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| 1 | Efficacy and safety of emergency endoscopic retrograde cholangiopancreatography for acute cholangitis in the elderly显示文摘AIM To investigate the efficacy and safety of emergency endoscopic retrograde cholangiopancreatography(ERCP) in elderly patients with acute cholangitis. METHODS From June 2008 to May 2016, emergency ERCPs were performed in 207 cases of acute cholangitis at our institution. Patients were classified as elderly if they were aged 80 years and older(n = 102); controls were under the age of 80 years(n = 105). The patients' medical records were retrospectively reviewed for comorbidities, laboratory data, etiology of cholangitis(presence of biliary stones, biliary stricture and malignancy), details of the ERCP(therapeutic approaches, technical success rates, procedure duration), ERCP-related complications and mortality. RESULTS The frequency of comorbidities was higher in the elderly group than the control group(91.2% vs 67.6%). Periampullary diverticulum was observed in the elderly group at a higher frequency than the control group(24.5% vs 13.3%). Between the groups, there was no significant difference in the technical success rates(95.1% vs 95.2%) or endoscopicprocedure durations. With regard to the frequency of ERCP-related complications, there was no significant difference between the two groups(6.9% vs 6.7%), except for a lower rate of post-ERCP pancreatitis in the elderly group than in the control group(1.0% vs 3.8%). Neither angiographic nor surgical intervention was required in any of the cases with ERCP-related complications. There was no mortality during the observational periods. CONCLUSION Emergency ERCP for acute cholangitis can be performed safely even in elderly patients aged 80 years and older. | Gen Tohda Masahiro Ohtani Masaki Dochin | 2016 | World Journal of Gastroenterology2016，22，37： | 28 |
| 2 | Gastric adenocarcinoma of fundic gland type:Endoscopicand clinicopathological features显示文摘Gastric adenocarcinoma of fundic gland type(GA-FG) with chief cell differentiation was recently proposed as an extremely rare type of gastric adenocarcinoma. Here, we report 4 cases of GA-FG with chief cell differentiation. Endoscopic features included a submucosal tumor shape or a flat shape, whitish discoloration and dilated vessels on the surface. The tumors were located in the upper or middle third of the stomach. All cases were preoperatively diagnosed as GA-FG by biopsy, and endoscopic submucosal dissection was performed. Resected specimens revealed well-differentiated adenocarcinomas resembling chief cells. Tumor cells were diffusely positive for pepsinogen-Ⅰ, but partially positive for H+/K+-ATPase in scattered locations around the tumor margin. Despite the presence of minimal invasion of the carcinoma into the submucosal layer, which was observed in two cases, neither lymphatic nor venous invasion was detected in any of the cases. Finally, all cases showed less aggressive clinical behavior with low grade malignancy. | Gen Tohda Takeshi Osawa Yasuyuki Asada Masaki Dochin Shintarou Terahata | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 26 |
| 3 | Management of endoscopic biliary stenting for choledocholithiasis: Evaluation of stent-exchange intervals显示文摘AIM To evaluate the best management of plastic stents in patients with choledocholithiasis who were unfit for endoscopic stone removal or surgery. METHODS Between April 2007 and September 2017, 87 patients(median age 83.7 years) with symptomatic choledocholithiasis were treated with insertion of 7-Fr plastic stents because complete endoscopic stone retrieval was difficult, and their general condition was not suitable for surgery. Seventy of these patients agreed to regular stent management and stent exchange was carried out at every 6 mo(Group A, n = 35) or every 12 mo(Group B, n = 35). The remaining 17 patients did not accept regular stent exchange, and stents were replaced when clinical symptoms appeared(Group C). We evaluated the frequency of biliary complication and stent patency rate during follow-up periods. RESULTS The patency rate of biliary plastic stents was 91.4% at 6 mo(Group A) and 88.6% at 12 mo(Group B), respectively. Acute cholangitis occurred in 2.9% of Group A patients and in 8.6% of Group B patients. In Group C, median stent patency was 16.3 mo, and stent exchange was carried out in 70.6% of cases because of acute cholangitis or obstructive jaundice. Although a high incidence of acute cholangitis occurred, there was no biliary-related mortality. CONCLUSION Plastic stent exchange at 12-mo intervals is considered a safe procedure for patients with choledocholithiasis. Long-term biliary stenting increases biliary complications, but it can be an acceptable option for select patients who are medically unfit for further invasive procedures. | Gen Tohda Masaki Dochin | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 5 |
| 4 | Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury显示文摘In chronic phase of spinal cord injury, functional recovery is more untreatable compared with early intervention in acute phase of spinal cord injury. In the last decade, several combination therapies successfully improved motor dysfunction in chronic spinal cord injury. However, their effectiveness is not sufficient. We previously found a new effective compound for spinal cord injury, matrine, which induced axonal growth and functional recovery in acute spinal cord injury mice via direct activation of extracellular heat shock protein 90. Although our previous study clarified that matrine was an activator of extracellular heat shock protein 90, the potential of matrine for spinal cord injury in chronic phase has not been sufficiently evaluated. Thus, this study aimed to investigate whether matrine ameliorates chronic spinal cord injury in mice. Once daily intragastric administration of matrine(100 μmol/kg per day) to spinal cord injury mice were starte at 28 days after injury, and continued for 154 days. Continuous mat rine treatment improved hindlimb motor function in chronic spinal cord injury mice. In injured spinal cords of the matrine-treated mice, the density of neurofilament-H-positive axons was increased. Moreover, matrine treatment increased the density of bassoon-positive presynapses in contact with choline acetyltransferase-positive motor neurons in the lumbar spinal cord. These findings suggest that matrine promotes remodeling and reconnection of neural circuits to regulate hindlimb movement. All protocols were approved by the Committee for Animal Care and Use of the Sugitani Campus of the University of Toyama(approval No. A2013 INM-1 and A2016 INM-3) on May 7, 2013 and May 17, 2016, respectively. | Norio Tanabe Tomoharu Kuboyama Chihiro Tohda | 2019 | Neural Regeneration Research2019，14，11： | 5 |
| 5 | Posteruptive changes in human dental fluorosis- and histological and ultrastructural study 显示文摘 | Ferjerskov O Yanagisawa T Tohda H | 1991 | Proc Finn Dent Soc1991，87，4： | 1 |
| 6 | Assessment of serum CY- FRA21-1 in lung caner显示文摘 | Muraki M Tohda Y Lwangaga T | 2006 | Anticancer Res2006，77，12： | 1 |
| 7 | Assessment of serum CYFRA21-1 in lung cancer 显示文摘 | Tohda Y Iwanaga T | 1996 | Cancer1996，77，： | 1 |
| 8 | Abeta(25-35)-induced memory impairment,axonal atrophy,and synaptic loss are ameliorated by M1,A metabolite of protopanaxadiol-type saponins显示文摘 | Tohda C Matsumoto N Zou K | 2004 | Neuropsychopharmacology2004，29，： | 1 |
| 9 | Assessment of serum CYFRA21-1 in lung cancer显示文摘 | Muraki M Tohda Y Iwanaga T | 1996 | Cancer1996，77，： | 1 |
| 10 | Leukotriene receptor antagonist,montelukast,can reduce the need for inhaled steroid while maintaining the clinical stability of asthmatic patients显示文摘 | Tohda Y Fujimura M Taniguchi H | 2002 | Clin Exp Allergy2002，32，8： | 1 |
| 11 | Promotion of axonal maturation and prevention of memory loss in mice by extracts of astragalus mongholicus 显示文摘 | Tohda C Tamura T Matsuyama S | 2006 | Br J Pharmacol2006，149，5： | 1 |
| 12 | Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine显示文摘 | Hiroshi Watanabe Qi Zhao Kinzo Matsumoto Michihisa Tohda Yukihisa Murakami Shao-Hui Zhang Tae-Hyun Kang Pramote Mahakunakorn Yukiko Maruyama Iwao Sakakibara Norio Aimi Hiromitsu Takayama | 2003 | Pharmacology Biochemistry and Behavior2003，，3： | 1 |
| 13 | Assessment of serum CYFRA21-1 in lung cancer显示文摘 | Tohda Y lwanaga T | 1996 | Cancer1996，77，： | 1 |
| 14 | Selective potentiation of N-methyl-D-aspartate-induced current by protein kinase C in Xenopus oocytes injected with rat brain RNA显示文摘 | Urushihara H Tohda M Nomura Y | 1992 | J Biol Chem1992，267，11： | 1 |
| 15 | Fiber-Optic Magnesium and Calcium Ion Sensor Based on a Natural Carboxylic Polyether Antibiotic显示文摘 | Suzuki K Ohzora H Tohda K | 1989 | Anal Chem1989，61，4： | 1 |
| 16 | Propofol sedation during endoscopic procedures:Safe and effective administration by registered nurses supervised by endoscopists显示文摘 | Tohda G Higashi S Wakahara S Morikawa M Sakumoto H Kane T | 2006 | Endoscopy2006，38，： | 1 |
| 17 | Optimized LiMnyFe1-yPO4 as the cathode for lithium batteries显示文摘 | Li G H Azuma H Tohda M | 2002 | J Electrochem Soc2002，149，6： | 1 |
| 18 | Histopathology of the air- way epithelium in an experimental dual-phase model of bron- chial asthma显示文摘 | Tohda Y Kubo H Ito M | 2001 | Clin Exp Allergy2001，31，1： | 1 |
| 19 | Optimized LiMnyFe1-yPO4 as the cathode for lithium batteries显示文摘 | Azuma H Tohda M | 2002 | J Electrochem Soc2002，149，： | 1 |
| 20 | Assessment of serum CYRFA21-1 in lung cancer显示文摘 | Muraki M Tohda Y Iwanaga T | 1996 | Cancer1996，77，： | 1 |
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