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| 1 | Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection显示文摘Chemokines produced in the liver during hepatitis C virus(HCV) infection induce migration of activated T cells from the periphery to infected parenchyma.The milieu of chemokines secreted by infected hepatocytes is predominantly associated with the T-helper cell/Tc1 T cell(Th1/Tc1) response.These chemokines consist of CCL3(macrophage inflammatory protein-1α;MIP-1α),CCL4(MIP-1β),CCL5(regulated on activation normal T cell expressed and secreted;RANTES),CXCL10(interferon-γ-inducible protein-10;IP-10),CXCL11(interferon-inducible T-cell α chemoattractant;I-TAC),and CXCL9(monokine induced by interferon γ;Mig) and they recruit T cells expressing either CCR5 or CXCR3 chemokine receptors.Intrahepatic and peripheral blood levels of these chemokines are increased during chronic hepatitis C.The interaction between chemokines and their receptors is essential in recruiting HCV-specific T cells to control the infection.When the adaptive immune response fails in this task,non-specific T cells without the capacity to control the infection are also recruited to the liver,and these are ultimately responsible for the persistent hepatic damage.The modulation of chemokine receptor expression and chemokine secretion could be a viral escape mechanism to avoid specific T cell migration to the liver during the early phase of infection,and to maintain liver viability during the chronic phase,by impairing non-specific T cell migration.Some chemokines and their receptors correlate with liver damage,and CXCL10(IP-10) and CXCR3 levels have shown a clinical utility as predictors of treatment response outcome.The regulation of chemokines and their receptors could be a future potential therapeutic target to decrease liver inflammation and to increase specific T cell migration to the infected liver. | Juan R Larrubia Selma Benito-Martínez Miryam Calvino Eduardo Sanz-de-Villalobos Trinidad Parra-Cid | 2008 | World Journal of Gastroenterology2008，14，47： | 13 |
| 2 | Pathogenesis of H elicobacter pylori Infection显示文摘 | Trinidad Parra Cid Miryam Calvino Fernández Selma Benito Martínez Nicola L. Jones | 2013 | Helicobacter2013，，： | 4 |
| 3 | Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C显示文摘Hepatitis C virus (HCV)-specific CD8+ T cells play an important role in the resolution of HCV infection. Nevertheless, during chronic hepatitis C these cells lack their effector functions and fail to control the virus. HCV has developed several mechanisms to escape immune control. One of these strategies is the upregulation of negative co-stimulatory molecules such us programmed death-1 (PD-1). This molecule is upregulated on intrahepatic and peripheral HCV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HCV-specific CD8+ T cells are exhausted with impairment of several effector mechanisms, such as: type-1 cytokine production, expansion ability after antigen encounter and cytotoxic ability. However, PD-1 associated exhaustion can be restored by blocking the interaction between PD-1 and its ligand (PD-L1). After this blockade, HCV-specificCD8+ T cells reacquire their functionality. Nevertheless, functional restoration depends on PD-1 expression level. High PD-1-expressing intrahepatic HCV-specific CD8+ T cells do not restore their effector abilities after PD-1/PD-L1 blockade. The mechanisms by which HCV is able to induce PD-1 up-regulation to escape immune control are unknown. Persistent TCR stimulation by a high level of HCV antigens could favour early PD-1 induction, but the interaction between HCV core protein and gC1q receptor could also participate in this process. The PD-1/PD-L1 pathway modulation could be a therapeutic strategy, in conjunction with the regulation of others co-stimulatory pathways, in order to restore immune response against HCV to succeed in clearing the infection. | Juan Ramón Larrubia Selma Benito-Martínez Joaquín Miquel Miryam Calvino Eduardo Sanz-de-Villalobos Trinidad Parra-Cid | 2009 | World Journal of Gastroenterology2009，15，41： | 3 |
| 4 | Humoral Response to Recombinant Hepatitis B Virus Vaccine at Birth: Role of HLA and Beyond显示文摘 | Miryam Martinetti Annalisa De Silvestri Cesare Belloni Annamaria Pasi Carmine Tinelli Angela Pistorio Laura Salvaneschi Giorgio Rondini Maria Antonia Avanzini Mariaclara Cuccia | 2000 | Clinical Immunology2000，，： | 2 |
| 5 | Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity显示文摘 | Bindhu Madhavan Shijing Yue Uwe Galli Sanyukta Rana Wolfgang Gross Miryam Müller Nathalia A. Giese Holger Kalthoff Thomas Becker Markus W Büchler Margot Z?ller | 2015 | Int. J. Cancer2015，，11： | 2 |
| 6 | Retranslation of children's books as ev- idence of changes of norms显示文摘 | Du- Nour Miryam | 1995 | Target1995，7，2： | 1 |
| 7 | Neoformation of antioxidants in glycation model systems treated under subcriticalwater extraction conditions 显示文摘 | Merichel P Miryam A B Maria D C | 2010 | Food Research International2010，43，： | 1 |
| 8 | Retranslation of chil- dren' s books as evidence of changes of norms 显示文摘 | Du -Nour Miryam | 1995 | Target1995，7，2： | 1 |
| 9 | Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1 + /CD127 ? HCV-specific CD8 + cells targeting the virus in chronic hepatitis C virus infection显示文摘 | Juan R. Larrubia Selma Benito-Martínez Joaquín Miquel Miryam Calvino Eduardo Sanz-de-Villalobos Alejandro González-Praetorius Sonia Albertos Silvia García-Garzón Megha Lokhande Trinidad Parra-Cid | 2011 | Cellular Immunology2011，，2： | 1 |
| 10 | Celiac disease in children with autoimmune thyroid disease显示文摘 | Daniela Larizza Valeria Calcaterra Costantino De Giacomo Annalisa De Silvestri Margherita Asti Carla Badulli Michele Autelli Eliana Coslovich Miryam Martinetti | 2001 | The Journal of Pediatrics2001，，5： | 1 |
| 11 | Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1 + /CD127 ? HCV-specific CD8 + cells targeting the virus in chronic hepatitis C virus infection显示文摘 | Juan R. Larrubia Selma Benito-Martínez Joaquín Miquel Miryam Calvino Eduardo Sanz-de-Villalobos Alejandro González-Praetorius Sonia Albertos Silvia García-Garzón Megha Lokhande Trinidad Parra-Cid | 2011 | Cellular Immunology2011，，2： | 1 |
| 12 | Common immunogenetic profile in children with multiple autoimmune diseases: the signature of HLA-DQ pleiotropic genes显示文摘 | Daniela Larizza Valeria Calcaterra Catherine Klersy Carla Badulli Claudia Caramagna Antonio Ricci Paola Brambilla Laura Salvaneschi Miryam Martinetti | 2012 | Autoimmunity2012，，6： | 1 |
| 13 | Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway显示文摘 | Gabor Hbrvath Nathalie Schmid Miryam A Fragoso | 2007 | Am J Respir Cell Mol Biol2007，36，： | 1 |
| 14 | Copper isotope fractionation in sedimentary copper mineralization (Timna Valley,Israel)显示文摘 | Asael Dan Alan Matthews Miryam Bar-Matthe-ws | 2007 | Chem Geol2007，243，： | 1 |
| 15 | Bilateral ectopicpregnancy显示文摘 | De Los Ríos JF Castaeda JD Miryam A | 2007 | J Minim Invasive Gynecol2007，14，4： | 1 |
| 16 | Influence of serotype on the growth kinetics and the ability to form biofilms of Salmonella isolates from poultry显示文摘 | Miryam Díez-García Rosa Capita Carlos Alonso-Calleja | 2012 | Food Microbiology2012，，2： | 1 |
| 17 | Late Quaternary paleoclimate in the Eastern Mediterranean Region from Stable Istope Analysis of Speleothems at Soreq Cave,Israel显示文摘 | AVNER A | 1997 | Quaternary Research1997，47，： | 1 |
| 18 | Retranslation of children's books as evidence of changes of norms 显示文摘 | Du-Nour Miryam | 1995 | Target1995，7，2： | 1 |
| 19 | Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidativedamage and mitochondrial fission显示文摘 | Gabriel D A Miryam C Selma B | 2013 | Toxicol Lett2013，218，： | 1 |
| 20 | The Clinical Efficacy and Cost Effectiveness of the Vacuum-Assisted Closure Technique in the Management of Acute and Chronic Wounds: A Randomized Controlled Trial显示文摘 | Assa Braakenburg Miryam C. Obdeijn Reinier Feitz Iris A. L. M. van Rooij Arjanne J. van Griethuysen Jean H. G. Klinkenbijl | 2006 | Plastic and Reconstructive Surgery2006，，2： | 1 |
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