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| 1 | Bone Regeneration Based on Tissue Engineering Conceptions – A 21st Century Perspective显示文摘The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades.Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction.However,improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity.Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.Specifically,novel bioactive(second generation)biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment,whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue.Future generations of biomaterials(third generation)are designed to be not only osteoconductive but also osteoinductive,i.e.to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications.These techniques will lead to novel possibilities for tissue regeneration and repair.At present,tissue engineered constructs that may find future use as bone grafts for complex skeletal defects,whether from post-traumatic,degenerative,neoplastic or congenital/developmental'origin'require osseous reconstruction to ensure structural and functional integrity.Engineering functional bone using combinations of cells,scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties.This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts. | Jan Henkel Maria A.Woodruff Devakara R.Epari Roland Steck Vaida Glatt Ian C.Dickinson Peter F.M.Choong Michael A.Schuetz Dietmar W.Hutmacher | 2013 | Bone Research2013，1，3： | 33 |
| 2 | Age-related changes in seminal polymorphonuclear elastase in men with asymptomatic inflammation of the genital tract显示文摘瞄准:在男生殖道调查年龄相关的煽动性的事件。方法:总共 4 265 随机收集了出席的中心的 andrologicaloutpatient 诊所的病人皮肤学和 Andrology , Giessen 的大学,德国,精液体积,pH值,精子集中,总数和进步精子活动性, polymorphonuclear ( PMN )的集中弹性硬蛋白酶,peroxidase积极的房间和fructose 的数字被测量并且与病人的年龄相关。结果:当精液体积,活动性和 fructose 都与年龄否定地相关时,精子集中, PMN 弹性硬蛋白酶和 pH 值显示出积极关联。男生殖道发炎的流行(是由 PMN 弹性硬蛋白酶 >
250ng/mL 定义) 并且它的严厉显著地增加了。PMN 弹性硬蛋白酶没与精子活动性相关。尽管精囊功能的一个标记与 PMN 弹性硬蛋白酶层次 Fructose, peroxidase 积极的房间的数字和精子活动性显示出一种重要否定关系。结论:PMN 弹性硬蛋白酶层次的 Thesignificant 增加作为在老人的男生殖道发炎的标记看起来在本地免疫的年龄相关的变化指示规章的机制。Becausethere 不是有精子活动性的 PMN 弹性硬蛋白酶的协会,这酶的直接禁止的效果能被排除。 | Raft Henkel Gesa Maaβ Andreas Jung Gerhard Haidl Wolf-Bernhard Schill Hans-Christian Schuppe | 2007 | Asian Journal of Andrology2007，9，3： | 16 |
| 3 | Expanding etiology of progressive familial intrahepatic cholestasis显示文摘BACKGROUND Progressive familial intrahepatic cholestasis(PFIC)refers to a disparate group of autosomal recessive disorders that are linked by the inability to appropriately form and excrete bile from hepatocytes,resulting in a hepatocellular form of cholestasis.While the diagnosis of such disorders had historically been based on pattern recognition of unremitting cholestasis without other identified molecular or anatomic cause,recent scientific advancements have uncovered multiple specific responsible proteins.The variety of identified defects has resulted in an ever-broadening phenotypic spectrum,ranging from traditional benign recurrent jaundice to progressive cholestasis and end-stage liver disease.AIM To review current data on defects in bile acid homeostasis,explore the expanding knowledge base of genetic based diseases in this field,and report disease characteristics and management.METHODS We conducted a systemic review according to PRISMA guidelines.We performed a Medline/PubMed search in February-March 2019 for relevant articles relating to the understanding,diagnosis,and management of bile acid homeostasis with a focus on the family of diseases collectively known as PFIC.English only articles were accessed in full.The manual search included references of retrieved articles.We extracted data on disease characteristics,associations with other diseases,and treatment.Data was summarized and presented in text,figure,and table format.RESULTS Genetic-based liver disease resulting in the inability to properly form and secrete bile constitute an important cause of morbidity and mortality in children and increasingly in adults.A growing number of PFIC have been described based on an expanded understanding of biliary transport mechanism defects and the development of a common phenotype.CONCLUSION We present a summary of current advances made in a number of areas relevant to both the classically described FIC1(ATP8B1),BSEP(ABCB11),and MDR3(ABCB4)transporter deficiencies,as well as more recently described gene mutations--TJP2(TJP2),FXR(NR1H4),MYO5B(MYO5B),and others which expand the etiology and understanding of PFIC-related cholestatic diseases and bile transport. | Sarah AF Henkel Judy H Squires Mary Ayers Armando Ganoza Patrick Mckiernan James E Squires | 2019 | World Journal of Hepatology2019，11，5： | 13 |
| 4 | Leukocytes and oxidative stress: dilemma for sperm Function and male fertility显示文摘精子常常通过反应的氧的高数量暴露于在氧化之间的分裂期间种类(ROS ) 和白血球,和借助于 scavengers 和抗氧化剂的减小。认为是有如此的高度的唯一的房间的特殊功能是极化并且在身体外面施加他们的功能,甚至在一个不同个人,女生殖道,这些房间的膜化学上由多元不堡和的非凡的高数量组成丰满的酸。这接着,使他们变为很易受影响到氧化应力,它向氧化地位被定义为在氧化和减小之间的不平衡。作为结果,源于白血球和房间自己引起一个过程的男细菌的 ROS 把鈥榣i pid peroxidation 称为到精子房间的鈥 ? 和另外的损坏。在另一方面, ROS 的某个有限数量是必要的以便在房间触发重要生理的反应,包括在精子的 capacitation 或 acrosome 反应。当不受管束的抗氧化的治疗可能出轨,有氧化地位由氧化应力引起了补偿的抗氧化剂的病人的治疗高度被辩论向减少的地位的系统,它也是 unphysiological 并且能甚至导致癌症。这悖论被称为鈥榓n tioxidant 悖论鈥吗?因此,合适的 andrological 包括 ROS 层次的评估和精液的抗氧化剂能力,诊断病情的检查不得不预先被执行,瞄准了维持在氧化之间的好平衡并且 ROS 的重要数量清除。 | Ralf R Henkel | 2011 | Asian Journal of Andrology2011，13，1： | 12 |
| 5 | Bibliometrics: tracking research impact by selecting Lhe appropriate metrics显示文摘 | Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 6 | Sperm preparation: state-of-the-art--physiological aspects and application of advanced sperm preparation methods显示文摘为帮助繁殖技术(艺术) ,众多的技术被开发孤立能够使肥沃的精子卵母细胞。当早方法论仅仅集中了于孤立可行、能动精子时,与艺术的进步,特别地 intracytoplasmic 精子注射(ICSI ) ,这些参数为为授精的最合适的精子的鉴定是不够的,变得清楚。常规精子准备技术,也就是游泳起来,密度坡度 centrifugation 和玻璃羊毛过滤,不是足够有效的没有 DNA 损坏生产精子人口,因为这些技术不在紧精子上生理、不建模,选择处理发生在女生殖道。这些过程仅仅允许从百万中的十个的一个男细菌房间与卵母细胞熔化。在女生殖道的精子选择的地点是宫颈,子宫, uterotubal 连接,输卵管,丘 oophorus 和带 pellucida。精子准备的更新的策略上被成立:(i) 借助于 ‘ 的词法评价;能动精子细胞器词法检查(MSOME ) “(ii ) 电的充电;并且(iii ) 精子房间的分子的有约束力的特征。而分离方法基于电的充电利用精子的坚持到试管表面或在电气泳动分开,分子的有约束力的技术使用 Annexin V 或玻尿的酸(哈) 作为底层。在这个范畴的技术是激活磁铁的房间排序,为从哈涂的盘子和哈包含媒介的 ICSI (PICSI ) 的 Annexin 激活 V 的玻璃羊毛过滤,流动 cytometry 和拣的精子。未来开发可以包括拉曼 microspectrometry,共焦的轻吸收和散布分光镜的显微镜学和极化显微镜学。 | Ralf Henkel | 2012 | Asian Journal of Andrology2012，14，2： | 4 |
| 7 | 非线性器件的建模与测试显示文摘1引言
在快速发展、竞争激烈的非线性设计领域,能够用最短的时间将新器件技术转变为最终产品的能力是公司取得成功的关键。近来发展最好的方法是使用行为模型。此方法与相关测试测量方案的优点相结合,可以极大地缩短产品设计周期。 | Tudor Williams Randeep Saini Simon Mathias Andreas Henkel | 2015 | 国外电子测量技术2015，34，8： | 4 |
| 8 | Analysis of genomic rearrangement and subsequent gene deletion of the attenuated Orf virus strain D1701显示文摘 | Rosita Cottone Mathias Büttner Berthilde Bauer Marco Henkel Eduard Hettich Hanns-Joachim Rziha | 1998 | Virus Research1998，，1： | 3 |
| 9 | Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial显示文摘 | Jonathan M. Spergel Marc E. Rothenberg Margaret H. Collins Glenn T. Furuta Jonathan E. Markowitz George Fuchs Molly A. O’Gorman Juan Pablo Abonia James Young Timothy Henkel H. Jeffrey Wilkins Chris A. Liacouras | 2012 | The Journal of Allergy and Clinical Immunology2012，，： | 3 |
| 10 | Critical evaluation of two models of flow cytometers for the assessment of sperm DNA fragmentation:an appeal for performance verification显示文摘Lack of standardized,reproducible protocols and referencO values is among the challenges faced when using new or upgraded versions of instruments in reproductive laboratories and flow cytometry.Terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay combined with flow cytometry routinely used for diagnostic measurement of sperm DNA fragmentation(SDF)is a unique example.Any change in the setting of the standard instrument,including upgrades of hardware or software,can lead to different results and may affect clinicians'decision for treatment.Therefore,we compared TUNEL results of SDF obtained from a standard(C6)flow cytometer with a newer version of the same instrument(C6 Plus)and examined the cutoff,sensitivity,and specificity without calibration(adjustment)and after adjustment.Identical sperm preparation and matched acquisition settings were used to examine the performance of two flow cytometers.The strength of agreement of the results between the two observers was also assessed.After adjustment of the settings,overall concordance became high and the two cytometers showed 100%positive and negative predictive value with 100%area under the curve.The overall correlation coefficient observed between C6 and C6 Plus was highly significant(P<0.0001;r=0.992;95%confidence interval[Cl]:0.982-0.997).After adjustment,the two cytometers showed very high precisi on of 98%and accuracy of>99%.The in terobserver agreeme nt on C6 flow cytometer for the two observers was 0.801±0.062 and 0.746±0.044 for C6 Plus.We demonstrated a strong agreement between the samples tested on the two flow cytometers after calibration and established the robustness of both instruments. | Rakesh Sharma Sajal Gupta Ralf Henkel Ashok Agarwal | 2019 | Asian Journal of Andrology2019，21，5： | 3 |
| 11 | The new 6^(th) edition of the WHO Laboratory Manualfor the Examination and Processing of HumanSemen: is it a step toward better standard operatingprocedure?显示文摘Semen analysis(SA)remains the cornerstone of male infertility evaluation and should ideally be performed by an accredited andrology laboratory or in vitro fertilization(IVF)clinics based on the standards defined by the World Health Organization(WHO)for the Examination and Processing of Human Semen and in accordance with the International Organization for Standardization’s Basic Semen Examination on Specification and Test Methods. | Eric Chung Mohamed Arafa Florence Boitrelle Hussein Kandil Ralf Henkel Ramadan Saleh Rupin Shah Paraskevi Vogiatzi Armand Zini Ashok Agarwal | 2022 | Asian Journal of Andrology2022，24，2： | 2 |
| 12 | Monitoring concrete reinforced with bonded surface plates by the acoustic emission method显示文摘 | Henkel DP Wood JD | 1991 | NDT & E International1991，24，5： | 2 |
| 13 | 从天然提取物或分离部位中以碳酸酐酶II为靶点的抗骨质疏松活性筛选(英文)显示文摘目的是以碳酸酐酶II (CAII)为靶点筛选其抑制剂 ,以期寻找抗骨质疏松活性样品。实验是在 96孔酶标板上对来源于 1 78个科、 60 8个属、 1 0 2 0种动植物 2 91 9个提取物或分离部位样品在CA II模型上进行了批量筛选。结果表明在 1 0 μg ml浓度下发现了来源于 40个科、61个属、72个种的 1 0 0个样品有活性 ,其中 5个样品的IC50 小于 2 50 μg ml,2 2个样品的IC50 在 2 51~ 5 0 0 μg ml范围 ,73个样品的IC50 在 5 0 1~1 0 0 0 μg ml范围。通过以上工作我们认为以碳酸酐酶II为分子靶点的体外筛选方法稳定、方便、快速、微量、有效 ,特别适用于天然产物的抗骨质疏松活性筛选。 | 付祥 谭宁华 姜立花 贾锐锐 嵇长久 LANDRO James FEKETE Alexander MUELLER Hartwig HENKEL Thomas | 2003 | 云南植物研究2003，25，6： | 2 |
| 14 | Profiting from voluntary information spillovers: how users benefit by freely revealing their innovations显示文摘 | Dietmar Harhoff Joachim Henkel Eric von Hippel | 2003 | Research Policy2003，，10： | 2 |
| 15 | Selective revealing in open innovation processes: The case of embedded Linux显示文摘 | Joachim Henkel | 2006 | Research Policy2006，，7： | 2 |
| 16 | Sperm separation in patients with urogenital infections显示文摘 | Schill WB | 1998 | Andrologia1998，30，1： | 1 |
| 17 | Effect and safety of high-dose dienogest (20 mg/day) in the treatment of women with endometriosis显示文摘 | SCHINDLER AE HENKEL A MOORE C | 2010 | Arch Gynecol Obstet2010，282，5： | 1 |
| 18 | Anthoeyanin biosynthesis in distinct genoty Pes of China aster (Calliste Phuschinensis ) 显示文摘 | HENKEL J FORKMANN G MIN B W | 1998 | Acta Hortieulturae1998，508，： | 1 |
| 19 | Subclin-ical inflammation in newly detected Type Ⅱ diabetes and impaired glucose tolerance显示文摘 | Temelkova-Kurktschiev T Henkel E Koehler C | 2002 | Diabetologia2002，45，1： | 1 |
| 20 | Function and activation of NF-kappaB in the immune system显示文摘 | BAEUERLE P A HENKEL T | 1994 | Annual Review of Immunology1994，12，1： | 1 |
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