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| 1 | Adaptive immune response during hepatitis C virus infection显示文摘Hepatitis C virus(HCV)infection affects about 170 million people worldwide and it is a major cause of liver cirrhosis and hepatocellular carcinoma.HCV is a hepatotropic non-cytopathic virus able to persist in a great percentage of infected hosts due to its ability to escape from the immune control.Liver damage and disease progression during HCV infection are driven by both viral and host factors.Specifically,adaptive immune response carries out an essential task in controllingnon-cytopathic viruses because of its ability to recognize infected cells and to destroy them by cytopathic mechanisms and to eliminate the virus by non-cytolytic machinery.HCV is able to impair this response by several means such as developing escape mutations in neutralizing antibodies and in T cell receptor viral epitope recognition sites and inducing HCV-specific cytotoxic T cell anergy and deletion.To impair HCV-specific T cell reactivity,HCV affects effector T cell regulation by modulating T helper and Treg response and by impairing the balance between positive and negative co-stimulatory molecules and between pro-and antiapoptotic proteins.In this review,the role of adaptive immune response in controlling HCV infection and the HCV mechanisms to evade this response are reviewed. | Juan Ramon Larrubia Elia Moreno-Cubero Megha Uttam Lokhande Silvia Garcia-Garzon Alicia Lazaro Joaquin Miquel Cristian Perna Eduardo Sanz-de-Villalobos | 2014 | World Journal of Gastroenterology2014，20，13： | 7 |
| 2 | Efficient Synthesis of 3-Methyl-flavanones and Evaluation of Their Anti-bacterial Activity显示文摘一系列 2-phenyl-2,3-dihydrochromon-4-one 衍生物(黄烷酮衍生物) 被硅石胶化综合在 74%88% 产量的几 -methyl-2-hydroxy chalcones 的帮助异构化。这些黄烷酮被在 60 点在 dimethyl sulphoxide 使用碘进一步氧化到 3 甲基黄酮 ? 湡 ? 浩慰瑣猠湥楳楴楶祴獲轠吗?? | Nawghare Beena Funde Sharad Raheem Abdul Lokhande Pradeep | 2012 | Chinese Journal of Chemistry2012，30，8： | 6 |
| 3 | Assessment of pot-hole subsidence risk for Indian coal mines显示文摘Ground subsidence induced by extraction of coal seam belowground brings about changes in surface environment leading to trough and pot-hole subsidence.Pot-hole subsidence is extremely hazardous and does not give any prior indication before its occurrence.In India,several pot-holes have occurred in the coal mines of South Eastern Coalfields Limited triggering the need for in-depth studies.In line with the requirement,literature review and field investigations were conducted to develop an in-depth understanding of various parameters influencing the occurrence of pot-holes.The critical parameters identified were rock to soil ratio,depth to height of extraction ratio,brittleness index of rock and rock density.Risk assessment of pot-hole subsidence has been done by developing an empirical rating approach named as pot-hole subsidence rating(PHSR),involving the critical parameters with suitable corrections for certain structural and mining conditions to obtain corrected PHSR(CPHSR).CPHSR was then applied for all the 34pot-holes studied and it was found that all the pot-holes fall under Class I and Class II category of risk representing a very high to high risk class.An effort was made for the estimation of pot-hole depth utilizing the developed CPHSR in both the development and depillaring cases.The developed approach was found to yield consistent results in pot-hole depth prediction. | Lokhande D.Ritesh Murthy Vemavarapu M.S.R. Vellanky Venkateswarlu Singh B.Kalendra | 2015 | International Journal of Mining Science and Technology2015，25，2： | 3 |
| 4 | Persistent hepatitis C virus (HCV) infection impairs HCV‐specific cytotoxic T cell reactivity through Mcl‐1/Bim imbalance due to CD127 down‐regulation显示文摘 | J. R. Larrubia M. U. Lokhande S. García‐Garzón J. Miquel A. González‐Praetorius T. Parra‐Cid E. Sanz‐de‐Villalobos | 2012 | Journal of Viral Hepatitis2012，，2： | 3 |
| 5 | Role of T cell death in maintaining immune tolerance during persistent viral hepatitis显示文摘Virus-specific T cells play an important role in the resolution of hepatic infection. However, during chronic hepatitis infection these cells lack their effector functions and fail to control the virus. Hepatitis B virus and hepatitis C virus have developed several mechanisms to generate immune tolerance. One of these strategies is the depletion of virus-specific T cells by apoptosis. The immunotolerogenic liver has unique property to retain and activate na ve T cell to avoid the over reactivation of immune response against antigens which is exploited by hepatotropic viruses to persist. The deletion of the virus-specific T cells occurs by intrinsic (passive) apoptotic mechanism. The pro-apoptotic molecule Bcl-2 interacting mediator (Bim) has attracted increasing attention as a pivotal involvement in apoptosis, as a regulator of tissue homeostasis and an enhancer for the viral persistence. Here, we reviewed our current knowledge on the evidence showing critical role of Bim in viral-specific T cell death by apoptotic pathways and helps in the immune tolerance. | Juan Ramón Larrubia Megha Uttam Lokhande Silvia García-Garzón Joaquín Miquel Dolores Subirá Eduardo Sanz-de-Villalobos | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 6 | Amine loaded zeolites for carbon dioxide capture: Amine loading and adsorption studies显示文摘 | Ravikrishna Chatti Amit K. Bansiwal Jayashri A. Thote Vivek Kumar Pravin Jadhav Satish K. Lokhande Rajesh B. Biniwale Nitin K. Labhsetwar Sadhana S. Rayalu | 2009 | Microporous and Mesoporous Materials2009，，1： | 2 |
| 7 | Chemical synthesis of nano-porous ruthenium oxide(RuO2) thin films for supercapacitor application显示文摘 | PATAKE V D LOKHANDE C D | 2008 | Applied Surface Science2008，254，： | 1 |
| 8 | Biotransformation of nitroaromatics and their effects on mixed function oxidase sys- tem显示文摘 | Soojhawon I Lokhande P D Kodam K M | 2005 | Enzyme and Microbial Technology2005，37，5： | 1 |
| 9 | Formation of GuxS Films through a Chemical Bath Depositon Process显示文摘 | Gadave K M Lokhande C D | 1993 | Thin Solid Films1993，，229： | 1 |
| 10 | 显示文摘 | Sankapal B R Mane R S Lokhande C D | 2000 | Mater Chem Phys2000，63，： | 1 |
| 11 | Electrodeposition of yttrium from a nonaqueous bath显示文摘 | Kumbhar Lokhande C D | 1995 | Metal Finishing1995，，4： | 1 |
| 12 | Process and characterisation of chemical bath deposited manganese sulphide (MnS) thin films 显示文摘 | Lokhande C D Ennaoui A Patil P S | 1998 | Thin Solid Films1998，330，： | 1 |
| 13 | Cathodic electrodeposition of RuO2 thin films from Ru(III)CI3 solution 显示文摘 | PARK B O LOKHANDE C D PARK H S JUNG K D JOO O S | 2004 | Materials Chemistry and Physics2004，87，： | 1 |
| 14 | Electrodeposition of Samarium显示文摘 | Lokhande C D Madhale R D Pawar S H | 1988 | Metal Finishing1988，，8： | 1 |
| 15 | Electrodeposition of thin film semiconductors显示文摘 | Lokhande C D Pawar S H | 1989 | Physica Status Solidi (A)Applied Research1989，111，1： | 1 |
| 16 | Electrodeposition of yttrium from a nonaqueous bath显示文摘 | Kumbhar P P Lokhande C D | 1995 | Metal Finishing1995，93，4： | 1 |
| 17 | Deposition of highly oriented ZnO films by sp-ray pyrolysis and their structural, opti cal and electrical characterization显示文摘 | Lokhande B J Patil P S U plane M D | 2002 | Mater Lett2002，57，： | 1 |
| 18 | Preparation of cobalt oxide thin films and its use in supercapacitor application显示文摘 | KANDALKAR S G GUNJAKAR J L LOKHANDE C D | 2008 | Applied Surface Science2008，254，17： | 1 |
| 19 | Electrodeposition of Lanthanum from Aqueous Bath显示文摘 | Lokhande C D Jadhav M S Pawar S H | 1988 | Metal Finishing1988，，11： | 1 |
| 20 | Electrodeposition of dysprosium from a nonaqueous bath显示文摘 | Lokhande C Kumbhar P | 1994 | Metal Finishing1994，92，11： | 1 |
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