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| 1 | Gut microbiome in acute pancreatitis:A review based on current literature显示文摘The gut microbiome is a complex microbial community,recognized for its potential role in physiology,health,and disease.The available evidence supports the role of gut dysbiosis in pancreatic disorders,including acute pancreatitis(AP).In AP,the presence of gut barrier damage resulting in increased mucosal permeability may lead to translocation of intestinal bacteria,necrosis of pancreatic and peripancreatic tissue,and infection,often accompanied by multiple organ dysfunction syndrome.Preserving gut microbial homeostasis may reduce the systemic effects of AP.A growing body of evidence suggests the possible involvement of the gut microbiome in various pancreatic diseases,including AP.This review discusses the possible role of the gut microbiome in AP.It highlights AP treatment and supplementation with prebiotics,synbiotics,and probiotics to maintain gastrointestinal microbial balance and effectively reduce hospitalization,morbidity and mortality in an early phase.It also addresses novel therapeutic areas in the gut microbiome,personalized treatment,and provides a roadmap of human microbial contributions to AP that have potential clinical benefit. | Bharati Kadamb Patel Kadamb H Patel Madhav Bhatia Shridhar Ganpati Iyer Krishnakumar Madhavan Shabbir M Moochhala | 2021 | World Journal of Gastroenterology2021，27，30： | 10 |
| 2 | Comparative study and systematic review of laparoscopic liver resection for hepatocellular carcinoma显示文摘AIM: To compare the surgical outcomes between laparoscopic liver resection(LLR) and open liver resection(OLR) as a curative treatment in patients with hepatocellular carcinoma(HCC). METHODS: A Pub Med database search was performed systematically to identify comparative studies of LLR vs OLR for HCC from 2000 to 2014. An extensive text word search was conducted, using combinations of search headings such as 'laparoscopy', 'hepatectomy', and 'hepatocellular carcinoma'. A comparative study was also performed in our institution where we analysed surgical outcomes of 152 patients who underwent liver resection between January 2005 to December 2012, of which 42 underwent laparoscopic or hand-assisted laparoscopic resection and 110 underwent open resection. RESULTS: Analysis of our own series and a review of 17 high-quality studies showed that LLR was superior to OLR in terms of short-term outcomes, as patients in the laparoscopic arm were found to have less intraoperative blood loss, less blood transfusions, and a shorter length of hospital stay. In our own series, both LLR and OLR groups were found to have similar overall survival(OS) rates, but disease-free survival(DFS) rates were higher in the laparoscopic arm. CONCLUSION: LLR is associated with better short-term outcomes compared to OLR as a curative treatment for HCC. Long-term oncologic outcomes with regards to OS and DFS rates were found to be comparable in both groups. LLR is hence a safe and viable option for curative resection of HCC. | Wei Qi Leong Iyer Shridhar Ganpathi Alfred Wei Chieh Kow Krishnakumar Madhavan Stephen Kin Yong Chang | 2015 | World Journal of Hepatology2015，7，27： | 7 |
| 3 | An overview of the recent developments in polylactide (PLA) research显示文摘 | K. Madhavan Nampoothiri Nimisha Rajendran Nair Rojan Pappy John | 2010 | Bioresource Technology2010，，22： | 6 |
| 4 | Fatigue reliability analysis of fixed offshore structures:A first passage problem approach显示文摘This paper describes a methodology for computation of reliability of members of fixed offshore platform structures, with respect to fatigue. Failure criteria were formulated using fracture mechanics principle. The problem is coined as a “first passage problem”. The method was illustrated through application to a typical plane frame structure. The fatigue reliability degradation curve established can be used for planning in-service inspection of offshore platforms. A very limited parametric study was carried out to obtain insight into the effect of important variables on the fatigue reliability. | MADHAVAN PILLAI T.M. VEENA G. | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，11： | 6 |
| 5 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 6 | Tunable synthesis solid or hollow Au-Ag nanostructure, assembled with GO and comparative study of their catalytic properties显示文摘在这个工作,我们由调整 pH 作为种子与 Ag nanoparticles ( AgNPs )为 Ag@Au 核心壳 nanoparticles ( Ag@AuNPs )和 Ag/Au 空 nanocages ( Ag/AuNCs )的合成表明了一个简单、有效的二拍子的圆舞方法,并且混合 Ag@AuNPs-graphene 或 Ag/AuNCs-graphene 氧化物 nanocomposites (Ag@AuNPs去或 Ag/AuNCs-GO )的准备基于自己组装。它从静电的集会实验被注意 Ag/AuNCs 在上的装载数量去 nanosheet 多于 Ag@AuNPs 的。同样综合的混合材料被传播电子显微镜学描绘,原子力量显微镜学, -potential, 高角度的环形的黑暗地的扫描传播电子显微镜学, thermogravimetric 分析器和 X 光检查衍射。Ag@AuNPs, Ag/AuNCs 和 Ag/AuNCs-GO nanostructures 的催化活动在 4- , 3-nitrophenol 或 2-nitrophenol 的减小被调查到 4- , 3-aminophenol, 或 2-aminophenol,并且根据比较运动研究,下列趋势为相关催化活动被获得:Ag/AuNCs-GO ?>? Ag/AuNCs ?>? Ag@AuNPs。这些观察被归因于为混合 nanostructures 的催化反应和作文可得到的表面区域的同时的效果。 | Lidan Xu Min Hong Yongliang Wang Ming Li Haibo Li Madhavan P. N. Nair Chen-Zhong Li | 2016 | Science Bulletin2016，61，19： | 4 |
| 7 | Gastric digestion of pea ferritin and modulation of its iron bioavailability by ascorbic and phytic acids in caco-2 cells显示文摘瞄准:在 caco-2 房间线模型理解版本和豌豆含铁听铁的肠的举起的消化稳定性和机制。方法:豌豆种子含铁锡用分别由胶化过滤层析跟随了的盐被净化。含铁听铁的简历可获得性当面用联合在试管内 digestion/Caco-2 房间模型被估计或抗坏血酸和 phytic 的缺席。Caco-2 房间含铁听形成被用作铁举起的一个代理人标记。在模仿的胃的 pH 下面的豌豆含铁锡的结构的变化用电气泳动,胶化过滤和圆形的二色性光谱学被描绘。结果:caco-2 房间含铁听形成显著地被增加(P <
0.001 ) 与 FeSO4 (19.3 +/- 9.8 ng/mg 蛋白质) 并且豌豆含铁锡(13.9 +/- 6.19 ng/mg 蛋白质) 与空白的文摘相比(3.7 +/- 1.8 ng/mg 蛋白质) 。当 phytic 减少了时,提高的抗坏血酸豌豆含铁听铁简历可获得性。然而,也当面或抗坏血酸的缺席, caco-2 房间的含铁听内容是显著地有豌豆含铁锡的更少比与 FeSO4。在胃的 pH,相应于含铁锡的乐队都没在本国的页或 SDS 页上面对胃朊酶任何一个被观察。胶化过滤层析和圆形的二色性光谱学揭示了第四级、第二等的结构的 pH 依赖者损失。结论:在胃的条件下面,豌豆含铁锡的铁核心由于酸被释放进消化媒介蛋白质的导致的结构的改变和分离。释放的铁与导致豌豆含铁听铁简历可获得性的调整的饮食的因素交往,类似于 non-heme 铁的典型特征。 | Satyanarayana Bejjani Raghu Pullakhandam Ravinder Punjal K Madhavan Nair | 2007 | World Journal of Gastroenterology2007，13，14： | 3 |
| 8 | The utility of laparoscopic assessment in the preoperative staging of suspected hilar cholangiocarcinoma显示文摘 | Saxon Connor F.R.A.C.S. Emma Barron B.Sc. Stephen J. Wigmore M.D. F.R.C.S. Krishnakumar K. Madhavan M.S. F.R.C.S. Rowan W. Parks M.D. F.R.C.S. O. James Garden M.D. F.R.C.S | 2005 | Journal of Gastrointestinal Surgery2005，，4： | 3 |
| 9 | Characterization of microstructure, toughness, and chemical composition of friction-welded joints of UNS S32205 duplex stainless steel显示文摘Friction welding is a solid-state joining process which is applied extensively because of its advantages such as low heat input,efficient application,ease in manufacturing,and environmental friendliness.The present study investigates the mechanical and metallurgical properties of UNS S32205 duplex stainless steel friction-welded joints.The process parameters,namely friction pressure,upsetting pressure,and rotational speed are individually varied from low level to high level(within the range of the machine setup)and their effects on the joint properties are analyzed.The partial-deformation zone had higher hardness than the weld and base metal.The toughness of the joints was evaluated at room temperature and at subzero temperature conditions.The impact toughness of the friction-welded joints was found to be superior to fusion-joined duplex stainless steel in room and cryogenic conditions. | Puthuparambil Madhavan AJITH Paulraj SATHIYA Sivanandam ARAVINDAN | 2014 | Friction2014，2，1： | 2 |
| 10 | Inverse trajectory control and zero-dynamics sensitivity of an elastic manipulator显示文摘 | Madhavan S K Singh S N | 1991 | Int J of Robotic Automation1991，6，4： | 2 |
| 11 | Dysphagia in the elderly: management and nutritional considerations显示文摘 | Michael Crary Giselle Carnaby-Mann Aarthi Madhavan Livia Sura | 2012 | Clinical Interventions in Aging (default)2012，，： | 2 |
| 12 | Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity显示文摘 | Bindhu Madhavan Shijing Yue Uwe Galli Sanyukta Rana Wolfgang Gross Miryam Müller Nathalia A. Giese Holger Kalthoff Thomas Becker Markus W Büchler Margot Z?ller | 2015 | Int. J. Cancer2015，，11： | 2 |
| 13 | Laparoendoscopic single-site minor hepatectomy for liver tumors显示文摘 | Ek Tan Victor Lee Stephen Chang Iyer Ganpathi Krishnakumar Madhavan Davide Lomanto | 2012 | Surgical Endoscopy2012，，7： | 2 |
| 14 | An overview of the recent developments in polylactide (PLA) research显示文摘 | K. Madhavan Nampoothiri Nimisha Rajendran Nair Rojan Pappy John | 2010 | Bioresource Technology2010，，22： | 2 |
| 15 | Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human显示文摘AIM: To elucidate the sequential transfer of iron amongst ferritin, transferrin and transferrin receptor under various iron status conditions. METHODS: Incorporation of 59Fe into mucosal and luminal proteins was carried out in control WKY rats. The sequential transfer of iron amongst ferritin, transferrin and transferrin receptor was carried out in iron deficient, control and iron overloaded rats. The duodenal proteins were subjected to immunoprecipitation and quantitation by specific ELISA and in situ localization by microautoradiography and immunohistochemistry in tandem duodenal sections. Human duodenal biopsy (n = 36) collected from subjects with differing iron status were also stained for these proteins. RESULTS: Ferritin was identified as the major protein that incorporated iron in a time-dependent manner in the duodenal mucosa. The concentration of mucosal ferritin was significantly higher in the iron excess group compared to control, iron deficient groups (731.5 ± 191.96 vs 308.3 ± 123.36, 731.5 ± 191.96 vs 256.0 ± 1.19, P < 0.005), while that of luminal transferrin which was significantly higher than the mucosal did not differ among the groups (10.9 ± 7.6 vs 0.87 ± 0.79, 11.1 ± 10.3 vs 0.80 ± 1.20, 6.8 ± 4.7 vs 0.61 ± 0.63, P < 0.001). In situ grading of proteins and iron, and their superimposition, suggested the occurrence of a sequential transfer of iron. This was demonstrated to occur through the initial binding of iron to luminal transferrin then to absorptive cell surface transferrin receptors. The staining intensity of these proteins variedaccording to the iron nutrition in humans, with intense staining of transferrin receptor observed in iron deficient subjects. CONCLUSION: It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin. | Vasantha L Kolachala B Sesikeran K Madhavan Nair | 2007 | World Journal of Gastroenterology2007，13，7： | 2 |
| 16 | Acute Heart Failure in Apical Ballooning Syndrome (TakoTsubo/Stress Cardiomyopathy)显示文摘 | Malini Madhavan Charanjit S. Rihal Amir Lerman Abhiram Prasad | 2011 | Journal of the American College of Cardiology2011，，12： | 2 |
| 17 | Liver Resection and Transplantation in the Management of Iatrogenic Biliary Injury显示文摘 | B. N. J. Thomson R. W. Parks K. K. Madhavan O. J. Garden | 2007 | World Journal of Surgery2007，，12： | 2 |
| 18 | Rotating stall caused by pressure surface flow separation on centrifugal fan blades 显示文摘 | MADHAVAN S WRIGHT T | 1985 | ASME Journal of Engineering for Gas Turbines and Power1985，107，： | 2 |
| 19 | Price discovery in auction markets: a look inside the black box显示文摘 | Madhavan A Panchapagesan V | 2000 | Review of Financial Studies2000，13，3： | 1 |
| 20 | Serum uric acid and cardiovascular evetlts in successfully treated htpertensive patients 显示文摘 | Alderman MH Cohen H Madhavan S | 1999 | Hypertension1999，34，1： | 1 |
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