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| 1 | Exosomes:Small vesicles with big roles in cancer,vaccine development,and therapeutics显示文摘Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year.Despite the availability of chemotherapy,radiotherapy,immunotherapy,and surgery,a cure for cancer has not been attained.Recently,exosomes have gained significant attention due to the therapeutic potential of their various components including proteins,lipids,nucleic acids,miRNAs,and lncRNAs.Exosomes constitute a set of tiny extracellular vesicles with an approximate diameter of 30-100 nm.They are released from different cells and are present in biofluids including blood,cerebrospinal fluid(CSF),and urine.They perform crucial multifaceted functions in the malignant progression of cancer via autocrine,paracrine,and endocrine communications.The ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer therapeutics.In this review,we discuss the major components of exosomes and their role in cancer progression.We also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics. | Abhimanyu Thakur Diana Carolina Parra Pedram Motallebnejad Marcelo Brocchi Huanhuan Joyce Chen | 2022 | Bioactive Materials2022，7，4： | 8 |
| 2 | Stroke and sleep-disordered breathing: A relationship under construction显示文摘The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent years.Sleep disorders are emerging risk factors for cardiovascular disease and have been related to the whole spectrum of stroke,including transient ischemic attack,ischemic cerebral infarction and intracerebral haemorrhage.It has been shown that lacunar stroke or lacunar infarctions affecting the internal capsule or the protuberance are associated with a higher frequency of SDB.Acute stroke patients with associated SDB have a worse prognosis and a higher mortality as compared to patients with first-ever stroke without SDB.Preliminary studies provide evidence of the usefulness of treatment with continuous positive airway pressure when SDB is present in stroke patients. | Olga Parra Adrià Arboix | 2016 | World Journal of Clinical Cases2016，4，2： | 5 |
| 3 | A model for strong attenuation and dispersion of seismic P-waves in a partially saturated fractured reservoir显示文摘In this work we interpret the data showing unusually strong velocity dispersion of P-waves (up to 30%) and attenuation in a relatively narrow frequency range. The cross-hole and VSP data were measured in a reservoir, which is in the porous zone of the Silurian Kankakee Limestone Formation formed by vertical fractures within a porous matrix saturated by oil, and gas patches. Such a medium exhibits significant attenuation due to wave-induced fluid flow across the interfaces between different types of inclusions (fractures, fluid patches) and background. Other models of intrinsic attenuation (in particular squirt flow models) cannot explain the amount of observed dispersion when using realistic rock properties. In order to interpret data in a satisfactory way we develop a superposition model for fractured porous rocks accounting also for the patchy saturation effect. | BRAJANOVSKI Miroslav MüLLER Tobias M PARRA Jorge O | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，8： | 4 |
| 4 | Cardiorenal biomarkers in acute heart failure显示文摘与心失败(HF ) 管理病人是在肾的功能能极大地增加的变得更坏联系的本身,而是存在以内的一项挑战性的任务死亡和病态。早诊断和治疗是钥匙阻止再进医院和还原剂保健费用。Biomarkers 长在与 HF 诊断和预言的病人作为高度敏感、特定的工具被建立了。思考不同 pathophysiological 事件和进行中的细胞的侮辱, biomarkers 被证明优异到常规实验室测试。更好的试金和快速的分析的可获得性作为紧急情况部门并且在病人的床边的 point-of-care 测试允许 biomarkers 的使用。尖锐 HF 病人经常继续发展变得更坏肾的功能,称为的同样尖锐的 cardiorenal 症候群。研究的成长宽度显示出联合多重 biomarkers 更好制定结果并且在如此的病人生产理想的结果的含意。 | Rajiv Choudhary Dipika Gopal Ben A. Kipper Alejandro De La Parra Landa Hermineh Aramin Elizabeth Lee Saloni Shah Alan S. Maisel | 2012 | Journal of Geriatric Cardiology2012，9，3： | 4 |
| 5 | Pathogenesis of H elicobacter pylori Infection显示文摘 | Trinidad Parra Cid Miryam Calvino Fernández Selma Benito Martínez Nicola L. Jones | 2013 | Helicobacter2013，，： | 4 |
| 6 | 用熔解曲线法分析插入/缺失多态性和Y染色体SNPs多态性显示文摘随着单核苷酸多态性SNPs (SingleNucleotidePolymorphisms)及插入 /缺失多态性Indels (Insertion/Dele tion)的分型技术研究的深入 ,SNPs和Indels在法医学上的应用将受到深刻的影响。本文研究和探讨Indels的分型方法 ,通过测定扩增DNA片段在溶液中的溶解曲线图确定每个样品的基因型 ,称为溶解曲线Indels基因分型方法(McI/D)。溶解曲线图由被测样品DNA片段的特殊溶解温度组成 ,扩增结果直接由仪器分析不需要繁杂的PCR后期操作。 | 叶健 郑秀芬 季安全 Esteban J Parra Donna M Sosnoski Mark D Shriver | 2001 | 中国法医学杂志2001，16，4： | 3 |
| 7 | 再谈闪光刺激方法学:新版欧洲脑电图室视觉刺激方法显示文摘间断性闪光刺激(IPS)是脑电图监测中常用的检测方法,旨在发现儿童及成人异常癫痫样放电对闪光的敏感性(即光敏感性).但在临床实践中,不同的国家以及不同的脑电图室采用的IPS方法不同,导致结果有所差异.我们认为应该建立标准的检测方法,从而能够可重复地定性和定量检测光敏感性,更利于监测和识别癫痫和光敏感性患者.与1999年发表的方法相比较,新方法不仅增加了内容,而且对IPS检测技术以及相关的操作原理进行了详述.为了提高有效性及实用性,该方法通过6年的欧洲神经病学及癫痫专家实践反馈并且反复讨论形成了共识. | Dorothee Kasteleijn-Nolst Trenite Guido Rubboli Edouard Hirsch Antonio Martins da Silva Stefano Seri Arnold Wilkins Jaime Parra Athanasios Covanis Maurizio Elia 刘永红(译) 张文娟(译) 来江(译) | 2014 | 中华神经科杂志2014，47，4： | 3 |
| 8 | Persistent hepatitis C virus (HCV) infection impairs HCV‐specific cytotoxic T cell reactivity through Mcl‐1/Bim imbalance due to CD127 down‐regulation显示文摘 | J. R. Larrubia M. U. Lokhande S. García‐Garzón J. Miquel A. González‐Praetorius T. Parra‐Cid E. Sanz‐de‐Villalobos | 2012 | Journal of Viral Hepatitis2012，，2： | 3 |
| 9 | Developing Flexible Dual Master's Degree Programs at UPAEP (Universidad Popular Autonoma del Estado de Puebla) and OSU (Oklahoma State University)显示文摘 | Mafia G. Fabregas-Janeiro Pablo Nuno de la Parra | 2012 | US-China Education Review(A)2012，2，2： | 2 |
| 10 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 11 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 12 | Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals显示文摘 | J. E. Below E. R. Gamazon J. V. Morrison A. Konkashbaev A. Pluzhnikov P. M. McKeigue E. J. Parra S. C. Elbein D. M. Hallman D. L. Nicolae G. I. Bell M. Cruz N. J. Cox C. L. Hanis | 2011 | Diabetologia2011，，8： | 2 |
| 13 | Modeling of cyclic mobility in saturated cohesionless soils显示文摘 | Ahmed Elgamal Zhaohui Yang Ender Parra Ahmed Ragheb | 2002 | International Journal of Plasticity2002，，6： | 2 |
| 14 | A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas显示文摘Background:Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban settings.There is a need to know what rapid diagnostic technologies are available,have been properly assessed,and are being implemented to improve control of these diseases in the urban context.This paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty.Main body:A scoping review was conducted.Peer-reviewed and grey literature were searched using terms describing the targeted infectious diseases,diagnostics evaluations,rapid tests,and urban setting.The review was limited to studies published between 2000 and 2016 in English,Spanish,French,and Portuguese.Inclusion and exclusion criteria were refined post hoc to identify relevant literature regardless of study design and geography.A total of 179 documents of the 7806 initially screened were included in the analysis.Malaria(n=100)and tuberculosis(n=47)accounted for the majority of studies that reported diagnostics performance,impact,and implementation outcomes.Fewer studies,assessing mainly performance,were identified for visceral leishmaniasis(n=9),filariasis and leptospirosis(each n=5),enteric fever and schistosomiasis(each n=3),dengue and leprosy(each n=2),and Chagas disease,human African trypanosomiasis,and cholera(each n=1).Reported sensitivity of rapid tests was variable depending on several factors.Overall,specificities were high(>80%),except for schistosomiasis and cholera.Impact and implementation outcomes,mainly acceptability and cost,followed by adoption,feasibility,and sustainability of rapid tests are being evaluated in the field.Challenges to implementing rapid tests range from cultural to technical and administrative issues.Conclusions:Rapid diagnostic tests for vector-borne and other diseases of poverty are being used in the urban context with demonstrated impact on case detection.However,most evidence comes from malaria rapid diagnostics,with variable results.While rapid tests for tuberculosis and visceral leishmaniasis require further implementation studies,more evidence on performance of current tests or development of new alternatives is needed for dengue,Chagas disease,filariasis,leptospirosis,enteric fever,human African trypanosomiasis,schistosomiasis and cholera. | Lyda Osorio Jonny Alejandro Garcia Luis Gabriel Parra Victor Garcia Laura Torres Stephanie Degroote Valery Ridde | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 15 | Presence of three dengue serotypes in Ouagadougou(Burkina Faso):research and public health implications显示文摘Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity impacts.Methods:An exploratory cross-sectional survey was performed from December 2013 to January 2014.Six primary healthcare centers in Ouagadougou were selected based on previously reported presence of Flavivirus.All patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to participate.Sociodemographic data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a questionnaire.Blood samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)analysis.In a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and described.Larvae were collected and brought to the laboratory to monitor the emergence of adults and identify the species.Results:Of the 379 subjects,8.7%(33/379)had positive RDTs for dengue.Following the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory testing.Of 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were positive.The serotypes observed were DENV2,DENV3,and DENV4.Odds of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under five.Average total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.Potential Aedes breeding sites were found near 71.4%(21/28)of patients,but no adult Aedes were found.The most frequently identified potential breeding sites were water storage containers(45.2%).Most specimens collected in yards were Culex(97.9%).Conclusions:The scientific community,public health authorities,and health workers should consider dengue as a possible cause of febrile illness in Burkina Faso. | Valéry Ridde Isabelle Agier Emmanuel Bonnet Mabel Carabali Kounbobr Roch Dabiré Florence Fournet Antarou Ly Ivlabèhiré Bertrand Meda Beatriz Parra | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 16 | Science Letters:Visual odometry for road vehicles—feasibility analysis显示文摘Estimating the global position of a road vehicle without using GPS is a challenge that many scientists look forward to solving in the near future. Normally, inertial and odometry sensors are used to complement GPS measures in an attempt to provide a means for maintaining vehicle odometry during GPS outage. Nonetheless, recent experiments have demonstrated that computer vision can also be used as a valuable source to provide what can be denoted as visual odometry. For this purpose, vehicle motion can be estimated using a non-linear, photogrametric approach based on RAndom SAmple Consensus (RANSAC). The results prove that the detection and selection of relevant feature points is a crucial factor in the global performance of the visual odometry algorithm. The key issues for further improvement are discussed in this letter. | SOTELO Miguel-angel GARCíA Roberto PARRA Ignacio FERNNDEZ David GAVILN Miguel LVAREZ Sergio NARANJO José-eugenio | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，12： | 2 |
| 17 | Purification and characterization of a ealicivirus as the causative agent of a lethal hemorrhagic disease in rabbits显示文摘 | Parra F Prieto M | 1990 | J Virol1990，64，8： | 2 |
| 18 | Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorr hage显示文摘 | Borel C O McKee A Parra A | 2003 | Stroke2003，34，2： | 1 |
| 19 | Cortically Coupled Computer Vision for Rapid Image Search显示文摘 | Parra L C Sajda P | 2006 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2006，14，2： | 1 |
| 20 | Time course of sleep - relatedbreathing disorders in first - ever stroke or transient ischemic attack显示文摘 | Parra O Arboix A Bechich S | 2000 | Am J Re-spir Crit Care Med2000，161，： | 1 |
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