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| 1 | Contrast-enhanced ultrasound of the pancreas显示文摘The introduction of contrast-enhanced ultrasonography(CEUS) has led to major improvements in the diagnostic capabilities of ultrasound(US).The innovative use of CEUS for study of the pancreas has created the need for a definition of the most frequent dynamic features of solid and cystic masses.CEUS is less expensive compared to computed tomography and magnetic resonance imaging and is able to significantly improve the accuracy of US,allowing better characterization and staging of pancreatic pathologies. | Mirko D'Onofrio Anna Gallotti Francesco Principe Roberto Pozzi Mucelli | 2010 | World Journal of Radiology2010，2，3： | 8 |
| 2 | Seismic response of tall building considering soil-pile-structure interaction显示文摘The seismic behavior of tall buildings can be greatly affected by non-linear soil-pile interaction during strongearthquakes. In this study a 20-storey building is examined as a typical structure supported on a pile foundation for differentconditions: (1) rigid base, i.e. no deformation in the foundation: (2) linear soil-pile system; and (3) nonlinear soil-pile system.The effects of pile foundation displacements on the behavior of tall building are investigated, and compared with the behavior ofbuildings supported on shallow foundation. With a model of non-reflective boundary between the near field and far field,Novak's method of soil-pile interaction is improved. The computation method for vibration of pile foundations and DYNANcomputer program are introduced comprehensively. A series of dynamic experiments have been done on full-scale piles,including single pile and group, linear vibration and nonlinear vibration, to verify the validity of boundary zone model. | Han Yingcai Fluor Canada Ltd.,Calgary,AB,Canada Ph.D.,Principal Engineering Specialist | 2002 | Earthquake Engineering and Engineering Vibration2002，1，1： | 5 |
| 3 | LOCAL SCOUR AROUND BRIDGE ABUTMENTS显示文摘This paper summarizes the design equations for local scour depth around bridge abutments as proposed by different investigators, and also the different factors, affecting the scour depth. Methods for the estimation of local scour depth based on dimensional analysis are also presented. The design methods based on empirical relations such as flow depth, flow intensity, sediment characteristics, abutments shape and size, alignment, and approach channel geometry are also discussed. Since clear-water scour is the maximum scour depth, the equation for clear-water scour is recommended for the computation of local scour depth around bridge abutments for uniformly and non- uniformly graded sediments. | Er. Shri Ram CHAURASIA1 and Pande B.B. LAL2 1 Assistant Professor, Civil Engineering Department, Madan Mohan Malaviya Engineering College, Gorakhpur-273 010 (U.P.) India, 2 Dr., Principal, Mada | 2002 | International Journal of Sediment Research2002，17，1： | 5 |
| 4 | Mycoplasma pneumoniae in children with acute and refractory asthma显示文摘 | Pamela R. Wood Vanessa L. Hill Margaret L. Burks Jay I. Peters Harjinder Singh Thirumalai R. Kannan Shruthi Vale Marianna P. Cagle Molly F.R. Principe Joel B. Baseman Edward G. Brooks | 2013 | Annals of Allergy Asthma & Immunology2013，，5： | 2 |
| 5 | 重组大肠杆菌全细胞催化合成4-羟基异亮氨酸显示文摘4-羟基异亮氨酸(4-HIL)是一种很有前景的药物,它具有促进胰岛素分泌、改善外周组织对胰岛素的抵抗性和调节血脂异常等作用,而L-异亮氨酸羟化酶(IDO)常用于4-HIL的生产。首先,克隆了苏云金芽孢杆菌来源的L-异亮氨酸羟化酶,实现了其在E.coli BL21(DE3)中的异源表达。其次,通过同源建模和蛋白质结构分析,本着将与底物氨基酸侧链结合的氨基酸残基从亲水性或长链疏水性结构突变成丙氨酸Ala的原则,对I156位点进行了定点突变,以增大底物结合口袋,扩宽底物通遒进而提高4-HIL的产量。最后,对野生酶及突变酶的酶学性质、突变酶的羟基化反应体系进行研究,在最优催化条件下,分批补料转化底物进行4-HIL的生产。酶学性质结果显示,野生酶及突变酶I156A的最适温度均为25℃,最适pH均为7.0;突变酶I156A比酶活比野生酶提高了1.9倍,L-ILe转化率提高了28%。羟基化反应体系的最优转化条件为:20 mmol/L L-ILe,20 mmol/Lα-酮戊二酸,8 mmol/L Fe^(2+),30 mmol/L抗坏血酸和HEPES(50 mmol/L,pH 7.0)缓冲液。在最优转化条件下,重组菌E.coli BL21/pET28a-ido^(I156A)进行分批补料转化底物,时间间隔为4 h,32 h后得到77.3 mmol/L 4-HIL,底物最高转化率98.35%e。 | Umutumwa Eric Principe 乔郅钠 龙梦飞 邵明龙 徐美娟 杨套伟 张显 饶志明 | 2021 | 食品与生物技术学报2021，40，4： | 2 |
| 6 | Detection and classification of insect sounds in a grain silo using a neural network显示文摘 | Coggins K M Principe J | 1998 | IEEE Iht Conf Neural Networks Conf Proc IEEE Piscataway N J(USA)1998，3，： | 1 |
| 7 | Characterization of re- sistance mechanisms and genetic relatedness of carbapenem-resist- ant Acinetobacter baumannii isolated from blood, Italy显示文摘 | Migliavaeca R Espinal P Principe L | 2013 | Diagn Microbiol Infect Dis2013，75，2： | 1 |
| 8 | Prevalence of autism spectrum disorders-autism and develop mental disabilities monitoring network, 14 sites, United States, 2002显示文摘 | Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators Centers for Disease Control and Pre vention | 2007 | MMWR Surveill Summ2007，56，1： | 1 |
| 9 | Prognostic im- pact of ZAP-70 expression in chronic ly mphocytic leukemia:mean fluorescence intensity T/B ratio versus percentage of positive cells 显示文摘 | Rossi FM Del Principe MI Rossi D | 2010 | J Transl Med2010，3，8： | 1 |
| 10 | Design and Implementation of a Biologically Realistic Olfactory Cortex in Analog VLSI显示文摘 | Principe Jose C Tavares Vitor G Harris John G Freeman Walter J | 2001 | Proceedings of the IEEE2001，89，7： | 1 |
| 11 | Coronary Arter- y Surgery Study (CASS) : Arandomized trial of coronary artery by pass surgery显示文摘 | CASS Principal investigators and their associates | 1983 | Circulation1983，68，： | 1 |
| 12 | Influence of prognostic factors on the outcome of liver transplantation for hepatocellular carcinoma on cirrhosis:a univariate and multivariate analysis显示文摘 | Del Gaudio M Grazi GL Principe A | 2004 | Hepatogastroenterology2004，51，56： | 1 |
| 13 | Radical surgery for gall- bladder carcinoma : possibilities of survival 显示文摘 | Principe A Del-Gaudio M Ercolani G | 2006 | Hepatogastroenterolo- gy2006，53，71： | 1 |
| 14 | Information theoretic clustering显示文摘 | GOKCA E PRINCIPE I C | 2002 | IEEE Trans on Pattern Analysis and Machine Intelligence2002，24，2： | 1 |
| 15 | Toward Defining Spirituality显示文摘 | Waiter Principe | 1983 | Studies in Religion 121983，，2： | 1 |
| 16 | The Kernel least-meansquare algorithm 显示文摘 | Li Weifeng Pokharel P P Principe J C | 2008 | IEEE Trans on Signal Processing2008，5，2： | 1 |
| 17 | Revalence of autism spectrum disorders-Autism and Developmental Disabilities Monito- ring Newwork, 14 Sites, United States, 2002 显示文摘 | Autism and Developmental Disabilities Monitoring Newwork Sur-veilance Year 2002 Principal Investigators | 2007 | MMWR Surveill Summ2007，56，1： | 1 |
| 18 | The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration显示文摘 | WHO MONICA Project Principal Investigators | 1988 | J Clin Epidemiol1988，41，10： | 1 |
| 19 | Thin plate Splines and the Decomposition of Deformations显示文摘 | Bookstein F L Principal Warps | 1989 | IEEE Trans Pattern Anal Mach Intell1989，11，6： | 1 |
| 20 | An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent 显示文摘 | Nair SP Shiau DS Principe JC | 2009 | Exp Neurol2009，216，1： | 1 |
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