper gastrointestinal tract has gained great importance as it avoids the morbidity and mortality of surgical intervention.In the past years,covered selfexpanding metal stents were the mainstay of endoscopic therapy.However,two new techniques are now available that enlarge the possibilities of defect closure:endoscopic vacuum therapy(EVT),and over-the-scope clip(OTSC).EVT is performed by mounting a polyurethane sponge on a gastric tube and placing it into the leakage.Continuous suction is applied via the tube resulting in effective drainage of the cavity and the induction of wound healing,comparable to the application of vacuum therapy in cutaneous wounds.The system is changed every 3-5 d.The overall success rate of EVT in the literature ranges from 84%to 100%,with a mean of 90%;only few complications have been reported.OTSCs are loaded on a transparent cap which is mounted on the tip of a standard endoscope.By bringing the edges of the perforation into the cap,by suction or by dedicated devices,such as anchor or twin grasper,the OTSC can be placed to close the perforation.For acute endoscopy associated perforations,the mean success rate is 90%(range:70%-100%).For other types of perforations(postoperative,other chronic leaks and fistulas)success rates are somewhat lower(68%,and59%,respectively).Only few complications have been reported.Although first reports are promising,further studies are needed to define the exact role of EVT and OTSC in treatment algorithms of upper gastrointestinal perforations. | Rudolf Mennigen Norbert Senninger Mike G Laukoetter | 2014 | World Journal of Gastroenterology2014，20，24： | 25 |
| 2 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 3 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 4 | The Effect of Corporate Social Responsibility (CSR) Activities on Companies With Bad Reputations显示文摘 | Yeosun Yoon Zeynep Gürhan-Canli Norbert Schwarz | 2006 | Journal of Consumer Psychology2006，，4： | 2 |
| 5 | The red-cell immune system 显示文摘 | SIEGEL I TIAN Liu-liu NORBERT G | 1981 | Lancet1981，318，9： | 1 |
| 6 | The Effect of Corporate Social Responsibility (CSR) Activities on Companies With Bad Reputations显示文摘 | Yeosun Yoon Zeynep Gürhan-Canli Norbert Schwarz | 2006 | Journal of Consumer Psychology2006，，4： | 1 |
| 7 | Giant outbursts of luminous blue variables and the formation of the homunculus nebula around η carinae显示文摘 | Guillermo G | 1999 | The Astrophysical Journal1999，520，7： | 1 |
| 8 | Study of the phase structure of linear polyethylene by means of small-angle X-ray scattering and Raman spectroscopy 显示文摘 | NORBERT S RUFINA G A LEO M | 1995 | Maeromoleeules1995，28，14： | 1 |
| 9 | An Ontology-Based Approach to Personalized Situation-Aware Mobile Service Supply显示文摘 | Norbert W Agnes V Rudiger G | 2006 | GeoInformatica2006，，10： | 1 |
| 10 | The Effect of Corporate Social Responsibility Activities on Companies with Bad Reputations显示文摘 | Yoon Yeosun Gürhan-Canli Zeynep Schwarz Norbert | 2006 | Journal of Consumer Psychology2006，16，4： | 1 |
| 11 | Biotechnological intensification of biogas production显示文摘 | Zoltán Bagi Norbert ács Balázs Bálint Lenke Horváth Krisztina Dobó Katalin R. Perei Gábor Rákhely Kornél L. Kovács | 2007 | Applied Microbiology and Biotechnology2007，，2： | 1 |
| 12 | An automated salt-tracing gauge for flow-velocity measurement 显示文摘 | Olivier P Norbert S Raphael G | 2005 | Earth Surf Process Landforms2005，30，： | 1 |
| 13 | late clonal diseases of treated aplastic anemia显示文摘 | Gérard S Stephen R Norbert F | 2000 | Semin Hematol2000，37，： | 1 |
| 14 | Biological treatment strategies for disc degeneration: potentials and shortcomings显示文摘 | Günther Paesold Andreas G. Nerlich Norbert Boos | 2007 | European Spine Journal2007，，4： | 1 |
| 15 | Biomechanical comparison of hamstring and patellar tendon graft anterior cruciate ligament reconstruction techniques: The impact of fixation level and fixation method under cyclic loading显示文摘 | Sven US Norbert PS Andreas G | 2002 | Arthroscopy2002，18，3： | 1 |
| 16 | Mutation analysis of p53 in ovarian tumors by DHPLC 显示文摘 | Eva G Marion K Norbert A | 2001 | J Bioehem Biophys Methods2001，47，12： | 1 |
| 17 | Spontane- ous breathing during ventilatory support improves ventilation- perfusion distributions in patients with acute respiratory dis- tress syndrome显示文摘 | Putensen C Norbert JM Putensen-Himmer G | 1999 | Am J Respir Crit Care Med1999，159，： | 1 |
| 18 | Optimization of the index assignments for multiple descriptions vector quantizers 显示文摘 | Norbert G Pornchai I | 2003 | IEEE Transactions on Communications2003，15，3： | 1 |
| 19 | Molecular Genetics of human hypertension显示文摘 | Maolian G Norbert H | 2006 | Clinical Science2006，110，3： | 1 |
| 20 | The Effect of Corporate Social Responsibility (CSR) Activities on Companies With Bad Reputations显示文摘 | Yeosun Yoon Zeynep Gürhan-Canli Norbert Schwarz | 2006 | Journal of Consumer Psychology2006，，： | 1 |
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