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| 1 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 2 | Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps显示文摘 | Viet Loan Dao Thi Christelle Granier Mirjam B. Zeisel Maryse Guérin Jimmy Mancip Ophélia Granio Fran?ois Penin Dimitri Lavillette Ralf Bartenschlager Thomas F. Baumert Fran?ois-Lo?c Cosset Marlène Dreux | 2012 | Journal of Biological Chemistry2012，，37： | 2 |
| 3 | Mutations within a conserved region of the hepatitis C virus E2 glycoprotein that influence virus-receptor interactions and sensitivity to neutralizing antibodies显示文摘 | Dhillon S Witteveldt J Gatherer D Owsianka A M Zeisel M B Zahid M N | | 0，，： | 1 |
| 4 | Getting closer to the patient:Upgrade of hepatitis C virus infection in primary human hepatocytes显示文摘 | Zeisel MB Turek M Baumert TF | 2010 | J hepatology2010，53，2： | 1 |
| 5 | Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains显示文摘 | NICULESCU M D CRACIUNESCU C N ZEISEL S H | 2006 | FASEB J2006，20，： | 1 |
| 6 | Accurate measure- ment of stable isotopes of lithium by inductively coupled plasma mass spectrometry 显示文摘 | Sun X F Ting B T G Zeisel S H | 1987 | Analyst1987，，112： | 1 |
| 7 | Choline,homocysteine,and pregnancy显示文摘 | Zeisel SH | 2005 | Am J Clin Nutr2005，82，4： | 1 |
| 8 | Creating a Therapeutic Garden That Works for People Living with Alzheimers显示文摘 | Zeisel J | 2007 | Journal of Housing for the Elderly2007，21，34： | 1 |
| 9 | Small molecule scav- enger receptor BI antagonists are potent HCV entry inhibitors 显示文摘 | SYDER A J LEE H ZEISEL MB | 2011 | J Hepatol2011，54，： | 1 |
| 10 | Virus-host Interactions during Hepatitis C Virus Entry-Implications for Pathogenesis and Novel Treatment Approaches显示文摘Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. The liver is the primary target organ of HCV, and the hepatocyte is its primary target cell. Attachment of the virus to the cell surface followed by viral entry is the first step in a cascade of interactions between the virus and the target cell that is required for successful entry into the cell and initiation of infection. This step is an important determinant of tissue tropism and pathogenesis; it thus represents a major target for antiviral host cell responses, such as antibody-mediated virus neutralization. Following the development of novel cell culture models for HCV infection our understanding of the HCV entry process and mechanisms of virus neutralization has been markedly advanced. In this review we summarize recent developments in the molecular biology of viral entry and its impact on pathogenesis of HCV infection, development of novel preventive and therapeutic antiviral strategies. | Joachim Lupberger Mirjam B. Zeisel Anita Haberstroh Eva K. Schnober Sophie Krieger Eric Soulier Christine Thumann Cathy Royer Samira Fafi-Kremer Catherine Schuster Franoise Stoll-Keller Hubert E. Blum Thomas F. Baumert | 2008 | Virologica Sinica2008，23，2： | 1 |
| 11 | Dietary choline:biochemistry,physiology,and pharmacology显示文摘 | Zeisel S H | 1981 | Annual Review of Nutrition1981，1，1： | 1 |
| 12 | Is maternal diet supplementation beneficial Optimal development of infant depends on mother's diet显示文摘 | Zeisel SH | 2009 | The American Journal of Clinical Nutrition2009，89，2： | 1 |
| 13 | Choline deficiency显示文摘 | Zeisel S H | 1990 | Nutrition reports international1990，1，7： | 1 |
| 14 | Choline:needed for normal development of memory显示文摘 | Zeisel S H | 2000 | Journal of the American College of Nutrition2000，19，5： | 1 |
| 15 | Conversion of dietary choline to trimethylamine and dimethylamine in rats:Dose-response relationship显示文摘 | Zeisel SH daCosta KA Youssef M | | 0，，05： | 1 |
| 16 | Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolarnine in bovine brain 显示文摘 | BLUSZTAJN J K ZEISEL S H WURTMAN R J | 1979 | Brain Research1979，179，2： | 1 |
| 17 | EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy显示文摘 | Lupberger J Zeisel MB Xiao F | 2011 | Nature Medicine2011，17，5： | 1 |
| 18 | Nutrigenomics and metabolomics will change clinical nutrition and public health practice : insights from studies on dietary requirements for choline显示文摘 | Zeisel S H | 2007 | The American Journal of Clinical Nutrition2007，86，3： | 1 |
| 19 | Getting closer to the patient:upgrade of hepatitis C virus infection in primary human hepatocytes显示文摘 | Zeisel MB Turek M Baumert TF | 2010 | J Hepatol2010，53，2： | 1 |
| 20 | Towards an HBV cure : state - of - the - art and unresolved questions - report of the ANRS workshop on HBVcure显示文摘 | ZEISEL MB LUCIFORA J MASON WS | 2015 | Gut2015，64，8： | 1 |
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