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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | An integrated system for planning, navigation and robotic assistance for skull base surgery显示文摘BACKGROUND: We developed an image-guided robot system to provide mechanical assistance for skull base drilling,which is performed to gain access for some neurosurgical interventions, such as tumour resection. The motivation for introduc-ing this robot was to improve safety by preventing the surgeon from accidentally damaging critical neurovascular structures dur- | Baird C Jallo G Hayes K Nakajima N Hata N Kazanzides P | 2008 | 中国神经肿瘤杂志2008，6，3： | 6 |
| 3 | The current status of nitrogen fertiliser use efficiency and future research directions for the Australian cotton industry显示文摘Fifty years of sustained investment in research and development has left the Australian cotton industry well placed to manage nitrogen(N) fertiliser. The average production in the Australian cotton industry today is greater than two tonnes of lint per hectare due to improved plant genetics and crop management. However, this average yield is well below the yield that would be expected from the amount of N fertiliser used. It is clear from the recent studies that across all growing regions, conversion of fertiliser N into lint is not uniformly occurring at application rates greater than 200-240 kg·hm^(-2) of N. This indicates that factors other than N availability are limiting yield, and that the observed nitrogen fertiliser use efficiency(NFUE) values may be caused by subsoil constraints such as sodicity and compaction. There is a need to investigate the impact of subsoil constraints on yield and NFUE.Gains in NFUE will be made through improved N fertiliser application timing, better targeting the amount of fertiliser applied for the expected yield, and improved soil N management. There is also a need to improve the ability and confidence of growers to estimate the contribution of soil N mineralisation to the crop N budget. Many Australian studies including data that could theoretically be collated in a meta-analysis suggest relative NFUE values as a function of irrigation technique; however, with the extensive list of uncontrolled variables and few studies using non-furrow irrigation, this would be a poor substitute for a single field-based study directly measuring their efficacies. In irrigated cotton, a re-examination of optimal NFUE is due because of the availability of new varieties and the potential management and long-term soil resilience implications of the continued removal of mineralised soil N suggested by high NFUE values. NFUE critical limits still need to be derived for dryland systems. | MACDONALD Ben C.T. LATIMER James O. SCHWENKE Graeme D. NACHIMUTHU Gunasekhar BAIRD Jonathan C. | 2018 | Journal of Cotton Research2018，1，3： | 5 |
| 4 | Deep Scalogram Representations for Acoustic Scene Classification显示文摘Spectrogram representations of acoustic scenes have achieved competitive performance for acoustic scene classification. Yet, the spectrogram alone does not take into account a substantial amount of time-frequency information. In this study, we present an approach for exploring the benefits of deep scalogram representations, extracted in segments from an audio stream. The approach presented firstly transforms the segmented acoustic scenes into bump and morse scalograms, as well as spectrograms; secondly, the spectrograms or scalograms are sent into pre-trained convolutional neural networks; thirdly,the features extracted from a subsequent fully connected layer are fed into(bidirectional) gated recurrent neural networks, which are followed by a single highway layer and a softmax layer;finally, predictions from these three systems are fused by a margin sampling value strategy. We then evaluate the proposed approach using the acoustic scene classification data set of 2017 IEEE AASP Challenge on Detection and Classification of Acoustic Scenes and Events(DCASE). On the evaluation set, an accuracy of 64.0 % from bidirectional gated recurrent neural networks is obtained when fusing the spectrogram and the bump scalogram, which is an improvement on the 61.0 % baseline result provided by the DCASE 2017 organisers. This result shows that extracted bump scalograms are capable of improving the classification accuracy,when fusing with a spectrogram-based system. | Zhao Ren Kun Qian Zixing Zhang Vedhas Pandit Alice Baird Bjorn Schuller | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，3： | 4 |
| 5 | An unusual emergency department case: ruptured ectopic pregnancy presenting as chest pain显示文摘INTRODUCTION Ectopic pregnancy occurs at a rate of 1%–2%of all pregnancies,and tends to occur at a higher rate(up to4%)in patients receiving fertility treatments.[1]Women with ectopic pregnancies are often asymptomatic or may complain of amenorrhea,vaginal spotting,and lower abdominal cramping pain.They may also report common symptoms of early pregnancy such as nausea,vomiting, | Eric Dichter James Espinosa James Baird Alan Lucerna | 2017 | World Journal of Emergency Medicine2017，8，1： | 4 |
| 6 | Modification and characterization of fibers of three sandy willow shrub species显示文摘Periploca sepium, Salix psammophila and Tamarix spp. make up an important part of the local vegetation in the sandland of China. This paper described a novel method on modification of the three shrub fibers as oil sorbents. Natural and modified fibers were chemically studied by non-destructive methods, infrared spectroscopy (IR) and cross-polarization nuclear magnetic resonance (CP-MAS 13C-NMR). The results show that during the reaction with acetic anhydride under mild conditions, the use of N-bromoscciniamide (NBS) catalyst resulted in a high weight percent gain (WPG). The acetylation of P. sepium fiber gave rise to the highest WPG (20.0%) compared with S. psammophila and Tamarix spp. fiber. IR and CP-MAS 13C-NMR analysis elaborates the chemical features of natural and acetylated willow fiber in detail. | Sun Xiao-feng Xiao Bin Mark S. Baird | 2006 | Forestry Studies in China2006，8，3： | 3 |
| 7 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 8 | Sandwich injection-molding of thermotropic copolyesters and filled polyester 显示文摘 | Baird D G Wilkes G L | 1983 | Polym Eng Sci1983，23，11： | 2 |
| 9 | Recent advances and future directions for the pharmacogenetic basis of anti-VEGF treatment response in neovascular age-related macular degeneration显示文摘Age related macular degeneration(AMD)is a complex progressive neurodegenerative disease causing blindness in 30–35 million people worldwide.It affects the macula region of the retina leading to severe vision loss and legal blindness in individuals>50 years of age(Wong et al.,2014).The precise aetiology of AMD is unknown but smoking,age and genetic factors are major risk factors for AMD predisposition(Ding et al.,2009). | Moeen Riaz Paul N. Baird | 2017 | Neural Regeneration Research2017，12，4： | 2 |
| 10 | Evidence-based guideline: Treatment of parenchymal neurocysticercosis: Report of the Guideline Development Subcommittee of the American Academy of Neurology显示文摘 | Ruth Ann Baird Sam Wiebe Joseph R. Zunt John J. Halperin Gary Gronseth Karen L. Roos | 2013 | Neurology2013，，15： | 2 |
| 11 | Posterolateral Transfibular Approach to Tibial Plateau Fractures: Technique, Results, and Rationale显示文摘 | Lucian B Solomon Aaron W Stevenson Robert P V Baird Anthony P Pohl | 2010 | Journal of Orthopaedic Trauma2010，，8： | 2 |
| 12 | Seismic performance of non-structural components and contents in buildings: an overview of NZ research显示文摘This paper summarizes the research on non-structural elements and building contents being conducted at University of Canterbury in New Zealand.Since the 2010-2011 series of Canterbury earthquakes,in which damage to non-structural components and contents contributed heavily to downtime and overall financial loss,attention to seismic performance and design of non-structural components and contents in buildings has increased exponentially in NZ.This has resulted in an increased allocation of resources to research leading to development of more resilient non-structural systems in buildings that would incur substantially less damage and cause little downtime during earthquakes.In the last few years,NZ researchers have made important developments in understanding and improving the seismic performance of secondary building elements such as partitions,facades,ceilings and contents. | Rajesh P Dhakal Atefeh Pourali Ali Sahin Tasligedik Trevor Yeow Andrew Baird Gregory Mac Rae Stefano Pampanin Alessandro Palermo | 2016 | Earthquake Engineering and Engineering Vibration2016，15，1： | 2 |
| 13 | Are fibre supplements really necessary in diverticular disease of the colon? A controlled clinical trial显示文摘 | Ornstein MH Littlewood ER Baird IM | 1981 | BMJ1981，282，： | 1 |
| 14 | Adherence to cardiac therapy for men with coronary artery disease显示文摘 | Baird K-K & Pierce L-L | 2001 | Rehabil-Nurs2001，26，6： | 1 |
| 15 | Selective elimination of fibroblasts from pancreatic islet monolayers by basic fibroblast growth factor-saporin mitotoxin显示文摘 | Lappi DA Baird A | 1990 | Diabetes1990，39，8： | 1 |
| 16 | Surgical aspect of regional myocardial blood flow and myocardial pressure 显示文摘 | Dutka F Okumari M etal | 1975 | J Thorac Cardiovasc Surg1975，69，： | 1 |
| 17 | The inhibitors of apoptosis (IAPs) and their emerging role in cancer 显示文摘 | Baird S Komeluk RG | 1998 | Oncogene1998，17，25： | 1 |
| 18 | Cardiac disease in pregnancy显示文摘 | Arafeh JM Baird SM | 2006 | Crit Care Nuts Q2006，29，1： | 1 |
| 19 | Expression of chondrocyte markers by cells of normal and degenerate inter-vertebral discs显示文摘 | Sive JI Baird P Jeziorsk M | 2002 | Mol Pathol2002，55，2： | 1 |
| 20 | Application of PCR to the identification of dermatophyte fungi 显示文摘 | LIU D COLOE S BAIRD R | 2000 | J Med Microbiol2000，49，2000： | 1 |
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