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| 1 | The Immune System,Cytokines,and Biomarkers in Autism Spectrum Disorder显示文摘Autism Spectrum Disorder(ASD) is a pervasive neurodevelopmental condition characterized by variable impairments in communication and social interaction as well as restricted interests and repetitive behaviors.Heterogeneity of presentation is a hallmark. Investigations of immune system problems in ASD, including aberrations in cytokine pro?les and signaling, have been increasing in recent times and are the subject of ongoing interest. With the aim of establishing whether cytokines have utility as potential biomarkers that may de?ne a subgroup of ASD,or function as an objective measure of response to treatment, this review summarizes the role of the immune system, discusses the relationship between the immune system, the brain, and behavior, and presents previouslyidenti?ed immune system abnormalities in ASD, speci?-cally addressing the role of cytokines in these aberrations.The roles and identi?cation of biomarkers are also addressed, particularly with respect to cytokine pro?les in ASD. | Anne Masi Nicholas Glozier Russell Dale Adam J.Guastella | 2017 | Neuroscience Bulletin2017，33，2： | 13 |
| 2 | Purines:From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury显示文摘The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological functions.In particular,adenosine triphosphate(ATP)and its metabolite and precursor,adenosine,regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency,to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic stress.This inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke,and the replenishment of ATP after such events.In this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents. | Bruno G.Frenguelli Nicholas Dale | 2020 | Neuroscience Bulletin2020，36，11： | 2 |
| 3 | Assessment of air quality benefits from national air pollution control policies in China. Part II: Evaluation of air quality predictions and air quality benefits assessment显示文摘 | Litao Wang Carey Jang Yang Zhang Kai Wang Qiang Zhang David Streets Joshua Fu Yu Lei Jeremy Schreifels Kebin He Jiming Hao Yun-Fat Lam Jerry Lin Nicholas Meskhidze Scott Voorhees Dale Evarts Sharon Phillips | 2010 | Atmospheric Environment2010，，28： | 1 |
| 4 | Modulating Endothelial Barrier Function by Targeting Vimentin Phosphorylation显示文摘 | Tiegang Liu Maher M. Ghamloush Ali Aldawood Rod Warburton Deniz Toksoz Nicholas S. Hill Dale D. Tang Usamah S. Kayyali | 2014 | Physiol2014，，10： | 1 |
| 5 | A Versatile Gene-Based Test for Genome-wide Association Studies显示文摘 | Jimmy Z. Liu Allan F. Mcrae Dale R. Nyholt Sarah E. Medland Naomi R. Wray Kevin M. Brown Nicholas K. Hayward Grant W. Montgomery Peter M. Visscher Nicholas G. Martin Stuart Macgregor | 2010 | The American Journal of Human Genetics2010，，1： | 1 |
| 6 | A Versatile Gene-Based Test for Genome-wide Association Studies显示文摘 | Jimmy Z. Liu Allan F. Mcrae Dale R. Nyholt Sarah E. Medland Naomi R. Wray Kevin M. Brown Nicholas K. Hayward Grant W. Montgomery Peter M. Visscher Nicholas G. Martin Stuart Macgregor | 2010 | The American Journal of Human Genetics2010，，1： | 1 |
| 7 | Elemental Mapping of Mierostnxctures by Scanning Electron Microscopy-Energy Dispersive X-ray Spectrometry ( SEM-EDS ) : Extra- ordinary Advances with the Silicon Drift Detector (SDD) 显示文摘 | Dale E N Nicholas W M R | 2013 | Journal of Analytical Atomic Spectrometry2013，28，7： | 1 |
| 8 | Prussian Blue acts as a mediator in a reagentless eytokinin biosensor 显示文摘 | Maria Kowalska Faming Tian Mdria Smehilova Petr Galuszka Ivo Frebort Richard Napier Nicholas Dale | 2011 | Analytica China Aaa2011，701，： | 1 |
| 9 | The absence of intrarenal ACE protects against hypertension显示文摘 | Gonzalez-Villalobos Romer A Janjoulia Tea Fletcher Nicholas K Giani Jorge F Nguyen Mien TX Riquier-Brison Anne D Seth Dale M Fuchs Sebastien Eladari Dominique Picard Nicolas Bachmann Sebastian Delpire Eric Peti-Peterdi Janos Navar L Gabriel | 2013 | Journal of Clinical Investigation2013，，5： | 1 |
| 10 | Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxide显示文摘 | Laila H. Abou-agag Nicholas K. Khoo Ralf Binsack C. Roger White Victor Darley-Usmar Hernan E. Grenett Francois M. Booyse Stanley B. Digerness Fen Zhou Dale A. Parks | 2005 | Free Radical Biology and Medicine2005，，4： | 1 |
| 11 | T cell–tumor cell: a fatal interaction?显示文摘 | Dale B. Chappell Nicholas P. Restifo | 1998 | Cancer Immunology Immunotherapy1998，，2： | 1 |
| 12 | Melioidosis epidemiology and risk factors from a prospective whole‐population study in northern Australia显示文摘 | Bart J.Currie Susan P.Jacups Allen C.Cheng Dale A.Fisher Nicholas M.Anstey Sarah E.Huffam Vicki L.Krause | 2004 | Tropical Medicine & International Health2004，，： | 1 |
| 13 | 神经胶质细胞感知并控制脑内的H^(+)/CO_(2)显示文摘维持恒定的大脑pH值对于支持神经元的活动、神经元回路内的有效交流以及大脑对信息的有效处理至关重要。本综述重点关注神经胶质细胞如何检测和响应脑组织pH值和CO_(2)浓度的变化,然后触发系统和局部的适应机制,确保脑回路运行环境的稳定。本文详细介绍了神经胶质细胞对H+和CO_(2)敏感的细胞和分子机制,并讨论了神经胶质化学敏感性和信号传导在3个协同工作以保持大脑pH值恒定的关键机制中的作用。本文讨论的证据表明,脑干的星形胶质细胞和边缘神经胶质细胞对中枢呼吸二氧化碳化学感受至关重要——这是机体依据血液和大脑pH值和二氧化碳分压的变化来调节呼吸,以维持系统pH值稳态的一种基本生理机制。本文还回顾了在与神经元活动和代谢变化相关的酸变化负荷条件下,星形胶质细胞参与维持局部脑组织细胞外pH值的证据,并讨论了神经胶质细胞在介导CO_(2)对脑血管影响中的潜在作用。 | Alexander V Gourine Nicholas Dale 杜一星(编译) | 2022 | 神经损伤与功能重建2022，17，8： | 0 |
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