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| 1 | Bariatric surgery and long-term nutritional issues显示文摘Bariatric surgery is recognized as a highly effective therapy for obesity since it accomplishes sustained weight loss, reduction of obesity-related comorbidities and mortality, and improvement of quality of life. Overall, bariatric surgery is associated with a 42% reduction of the cardiovascular risk and 30% reduction of all-cause mortality. This review focuses on some nutritional consequences that can occur in bariatric patients that could potentially hinder the clinical benefits of this therapeutic option. All bariatric procedures, to variable degrees, alter the anatomy and physiology of the gastrointestinal tract; this alteration makes these patients more susceptible to developing nutritional complications, namely, deficiencies of macro-and micro-nutrients, which could lead to disabling diseases such as anemia, osteoporosis, protein malnutrition. Of note is the evidence that most obese patients present a number of nutritional deficits already prior to surgery, the most important being vitamin D and iron deficiencies. This finding prompts the need for a complete nutritional assessment and, eventually, an adequate correction of pre-existing deficits before surgery. Another critical issue that follows bariatric surgery is post-operative weight regain, which is commonly associated with the relapse of obesity-related comorbidities. Nu-tritional complications associated with bariatric surgery can be prevented by life-long nutritional monitoring with the administration of multivitamins and mineral supplements according to the patient's needs. | Roberta Lupoli Erminia Lembo Gennaro Saldalamacchia Claudia Kesia Avola Luigi Angrisani Brunella Capaldo | 2017 | World Journal of Diabetes2017，8，11： | 8 |
| 2 | American Gastroenterological Association Medical Position Statement on Constipation显示文摘 | Adil E. Bharucha Spencer D. Dorn Anthony Lembo Amanda Pressman | 2013 | Gastroenterology2013，，1： | 3 |
| 3 | Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue显示文摘AIM: To evaluate the intestinal motility changes evoked by 8 bacterial strains belonging to Bifidobacterium , Lactobacillus and Streptococcus genera within the probiotic preparation VSL#3. METHODS: Ileum and proximal colon segments isolated from guinea-pigs were used as a study model. Entire cells and cell fractions (cell debris, cell wall fraction, cytoplasmatic fraction, proteinaceous and non- proteinaceous cytoplasmatic components) of VSL#3 strains and, as controls, Escherichia coli, Salmonella aboni and Bacillus licheniformis were tested in this in vitro model. RESULTS: Among the bacterial cell fractions tested, only the cytoplasmatic fraction modified intestinal motility. Lactobacillus strains stimulated the contraction of ileum segment, whereas all probiotic strains tested induced proximal colon relaxation response. The non-proteinaceous cytoplasmatic components were responsible for the colon relaxation. CONCLUSION: The results obtained in this study suggest that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in regulating intestinal motility. | Matteo Massi Pierfranco Ioan Roberta Budriesi Alberto Chiarini Beatrice Vitali Karen M Lammers Paolo Gionchetti Massimo Campieri Anthony Lembo Patrizia Brigidi | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 4 | Efficacy of Linaclotide for Patients With Chronic Constipation显示文摘 | Anthony J. Lembo Caroline B. Kurtz James E. MacDougall B.J. Lavins Mark G. Currie Donald A. Fitch Brenda I. Jeglinski Jeffrey M. Johnston | 2010 | Gastroenterology2010，，3： | 3 |
| 5 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 6 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 7 | The Crohn’s disease activity index (CDAI) is similarly elevated in patients with Crohn’s disease and in patients with irritable bowel syndrome显示文摘 | C. Lahiff P. Safaie A. Awais M. Akbari L. Gashin S. Sheth A. Lembo D. Leffler A. C. Moss A. S. Cheifetz | 2013 | Aliment Pharmacol Ther2013，，8： | 2 |
| 8 | Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea‐predominant IBS显示文摘 | F. Cremonini J. P. Nicandro V. Atkinson R. Shringarpure E. Chuang A. Lembo | 2012 | Aliment Pharmacol Ther2012，，5： | 2 |
| 9 | Inpatient burden of childhood functional GI disorders in the USA: an analysis of national trends in the USA from 1997 to 2009显示文摘 | R. Park S. Mikami J. LeClair A. Bollom C. Lembo S. Sethi A. Lembo M. Jones V. Cheng E. Friedlander S. Nurko | 2015 | Neurogastroenterol. Motil2015，，5： | 2 |
| 10 | Efficacy of linaclotide for patients with chronic constipation显示文摘 | Lembo AJ Kurtz CB Macdougall JE | 2010 | Gastroenterology2010，138，3： | 1 |
| 11 | Chronic constipation显示文摘 | Lembo A Camilleri M | 2003 | N Engl J Med2003，349，14： | 1 |
| 12 | Helicobacter pylori regulates iNOS promoter by histone modifications in human gastric epithelial cells显示文摘 | Tiziana Angrisano Francesca Lembo Silvia Peluso Simona Keller Lorenzo Chiariotti Raffaela Pero | 2012 | Medical Microbiology and Immunology2012，，： | 1 |
| 13 | Linking data to ontologies 显示文摘 | Poggi A Lembo D Calvanese D | 2008 | Journal on Data Semantics2008，，： | 1 |
| 14 | Prevalence of textile dye contact sensitization 显示文摘 | BALATO N LEMBO G AVALA F | 1990 | Contact Dermatitis1990，23，： | 1 |
| 15 | The murine homolog of the HIN-200 family, Ifi204, is constitutively expressed in myeloid cells and selectively induced in the monocyte/macrophage lineage显示文摘 | Gariglio M De Andrea M Lembo M | 1998 | J Leukoc Biol1998，64，5： | 1 |
| 16 | Proenkephalin Agene products activate a new family of sensory neuron-specificGPCRs显示文摘 | Lembo P M Grazzini E Groblewski T | 2002 | Nat Neurosci2002，5，3： | 1 |
| 17 | Leptin induces direct vasodilation through distinct endothelial mechanisms显示文摘 | Lembo G Vecchione C Fratta L | | 0，，2： | 1 |
| 18 | Influence of genetics on ir- ritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: A twin study 显示文摘 | LEMBO A ZAMAN M JONES M | 2007 | Aliment Pharmacol Ther2007，25，11： | 1 |
| 19 | Gas- tric volvulus associated with congenital diaphragmatic her- nia, wandering spleen, and intrathoracic left kidney: CT findings显示文摘 | PELIZZO G LEMBO M A FRANCHELLA A | 2001 | Abdom Imaging2001，26，3： | 1 |
| 20 | Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy显示文摘 | Tarone G Lembo G | 2003 | Trends Mol Med2003，9，9： | 1 |
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