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| 1 | Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions显示文摘AIM To investigate daclatasvir(DCV) and asunaprevir(ASV) efficacy in hepatitis C(HCV) patients, with respect to resistance-associated substitutions(RASs).METHODS A total of 392 HCV-infected patients from multiple centers were included in this study. We evaluated their clinical courses and sustained virologic responses(SVR) according to pretreatment factors(gender, age, history of interferon-based regimens, platelet counts, level of viremia, pretreatment NA5A:L31, and Y93 substitutions). We also analyzed the pretreatment and post-treatment major RASs of NS3:D168, NS5A:L31 and Y93 substitutions using a direct-sequencing method in 17 patients who were unable to achieve SVR at 12 wk after treatment completion(SVR12).RESULTS The overall SVR12 rate was 88.3%. Thirty-one patients discontinued treatment before 24 wk because of adverse events, 23 of whom achieved SVR12. There were no significant differences in SVR12 rates with respect to gender, age, history of interferon-based regimens, and platelet counts. The SVR12 rate in patients with viral loads of ≥ 6.0 log IU/m L was significantly lower than those with viral loads of < 6.0 log IU/m L(P < 0.001). The SVR12 rate in patients with Y93 substitution-positive was significantly lower than those with Y93 substitution-negative(P < 0.001). The L31 substitution-positive group showed a lower SVR12 rate than the L31 substitution-negative group, but the difference was not statistically significant. Seventeen patients who did not achieve SVR12 and had available pretreatment and post-treatment sera had additional RASs in NS3:D168, NS5:L31, and Y93 substitution at treatment failure.CONCLUSION Combination of DCV and ASV is associated with a high SVR rate. Baseline RASs should be thoroughly assessed to avoid additional RASs after treatment failure. | Hideki Fujii Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi Hideki Nakamura Kohichiroh Yasui Masahito Minami Saiyu Tanaka Hiroki Ishikawa Hiroyuki Kimura Shiro Takami Yasuyuki Nagao Toshihide Shima Yoshito Itoh | 2017 | World Journal of Hepatology2017，9，25： | 3 |
| 2 | Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine显示文摘 | Hiroshi Watanabe Qi Zhao Kinzo Matsumoto Michihisa Tohda Yukihisa Murakami Shao-Hui Zhang Tae-Hyun Kang Pramote Mahakunakorn Yukiko Maruyama Iwao Sakakibara Norio Aimi Hiromitsu Takayama | 2003 | Pharmacology Biochemistry and Behavior2003，，3： | 1 |
| 3 | Development of impact type sensor for heading feeding combine 显示文摘 | Choung Koun Lee Michihisa Iida Toshikazu Kaho | 2000 | Journal of the JSAM2000，62，4： | 1 |
| 4 | Development of an end-effector for a tomato cluster harvesting robot显示文摘 | Naoshi Kondo Koki Yata Michihisa Iida | 2010 | Engineering in Agriculture Environment and Food2010，3，1： | 1 |
| 5 | Liver-specific contrast agent-enhanced magnetic resonance and 18F-fluorodeoxyglucose positron emission tomography findings of hepatocellular adenoma: report of a case显示文摘 | Tatsuaki Sumiyoshi Michihisa Moriguchi Hideyuki Kanemoto Kouiku Asakura Keiko Sasaki Teiichi Sugiura Takashi Mizuno Katsuhiko Uesaka | 2012 | Surgery Today2012，，2： | 1 |
| 6 | Free volumes in polystyrene probed by positron annihilation显示文摘 | Megumi Ban Michihisa Kyoto Akira Uedono Takao Kawano Shoichiro Tanigawa | 1996 | Joumal of Polymer Science: Part B: Polymer Physics1996，34，： | 1 |
| 7 | Coatings of Nb-based alloy by Cr and/or Al pack cementations and its oxidations behavior in air at 1273-1473K 显示文摘 | Michihisa Fukumoto Yuzi Matsumura higenari Hayashi | 2003 | Materials Transactions2003，44，4： | 1 |
| 8 | A collaborative platform for sustainable building design based on model integration over the internet显示文摘 | Kraines Steven Koyama Michihisa Weber Celine | 2005 | International Journal of Environmental Technology and Management2005，5，23： | 1 |
| 9 | Tight -binding quantum chemical molecular dynamics simulation ofmechano- chemical reactions during chemical mechanical polishing process of SiO2 surface by CeOz particle 显示文摘 | Arivazhagan Rajendran Yasufumi Takahashi Michihisa Koyama | 2005 | Applied Surface Science2005，244，： | 1 |
| 10 | Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic respon ses in the rat hippocampus显示文摘 | Yaowared S Yukihis N Michihisa M | 2007 | Biol Pharm Bull2007，30，9： | 1 |
| 11 | Development of impact type sensor for heading feeding combine显示文摘 | Choung Koun Lee Michihisa Iida Toshikazu Kaho | 2000 | Journal of the JSAM2000，62，4： | 1 |
| 12 | Milbemycin:Discovery and Development显示文摘 | Junya Ide Takao Okazaki Michihisa Ono | 1993 | Annu Rep Sankyo Res Lab1993，45，： | 1 |
| 13 | The potential of brain natriuretic peptide as a biomarker for New York Heart Association class during the outpatient treatment of heart failure显示文摘 | Shang-Chiun Lee Tracy L. Stevens Sharon M. Sandberg Denise M. Heublein Susan M. Nelson Michihisa Jougasaki Margaret M. Redfield John C. Burnett | 2002 | Journal of Cardiac Failure2002，，3： | 1 |
| 14 | Coalings ofNb-Bascxt AUoy by Cr and/or A1 Pack Cementations and its Oxidation Behavior in Air at 1273 1473 K显示文摘 | Michihisa Fukumoto Yuzi Matsumura Shigenari Hayashi et al | 2003 | Transactions2003，44，4： | 1 |
| 15 | Cytoprotective and cytotoxic effects of curcumin: dual action on H2O2-induced oxidative cell damage in NG108-15 Cells显示文摘 | Pramote M Michihisa T Yukihisa M Kinzo M Hiroshi W Opa V | 2003 | Biol Pharm Bull2003，26，： | 1 |
| 16 | Coatings of Nb-Based Alloy by Cr and/or Al Pack Cementations and its Oxidation Behavior in Air at 1273 ~1473 K显示文摘 | Yuzi Matsumura Shigenari Hayashi | 2003 | Materials Transactions2003，44，4： | 1 |
| 17 | Cardiotrophin-1 in Cardiovascular Regulation显示文摘 | Michihisa Jougasaki | 2010 | Advances in Clinical Chemistry2010，，： | 1 |
| 18 | Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin 显示文摘 | Yaowared Sumanont Yukihisa Murakami Michihisa Tohda | 2006 | Life Sciences2006，78，1： | 1 |
| 19 | Predictors of malignancies and overall mortality in J apanese patients with biopsy‐proven non‐alcoholic fatty liver disease显示文摘 | Yuya Seko Yoshio Sumida Saiyu Tanaka Hiroyoshi Taketani Kazuyuki Kanemasa Hiroshi Ishiba Akira Okajima Takeshi Nishimura Kanji Yamaguchi Michihisa Moriguchi Hironori Mitsuyoshi Kohichiroh Yasui Masahito Minami Yoshito Itoh | 2015 | Hepatol Res2015，，7： | 1 |
| 20 | Effect of Water Vapor on the Oxidation Behavior of Fe–1.5Si in Air at 1073 and 1273 K显示文摘 | Michihisa Fukumoto Shigeru Maeda Shigenari Hayashi Toshio Narita | 2001 | Oxidation of Metals (-)2001，，5： | 1 |
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