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| 1 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Eosinophilic Esophagitis in Adults is Associated with IgG4 and Not Mediated by IgE显示文摘 | Frederic Clayton John C. Fang Gerald J. Gleich Alfredo J. Lucendo Jose M. Olalla Laura A. Vinson Amy Lowichik Xinjian Chen Lyska Emerson Kristen Cox Molly A. O’Gorman Kathryn A. Peterson | 2014 | Gastroenterology2014，，： | 3 |
| 3 | Postoperative blood salvage and reinfusion in spinal surgery:blood quality,effectiveness and impact on patient blood parameters显示文摘 | Sebastian C Romero R Olalla E | 2000 | Eu Spine J2000，9，6： | 1 |
| 4 | Basic fibroblast growth factor promotes epidermal growth factor responsiveness and survival of mesencephalic neural precursor cell显示文摘 | Santa Olalla J Covarrubias L | 1999 | J Neurohiol1999，40，1： | 1 |
| 5 | Basic fibroblast growth factor promotes epidedemal growth factor responsiveness and survival of mesencephalic neural precursor cells显示文摘 | Santa Olalla J Covarrubias L | 1999 | J Neurobiol1999，40，1： | 1 |
| 6 | Transfusion of post-operative shed blood: laboratory characteristics and clinical utility显示文摘 | M. Mu?oz J. J. García-Vallejo M. D. Ruiz R. Romero E. Olalla C. Sebastián | 2004 | European Spine Journal2004，，1： | 1 |
| 7 | Ultimate Bearing Capacity of Rock Masses 显示文摘 | SERRANO A OLALLA C | 1994 | International Journal of Rock Mechanics and Mining Science1994，31，： | 1 |
| 8 | Measles in Spain:its move into the adult population显示文摘 | Pena Rey Lorenzo I Santa Olalla Peralta P Amela Heras C | 2004 | Aten Primaria2004，33，4： | 1 |
| 9 | The influence of intravenous drug use and HIV infection in the transmission of tuberculosis显示文摘 | Cayla JA Garcia de Olalla P Galdos-Tanguis H | 1996 | AIDS1996，10，： | 1 |
| 10 | Occurrence of raceand pathotypes of cucurbit powdery mildew in southeasternSpain显示文摘 | Pino D Olalla L Perez-Garda A | 2002 | Phytoparasitica2002，30，5： | 1 |
| 11 | Yield and size of deficit irrigated potatoes 显示文摘 | Fabeiro C de Santa Olalla F M de Juan J A | 2001 | Agric Water Manage2001，48，： | 1 |
| 12 | Transfusion of post-operative shed blood: laboratory characteristics and clinical utility显示文摘 | M. Mu?oz J. J. García-Vallejo M. D. Ruiz R. Romero E. Olalla C. Sebastián | 2004 | European Spine Journal2004，，1： | 1 |
| 13 | Yield and size of deficit irrigation potatoes显示文摘 | Fabeiro C Martin de Santa Olalla F J A de Juan | 2001 | Agricultural Water Management2001，48，： | 1 |
| 14 | Tensile resistance of rock and anchors显示文摘 | SERRANO A OLALLA C | 1999 | International Journal of Rock Mechanics and Mining Science1999，36，10： | 1 |
| 15 | Ultimate beating capacity at the tip of a pile in rock part 1:theory显示文摘 | SERRANO A OLALLA C | 2002 | International Journal of Rock Mechanics andMiningSeiences2002，39，7： | 1 |
| 16 | Short-term effects of extreme hot summer temperatures on total daily mortality in Barcelona,Spain显示文摘 | Tobías A de Olalla P G Linares C | | 0，，54： | 1 |
| 17 | Architectures and control of submodule integrated DC-DC converters for photovohaic applications 显示文摘 | Olalla C Clement D Rodriguez M | 2013 | IEEE Transactions on Pow- er Electronics2013，28，6： | 1 |
| 18 | Tensile resistance of rock anchor 显示文摘 | Serrano A Olalla C | 1999 | J Rock Mech Min Sci1999，，36： | 1 |
| 19 | Short-term effects of extreme hot summer temperatures on total daily mortality in Barcelona,Spain显示文摘 | Tobías A de Olalla P G Linares C | | 0，，02： | 1 |
| 20 | Ultimate bearing capacity of rock masses based on the modified Hoek-Brown criterion显示文摘 | SERRANO A OLALLA C GONZáLEZ J | 2000 | 37(6):1013-10182000，37，6： | 1 |
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