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| 1 | Performance of liver stiffness measurements by transient elastography in chronic hepatitis显示文摘AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published meta-analysis.METHODS:This was a single center cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled.TE was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case procedure.Fibrosis was staged according to the Metavir scoring system.The diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve analysis.RESULTS:Two hundred and fifty-two patients met the inclusion criteria.Six(2%) patients were excluded due to unreliable TE measurements.Thus,246(171 men and 75 women) patients were analyzed.One hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency virus.ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).CONCLUSION:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies. | Giovanna Ferraioli Carmine Tinelli Barbara Dal Bello Mabel Zicchetti Raffaella Lissandrin Gaetano Filice Carlo Filice Elisabetta Above Giorgio Barbarini Enrico Brunetti Willy Calderon Marta Di Gregorio Roberto Gulminetti Paolo Lanzarini Serena Ludovisi Laura Maiocchi Antonello Malfitano Giuseppe Michelone Lorenzo Minoli Mario Mondelli Stefano Novati Savino FA Patruno Alessandro Perretti Gianluigi Poma Paolo Sacchi Domenico Zanaboni Marco Zaramella | 2013 | World Journal of Gastroenterology2013，19，1： | 18 |
| 2 | Point shear wave elastography method for assessing liver stiffness显示文摘AIM:To estimate the validity of the point shear-wave elastography method by evaluating its reproducibility and accuracy for assessing liver stiffness.METHODS:This was a single-center,cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy(LB)(Group 1)and healthy volunteers(Group 2)were studied.In each subject 10 consecutive point shear-wave elastography(PSWE)measurements were performed using the iU22 ultrasound system(Philips Medical Systems,Bothell,WA,United States).Patients in Group 1 underwent PSWE,transient elastography(TE)using FibroScan(Echosens,Paris,France)and ultrasound-assisted LB.For the assessment of PSWE reproducibility two expert raters(rater 1 and rater 2)independently performed the examinations.The performance of PSWE was compared to that of TE using LB as a reference standard.Fibrosis was staged according to the METAVIR scoring system.Receiver operating characteristic curve analyses were performed to calculate the area under the receiver operating characteristic curve(AUC)for F≥2,F≥3and F=4.The intraobserver and interobserver reproducibility of PSWE were assessed by calculating Lin’s concordance correlation coefficient.RESULTS:To assess the performance of PSWE,134consecutive patients in Group 1 were studied.The median values of PSWE and TE(in kilopascals)were 4.7(IQR=3.8-5.4)and 5.5(IQR=4.7-6.5),respectively,in patients at the F0-F1 stage and 3.5(IQR=3.2-4.0)and 4.4(IQR=3.5-4.9),respectively,in the healthy volunteers in Group 2(P<10-5).In the univariate analysis,the PSWE and TE values showed a high correlation with the fibrosis stage;low correlations with the degree of necroinflammation,aspartate aminotransferase and gamma-glutamyl transferase(GGT);and a moderate negative correlation with the platelet count.A multiple regression analysis confirmed the correlations of both PSWE and TE with fibrosis stage and GGT but not with any other variables.The following AUC values were found:0.80(0.71-0.87)for PSWE and 0.82(0.73-0.89)for TE(P=0.42);0.88(0.80-0.94)for PSWE and 0.95(0.88-0.98)for TE(P=0.06);and 0.95(0.89-0.99)for PSWE and 0.92(0.85-0.97)for TE(P=0.30)for F≥2,F≥3 and F=4,respectively.To assess PSWE reproducibility,116 subjects were studied,including 47consecutive patients scheduled for LB(Group 1)and 69 consecutive healthy volunteers(Group 2).The intraobserver agreement ranged from 0.83(95%CI:0.79-0.88)to 0.96(95%CI:0.95-0.97)for rater 1 and from 0.84(95%CI:0.79-0.88)to 0.96(95%CI:0.95-0.97)for rater 2.The interobserver agreement yielded values from0.83(95%CI:0.78-0.88)to 0.93(95%CI:0.91-0.95).CONCLUSION:PSWE is a reproducible method for assessing liver stiffness,and it compares with TE.Compared with patients with nonsignificant fibrosis,healthy volunteers showed significantly lower values. | Giovanna Ferraioli Carmine Tinelli Raffaella Lissandrin Mabel Zicchetti Barbara Dal Bello Gaetano Filice Carlo Filice | 2014 | World Journal of Gastroenterology2014，20，16： | 12 |
| 3 | Controlled attenuation parameter for evaluating liver steatosis in chronic viral hepatitis显示文摘AIM:To assess the performance of controlled attenuation parameter(CAP)in patients with chronic viral hepatitis.METHODS:CAP is a new technique that measures the attenuation in the liver of an ultrasound beam,which is directly related to lipid accumulation.Consecutive patients undergoing liver biopsy for chronic viral hepatitis were studied using the M probe of FibroScan device(Echosens,Paris,France).The device estimates liver st-eatosis in decibel per meter(dB/m).An expert operator performed all measurements.Steatosis was graded according to Kleiner’s classification.Pearson or Spearman rank coefficient was used to test correlation between two study variables.Linear regression was used for multivariate model to assess the association between CAP and other variables.Receiver operating characteristic curve analysis was performed to calculate area under the curve(AUROC)for S0 vs S1-S3 and S0-S1 vs S2-S3.RESULTS:115 subjects(85 males and 30 females)were prospectively studied.The mean values of CAP were 227.1±43.1 for S0;254.6±38.9 for S1;297.8±49.4 dB/m for S2-S3.In univariate analysis CAP showed a significant correlation with age,body mass index(BMI),degree of steatosis,and cholesterol.Multivariate regression analysis confirmed the correlation with the degree of steatosis[coefficient,1.2(0.60-1.83);P<10-5]and BMI[coefficient,4.1(0.5-7.8);P=0.03]but not with all other variables.Optimal cutoff values for S≥1 and S≥2 were 219 dB/m[AUROC,0.76(0.67-0.84);sensitivity,91.1%(78.8-97.5);specificity,51.6%(38.7-64.2);positive predictive value,56.9%(44.7-68.6);negative predictive value,89.2%(74.3-97.0);positive likelihood ratio,1.88(1.4-2.5);negative likelihood ratio,0.17(0.07-0.5)]and 296 dB/m[AUROC,0.82(0.74-0.89);sensitivity,60.0%(32.3-83.7);specificity,91.5%(83.9-96.3);positive predictive value,52.9%(27.8-77.0);negative predictive value,93.5%(86.3-97.6);positive likelihood ratio,7.05(3.2-15.4);negative likelihood ratio,0.44(0.2-0.8)],respectively.CONCLUSION:Controlled attenuation parameter could be a useful tool in the clinical management of patients with chronic viral hepatitis for detecting liver steatosis. | Giovanna Ferraioli Carmine Tinelli Raffaella Lissandrin Mabel Zicchetti Barbara Dal Bello Gaetano Filice Carlo Filice | 2014 | World Journal of Gastroenterology2014，20，21： | 7 |
| 4 | Humoral Response to Recombinant Hepatitis B Virus Vaccine at Birth: Role of HLA and Beyond显示文摘 | Miryam Martinetti Annalisa De Silvestri Cesare Belloni Annamaria Pasi Carmine Tinelli Angela Pistorio Laura Salvaneschi Giorgio Rondini Maria Antonia Avanzini Mariaclara Cuccia | 2000 | Clinical Immunology2000，，： | 2 |
| 5 | Contrast-enhanced ultrasonography and spiral computed tomography in the detection and characterization of portal vein thrombosis complicating hepatocellular carcinoma显示文摘 | Sandro Rossi Giorgia Ghittoni Valentina Ravetta Francesca Torello Viera Laura Rosa Martina Serassi Mara Scabini Alessandro Vercelli Carmine Tinelli Barbara Dal Bello Peter N. Burns Fabrizio Calliada | 2008 | European Radiology2008，，8： | 2 |
| 6 | Adhesion formation after intracapsular myomectomy with or without adhesion barrier显示文摘 | Andrea Tinelli Antonio Malvasi Marcello Guido Daniel Alberto Tsin Gernot Hudelist Brad Hurst Michael Stark Liselotte Mettler | 2011 | Fertility and Sterility2011，，5： | 2 |
| 7 | Safety and efficacy of a modified-live canine coronavirus vaccine in dogs 显示文摘 | Pratelli A Tinelli A Decaro N | 2004 | Vet Microbiol2004，99，1： | 1 |
| 8 | An outlook on ovarian cancer and borderline ovarian tumors:focus on genomic and proteomic findings显示文摘 | Tinelli A Vergara D Martignago R Leo G Pisanò M Malvasi A | | 0，，： | 1 |
| 9 | Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment 显示文摘 | Cicinelli E Matteo M Tinelli R | 2014 | Reprod Sci2014，21，5： | 1 |
| 10 | Long-term epidural analgesia treatment in pre-eclamptic women:a preliminary trial显示文摘 | Malvasi A Tinelli A Brizzi A | 2009 | J Obstet Gynaecol2009，29，2： | 1 |
| 11 | l Comparison of nebu lized budeson ide and oral predn iso lone with p lacebo in th e treatment of acu te exacerbations of chron ic obstructive pulmon ary disease:a randomized controlled tria显示文摘 | Maltais F Os tinelli J Bou rbeau J et a | 2002 | l Am J Resp ir Crit CareM ed2002，165，： | 1 |
| 12 | Contrast-enhanced ultrasonography and spiral computed tomography in the detection and characterization of portal vein thrombosis complicating hepatocellular carcinoma显示文摘 | Sandro Rossi Giorgia Ghittoni Valentina Ravetta Francesca Torello Viera Laura Rosa Martina Serassi Mara Scabini Alessandro Vercelli Carmine Tinelli Barbara Dal Bello Peter N. Burns Fabrizio Calliada | 2008 | European Radiology2008，，8： | 1 |
| 13 | Validation of the Ital- ian version of the Sunnybrook Facial Grading System显示文摘 | PAVESE C TINELLI C FURINI F | 2013 | Neuro- logical Sciences2013，34，4： | 1 |
| 14 | Laparoscopy versus minilaparotomy in women with symptomatic uterine myomas:short-term and fertility results显示文摘 | Malzoni M Tinelli R Cosentino F | 2009 | Fertil Steril2009，12，： | 1 |
| 15 | Laparoscopic management of cervi- eal-isthmic pregnancy: a proposal method 显示文摘 | Tinelli A Tinelli R Malvasi A | 2009 | Fertil Steril2009，92，： | 1 |
| 16 | Laparoscopic management of cervical-isthmic pregnancy a proposal method显示文摘 | Tinelli A Tinelli R Malvasi A | 2009 | Fert Ster2009，92，2： | 1 |
| 17 | Total laparoscopic hysterectomy versus abdominal hysterectomy with lymphodenectomy for early-stage endometrial cancer:a prospective randomized study显示文摘 | Malzoni M Tinelli R Cosentiuo F | 2009 | Gynecol Oncol2009，112，1： | 1 |
| 18 | Risk of long-term pelvic recurrences after fluid minihysteroscopy in women with endometrial carcinoma:a controlled randomized study显示文摘 | Cicinelli E Tinelli R Colafiglio G | 2010 | Menopause2010，17，3： | 1 |
| 19 | Total la-paroscopic radical hysterectomy versus abdominal radicalhysterectomy with lymphadenectomy in patients with earlycervical cancer: our experience 显示文摘 | MALZONI M TINELLI R COSENTINO F etal | 2009 | Annals of surgicaloncology2009，16，5： | 1 |
| 20 | Substance P (SP) and vasoactive intestinal polypeptide (VIP) in the lower uterine segment in first and repeated cesarean sections显示文摘 | Antonio Malvasi Andrea Tinelli Carlo Cavallotti Stefano Bettocchi Gian Carlo Di Renzo Michael Stark | 2010 | Peptides2010，，11： | 1 |
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