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| 1 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 2 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 3 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 4 | Developing pharmaceutical care plans for desired outcomes显示文摘 | Dennis JM Bruce CC Michael TR | 1996 | J Am Pharm Assoc1996，36，4： | 1 |
| 5 | Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence显示文摘 | Akial NV Michael TD Pedro TR | 2004 | Gynecol Oncol2004，93，： | 1 |
| 6 | Clinical, angiographic, and procedural predictors of periprocedural complications during chronic total occlusion percutaneous coronary intervention 显示文摘 | Patel VG Michael Tr Mogabgab O | 2014 | J In- vasive Cardiol2014，26，3： | 1 |
| 7 | Developing pharmaceutical care plans for desired utcomes显示文摘 | Dennis JM Bruce CC Michael TR | 1996 | J Am Pharrn Assoc1996，36，4： | 1 |
| 8 | Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas显示文摘 | Michael Pfreundschuh Lorenz Trümper Marita Kloess | 2004 | Blood2004，104，： | 1 |
| 9 | Developing pharmaceutical care plans for desired outcomes显示文摘 | Bruce CC Michael TR | 1996 | J Am Pharm Assoc1996，36，4： | 1 |
| 10 | Bacterial endophthalmttis: Therapeutic challenges and host-pathogen intemctions显示文摘 | Michelle CC Michael SG Meredith G Raniyah TR Brandt JW Andrea LM | 2007 | Pro Re tinal E vie Res2007，26，： | 1 |
| 11 | Developing pharmaceutical care plans fordesired outcomes 显示文摘 | Dennis JIII Brace CC Michael TR | 1996 | JAm PharmAssoc1996，36，4： | 1 |
| 12 | The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity 显示文摘 | John TR Michael CA Chris JM | 2007 | Neuron2007，54，： | 1 |
| 13 | Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: initial clinical experience显示文摘 | Michael JM Scott TR | 1997 | Am Heart J1997，133，11： | 1 |
| 14 | CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group显示文摘 | Michael Pfreundschuh Lorenz Trümper Anders ?sterborg Ruth Pettengell Marek Trneny Kevin Imrie David Ma Devinder Gill Jan Walewski Pier-Luigi Zinzani Rolf Stahel Stein Kvaloy Ofer Shpilberg Ulrich Jaeger Mads Hansen Tuula Lehtinen Armando López-Guillermo C | 2006 | Lancet Oncology2006，，5： | 1 |
| 15 | Treatment of medically- and surgically refractory angina pectoriswith high thoracic epidural an- algesia:initial clinical experience显示文摘 | Grambling-Babb P Michael JM Scott TR | 1997 | Am Heart J1997，133，6： | 1 |
| 16 | Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: initial clinical experience显示文摘 | Grambling-Babb P Michael JM Scott TR | 1997 | Am Heart J1997，133，： | 1 |
| 17 | CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group显示文摘 | Michael Pfreundschuh Evelyn Kuhnt Lorenz Trümper Anders ?sterborg Marek Trneny Lois Shepherd Devinder S Gill Jan Walewski Ruth Pettengell Ulrich Jaeger Pier-Luigi Zinzani Ofer Shpilberg Stein Kvaloy Peter de Nully Brown Rolf Stahel Noel Milpied Armando Ló | 2011 | Lancet Oncology2011，，11： | 1 |
| 18 | Growth characteristics and imaging properties of the morris hepatoma 3924a in ACI rats: A suitable model for transarterial chemoembolization显示文摘 | Jochen Trübenbach Florian Graepler Philippe L Pereira Peter Ruck Ulrich Lauer Michael Gregor Claus-D. Claussen Peter E. Huppert | 2000 | Cardiovascular and Interventional Radiology2000，，3： | 1 |
| 19 | A phase I study of Adp53(INGN 201; ADVEXIN) for patients with platinum-and paclitaxel-resistant epithelial ovarian cancer显示文摘 | Judith KW Diane CB Jacalyn BG Michael D Lois R Pedro TR | 2004 | Gynecol Oncol2004，94，： | 1 |
| 20 | Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease显示文摘 | Michael Fernandez Eric Trépo Delphine Degré Thierry Gustot Laurine Verset Pieter Demetter Jacques Devière Michael Adler Christophe Moreno | 2015 | European Journal of Gastroenterology & Hepatology2015，，： | 1 |
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