|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 2 | Humoral Response to Recombinant Hepatitis B Virus Vaccine at Birth: Role of HLA and Beyond显示文摘 | Miryam Martinetti Annalisa De Silvestri Cesare Belloni Annamaria Pasi Carmine Tinelli Angela Pistorio Laura Salvaneschi Giorgio Rondini Maria Antonia Avanzini Mariaclara Cuccia | 2000 | Clinical Immunology2000，，： | 2 |
| 3 | Are capecitabine and oxaliplatin (XELOX) suitable treatments for progressing low-grade and high-grade neuroendocrine tumours?显示文摘 | Emilio Bajetta Laura Catena Giuseppe Procopio Sara Dosso Ettore Bichisao Leonardo Ferrari Antonia Martinetti Marco Platania Elena Verzoni Barbara Formisano Roberto Bajetta | 2007 | Cancer Chemotherapy and Pharmacology2007，，： | 2 |
| 4 | Prognostic Value of Circulating Tumor Markers in Patients with Pseudomyxoma Peritonei Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy显示文摘 | Dario Baratti MD Shigeki Kusamura MD PhD Antonia Martinetti MD Ettore Seregni MD Barbara Laterza MD Daniela G. Oliva MD Marcello Deraco MD | 2007 | Annals of Surgical Oncology2007，，8： | 2 |
| 5 | Disulfiram,an old drug with new potential therapeutic uses for human hematological malignancies显示文摘 | Conticello C Martinetti D Adamo L | 2012 | Int J Cancer2012，131，9： | 1 |
| 6 | Family study of non- responsiveness to hepatitis B vaeeine eonfirms the importance of HLA class m C4A loeus显示文摘 | De Silvest A Pasi A Martinetti M | 2001 | Genes Immun2001，2，7： | 1 |
| 7 | Normal osteoconduction and repair in and around submerged highly bisphosphonate-complexed hydroxyapatite implants in rat tibiae 显示文摘 | Denissen H Martinetti R van Lingen A | 2000 | Journal of periodontology2000，71，2： | 1 |
| 8 | Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics显示文摘 | Mastrogiacomo M Scaglione S Martinetti R | 2006 | Biomaterials2006，27，17： | 1 |
| 9 | Circulating CA125 in Patients with Peritoneal Mesothelioma Treated with Cytoreductive Surgery and Intraperitoneal Hyperthermic Perfusion显示文摘 | Dario Baratti MD Shigeki Kusamura MD Antonia Martinetti MD Ettore Seregni MD Daniela G. Oliva MD Barbara Laterza MD Marcello Deraco MD | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 10 | Celiac disease in children with autoimmune thyroid disease显示文摘 | Daniela Larizza Valeria Calcaterra Costantino De Giacomo Annalisa De Silvestri Margherita Asti Carla Badulli Michele Autelli Eliana Coslovich Miryam Martinetti | 2001 | The Journal of Pediatrics2001，，5： | 1 |
| 11 | Chromogranin A,neuron specific enolase,carcinoembryonic antigen,and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors显示文摘 | BAJETTA E FERRARI L MARTINETTI A | 1999 | Cancer1999，86，5： | 1 |
| 12 | Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics 显示文摘 | MASTROGIACOMO M SCAGLIONE S MARTINETTI R | 2006 | Biomaterials2006，27，17： | 1 |
| 13 | Osteoprotegerin and osteopontin serum values in postmenopausal advanced breast cancer patients treated with anastrozole显示文摘 | Martinetti A Bajetta E Ferrari L | 2004 | Endocr Relat Cancer2004，11，4： | 1 |
| 14 | Transarterial Chemoembolization with Epirubicin-eluting Beads versus Transarterial Embolization before Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Antonio Nicolini Laura Martinetti Silvia Crespi Marco Maggioni Angelo Sangiovanni | 2010 | Journal of Vascular and Interventional Radiology2010，，3： | 1 |
| 15 | Exaggerated 17-hydroxyprogesterone response to short-term adrenal stimulation and evidence for CYP21B gene point nutations in true precocious puberty显示文摘 | Cistemino M Dondi E Martinetti M | | 0，，： | 1 |
| 16 | Family study of non-responsiveness to hepatitis B vaccine confirms the importance of HLA class III C4A locus显示文摘 | de SILVESTRI A PASI A MARTINETTI M | 2001 | Genes and Immunity2001，2，： | 1 |
| 17 | Common immunogenetic profile in children with multiple autoimmune diseases: the signature of HLA-DQ pleiotropic genes显示文摘 | Daniela Larizza Valeria Calcaterra Catherine Klersy Carla Badulli Claudia Caramagna Antonio Ricci Paola Brambilla Laura Salvaneschi Miryam Martinetti | 2012 | Autoimmunity2012，，6： | 1 |
| 18 | Clinical utility of biochemical markers of bone remodelling in patients with bone metastases of solid tumors显示文摘 | Martinetti A Ferrari L | 2001 | Q J Nucl Med2001，45，1： | 1 |
| 19 | Prognostic value of circulating tumor markers in patients with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy 显示文摘 | Baratti D Kusamura S Martinetti A | 2007 | Ann Surg Oncol2007，14，8： | 1 |
| 20 | Persistence and translocation of a benzothiadiazole derivative in tomato plants in relation to systemic aquired resistance against Pseudomonas syringae pv tomato显示文摘 | Scarponi L Buonaurio R Martinetti L | 2001 | Pest Manag Sci2001，57，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员