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| 1 | 黄瓜全雌性基因连锁的AFLP和SCAR分子标记显示文摘本研究以全雌品种‘戴多星’自交系和弱雌品种‘北京截头’自交系为双亲杂交获得F1,然后得到F2性型分离群体,利用分离群体分组分析法(BulkedSegregantAnalysis,BSA)构建全雌和弱雌两个基因池,筛选了64对AFLP选择性引物EcoRINN+MseINNN组合,发现EcoRITG+MseICAC引物组合在全雌基因池中扩增出一条分子量为234bp的特异带。经F2代单株验证,该特异条带能在全雌单株中稳定出现。以MAPMAKER(Version3.0)软件分析,该标记与全雌性位点的连锁距离在6.7cM。命名该连锁标记为TG/CAC234。将该特异条带回收、克隆、测序,设计特异SCAR引物,再对F2代单株基因组DNA进行扩增,仅在全雌单株中扩增出1条分子量为166bp的特异带,表明已成功地将与黄瓜全雌性连锁的AFLP标记转化为操作简便、表现稳定的SCAR标记,该标记命名为SA166。 | 娄群峰 陈劲枫 Molly Jahn 陈龙正 耿红 罗向东 | 2005 | 园艺学报2005，32，2： | 50 |
| 2 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 33 |
| 3 | Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy显示文摘Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management. | Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang Lee Mollie Clarke Ferris David James Sadler Robin Ritchie Gray Jason Kam Wong | 2017 | World Journal of Gastroenterology2017，23，10： | 14 |
| 4 | Environmental Stresses Modulate Abundance and Timing of Alternatively Spliced Circadian Transcripts in Arabidopsis显示文摘环境压力深刻地包括保留 intron (红外) 改变了胡说八道 mRNAs 的累积在 Arabidopsis 的抄本。导致压力的红外 mRNAs 的时间的模式用震荡和不振荡的抄本被把。宽广范围的热周期在长红外 CCA1 isoforms 触发了锋利的增加并且改变了他们分阶段执行到白天的不同时间。象干旱或 Pseudomonas syringae 感染那样的不能生活、关於生命的压力导致了类似的增加。热应力在 CCA1 I4Rb 抄本的累积导致了时间延期,而功能的 mRNA 显示出稳定的摆动。我们的数据帮助中央振荡器的导致压力的不稳定性能部分地在丰富和 CCA1 红外抄本的 out-of-phase 摆动通过变化被补偿的一个假设。一起拿,我们的结果支持 mRNA 丰富能通过改变比率在之间被调制的一个概念功能并且胡说八道 / 红外抄本。明确地绑在保留的 CCA1 intron 在的 SR45 蛋白质 ? vitro,建议这个拼接的因素能涉及 intron 保留的规定。调停胡说八道的 mRNA 腐烂(NMD ) 的 Transcriptomes 损害了,强调热的植物分享了与压力可诱导、防卫可诱导的抄本联系的一套保留的 introns。在 NMD 异种的某些压力反应网络的组成的激活能被连接到不平衡在之间功能并且胡说八道 mRNAs。 | Sergei A. Filichkin Jason S. Cumbie Palitha Dharmawardhana Pankaj Jaiswal Jeff H. Chang Saiprasad G. Palusa A.S.N. Reddy Molly Megraw Todd C. Mockler | 2015 | Molecular Plant2015，8，2： | 11 |
| 5 | Association between heavy metals and antibiotic-resistant human pathogens in environmental reservoirs: A review显示文摘Antibiotic resistance in human pathogens can proliferate under selective pressures. Heavy metals in environmental reservoirs may contribute to selecting antibiotic-resistant strains. To determine the associations between heavy metals and antibiotic resistance, a literature review was conducted to systematically collect and categorize evidence for co-occurrence of resistance to heavy metals and antibiotics within human pathogenic bacteria in water, wastewater, and soil. In total, 42 publications adhered to inclusion criteria. Across the reservoirs, zinc and cadmium were the most commonly observed heavy metals associated with resistance to antibiotics. Pseudomonas aeruginosa and Escherichia coli were the most commonly studied bacteria with reported co-occurrence of resistance to several heavy metals and antibiotic classes. As co-selecting agents, prevalence of heavy metals in the environment can proliferate resistance to heavy metals and antibiotics through co-resistance and crossresistance mechanisms. In comparing different reservoirs, soils and sediments harbor higher heavy metal and antibiotic resistances compared to water environments. Additionally, abiotic factors such as pH can affect the solubility and hence, the availability of heavy metals to bacterial pathogens. Overall, our review demonstrates heavy metals act as co-selecting agents in the proliferation of antibiotic resistance in human pathogens in multiple environmental reservoirs. More studies that include statistical data are needed to further describe the exposure-response relationships between heavy metals and antibiotic resistance in different environmental media. Moreover, integration of culturebased and molecular-based methods in future studies are recommended to better inform our understanding of bacterial co- and cross-resistance mechanisms to heavy metals and antibiotics. | Christine C. Nguyen Cody N. Hugie Molly L. Kile Tala Navab-Daneshmand | 2019 | Frontiers of Environmental Science & Engineering2019，13，3： | 5 |
| 6 | Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)显示文摘Tolerogenic dendritic cells(DCs)are key players in maintaining immunological homeostasis,dampening immune responses,and promoting tolerance.DC-10,a tolerogenic population of human IL-10-producing DCs characterized by the expression of HLA-G and ILT4,play a pivotal role in promoting tolerance via T regulatory type 1(Tr1)cells.Thus far,the absence of markers that uniquely identify DC-10 has limited in vivo studies.By in vitro gene expression profiling of differentiated human DCs,we identified CD141 and CD163 as surface markers for DC-10.The coexpression of CD141 and CD163 in combination with CD14 and CD16 enables the ex vivo isolation of DC-10 from the peripheral blood.CD14+CD16+CD141+CD163+cells isolated from the peripheral blood of healthy subjects(ex vivo DC-10)produced spontaneously and upon activation of IL-10 and limited levels of IL-12.Moreover,in vitro stimulation of allogeneic naive CD4+T cells with ex vivo DC-10 induced the differentiation of alloantigen-specific CD49b+LAG-3+Tr1 cells.Finally,ex vivo DC-10 and in vitro generated DC-10 exhibited a similar transcriptional profile,which are characterized by an anti-inflammatory and pro-tolerogenic signature.These results provide new insights into the phenotype and molecular signature of DC-10 and highlight the tolerogenic properties of circulating DC-10.These findings open the opportunity to track DC-10 in vivo and to define their role in physiological and pathological settings. | Michela Comi Daniele Avancini Francesca Santoni de Sio Matteo Villa Molly Javier Uyeda Matteo Floris Daniela Tomasoni Alessandro Bulfone Maria Grazia Roncarolo Silvia Gregori | 2020 | Cellular & Molecular Immunology2020，17，1： | 4 |
| 7 | Continuous Action Reinforcement Learning for Control-Affine Systems with Unknown Dynamics显示文摘Control of nonlinear systems is challenging in realtime.Decision making,performed many times per second,must ensure system safety.Designing input to perform a task often involves solving a nonlinear system of differential equations,which is a computationally intensive,if not intractable problem.This article proposes sampling-based task learning for controlaffine nonlinear systems through the combined learning of both state and action-value functions in a model-free approximate value iteration setting with continuous inputs.A quadratic negative definite state-value function implies the existence of a unique maximum of the action-value function at any state.This allows the replacement of the standard greedy policy with a computationally efficient policy approximation that guarantees progression to a goal state without knowledge of the system dynamics.The policy approximation is consistent,i.e.,it does not depend on the action samples used to calculate it.This method is appropriate for mechanical systems with high-dimensional input spaces and unknown dynamics performing Constraint-Balancing Tasks.We verify it both in simulation and experimentally for an Unmanned Aerial Vehicles(UAVs) carrying a suspended load,and in simulation,for the rendezvous of heterogeneous robots. | Aleksandra Faust Peter Ruymgaart Molly Salman Rafael Fierro Lydia Tapia | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，3： | 3 |
| 8 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 3 |
| 9 | Eosinophilic Esophagitis in Adults is Associated with IgG4 and Not Mediated by IgE显示文摘 | Frederic Clayton John C. Fang Gerald J. Gleich Alfredo J. Lucendo Jose M. Olalla Laura A. Vinson Amy Lowichik Xinjian Chen Lyska Emerson Kristen Cox Molly A. O’Gorman Kathryn A. Peterson | 2014 | Gastroenterology2014，，： | 3 |
| 10 | Analysis of corneal nerve plexus in corneal confocal microscopy images显示文摘Small Aδand C nerve fibers of the sensory and autonomic nervous systems constitute 70–90%of peripheral nerve fibers including corneal nerves(Muller et al.,2003).Corneal nerves originate from the ophthalmic branch of the trigeminal nerve and enter the cornea at the limbus radially from all directions toward the central cornea at the level of anterior and middle stroma.The subepithelial nerve plexus lies at the interface between the Bowman layer and anterior stroma.They then divide into smaller branches and turn 90°toward Bowman’s layer(Muller et al.,2003),travelling between Bowman’s layer and the basal epithelial layer and forming the sub-basal nerve plexus(Muller et al.,2003). | Yu-Chi Liu Molly Tzu-Yu Lin Jodhbir S.Mehta | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 11 | Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy显示文摘Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus,affecting nerves in all parts of the body including corneal nerves and peripheral nervous system,leading to diabetic corneal neuropathy and diabetic peripheral neuropathy,respectively.Diabetic peripheral neuropathy is diagnosed in clinical practice using electrophysiological nerve conduction studies,clinical scoring,and skin biopsies.However,these diagnostic methods have limited sensitivity in detecting small-fiber disease,hence they do not accurately reflect the status of diabetic neuropathy.More recently,analysis of alterations in the corneal nerves has emerged as a promising surrogate marker for diabetic peripheral neuropathy.In this review,we will discuss the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy,elaborating on the foundational aspects of each:pathogenesis,clinical presentation,evaluation,and management.We will further discuss the relevance of diabetic corneal neuropathy in detecting the presence of diabetic peripheral neuropathy,particularly early diabetic peripheral neuropathy;the correlation between the severity of diabetic corneal neuropathy and that of diabetic peripheral neuropathy;and the role of diabetic corneal neuropathy in the stratification of complications of diabetic peripheral neuropathy. | Wei Zheng So Natalie Shi Qi Wong Hong Chang Tan Molly Tzu Yu Lin Isabelle Xin Yu Lee Jodhbir S.Mehta Yu-Chi Liu | 2022 | Neural Regeneration Research2022，17，10： | 3 |
| 12 | Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial显示文摘 | Jonathan M. Spergel Marc E. Rothenberg Margaret H. Collins Glenn T. Furuta Jonathan E. Markowitz George Fuchs Molly A. O’Gorman Juan Pablo Abonia James Young Timothy Henkel H. Jeffrey Wilkins Chris A. Liacouras | 2012 | The Journal of Allergy and Clinical Immunology2012，，： | 3 |
| 13 | 舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者安全性的评价:随机双盲临床研究显示文摘目的评价舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者术后拮抗神经肌肉阻滞的安全性。尤其着重评估了心脏不良事件以及其他预先指定的临床关注不良事件的影响。方法符合ASA分级Ⅲ或Ⅳ级标准的患者,根据ASA分级和神经肌肉阻滞剂(罗库溴铵或维库溴铵)进行随机分组,新斯的明/格隆溴铵组:中度神经肌肉阻滞;舒更葡糖钠2 mg/kg组,中度神经肌肉阻滞;舒更葡糖钠4 mg/kg组,深度神经肌肉阻滞;舒更葡糖钠16 mg/kg组,深度神经肌肉阻滞(仅罗库溴铵)。主要研究终点包括治疗期间窦性心动过缓、窦性心动过速和其他心律失常的发生情况。结果344例患者进入随机化分配,331例患者接受了治疗[61%为男性,BMI(28.5±5.3)kg/m^(2),年龄(69±11)岁]。舒更葡糖钠2 mg/kg组治疗期间窦性心动过缓发生率显著降低,舒更葡糖钠2 mg/kg组和4 mg/kg组治疗期间窦性心动过速发生率显著降低(P<0.05)。4组间治疗期间其他心律失常发生率比较差异无统计学意义(P>0.05)。结论ASA分级Ⅲ或Ⅳ级高风险手术患者使用舒更葡糖钠拮抗罗库溴铵或维库溴铵诱导的中度和深度神经肌肉阻滞的安全性良好。 | W.Joseph Herring Yuki Mukai Aobo Wang Jeannine Lutkiewicz John F.Lombard Li Lin Molly Watkins David M.Broussard Manfred Blobner | 2022 | 中华麻醉学杂志2022，42，1： | 3 |
| 14 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 15 | 仙人掌果提取液对卵巢癌的抑制作用显示文摘目的:研究仙人掌果提取液在动物体内和体外对卵巢癌的抑制作用。方法:用Crystalviolet方法测定、细胞周期分析及细胞凋亡TUNEL分析观察仙人掌果提取液在体外对卵巢癌细胞生长的抑制作用;仙人掌果提取液对人卵巢癌的动物模型的治疗效果。结果:2种卵巢癌细胞(OVCA420和SKOV3)对于不同浓度仙人掌果提取液反应敏感程度不同,IC50分别是0·8%和8%,正常卵巢上皮细胞(IOSE)的IC50为2%;仙人掌果提取液可以有效的抑制卵巢癌在动物体内的生长(P<0·05),与N-(4-hydroxyphernyl)retinamide(4HPR)作用相似(P>0·05)。结论:仙人掌果提取液对体外卵巢癌细胞生长和动物体内的卵巢癌生长均有明显抑制作用。 | 邹大明 刘华钢 Molly Brewer Jean M Feugang 梁秋云 Kenneth D. Hatch Changping Zou | 2008 | 广西医学院学报2008，18，2： | 3 |
| 16 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 17 | Hepatoprotective effect of Averrhoea carambola fruit extract on carbon tetrachloride induced hepatotoxicity in mice显示文摘Objective:To investigate the hepatoprotective activity of Averroha carambola fruit extract against carbon tetrachloride induced hepatic injury.Methods:Hepatotoxicity was induced on albino mice by intraperitoneal administration of CCl4.half an hour after the administration of the last dose of the extract of Averroha carambola fruit.Aqueous extract of the fruit of Averroha carambola was administered at a dose of 0.9 g/kg body weight once daily for seven days.The hepatic injury and its prevention was assessed by the estimation of serum activities of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphates(ALP),glutathione level and histopathological studies of liver.Results:Pre-treatment of mice with the fruit extract of Averrhoea carambola significantly reduced serum levels of ALT,AST and ALP enzyme and significantly increased the liver reduced glutathione levels 24 h after the administration of carbon tetrachloride.A marked improvement in the enzyme activities and the liver reduced glulathione level was observed in the pre-treated mice 4 days after the administration of carbon tetrachloride. Histopathological studies provided supportive evidence for the biochemical analvsis. Conclusions:The aqueous extract of the fruit of Averrhoea carambola has hepatoprotective effect against carbon tetrachloride induced liver damage in mice. | A.K.Azeem Molly Mathew Chandraniohan Nair Dilip.C | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，8： | 3 |
| 18 | 新一代渴望导管: 在肺的栓塞的处理的可行性显示文摘 AIM: To report our preliminary experience with a new generation aspiration catheter in the treatment of symptomatic pulmonary embolism(PE). METHODS: A retrospective database search for pulmonary artery embolectomy since introduction of the Pronto.035' and XL extraction catheter(Vascular Solutions, Minneapolis, MN) at our institution in 10/2009 was performed. Ten consecutive patients were identified in which the Pronto.035' or XL catheter was used between 01/2010 and 03/2013. All patients were referred for catheter based embolectomy due to contraindications to systemic lysis, or for being in such a critical clinical condition that immediate percutaneous treatment deemed warranted. The computed tomography(CT) right to left heart ratio as predictor for the severity of the PE was retrospectively evaluated on standard axial views. The difference between pre- and post-procedure pulmonary pressure measures was taken to assess the procedural effect.RESULTS: Extensive PE was confirmed angiographically in all patients. Measured right- to left ventricle(RV/LV) ratios were elevated beyond one in seven of the eight available CTs. Acute procedural success defined as clinical removal of visible thrombus and improvement in mean pulmonary artery pressure was seen in all recorded patients(n = 8), the mean pulmonary pressures declined from a median(range) of 35.5(19-46) to 23(10-37, P = 0.008) mmHg. Neither death nor other complications occurred intra- or immediately periprocedural, yet short term mortality within 30 d was found in 6 out of 9 patients, one patient was lost in follow up. The cause of death within 30 d in the 6 patients was identified as: Circulatory failure in direct connection with the PE(n = 2), stroke, sepsis, or succumbing to malignancy in a hospice setting(n = 2). CONCLUSION: Success in thrombus removal with improved pulmonary hypertension and systemic hypotension suggests this aspiration technique to be effective. Aspiration catheters should be part of further trials. | Wolf E Heberlein Mollie E Meek Omar Saleh James C Meek Shelly Y Lensing William C Culp | 2013 | World Journal of Radiology2013，5，11： | 2 |
| 19 | MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells显示文摘 | David F. Steiner Molly F. Thomas Joyce K. Hu Zhiyong Yang Joshua E. Babiarz Christopher D.C. Allen Mehrdad Matloubian Robert Blelloch K. Mark Ansel | 2011 | Immunity2011，，2： | 2 |
| 20 | Mycoplasma pneumoniae in children with acute and refractory asthma显示文摘 | Pamela R. Wood Vanessa L. Hill Margaret L. Burks Jay I. Peters Harjinder Singh Thirumalai R. Kannan Shruthi Vale Marianna P. Cagle Molly F.R. Principe Joel B. Baseman Edward G. Brooks | 2013 | Annals of Allergy Asthma & Immunology2013，，5： | 2 |
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