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| 1 | Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-nave patients显示文摘AIM: To determine whether adding vitamin D, a potent immunomodulator, improves the hepatitis C virus (HCV) response to antiviral therapy. METHODS: Seventy-two consecutive patients with chronic HCV genotype 1 were randomized into two groups: the treatment group (n = 36, 50% male, mean age 47 ± 11 years) received Peg-α-2b interferon (1.5 μg/kg per week) plus ribavirin (1000-1200 mg/d) together with vitamin D3 (2000 IU/d, target serum level > 32 ng/mL), and the control group (n = 36, 60% male, mean age 49 ± 7 years) received identical therapy without vitamin D. HCV-RNA was assessed by realtime polymerase chain reaction (sensitivity, 10 IU/mL). The sustained virologic response (SVR) was defined as undetectable HCV-RNA at 24 wk post-treatment. RESULTS: Clinical characteristics were similar in both groups. The treatment group had a higher mean bodymass index (27 ± 4 kg/m2 vs 24 ± 3 kg/m2, P < 0.01), viral load (50% vs 42%, P < 0.01), and fibrosis score (> F2: 42% vs 19%, P < 0.001) than the controls. At week 4, 16 (44%) treated patients and 6 (17%) controls were HCV-RNA negative (P < 0.001). At week 12, 34 (94%) treated patients and 17 (48%) controls were HCV-RNA negative (P < 0.001). At 24 wk post-treatment (SVR), 31 (86%) treated patients and 15 (42%) controls were HCV-RNA negative (P < 0.001). Viral load, advanced fibrosis and vitamin D supplementation were strongly and independently associated with SVR (multivariate analysis). Adverse events were mild and typical of Peg-α-2b/ribavirin. CONCLUSION: Adding vitamin D to conventional Peg-α-2b/ribavirin therapy for treatment-na■ve patients with chronic HCV genotype 1 infection significantly improves the viral response. | Saif Abu-Mouch Zvi Fireman Jacob Jarchovsky Abdel-Rauf Zeina Nimer Assy Liver Unit | 2011 | World Journal of Gastroenterology2011，17，47： | 29 |
| 2 | Capsule endoscopy: Improving transit time and image view显示文摘AIM: To evaluate the effect of various methods of small bowel preparation on the transit time and the quality of visualization of the entire small bowel mucosa.METHODS: Ninety-five patients underwent capsule endoscopy (CE) by easily swallowing the capsule. They were divided into three study groups according to the preparation used: group A (n = 26) by polyethylene glycol (PEG) liter or with sodium phosphate (SP) 12 h prior to the CE study; group B (n = 29) by erythromycin 1 h prior to the CE study; and group C (n = 40) without any preparation. Visualization ranged from good to satisfactory to poor.RESULTS: The gastric emptying time in the group prepared with erythromycin was shorter but without statistical significance and the small bowel transit time was unaffected. In elderly subjects prepared by PEG or SP, the gastric emptying time was significantly longer (163.7 min, P = 0.05). The transit times of the three sub-groups were not affected by gender or pathology.The grade of cleaning of the entire study group was 3.27±1.1. The erythromycin group presented significantly the worst quality of images (P = 0.05) compared to the other sub-groups. Age, gender, and pathology had no effect on the quality of the cleaning of the small bowel in the sub-groups. One (1.05%) case had no natural excretion.CONCLUSION: Erythromycin markedly reduces gastric emptying time, but has a negative effect on the quality of the image in the small bowel. The preparation of elderly subjects with PEG or SP has a negative effect on the small bowel transit time. | Zvi Fireman D Paz Y Kopelman | 2005 | World Journal of Gastroenterology2005，11，37： | 25 |
| 3 | Efficacy and safety of Firebird sirolimus-eluting stent in treatment of complex coronary lesions in Chinese patients: one-year clinical and eight-month angiographic outcomes from the FIREMAN registry显示文摘 | LI Yan LI Cheng-xiang WANG Hai-chang XU Bo FANG Wei-yi GE Jun-bo WANG Wei-min CHEN Jack-P SHEN Wen-kuang JIANG Hong CONG Hong-liang PU Xiao-qun QIN Yong-wen JIN Hui-gen CAO Yu FIREMAN Investigators | 2011 | Chinese Medical Journal2011，，6： | 17 |
| 4 | Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study显示文摘AIM: To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology. METHODS: We conducted a retrospective, blinded (to the type of preparation) review of 100 CE studies, 50 with no preparation with prokinetics from one medical center (Group A) and 50 from another center with administration of a single dose of 200 mg oral erythromycin 1 h prior to CE (Group B). Gastric, SB and total transit times were calculated, the presence of bile in the duodenum was scored, as was cleanliness within the proximal, middle and distal intestine. RESULTS: The erythromycin group had a slightly shorter gastric transit time (21 min vs 28 min, with no statistical significance). SB transit time was similar for both groups (all P > 0.05). Total transit time was almost identical in both groups. The rate of incomplete examination was 16% for Group A and 10% for Group B (P = 0.37). Bile and cleanliness scores in different parts of the intestine were similar for the two groups (P > 0.05). CONCLUSION: Preparation for capsule endoscopy with erythromycin does not affect SB or total transit time. It tends to reduce gastric transit time, but it does not increase the cecum-reaching rate. Erythromycin does not adversely affect image quality. We consider the routine use of oral erythromycin preparation as being unjustified, although it might be considered in patients with known prolonged gastric emptying time. | Eva Niv Ido Bogner Olga Barkey Zamir Halpern Elisabeth Mahajna Roman Depsames Yael Kopelman Zvi Fireman | 2008 | World Journal of Gastroenterology2008，14，16： | 10 |
| 5 | Validation of the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI or Niv score): a multicenter prospective study显示文摘 | Y. Niv S. Ilani Z. Levi M. Hershkowitz E. Niv Z. Fireman S. O’Donnel C. O’Morain R. Eliakim E. Scapa N. Kalantzis C. Kalantzis P. Apostolopoulos E. Gal | 2012 | Endoscopy2012，，01： | 2 |
| 6 | 胶囊内窥镜在诊断不明原因消化道出血中的应用 | Fireman Z. Friedman S. 徐小洁 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，6： | 2 |
| 7 | Variation of Adenoma Prevalence by Age, Sex, Race, and Colon Location in a Large Population: Implications for Screening and Quality Programs显示文摘 | Douglas A. Corley Christopher D. Jensen Amy R. Marks Wei K. Zhao Jolanda de Boer Theodore R. Levin Chyke Doubeni Bruce H. Fireman Charles P. Quesenberry | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 8 | Age and indication for referral to capsule endoscopy significantly affect small bowel transit times : the given database 显示文摘 | Fireman Z Kopelman Y Friedman S | 2007 | Dig Dis Sci2007，52，10： | 1 |
| 9 | Morphological and biochemical properties of alveolar fibroblasts in interstitiiallung diseases 显示文摘 | Fireman E Shahar I Shoval S | 2001 | Lung2001，179，2： | 1 |
| 10 | Efficacy,safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in chikdren显示文摘 | Black S Shinefield H Fireman B | 2000 | Pediatr Infect Dis J2000，19，： | 1 |
| 11 | Diagnostic yield of capsule endoscopy in obscure gastrointestinal bleeding 显示文摘 | FIREMAN Z FIREMAN S | 2004 | Digestion2004，70，： | 1 |
| 12 | Long-term safety and efficacy of a chlorofluorocarbon-free beclometha-sone dipropionate extrafine aerosol显示文摘 | Fireman P Prenner B M Vinckin W | 2001 | Ann Allergy Asthma2001，86，5： | 1 |
| 13 | Impact of the pneumococcal conjugate vaccine on otitis media显示文摘 | Fireman B Black SB Shinefield HR | 2003 | Pedialr Infect Dis J2003，22，1： | 1 |
| 14 | Sinusitis:bench to bedside,current findings,future directions显示文摘 | KALINER M A OSGUTHORPE J D FIREMAN P | 1997 | J Allergy Clin Immunol1997，99，63： | 1 |
| 15 | Laboratory studies of evaporation from soil columns in the presence of a water table显示文摘 | GARDNER W R MILTON FIREMAN | 1958 | Soil Sci1958，85，： | 1 |
| 16 | New frontiers in capsule endoscopy 显示文摘 | Fireman Z Kopelman Y | 2007 | J Gastroenterol Hepatol2007，22，8： | 1 |
| 17 | The role of video capsule endoscopy in the evaluation of iron defi ciency anaemia显示文摘 | Fireman Z Kopelman Y | 2004 | Digestive Disease and Sciences2004，36，2： | 1 |
| 18 | US navy studies on alternative fuel sources and power and propulsion methods for surface combatants and amphibious warfare ships 显示文摘 | WEBSTER J S FIREMAN H ALLEN D A | 2007 | Naval Engineers Jour- nal2007，119，2： | 1 |
| 19 | 显示文摘 | Onn A Levo Y | 1999 | Allergy1999，54，2： | 1 |
| 20 | Diagnosing small bowel Crohn's disease with wireless capsule endoscopy显示文摘 | Mahajna E Broide E | 2003 | Gut2003，52，3： | 1 |
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